Endocrine modulation of gamma-aminobutyric acidergic innervation in the rat fallopian tube.

Abstract:

:The present study investigates the effect of different endocrine manipulations on the gamma-aminobutyric acid (GABA)-ergic system in the rat fallopian tube. Either hypophysectomy or ovariectomy induced a significant decrease of glutamic acid decarboxylase (GAD) activity and of GABA levels in in situ tubes. This effect was completely reversed by either gonadotropins or combined estrogen-progesterone administration, respectively. Estrogen or progesterone alone proved less effective than the administration of both steroids in counteracting the effect of ovariectomy on GAD activity. The in vitro incubation of ovariectomized rat fallopian tubes with estrogen-progesterone for 1 h failed to counteract the reduction of the GAd activity induced by surgical manipulation. The in vivo effect of estrogen-progesterone administration on the GABA-ergic system seems to be specific since steroid treatment induced the synthesis of an enzyme which was immunologically identical to the GAD present in the fallopian tube and brain of normal diestrous rat. Autotransplantation of the fallopian tube under the skin brought about a decrease of GAD activity similar to that obtained after ovariectomy. In this situation, however, estrogen-progesterone administration did not counteract the decrease of GAD activity induced by fallopian tube deafferentation. The present results demonstrate that an interaction between the GABA-ergic system and the hypothalamo-pituitary-gonadal axis seems to be operative at the level of the rat fallopian tube. However, the physiological meaning of this interrelationship between the endocrine and the peripheral nervous systems remains to be clarified.

journal_name

Endocrinology

journal_title

Endocrinology

authors

Celotti F,Apud JA,Melcangi RC,Masotto C,Tappaz M,Racagni G

doi

10.1210/endo-118-1-334

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

334-9

issue

1

eissn

0013-7227

issn

1945-7170

journal_volume

118

pub_type

杂志文章
  • Estrogen acidifies vaginal pH by up-regulation of proton secretion via the apical membrane of vaginal-ectocervical epithelial cells.

    abstract::The objective of this study was to assess estrogen-dependent cellular mechanisms that could contribute to the acid pH of the vaginal lumen. Cultures of normal human cervical-vaginal epithelial (hECE) cells and endocervical cells were grown on filters, and acidification of the extracellular solutions on the luminal (L-...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2004-1153

    authors: Gorodeski GI,Hopfer U,Liu CC,Margles E

    更新日期:2005-02-01 00:00:00

  • Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro.

    abstract::The hypothalamic hormone, GnRH, is released and transported to the anterior pituitary in a pulsatile manner, where it binds to specific high-affinity receptors and regulates gonadotropin biosynthesis and secretion. The frequency of GnRH pulses changes under various physiological conditions, and varying GnRH pulse freq...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.138.3.4968

    authors: Kaiser UB,Jakubowiak A,Steinberger A,Chin WW

    更新日期:1997-03-01 00:00:00

  • Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response.

    abstract::It is known that the circadian rhythm in hepatic phosphoenolpyruvate carboxykinase expression (a limiting catalytic step of gluconeogenesis) and hepatic glucose production is maintained by both daily oscillation in autonomic inputs to the liver and night feeding behavior. However, increased glycemia and reduced melato...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2010-1088

    authors: Nogueira TC,Lellis-Santos C,Jesus DS,Taneda M,Rodrigues SC,Amaral FG,Lopes AM,Cipolla-Neto J,Bordin S,Anhê GF

    更新日期:2011-04-01 00:00:00

  • Insulin is a mitogen for isolated epiphyseal growth plate chondrocytes from the fetal lamb.

    abstract::Insulin acts directly as a mitogen on isolated embryonic tissues but has been shown to be inactive at physiological concentrations on several fetal cell types. Since insulin availability is obligatory for optimal fetal growth, we have investigated its mitogenic actions on chondrocytes isolated from the epiphyseal grow...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-126-5-2661

    authors: Hill DJ,de Sousa D

    更新日期:1990-05-01 00:00:00

  • Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland.

    abstract::We have shown that nonlactogenic rat (r) GH is far more potent than rPRL in inducing rat mammary development. To determine the relative roles of GH and PRL in mammary development and their mechanisms of action, we have compared the abilities of a group of native and mutant GHs, PRLs, and placental lactogens (PLs) to i...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.133.4.8404600

    authors: Feldman M,Ruan W,Cunningham BC,Wells JA,Kleinberg DL

    更新日期:1993-10-01 00:00:00

  • Regulation and function of deiodinases during decidualization in female mice.

    abstract::Thyroid dysfunction during human pregnancy is closely related to serious pregnancy outcome. However, the regulation and function of thyroid hormones during early pregnancy are largely unknown. We found that type II deiodinase, an enzyme converting T4 to activated T3, is highly expressed in the mouse uterus on days 3 a...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2014-1015

    authors: Deng WB,Liang XH,Liu JL,Yang ZM

    更新日期:2014-07-01 00:00:00

  • Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblasts.

    abstract::Differentiation of primary villous cytotrophoblasts into syncytia is associated with increasing production of alpha and beta human CG subunits, which is predominantly governed at the level of messenger RNA expression. Here, we present a detailed study on the mechanisms involved in the differentiation-dependent regulat...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.141.10.7713

    authors: Knöfler M,Saleh L,Bauer S,Vasicek R,Griesinger G,Strohmer H,Helmer H,Husslein P

    更新日期:2000-10-01 00:00:00

  • Effects of human erythrocyte guanine nucleotide-binding regulatory protein on parathyroid hormone-responsive adenylate cyclase from canine renal cortex.

    abstract::We studied the effects of the guanine nucleotide-binding regulatory protein (Gs) from human erythrocytes on PTH-responsive adenylate cyclase from partially purified membranes of canine renal cortex (CRC). Extracts of erythrocyte membranes, containing soluble Gs, was obtained by treatment with a detergent (Lubrol PX). ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-115-4-1386

    authors: Levine MA,Greene A,Turner RT,Bell NH

    更新日期:1984-10-01 00:00:00

  • Prokineticin-1: a novel mediator of the inflammatory response in third-trimester human placenta.

    abstract::Prokineticin-1 (PK1) is a recently described protein with a wide range of functions, including tissue-specific angiogenesis, modulation of inflammatory responses, and regulation of hemopoiesis. The aim of this study was to investigate the localization and expression of PK1 and PK receptor-1 (PKR1), their signaling pat...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2007-1695

    authors: Denison FC,Battersby S,King AE,Szuber M,Jabbour HN

    更新日期:2008-07-01 00:00:00

  • Increases in plasma insulin levels in response to electrical stimulation of the dorsal motor nucleus of the vagus nerve.

    abstract::In order to investigate the physiological counterpart of the anatomical finding showing that the dorsal motor nucleus of the vagus nerve (DMX) is a source of efferent vagal fibers innervating the pancreas, unilateral electrical stimulation using monopolar electrodes (50 microA, 30 Hz, 0.2 msec) at a glycemia of 150 mg...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-112-3-904

    authors: Ionescu E,Rohner-Jeanrenaud F,Berthoud HR,Jeanrenaud B

    更新日期:1983-03-01 00:00:00

  • Effects of somatostatin and urotensin II on tilapia pituitary prolactin release and interactions between somatostatin, osmotic pressure Ca++, and adenosine 3',5'-monophosphate in prolactin release in vitro.

    abstract::Both somatostatin (SRIF) and urotensin II, a dodecapeptide from the teleost caudal neurosecretory system, inhibit PRL release from the organ-cultured rostral pars distalis of the tilapia, Sarotherodon mossambicus, in a dose-related manner. The inhibitory action of SRIF on PRL release was completely prevented by the pr...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-110-3-910

    authors: Grau EG,Nishioka RS,Bern HA

    更新日期:1982-03-01 00:00:00

  • Insulin resistance in genetically obese (fa/fa) rats: changes in the glycosyl-phosphatidylinositol signaling system in isolated hepatocytes.

    abstract::In different types of mammalian cells, insulin has been shown to promote the release of an inositol phosphate glycan (InsP-glycan) through the hydrolysis of a glycosyl-phosphatidylinositol (glycosyl-PtdIns). This InsP-glycan, which has been demonstrated to be taken up by intact cells, may mediate some of the biologica...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.134.3.8119190

    authors: Sánchez-Gutiérrez JC,Sánchez-Arias JA,Valle JC,Guadaño A,Samper B,Mato JM,Felíu JE

    更新日期:1994-03-01 00:00:00

  • Alcohol and fatty acid stimulation of neurotensin release from rat small intestine.

    abstract::We have previously reported that neurotensin (NT) is released from the small intestine and elevated in the hepatic-portal circulation in response to the perfusion of the small intestine with a micellar solution of oleic acid. In order to determine the minimum acyl chain length and whether the presence of a carboxylic ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-116-3-1133

    authors: Ferris CF,Armstrong MJ,George JK,Stevens CA,Carraway RE,Leeman SE

    更新日期:1985-03-01 00:00:00

  • Medial prefrontal cortical estradiol rapidly alters memory system bias in female rats: ultrastructural analysis reveals membrane-associated estrogen receptors as potential mediators.

    abstract::High plasma levels of estradiol (E2) are associated with use of a place memory system over a response memory system. We examined whether infusing estradiol into the medial prefrontal cortex (mPFC) or anterior cingulate cortex (AC) could affect memory system bias in female rats. We also examined the ultrastructural dis...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2014-1463

    authors: Almey A,Cannell E,Bertram K,Filardo E,Milner TA,Brake WG

    更新日期:2014-11-01 00:00:00

  • FSH-induced Sertoli cell proliferation in the developing rat is modified by beta-endorphin produced in the testis.

    abstract::To probe the possible role of endogenous opiates in Sertoli cell proliferation during testicular development, the effect of interfering with beta-endorphin action either in vivo or in vitro was determined. The percent of Sertoli cells dividing was measured with quantitative autoradiography in [methyl 3H]-thymidine-exp...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-119-4-1876

    authors: Orth JM

    更新日期:1986-10-01 00:00:00

  • Role of tyrosine kinase receptors in angiotensin II AT2 receptor signaling: involvement in neurite outgrowth and in p42/p44mapk activation in NG108-15 cells.

    abstract::NG108-15 cells, which have a rounding-up morphology when cultured in serum-supplemented medium, extend neurites when stimulated for 3 d with angiotensin II (Ang II). The aim of the present study was to investigate whether growth factor receptors are necessary for mediating the effects of Ang II. A 3-d treatment with A...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2005-1315

    authors: Plouffe B,Guimond MO,Beaudry H,Gallo-Payet N

    更新日期:2006-10-01 00:00:00

  • Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats.

    abstract::Although implantation of GH3 pituitary epithelial cells has been shown to reverse thymic aging in rats, the differentiation pattern of T-lymphocytes within the reconstituted thymus glands has not been investigated. Syngeneic GH3 cells were implanted into 22-month-old female (old) Wistar-Furth rats. Eight weeks later, ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.130.5.1572290

    authors: Li YM,Brunke DL,Dantzer R,Kelley KW

    更新日期:1992-05-01 00:00:00

  • Monodeiodination of 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine to 3,3'-diiodothyronine in vitro.

    abstract::To study conversion of 3,5,3'-triiodothyroinine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (T2) in vitro, T3 or rT3 was incubated at pH 7.35 with homogenates of several rat tissues (liver, kidney, muscle, heart, ling, spleen, intestines, and brain) for 15 min at 37 C. The T2 generated during incub...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-102-4-1099

    authors: Chopra IJ,Wu SY,Nakamura Y,Solomon DH

    更新日期:1978-04-01 00:00:00

  • Transglutaminase activity in bovine calf testicular membranes: evidence for a possible role in the interaction of follicle-stimulating hormone with its receptor.

    abstract::Transglutaminase (TGase) activity, determined by incorporation of [1,4-14C]putrescine into casein, was demonstrated in a light membrane fraction derived from bovine calf testicular homogenates. In common with other TGases thus far identified, testicular TGase is calcium dependent. A concentration-dependent relationshi...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-121-2-459

    authors: Grasso P,Dattatreyamurty B,Dias JA,Reichert LE Jr

    更新日期:1987-08-01 00:00:00

  • Estradiol induces galanin gene expression in the pituitary of the mouse in an estrogen receptor alpha-dependent manner.

    abstract::Estradiol imprinting plays an important role in the regulation of galanin (GAL) gene expression in the rat. In the anterior pituitary gland, GAL gene expression is greatly induced by estrogen. The relative involvement that the two estrogen receptor subtypes, alpha and beta, have in regulating this induction is not kno...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.140.6.6932

    authors: Shen ES,Hardenburg JL,Meade EH,Arey BJ,Merchenthaler I,López FJ

    更新日期:1999-06-01 00:00:00

  • Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons.

    abstract::In mammals, lactation is associated with a period of infertility characterized by the loss of pulsatile secretion of GnRH and cessation of ovulatory cycles. Despite the importance of lactational infertility in determining overall fecundity of a species, the mechanisms by which the suckling stimulus suppresses GnRH sec...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2013-1621

    authors: Liu X,Brown RS,Herbison AE,Grattan DR

    更新日期:2014-01-01 00:00:00

  • Binding of 7 alpha, 17 alpha-dimethyl-19-nortestosterone (mibolerone) to androgen and progesterone receptors in human and animal tissues.

    abstract::In rat uterus and prostate, 7 alpha, 17 alpha-dimethyl-19-nortestosterone (DMNT) binds to the androgen receptor specifically and with high affinity. However, this steroid does not bind to glucocorticoid receptors, since it does not displace binding of [3H]triamcinolone acetonide in calf thymus cytosol. In calf uterine...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-118-4-1327

    authors: Traish AM,Müller RE,Wotiz HH

    更新日期:1986-04-01 00:00:00

  • The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent.

    abstract::To investigate the role of the C18 substituents in the agonist/antagonist properties of mineralocorticoids, the activities of certain C18-substituted progesterone (P) derivatives were examined. These compounds were characterized by an unsaturated side-chain in the case of 18-vinylprogesterone (18VP) and 18-ethynylprog...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.136.12.7588320

    authors: Souque A,Fagart J,Couette B,Davioud E,Sobrio F,Marquet A,Rafestin-Oblin ME

    更新日期:1995-12-01 00:00:00

  • The role of glycosylation in the molecular conformation and secretion of thyroxine-binding globulin.

    abstract::T4-binding globulin (TBG), the principal carrier of thyroid hormone in serum, is a glycoprotein containing 20% carbohydrate. The importance of the carbohydrate moiety has been previously studied by enzymatic deglycosylation, which showed that deglycosylated TBG retains its original immunological an T4-binding properti...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-118-4-1614

    authors: Murata Y,Magner JA,Refetoff S

    更新日期:1986-04-01 00:00:00

  • In vitro maturation of steroidogenic capacity of ovine fetal and neonatal adrenal cells.

    abstract::The in vitro production of total corticosteroids, corticosterone (B), and cortisol (F) by cultured adrenocortical cells from fetuses (115-120 days old) and newborn lambs exposed to ACTH-(1-24) was investigated in relation to the time of culture. Corticosteroids were measured by using an antibody against F, whereas B a...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-114-4-1128

    authors: Durand P,Cathiard AM,Saez JM

    更新日期:1984-04-01 00:00:00

  • Protection against procarbazine-induced testicular damage by GnRH-agonist and antiandrogen treatment in the rat.

    abstract::Suppression of spermatogenesis in LBNF1 rats by treatment with the GnRH agonist Zoladex combined with the antiandrogen flutamide was evaluated in order to rapidly achieve protection of spermatogenic stem cells against procarbazine with clinically used drugs. Zoladex-flutamide treatment required 3 weeks to suppress the...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.136.8.7628410

    authors: Kangasniemi M,Wilson G,Huhtaniemi I,Meistrich ML

    更新日期:1995-08-01 00:00:00

  • Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.

    abstract::Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide secretion in steroid target tissues. In addition to the binding of these hormones to their receptors, formation and metabolism are important in the action of steroids. Metabolism of the potent steroid hormones includes glucuroni...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.142.2.7958

    authors: Turgeon D,Carrier JS,Lévesque E,Hum DW,Bélanger A

    更新日期:2001-02-01 00:00:00

  • The nitric oxide synthase II inhibitor NG-nitro-L-arginine stimulates pancreatic islet insulin release in vitro, but not in the perfused pancreas.

    abstract::The effects of L-arginine and its derivatives NG-methyl-L-arginine (Meth-arg) and NG-nitro-L-arginine (Nit-arg) on the insulin release and glucose oxidation of isolated rat islets were investigated to evaluate possible influences of nitric oxide. Also, the insulin release and flow distribution within the perfused rat ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-128-6-3081

    authors: Jansson L,Sandler S

    更新日期:1991-06-01 00:00:00

  • Effects of estradiol-17beta on the induction of gonadotropin release by electrical stimulation of the hypothalamus in rhesus monkeys.

    abstract::Serum LH and FSH were measured at 60, 30, and 0 min before, at 5, 15, and 30 min during, and at 10, 45, and 90 min after bilateral electrical stimulation (ES) of various hypothalamic regions in 12 unanesthetized ovariectomized rhesus monkeys. ES of the arcuate-ventromedial nuclei (medial basal hypothalamus; MBH) induc...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-100-2-314

    authors: Spies HG,Norman RL,Quadri SK,Clifton DK

    更新日期:1977-02-01 00:00:00

  • The rat ovarian phospholipase A2 system: gene expression, cellular localization, activity characterization, and interleukin-1 dependence.

    abstract::We have previously demonstrated that interleukin-1 beta (IL-1 beta), a putative intermediary in the ovulatory process, is a potent stimulator of ovarian PG biosynthesis. In this communication, we examine the possibility that this IL-1 effect reflects in part the induction of arachidonic acid mobilization by phospholip...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.138.1.4826

    authors: Kol S,Ruutiainen-Altman K,Ben-Shlomo I,Payne DW,Ando M,Adashi EY

    更新日期:1997-01-01 00:00:00