Abstract:
:Prolactin (PRL) is an immunomodulatory hormone which promotes T-cell activation and proliferation. However, the intracellular mechanisms of this action in normal lymphocytes are unknown. Because the PRL receptor (PRLR) activates several signals also activated by the T-cell antigen receptor (TCR)/CD3 complex, we evaluated whether signaling "cross-talk" occurs between these distinct receptors. Using human thymocytes, human peripheral blood lymphocytes and the rat Nb2 lymphoma T-cell, we found that PRL induced rapid phosphorylation of multiple, TCR/CD3 complex proteins, an event required for lymphocyte activation. Two of these phosphorylated proteins were identified to be CD3 epsilon and ZAP-70 tyrosine kinase, molecules essential for TCR function. Further, PRL induced tyrosyl phosphorylation of ZAP-70 in each population of T-lymphocytes tested, demonstrating for the first time that ZAP-70 is a target of PRL action. Taken together, our results suggest that the PRLR directly affects T-lymphocyte activation by means of signaling cross-talk with the TCR/CD3 complex.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Montgomery DW,Krumenacker JS,Buckley ARdoi
10.1210/endo.139.2.5913subject
Has Abstractpub_date
1998-02-01 00:00:00pages
811-4issue
2eissn
0013-7227issn
1945-7170journal_volume
139pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::To investigate the regulation of expression of the TSH receptor (TSHR) in extrathyroidal tissues, the level of TSHR messenger RNA (mRNA) and TSH-dependent signal transduction were determined in isolated rat adipocytes and cultured preadipocytes. The epididymal, sc, and perirenal, but not the interscapular brown adipos...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.8.8754740
更新日期:1996-08-01 00:00:00
abstract::Estrogen-based hormone therapy (HT) in postmenopausal women may reduce the risk of Alzheimer's disease (AD), although HT remains controversial. One key concern with HT is the potential of adverse outcomes such as breast and uterine cancer. A promising strategy to maximize HT benefits and minimize HT risks is the use o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1346
更新日期:2008-05-01 00:00:00
abstract::The influence of periparturient secretion of PRL on cytological differentiation of mammary epithelial cells was studied in 17 multiparous, monotocous Holstein cows. Mammary tissue was obtained 10 days prepartum and 10 days postpartum from untreated cows and from cows treated with CB154 (2-Br-alpha-ergokryptin) or CB15...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-109-1-31
更新日期:1981-07-01 00:00:00
abstract::Mouse kidney and urinary glycosphingolipids from developing C57BL/6J and adults of several other inbred strains were analyzed by high performance liquid chromatographic techniques. Glycosphingolipids from male and female C57BL/6J kidneys were similar until the fifth week of age. Galactosylceramide containing nonhydrox...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-113-1-251
更新日期:1983-07-01 00:00:00
abstract::Studies were carried out to determine the actions of PRL on adrenocortical function in hypophysectomized female rats in the presence and absence of ACTH. PRL administration alone decreased 5 alpha-reductase activity but did not significantly affect the rates of corticosterone secretion or peripheral plasma corticoster...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-104-5-1299
更新日期:1979-05-01 00:00:00
abstract::Obesity and insulin resistance-related proteinuria is associated with oxidative stress and impaired tissue bioavailable nitric oxide. Recent data suggest that nicotinamide adenine dinucleotide phosphate oxidase-mediated oxidative injury to the proximal tubule, like that seen in the glomerulus, contributes to proteinur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-1038
更新日期:2011-02-01 00:00:00
abstract::An increased activity of the hypothalamo-pituitary-adrenal axis resulting in exaggerated glucocorticoid secretion has been repeatedly described in patients with diabetes mellitus and in animal models of this disease. However, it has been pointed out that experimental diabetes is accompanied by a decreased glucocortico...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0592
更新日期:2010-01-01 00:00:00
abstract::The effect of bovine corneal extracellular matrix (ECM) on gonadotropin-primed rat granulosa cells in vitro was studied by examining the following parameters: 1) rate of cell attachment to culture dishes; 2) modulation of cell morphology; 3) specific binding of [125I]human(h)CG to LH/hCG receptors; 4) cAMP response to...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-5-1878
更新日期:1986-05-01 00:00:00
abstract::The receptors for the two structurally related insulinotropic hormones Glucose-dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) share approximately 40% sequence identity and demonstrate complete specificity for their endogenous ligands, while utilizing similar second messenger pathways. I...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.6.9104
更新日期:1997-06-01 00:00:00
abstract::The action of added insulin-like growth factor-I (IGF-I) and dihydrotestosterone (DHT) on steroid 5 alpha-reductase (5 alpha R) activity was studied using primary cultures of rat or human scrotal skin fibroblasts. Agents were added to cultured cells (2 x 10(5) cells) for 2 days, and enzyme activity was measured by the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.2.8344190
更新日期:1993-08-01 00:00:00
abstract::The effects of leptin on the levels of CRF messenger RNA (mRNA) in the paraventricular hypothalamic nucleus (PVN), on the activation of the PVN CRF cells, and on the plasma levels of corticosterone were investigated in lean (+/?) and obese (ob/ob) C57BL/6J male mice. Murine leptin was s.c. infused using osmotic minipu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.4.5889
更新日期:1998-04-01 00:00:00
abstract::Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates, the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 and kiss2, and two kiss receptors (GPR54), kiss1r and kiss2r. To provide detailed information on the organization of the kiss systems in ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0948
更新日期:2011-04-01 00:00:00
abstract::The adrenergic control of cAMP and 3',5'-cyclic GMP (cGMP) in dispersed adult rat pinealocytes was investigated. Norepinephrine treatment increased cAMP and cGMP content 60- and 400-fold, respectively; both alpha- and beta-adrenoceptors had to be activated for these responses to occur. Beta-Adrenergic stimulation alon...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-6-2167
更新日期:1985-06-01 00:00:00
abstract::The effects of diabetes on basal calcium metabolism and the response to endocrine stimulation were studied in hepatocytes from acute and long term diabetic rats. Hepatocyte calcium sequestration and turnover were increased in both acute and chronic diabetes. Cytosolic free calcium (Cai2+) was significantly increased i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-5-2421
更新日期:1989-11-01 00:00:00
abstract::It was previously reported that PRL can stimulate FSH release in immature female rats and PRL-deficient male dwarf mice. We have examined the effects of PRL-producing ectopic pituitary grafts on plasma FSH and LH levels in adult male golden hamsters during exposure to both long (14 h of light, 10 h of darkness) and sh...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-1-133
更新日期:1981-01-01 00:00:00
abstract::Alterations in the maternal endocrine, nutritional, and metabolic environment disrupt the developmental trajectory of the fetus, leading to adult diseases. Female offspring of rats, subhuman primates, and sheep treated prenatally with testosterone (T) develop reproductive/metabolic defects during adult life similar to...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0478
更新日期:2004-02-01 00:00:00
abstract::Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during development. The activity of the GH/IGF-1 axis is controlled by complex neuroendocrine systems including two hypothalamic neuropeptides, GH-releasing hormone (GHRH) and ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-03175
更新日期:2018-04-01 00:00:00
abstract::CD36/FAT (fatty acid translocase) is associated with human and murine nonalcoholic fatty liver disease, but it has been unclear whether it is simply a marker or whether it directly contributes to disease pathogenesis. Mice with hepatocyte-specific deletion of Janus kinase 2 (JAK2L mice) have increased circulating free...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1866
更新日期:2016-02-01 00:00:00
abstract::Aromatase-deficient (ArKO) mice are deficient in estrogens due to deletion of the aromatase gene. We hypothesized that there may be changes in the cardiovascular system of ArKO mice because of evidence linking estrogens with improved cardiovascular outcomes and the induction of the glucocorticoid-metabolizing enzyme, ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0421
更新日期:2004-09-01 00:00:00
abstract::Endocrine cells isolated from the anterior pituitary fire intracellular Ca2+ ([Ca2+]i) transients due to voltage-gated Ca2+ entry. However, the patterns of [Ca2+]i transients within the glandular parenchyma of the anterior pituitary are unknown. Here we describe, using real-time confocal laser microscopy, several spon...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.3.7363
更新日期:2000-03-01 00:00:00
abstract::Type 1 transforming growth factor-beta (TGF beta 1) was found to be a potent inducer of the secretion of a 49,000 mol wt protein by normal rat kidney (NRK) cells. This protein was related to type 1 plasminogen activator inhibitor (PAI-1) on the basis of molecular mass, activity in the presence of sodium dodecyl sulfat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-6-2936
更新日期:1990-06-01 00:00:00
abstract::Treatment of rat islets with the cytokine IL-1 results in the inhibition of mitochondrial function and insulin secretion, events that are mediated by beta-cell expression of iNOS [inducible nitric oxide (NO) synthase] and production of NO. beta-Cells recover from the inhibitory actions of NO, produced following 24 h i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-0112
更新日期:2003-08-01 00:00:00
abstract::Recent studies have indicated that growth factors such as insulin-like growth factors (IGFs) increase the growth rate of cultured preimplantation embryos. We therefore hypothesized that the fallopian tube may produce IGFs which in turn participate in the regulation of preimplantation embryo development in vivo. In the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.5.8404650
更新日期:1993-11-01 00:00:00
abstract::The median eminence (ME), which is the common termination field for adenohypophysiotropic systems, has been shown to produce nitric oxide (NO), a signaling molecule involved in neuroendocrine secretion. Using an ex vivo technique, 17beta-estradiol exposure to ME fragments, including vascular tissues, stimulated NO rel...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.2.6484
更新日期:1999-02-01 00:00:00
abstract::Free radical production and lipid peroxidation are potentially important mediators in testicular physiology and toxicology. The cytochrome P450 enzymes of the steroidogenic pathway are known to produce free radicals. The present study was conducted to elucidate in vivo the gonadotropin regulation of free radical-media...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.1.8536600
更新日期:1996-01-01 00:00:00
abstract::To evaluate the possible existence of masked gonadotropin receptors in the corpus luteum, we characterized the effects of alcohols and neuraminidase on [125I]iodohuman LH binding to in vitro preparations of luteal tissue from the rhesus monkey and pseudopregnant rat. The presence of 1-8% (vol/vol) ethanol enhanced spe...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-2-747
更新日期:1985-08-01 00:00:00
abstract::Neonatal thymectomy at 3 days of age in mice results in ovarian dysgenesis, characterized by early follicular and oocyte loss, followed by a high incidence of ovarian tumorigenesis. Thymectomized animals with dysgenetic ovaries had extremely high levels of circulating PRL and gonadotropins before the appearance of the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-6-2375
更新日期:1981-06-01 00:00:00
abstract::The physicochemical and immunological properties of androgen receptors from kidney and brain of testicular-feminized (Tfm) mutant mice and wild-type mice were compared. Analysis by gel filtration and sucrose density gradients revealed that the mol wt of the mutant receptor was 66K (38A; 3.8S) which was significantly s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-2-771
更新日期:1989-02-01 00:00:00
abstract::We constructed seven chimeric molecules in which sequential segments in the cDNA for thyroid peroxidase (TPO) were replaced with the homologous regions of myeloperoxidase (MPO) cDNA. The sizes of the translated cDNA segments A through G ranged from 23-175 amino acid residues in length. The TPO-MPO cDNA chimeras, inser...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.6.8243270
更新日期:1993-12-01 00:00:00
abstract::Morphoregulator genes like members of the Hox gene family regulate uterine development and are associated with endocrine-related processes such as endometrial proliferation and differentiation in the adult uterus. Exposure to neonatal endocrine disruptors could affect signaling events governed by Hox genes, altering t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0651
更新日期:2008-11-01 00:00:00