Exogenously administered testosterone maintains spermatogenesis quantitatively in adult rats actively immunized against gonadotropin-releasing hormone.

abstract：:To study conversion of 3,5,3'-triiodothyroinine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (T2) in vitro, T3 or rT3 was incubated at pH 7.35 with homogenates of several rat tissues (liver, kidney, muscle, heart, ling, spleen, intestines, and brain) for 15 min at 37 C. The T2 generated during incub...

journal_title：Endocrinology

authors： Chopra IJ,Wu SY,Nakamura Y,Solomon DH

更新日期：1978-04-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indic...

journal_title：Endocrinology

authors： Williams DL

更新日期：2009-07-01 00:00:00

abstract：:Estrogens bind to two nuclear estrogen receptor (ER) subtypes, ERα and ERβ, which are expressed in differing amounts in various tissues. The endogenous estrogen, 17β-estradiol (E2), binds to both subtypes with nearly equal affinity and is the prototypical agonist. Selective estrogen receptor modulators (SERMs) may bin...

journal_title：Endocrinology

authors： Starkey NJE,Li Y,Drenkhahn-Weinaug SK,Liu J,Lubahn DB

更新日期：2018-05-01 00:00:00

abstract：:Immunohistochemical (immunoperoxidase) studies were performed on 478 sections from 97 rat pituitary glands with rabbit antisera to unconjugated human synthetic calcitonin beta-endorphin, and/or ACTH-(17--39). Calcitonin-positive cells were present in a majority of the anterior lobes studied, whereas they were present ...

journal_title：Endocrinology

authors： Watkins WB,Moore RY,Burton D,Bone HG 3rd,Catherwood BD,Deftos LJ

更新日期：1980-06-01 00:00:00

abstract：:The effect of beta-endorphin upon plasma arg8-vasopressin release was studied in vivo in rabbits and in vitro in rat neural lobes. Following intravenous administration of 200 mug/kg synthetic beta-endorphin plasma AVP rose significantly by five minutes after injection and remained elevated for twenty-five minutes comp...

journal_title：Endocrinology

authors： Weitzman RE,Fisher DA,Minick S,Ling N,Guillemin R

更新日期：1977-11-01 00:00:00

abstract：:Maintenance of cell polarity is essential for Sertoli cell and blood-testis barrier (BTB) function and spermatogenesis; however, the signaling mechanisms that regulate the integrity of the cytoskeleton and polarity of Sertoli cells are not fully understood. Here, we demonstrate that rapamycin-insensitive component of ...

journal_title：Endocrinology

authors： Dong H,Chen Z,Wang C,Xiong Z,Zhao W,Jia C,Lin J,Lin Y,Yuan W,Zhao AZ,Bai X

更新日期：2015-11-01 00:00:00

abstract：:Open pig thyroid follicles in which the apical surface of the follicle cells is in direct contact with the incubation medium were used to study the effect of stimulated exocytosis and stimulated H2O2 generation on the iodination of protein in the incubation medium. In previous studies on this system of follicles we ha...

journal_title：Endocrinology

authors： Björkman U,Ekholm R

更新日期：1988-02-01 00:00:00

abstract：:Within the preoptic region, nitric oxide (NO) production varies during the ovarian cycle and has the ability to impact hypothalamic reproductive function. One mechanism for the regulation of NO release mediated by estrogens during the estrous cycle includes physical association of the calcium-activated neuronal NO syn...

journal_title：Endocrinology

authors： Parkash J,d'Anglemont de Tassigny X,Bellefontaine N,Campagne C,Mazure D,Buée-Scherrer V,Prevot V

更新日期：2010-06-01 00:00:00

abstract：:Glucocorticoid hormones act in the nucleus of the cell to alter expression of specific genes and change cell metabolism. In liver, these hormones have been reported to increase mitochondrial respiratory activity, which is regulated by both nuclear and mitochondrial gene products. We examined the effects of the synthet...

journal_title：Endocrinology

authors： Van Itallie CM

更新日期：1992-02-01 00:00:00

abstract：:In previous studies we demonstrated a much greater rate of glucose cycling (glucose-->glucose-6-P-->glucose) in islets from ob/ob mice than from lean litter mates. Cycling was further augmented by dexamethasone treatment. To determine whether these findings could be accounted for by increased islet glucose-6-phosphata...

journal_title：Endocrinology

authors： Khan A,Hong-Lie C,Landau BR

更新日期：1995-05-01 00:00:00

abstract：:Homologous anterior pituitaries grafted under the kidney capsule in hypophysectomized rats were studied 30 days after transplantation. Some cells maintained the ultrastructural features peculiar to the various cell types of normotopic glands, while the others were characterized by few, small, dense granules, spherical...

journal_title：Endocrinology

authors： Zanini A,Giannattasio G,De Camilli P,Panerai AE,Müller EE,Meldolesi J

更新日期：1979-01-01 00:00:00

abstract：:Experiments were done to examine whether rat relaxin is dipsogenic and whether such dipsogenic effects of rat relaxin are related to time of injection during the light-dark cycle. Female rats were fitted with a chronic intra-cerebro-ventricular (i.c.v.) cannula. Rat relaxin (2.5, 5, 10, 25, 50, or 100 ng/2 microl in 0...

journal_title：Endocrinology

authors： Summerlee AJ,Hornsby DJ,Ramsey DG

更新日期：1998-05-01 00:00:00

abstract：:FSH stimulates follicular growth through inducing granulosa cell proliferation. Our working hypothesis is that mitogenesis is facilitated by a locally produced growth/differentiation factor(s) that modulates FSH action in developing granulosa cells. The present study was undertaken to examine the effect of the related...

journal_title：Endocrinology

authors： Miró F,Hillier SG

更新日期：1996-02-01 00:00:00

abstract：:Corticostatin-I (CSI) is the most potent of the corticostatic peptides isolated from rabbit lungs and neutrophils. CSI was localized in cells by immunohistochemistry using highly specific polyclonal antisera raised against the synthetic peptide. Western blot showed a single 4-kilodalton band, indicating that the antib...

journal_title：Endocrinology

authors： Hu J,Jothy S,Solomon S

更新日期：1993-06-01 00:00:00

abstract：:Several observations suggest that GH stimulates sebaceous gland growth and development. Therefore, we studied the effects of GH and insulin-like growth factors (IGFs), alone and with androgen, on sebaceous epithelial cell (sebocyte) growth and differentiation in vitro. The rat preputial cell culture model system was u...

journal_title：Endocrinology

authors： Deplewski D,Rosenfield RL

更新日期：1999-09-01 00:00:00

abstract：:We examined the effects of removing extracellular Ca2+ (Ca2+e), depleting intracellular Ca2+ (Ca2+i), inhibiting cAMP-dependent calmodulin, and blocking voltage-sensitive Ca2+ channels on the secretion of ACTH by perifused dispersed rat anterior pituitary cells. The cells were stimulated with synthetic arginine vasopr...

journal_title：Endocrinology

authors： Won JG,Oki Y,Orth DN

更新日期：1990-02-01 00:00:00

abstract：:A method has been developed for the purification of rat placental lactogen employing a specific radioreceptor assay (RRA). The method involves precipitation with ammonium sulfate, gel filtration on Sephadex G-100, ion-exchange chromatography on DEAE-cellulose and CM-Sephadex, and preparative isoelectric focusing. The ...

journal_title：Endocrinology

authors： Roberston MC,Friesen HG

更新日期：1975-09-01 00:00:00

abstract：:Androgens act to stimulate spermatogenesis through androgen receptors (ARs) on the Sertoli cells and peritubular myoid cells. Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis. To determine whether androgens can stimulate spermatogenesis through direct action on the peri...

journal_title：Endocrinology

authors： O'Shaughnessy PJ,Verhoeven G,De Gendt K,Monteiro A,Abel MH

更新日期：2010-05-01 00:00:00

abstract：:We recently identified a 32 K mol wt insulin-like growth factor (IGF)-binding protein (BP) which is markedly increased in the serum of streptozotocin-diabetic rats and recognized by antiserum against the human amniotic fluid IGFBP (hIGFBP-1). In the present study we sought to confirm that this protein represents the r...

journal_title：Endocrinology

authors： Unterman TG,Oehler DT,Gotway MB,Morris PW

更新日期：1990-08-01 00:00:00

abstract：:The expression of melatonin receptors (MR) of the Mel1a subtype in basolateral membrane of guinea pig kidney proximal tubule suggests that melatonin plays a role in regulating epithelial functions. To investigate the cellular basis of melatonin action on epithelia, we sought to establish an appropriate in vitro cultur...

journal_title：Endocrinology

authors： Chan CW,Song Y,Ailenberg M,Wheeler M,Pang SF,Brown GM,Silverman M

更新日期：1997-11-01 00:00:00

abstract：:RIAs specific for the alpha-subunit of glycoprotein hormones were used to monitor the subunit conformation in ovine FSH and TSH and in recombinants of ovine LH alpha with (ovine and porcine) LH beta and hCG beta. Differences in log-logit slopes of the RIA dilution curves were interpreted to indicate changes, presumabl...

journal_title：Endocrinology

authors： Strickland TW,Puett D

更新日期：1982-07-01 00:00:00

abstract：:The Caenorhabditis elegans death susceptibility gene, ced-3, has a number of homologs in vertebrate species, including interleukin-1 beta (IL-1 beta)-converting enzyme (ICE), Ich-1long, and CPP32. These genes, which encode a family of related proteases, have been shown to induce apoptosis when transfected into eukaryo...

journal_title：Endocrinology

authors： Flaws JA,Kugu K,Trbovich AM,DeSanti A,Tilly KI,Hirshfield AN,Tilly JL

更新日期：1995-11-01 00:00:00

abstract：:Prolactin has been associated with many effects and has been implicated in the pathogenesis of pregnancy-related hypertensive disorders, although little is known about its vascular effects. The present study was designed to determine the primary effect of prolactin on regional vascular beds and the mechanisms involved...

journal_title：Endocrinology

authors： Molinari C,Grossini E,Mary DA,Uberti F,Ghigo E,Ribichini F,Surico N,Vacca G

更新日期：2007-08-01 00:00:00

abstract：:In humans, the incidence and severity of abdominal aortic aneurysms (AAA) are greater in males than in females. Chronic infusion of angiotensin II (AngII) into apolipoprotein E-deficient (apoE(-/-)) mice promotes atherosclerosis and causes the formation of AAAs. Just as human males are more susceptible to developing A...

journal_title：Endocrinology

authors： Henriques TA,Huang J,D'Souza SS,Daugherty A,Cassis LA

更新日期：2004-08-01 00:00:00

abstract：:Whereas the stimulatory effect of interleukin-6 (IL-6) on the hypothalamic-pituitary-adrenal (HPA) axis is well established, its mode of action in this axis has yet to be fully elucidated. To further study the role of IL-6 in the HPA axis, we compared the expression of IL-6 messenger RNA (mRNA) in the rat hypothalamus...

journal_title：Endocrinology

authors： Muramami N,Fukata J,Tsukada T,Kobayashi H,Ebisui O,Segawa H,Muro S,Imura H,Nakao K

更新日期：1993-12-01 00:00:00

abstract：:Adrenals express a high level of neutral cholesteryl ester hydrolase (CEH) activity, and male rats have greater activity than females; however, the identity of the enzyme(s) responsible for this activity and the basis for the sex differences are unknown. Using mice in which hormone-sensitive lipase (HSL) was inactivat...

journal_title：Endocrinology

authors： Kraemer FB,Shen WJ,Natu V,Patel S,Osuga J,Ishibashi S,Azhar S

更新日期：2002-03-01 00:00:00

abstract：:The genetically obese Zucker rat is a widely used model of early-onset obesity. Like obese children, these obese rats are hyperinsulinemic and have low GH secretion. However, data on linear growth and insulin-like growth factor-I (IGF-I) levels in this model are scanty and contradictory. In the present study, we inves...

journal_title：Endocrinology

authors： Nguyen-Yamamoto L,Deal CL,Finkelstein JA,Van Vliet G

更新日期：1994-03-01 00:00:00

abstract：:In several mammalian species, luteinizing hormone-releasing hormone (LHRH) neurons have been shown to migrate from nasal regions to the brain during early development. Using immunocytochemistry, we have identified LHRH containing neurons in developing chick embryos. In embryonic day 4 (E4) and E5 animals, a small grou...

journal_title：Endocrinology

authors： Norgren RB Jr,Lehman MN

更新日期：1991-03-01 00:00:00

abstract：:Previous studies have shown that cysteamine [2-aminoethanethiol (CSH)], given in vivo or in vitro, rapidly but reversibly depletes immunoreactive PRL from the anterior pituitary (AP) through a mechanism which, in vitro, does not appear to involve the dopamine (DA) receptor. In the present investigation, these effects ...

journal_title：Endocrinology

authors： Millard WJ,Sagar SM,Simpkins JW,Owens RE,Badger TM,Friesen HG,Martin JB

更新日期：1983-12-01 00:00:00

abstract：:In previous studies we have shown that aromatase cytochrome P450 (P450arom) mRNA and protein increase markedly in luteal tissue between days 10-19 of gestation, whereas cholesterol side-chain cleavage cytochrome P450 (P450scc) appears to be constitutively maintained regardless of hormonal changes occurring during preg...

journal_title：Endocrinology

authors： Hickey GJ,Oonk RB,Hall PF,Richards JS

更新日期：1989-09-01 00:00:00