The number and distribution of detectable luteinizing hormone (LH)-releasing hormone cell bodies changes in association with the preovulatory LH surge in the brains of young but not middle-aged female rats.

abstract：:We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. 7alpha-Hydroxypregnenolone stimulates locomotor activity of male newts. Locomotor activity of male newts increases during the breeding period as in o...

journal_title：Endocrinology

authors： Haraguchi S,Koyama T,Hasunuma I,Vaudry H,Tsutsui K

更新日期：2010-05-01 00:00:00

abstract：:Oxytocin stimulates phosphoinositide turnover in myometrium. To elucidate whether the coupling mechanism involves the interaction of oxytocin receptor with GTP-binding proteins, we examined oxytocin stimulation of guanosine triphosphatase (GTPase) activity and phospholipase-C activity in rat and human myometrial membr...

journal_title：Endocrinology

authors： Ku CY,Qian A,Wen Y,Anwer K,Sanborn BM

更新日期：1995-04-01 00:00:00

abstract：:The injection of chlorpropamide into Brattleboro homozygous rats (di/di) has previously been shown to result in enhanced activation of renal medullary adenylate cyclase activity and increased renal medullary content of cAMP in response to 1-desamino-8-D-arginine vasopressin (dDAVP). In contrast, in vivo chlorpropamide...

journal_title：Endocrinology

authors： Moses AM,Fenner R,Schroeder ET,Coulson R

更新日期：1982-12-01 00:00:00

abstract：:It has been suggested that ewes carrying the Booroola gene (Fec(B)) consistently ovulate more follicles because they recruit more primordial follicles and/or have a lower rate of atresia. If the former is correct, the pool of follicles would be depleted sooner in Fec(B) animals. We have studied follicular dynamics and...

journal_title：Endocrinology

authors： Gonzalez-Bulnes A,Souza CJ,Campbell BK,Baird DT

更新日期：2004-06-01 00:00:00

abstract：:Thyroid dysfunction during human pregnancy is closely related to serious pregnancy outcome. However, the regulation and function of thyroid hormones during early pregnancy are largely unknown. We found that type II deiodinase, an enzyme converting T4 to activated T3, is highly expressed in the mouse uterus on days 3 a...

journal_title：Endocrinology

authors： Deng WB,Liang XH,Liu JL,Yang ZM

更新日期：2014-07-01 00:00:00

abstract：:We have previously established the value of 2-dimensional electrophoretic mRNA activity profiles for investigating the hepatic genomic response to several metabolic perturbations, such as thyroid hormone or GH treatment, diabetes, high carbohydrate diet, starvation, and uremia. We now report the effects of adrenalecto...

journal_title：Endocrinology

authors： Beyer HS,Carr FE,Mariash CN,Oppenheimer JH

更新日期：1985-06-01 00:00:00

abstract：:Adrenomedullin (ADM) is a potent vasorelaxant peptide that plays important roles in cardiovascular homeostasis and inflammatory response. ADM derived from macrophages is one of the major sources of ADM that is produced in the inflammatory process. To assess the functions of ADM in inflammation, we studied the temporal...

journal_title：Endocrinology

authors： Wong LY,Cheung BM,Li YY,Tang F

更新日期：2005-03-01 00:00:00

abstract：:The cells from the 2B8 clonal strain of pituitary cells which previously have been reported to produce only PRL were incubated with varying amounts of ovine PRL (oPRL) ranging from 0.01--1000 ng/ml. After 1 h, significantly less PRL was measured in culture media from cells incubated with all doses of oPRL employed. Th...

journal_title：Endocrinology

authors： Herbert DC,Ishikawa H,Rennels EG

更新日期：1979-01-01 00:00:00

abstract：:Previous studies established the existence of an FSH-inducible rat granulosa cell-derived insulin-like growth factor binding protein (IGFBP)-5 endopeptidase. It was the objective of this communication to characterize this activity in some detail. Exposure of [125I]rhIGFBP-5 substrate to media conditioned by FSH-treate...

journal_title：Endocrinology

authors： Resnick CE,Fielder PJ,Rosenfeld RG,Adashi EY

更新日期：1998-03-01 00:00:00

abstract：:Proper development of the seminiferous tubules (or testis cords in embryos) is critical for male fertility. Sertoli cells, somatic components of the seminiferous tubules, serve as nurse cells to the male germline, and thus their numbers decide the quantity of sperm output in adulthood. We previously identified activin...

journal_title：Endocrinology

authors： Archambeault DR,Tomaszewski J,Childs AJ,Anderson RA,Yao HH

更新日期：2011-11-01 00:00:00

abstract：:The objective of this study was to assess estrogen-dependent cellular mechanisms that could contribute to the acid pH of the vaginal lumen. Cultures of normal human cervical-vaginal epithelial (hECE) cells and endocervical cells were grown on filters, and acidification of the extracellular solutions on the luminal (L-...

journal_title：Endocrinology

authors： Gorodeski GI,Hopfer U,Liu CC,Margles E

更新日期：2005-02-01 00:00:00

abstract：:The present study investigates the effect of different endocrine manipulations on the gamma-aminobutyric acid (GABA)-ergic system in the rat fallopian tube. Either hypophysectomy or ovariectomy induced a significant decrease of glutamic acid decarboxylase (GAD) activity and of GABA levels in in situ tubes. This effect...

journal_title：Endocrinology

authors： Celotti F,Apud JA,Melcangi RC,Masotto C,Tappaz M,Racagni G

更新日期：1986-01-01 00:00:00

abstract：:GH is a pleiotropic hormone that plays a major role in proliferation, differentiation, and metabolism via its specific receptor. It has been previously suggested that GH signaling pathways are required for normal liver regeneration but the molecular mechanisms involved have yet to be determined. The aim of this study ...

journal_title：Endocrinology

authors： Zerrad-Saadi A,Lambert-Blot M,Mitchell C,Bretes H,Collin de l'Hortet A,Baud V,Chereau F,Sotiropoulos A,Kopchick JJ,Liao L,Xu J,Gilgenkrantz H,Guidotti JE

更新日期：2011-07-01 00:00:00

abstract：:A subline of an x-ray-induced transplantable rat insulinoma has been studied in vivo and in vitro. Tumors grew rapidly after sc transplantation and were rich in insulin, but contained only small amounts of glucagon and somatostatin. Despite marked basal hyperinsulinemia, iv glucose administration caused a further incr...

journal_title：Endocrinology

authors： Masiello P,Wollheim CB,Janjic D,Gjinovci A,Blondel B,Praz GA,Renold AE

更新日期：1982-12-01 00:00:00

abstract：:Daily treatment with 1 mg of the GnRH antagonist [Ac-delta 3-Pro1,pC1-D-Phe2,D-Trp3,6,N alpha MeLeu7]-GnRH abolished mating behavior and disrupted spermatogenesis in male rats within 2 weeks. This was accompanied by a sharp decrease in plasma testosterone (T) levels as well as sexual organ weights while body weight re...

journal_title：Endocrinology

authors： Rivier C,Rivier J,Vale W

更新日期：1981-05-01 00:00:00

abstract：:We have previously demonstrated that cultured rat thyroid cells do not exhibit constitutive expression of major histocompatibility (MHC) class II antigens. Using reovirus types 1 and 3, we infected 1B-6 cells (a cloned derivative of the Fisher rat cell line FRTL-5), and found a dose-dependent induction of thyroid cell...

journal_title：Endocrinology

authors： Neufeld DS,Platzer M,Davies TF

更新日期：1989-01-01 00:00:00

abstract：:Commercially available preparations of natural porcine glucose-dependent insulinotropic polypeptide (GIP) were subjected to reverse phase HPLC. The material was found to give rise to 4 peaks which were characterized by HPLC-retention time and N-terminal sequence analysis. They represented: intact porcine GIP(1-42), 58...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Kümmel H,Gallwitz B,Creutzfeldt W

更新日期：1987-02-01 00:00:00

abstract：:We have studied whether activation of cell adhesion kinase beta (CAKbeta) is involved in stretch-induced signaling pathway in cultured rat vascular smooth muscle cells. Cyclic stretch (1 Hz) induced a rapid (within 1 min) phosphorylation of CAKbeta, whose effect was time and strength dependent. Both Ca(2+) and Na(+) i...

journal_title：Endocrinology

authors： Iwasaki H,Yoshimoto T,Sugiyama T,Hirata Y

更新日期：2003-06-01 00:00:00

abstract：:Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues b...

journal_title：Endocrinology

authors： Karpuzoglu E,Fenaux JB,Phillips RA,Lengi AJ,Elvinger F,Ansar Ahmed S

更新日期：2006-02-01 00:00:00

abstract：:Ewes were treated systemically during the periovulatory period with the antihistamines diphenhydramine (H1-receptor antagonist) and(or) cimetidine (H2-receptor antagonist). None of the treatments prevented ovulation. However, the combination of drugs inhibited subsequent function of the corpus luteum (CL) as assessed ...

journal_title：Endocrinology

authors： Halterman SD,Murdoch WJ

更新日期：1986-12-01 00:00:00

abstract：:We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...

journal_title：Endocrinology

authors： Shimizu Y,Tanishita T,Minokoshi Y,Shimazu T

更新日期：1997-01-01 00:00:00

abstract：:Prolactin (PRL) is an immunomodulatory hormone which promotes T-cell activation and proliferation. However, the intracellular mechanisms of this action in normal lymphocytes are unknown. Because the PRL receptor (PRLR) activates several signals also activated by the T-cell antigen receptor (TCR)/CD3 complex, we evalua...

journal_title：Endocrinology

authors： Montgomery DW,Krumenacker JS,Buckley AR

更新日期：1998-02-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) and arcuate nucleus (ARC) have reciprocal connections; catabolic metabolic information activates the ARC and inhibits SCN neuronal activity. Little is known about the influence of the SCN on the ARC. Here, we investigated whether the SCN modulated the sensitivity of the ARC to catabol...

journal_title：Endocrinology

authors： Herrera-Moro Chao D,León-Mercado L,Foppen E,Guzmán-Ruiz M,Basualdo MC,Escobar C,Buijs RM

更新日期：2016-09-01 00:00:00

abstract：:The role of nutrients and hormones in the regulation of glucagon release is investigated in pancreatic A cells purified by autofluorescence-activated cell sorting. Purified A cells lack secretory activity in 1-h incubation at 1.4 mM glucose. Their release mechanism can be activated by arginine, alanine, and glutamine,...

journal_title：Endocrinology

authors： Pipeleers DG,Schuit FC,Van Schravendijk CF,Van de Winkel M

更新日期：1985-09-01 00:00:00

abstract：:We examined whether mitogen-activated protein (MAP) kinase was activated by stimulation of the cAMP pathway and whether MAP kinase activation was involved in synthesis of PRL and GH in GH(3) cells. Treatment of the cells with a cAMP analog, 8-(4-chlorophenylthio)cAMP (CPT-cAMP), activated MAP kinase and increased PRL ...

journal_title：Endocrinology

authors： Yonehara T,Kanasaki H,Yamamoto H,Fukunaga K,Miyazaki K,Miyamoto E

更新日期：2001-07-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) fed at 0.4% in the diet is known to exert strong antihyperglycemic effects in C57BL/KsJ genetically diabetic (db/db) mice. Three of the major metabolic products of DHEA; DHEA sulfate, alpha-hydroxyetiocholanolone (alpha-ET), and beta-hydroxyetiocholanolone (beta-ET) when fed at 0.1% in th...

journal_title：Endocrinology

authors： Coleman DL,Leiter EH,Applezweig N

更新日期：1984-07-01 00:00:00

abstract：:Sodium vanadate, an agent known to have multiple cellular actions, was studied for its effects on aspects of bone formation in cultures of 21-day-old fetal rat calvariae. Vanadate (0.1-10 microM) stimulated the incorporation of [3H] thymidine into acid-insoluble residues (DNA); the effect appeared after 3 h and was su...

journal_title：Endocrinology

authors： Canalis E

更新日期：1985-03-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) are proinflammatory cytokines that affect the secretion of several neuroendocrine hormones. In addition, glial cells synthesize and release IL-6, suggesting a paracrine role for this cytokine in the brain. We have examined the regulation of IL-6 release from glial ...

journal_title：Endocrinology

authors： Zumwalt JW,Thunstrom BJ,Spangelo BL

更新日期：1999-02-01 00:00:00

abstract：:We have examined expression of the chicken PRL receptor (cPRLR) gene in different tissues of the chicken by Northern blot analysis. Most tissues examined (ovary, testis, oviduct, kidney, and fat) possess a prominent full-length (4.6-kb) cPRLR transcript. A larger (11.7-kb) transcript is also detected in ovary, oviduct...

journal_title：Endocrinology

authors： Mao JN,Burnside J,Li L,Tang J,Davolos C,Cogburn LA

更新日期：1999-03-01 00:00:00

abstract：:Addition of calcitonin gene-related peptide (CGRP), 1 X 10(-7) M, to cultured neonatal rat heart cells resulted in rapid increases in beating rate and cellular concentrations of cAMP. Calcitonin (1 X 10(-7) M), in contrast, had no significant effect on heart cell beating rate or cAMP content. CGRP-stimulated increases...

journal_title：Endocrinology

authors： Fisher RA,Robertson SM,Olson MS

更新日期：1988-07-01 00:00:00