Abstract:
:It was previously reported that PRL can stimulate FSH release in immature female rats and PRL-deficient male dwarf mice. We have examined the effects of PRL-producing ectopic pituitary grafts on plasma FSH and LH levels in adult male golden hamsters during exposure to both long (14 h of light, 10 h of darkness) and short (5 h of flight, 19 h of darkness) photoperiods. In both groups, the presence of one pituitary graft resulted in a significant elevation of pituitary and plasma FSH levels. Although there were no statistically significant changes in the concentration of LH in the pituitary or plasma of either group. LH values were more variable than FSH values, and these findings do not rule out an effect on LH. To determine whether the ability of ectopic pituitary grafts to stimulate FSH release depends on changes in testicular or adrenal function, additional experiments were done in castrated male hamsters, in castrated males given testosterone propionate, and in castrated adrenalectomized hamsters maintained with injections of cortisol. The results indicate that the increase in FSH release in engrafted animals does not depend on the testes or the adrenals, but can be prevented by exogenous cortisol. In adult female hamsters, pituitary grafts increased plasma LH levels above the concentrations observed in diestrous, proestrous, or pregnant controls, but did not alter plasma FSH levels. In contrast, in ovariectomized and ovariectomized-estradiol benzoate-treated animals, pituitary grafts increased plasma FSH levels without significantly affecting plasma LH. It is concluded that PRL-producing ectopic pituitary homografts significantly stimulate FSH synthesis and release in male golden hamsters, and that this effect is probably not mediated through the changes in gonadal or adrenal function.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Bartke A,Siler-Khodr TM,Hogan MP,Roychoudhury Pdoi
10.1210/endo-108-1-133subject
Has Abstractpub_date
1981-01-01 00:00:00pages
133-9issue
1eissn
0013-7227issn
1945-7170journal_volume
108pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Previously, we reported that testicular macrophages constitutively release tumor necrosis factor (TNF) in vitro and are unresponsive to bacterial endotoxins [lipopolysaccharides (LPS)]. These properties are not typical of other tissue macrophages. The goals of the present study were, therefore, to establish 1) if test...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.1.8275970
更新日期:1994-01-01 00:00:00
abstract::The Rice H500 rat Leydig cell tumor is a well characterized model of humoral hypercalcemia of malignancy (HHM). Circulating concentrations of PTH-related protein (PTHRP) have not been reported in this or any other animal model of HHM. Taking advantage of the marked N-terminal amino acid homology between rodent and hum...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-3-1444
更新日期:1990-09-01 00:00:00
abstract::The present experiments examined the relationship between cholera toxin and TSH stimulation of the adenylate cyclase system in bovine thyroid tissue. Preincubation of thyroid slices for 20 min at 4 C with a maximal concentration of cholera toxin (100 microgram/ml) did not impair the subsequent stimulation of cAMP by s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-6-2076
更新日期:1980-12-01 00:00:00
abstract::Studies were performed to characterize the identity of the factors present in calf serum that stimulate endothelin (ET) production by vascular endothelial cells in culture. Two putative candidates responsible for the ET-releasing activity present in serum are members of the transforming growth factor-beta (TGF beta) s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-5-2355
更新日期:1991-11-01 00:00:00
abstract::Glucose-dependent insulinotropic peptide (GIP) is a 42-amino acid peptide synthesized and secreted from endocrine cells in the small intestine. The role of GIP in coupling nutrient intake and insulin secretion, the incretin effect, is well known. We report that GIP receptor messenger RNA and protein are present in nor...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.3.7366
更新日期:2000-03-01 00:00:00
abstract::Mice bearing IL-1beta-secreting tumor were used to study the chronic effect of IL-1beta on glucose metabolism. Mice were injected with syngeneic tumor cells transduced with the human IL-1beta gene. Serum IL-1beta levels increased exponentially with time. Secretion of IL-1beta from the developed tumors was associated w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0323
更新日期:2004-11-01 00:00:00
abstract::Glucocorticoid hormones act in the nucleus of the cell to alter expression of specific genes and change cell metabolism. In liver, these hormones have been reported to increase mitochondrial respiratory activity, which is regulated by both nuclear and mitochondrial gene products. We examined the effects of the synthet...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.2.1370790
更新日期:1992-02-01 00:00:00
abstract::The DHCR24 gene encodes an enzyme catalyzing the last step of cholesterol biosynthesis, the conversion of desmosterol to cholesterol. To elucidate the physiological significance of cholesterol biosynthesis in mammalian cells, we investigated proliferation of mouse embryonic fibroblasts (MEFs) prepared from DHCR24(-/-)...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-1426
更新日期:2006-06-01 00:00:00
abstract::The glycoprotein FSH, a product of pituitary gonadotrope cells, regulates ovarian follicle development in females and spermatogenesis in males. FSH is a heterodimer of the common α gonadotropin subunit and the hormone-specific FSHβ subunit (a product of the Fshb gene). Using a conditional knockout approach (Cre-lox), ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00100
更新日期:2018-07-01 00:00:00
abstract::Oxytocin (OT) is a hypothalamic nonapeptide that is synthesized as part of a larger precursor protein that also contains an approximately 10-kDa protein called neurophysin at its C-terminus. This precursor protein is trafficked through the regulated secretory pathway into secretory granules and then axonally transport...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.3.8700
更新日期:2002-03-01 00:00:00
abstract::The intraislet insulin hypothesis has been proposed to explain absent glucagon responses to hypoglycemia. Recently we directly confirmed this hypothesis by restoring glucagon secretion via provision of a pancreatic artery insulin infusion, which was switched off at the time of hypoglycemia in Wistar rats made diabetic...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-1375
更新日期:2007-06-01 00:00:00
abstract::Neuropeptide Y (NPY) is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. It is also secreted into hypophyseal portal vessels. The injection of NPY into the third ventricle (3V) lowered plasma GH levels in conscious, freely moving male rats. To determine the physiol...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-5-2296
更新日期:1990-05-01 00:00:00
abstract::Hormonal induction of steroidogenesis in the adrenal and gonads is dependent on the synthesis and function of the steroidogenic acute regulatory protein (StAR). As a first approach to investigate the role of translation in the control of StAR expression, we examined StAR protein synthesis and steroid production in MA-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.11.5535
更新日期:1997-11-01 00:00:00
abstract::We previously identified a highly conserved specificity protein 1 (Sp1) DNA element in mammalian PTH promoters that acted as an enhancer of gene transcription and bound Sp1 and Sp3 proteins present in parathyroid gland nuclear extracts. More recently, a nuclear factor (NF)-Y element (NF-Y(prox)) was also described by ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0272
更新日期:2005-08-01 00:00:00
abstract::Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1968
更新日期:2014-07-01 00:00:00
abstract::Mammary epithelial cells isolated from pregnant, nonlactating heifers were grown in vitro using collagen substrates. Using these systems, the truncated form of insulin growth factor-1 (IGF-1) (des-3-IGF-1), IGF-1, and IGF-2 all stimulated a significant (0.5 to 1 fold) increase in cell proliferation (des-3-IGF-1 greate...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-2-671
更新日期:1991-08-01 00:00:00
abstract::Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1331
更新日期:2012-10-01 00:00:00
abstract::Obesity and its associated comorbidities are of major worldwide concern. It is now recognized that there are a number of metabolically distinct pathways of obesity development. The present paper investigates the effect of moderate daily exercise on the underlying mechanisms of one such pathway to obesity, through inte...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1035
更新日期:2009-01-01 00:00:00
abstract::To assess the effect of breast feeding on circulating thyroid hormone levels in the suckling neonate, we examined serum concentrations of T4, T3, and rT3 by RIA in 12- and 15-day-old rat pups fasted for 3 or 6 h before, at, and hourly for 3 or 4 h after suckling. In both age groups, serum T4 levels decreased significa...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-123-1-127
更新日期:1988-07-01 00:00:00
abstract::Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites. We investigated the effects of dexamethasone on the biosynthesis and ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.4.8462460
更新日期:1993-04-01 00:00:00
abstract::Hepatic stellate cells (HSC) play a pivotal role in hepatic tissue repair and fibrogenesis. IGF-I has been considered a mitogenic signal for activation and proliferation of HSC in vitro. In the present study IGF-I and IGF-binding protein (IGFBP) gene expression was studied in a model of acute liver injury induced by a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1541
更新日期:2004-07-01 00:00:00
abstract::Previous descriptions of pulsatile LH release in immature female rats have been mostly inaccurate because of infrequent blood sampling, discontinuous and unbalanced blood replacement procedures, and possibly because of the use of a heterologous RIA. The present study was undertaken to circumvent these problems and to ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-2-644
更新日期:1985-08-01 00:00:00
abstract::Media from large vessel endothelial cells (pulmonary artery, aorta) contained intact connective tissue growth factor (CTGF) and a dominant 19-kDa band. N-terminal analysis of the 19-kDa band showed sequence corresponding to CTGF amino acid 181-190, suggesting that the 19-kDa band represented a proteolytic fragment of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.4.6633
更新日期:1999-04-01 00:00:00
abstract::Proper development of the seminiferous tubules (or testis cords in embryos) is critical for male fertility. Sertoli cells, somatic components of the seminiferous tubules, serve as nurse cells to the male germline, and thus their numbers decide the quantity of sperm output in adulthood. We previously identified activin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1288
更新日期:2011-11-01 00:00:00
abstract::To define the specific role of IGF-I receptor (IGF-IR) in adipogenic and thermogenic differentiation of brown adipocytes during late fetal life, we have established immortalized brown adipocyte cell lines from fetuses of IGF-IR-deficient mice (IGF-IR(-/-)) as well as from wild-type mice (IGF-IR(+/+)). IGF-IR(-/-) cell...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220828
更新日期:2003-02-01 00:00:00
abstract::Insulin-like growth factor (IGF)-1, IGF binding protein (IGFBP)-2, and IGFBP-3 are expressed in the rat brain in regions of neuronal loss by 3 days after hypoxic- ischemic (HI) brain injury and IGF-2 somewhat later. Central administration of rh-IGF-1 after HI injury reduces neuronal loss in vivo. To clarify the mode o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.3.8603600
更新日期:1996-03-01 00:00:00
abstract::Oxytocin (OT) has a dual action in the uterus: a uterotonic action on myometrial cells and a prostaglandin (PG)-releasing action on endometrial/decidual cells. It had not been determined whether the OT-binding sites or receptors on the myometrial and the endometrial/decidual membranes are of the same type or may repre...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.3.8382600
更新日期:1993-03-01 00:00:00
abstract::Prolactin (Prl) secreting cells in a mixed pituitary cell culture form microscopically-identifiable plaques (zones of hemolysis around the lactotropes) when incubated in a monolayer with staphylococcal protein-A-coated ovine erythrocytes in the presence of Prl antiserum and complement. Plaques form first at 15-30 min ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-3-1135
更新日期:1983-03-01 00:00:00
abstract::The administration of testosterone via Silastic capsules has been shown previously to maintain advanced spermatid number quantitatively in intact rats in which LH but not FSH was suppressed, but not in hypophysectomized rats, indicating that pituitary factors in addition to LH are required for the quantitative mainten...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.6.1597140
更新日期:1992-06-01 00:00:00
abstract::The present study was conducted to elucidate the role of activin A in tubulogenesis of vascular endothelial cells. Activin A was produced in bovine aortic endothelial cells (BAEC). These cells also expressed the type I and type II activin receptors. When added to BAEC cultured in a collagen gel, activin A induced capi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0213
更新日期:2004-08-01 00:00:00