Neurons that migrate from the olfactory epithelium in the chick express luteinizing hormone-releasing hormone.

abstract：:During the purification of skeletal growth factor/insulin-like growth factor-II and transforming growth factor-beta (TGF beta) from EDTA extracts of bovine bone matrix significant mitogenic activity for cultured osteoblast (Ob)-like cells eluted in fractions that contained a nearly homogeneous peptide with a mol wt of...

journal_title：Endocrinology

authors： Jennings JC,Mohan S,Baylink DJ

更新日期：1989-07-01 00:00:00

abstract：:Three distinct receptor types for natriuretic peptides (NP) have been identified in human tissue. "A" and "B" receptors initiate biological actions, whereas the "C" receptor has a clearance function. It has been proposed that the natural ligand for the B receptor is c-type natriuretic peptide (CNP), rather than atrial...

journal_title：Endocrinology

authors： Canaan-Kühl S,Jamison RL,Myers BD,Pratt RE

更新日期：1992-01-01 00:00:00

abstract：:The ileal proglucagon-derived peptides (PGDPs) play important roles in the regulation of gastric function and insulin secretion. We have previously demonstrated the existence of a proximal-distal enteroendocrine loop mediated by glucose-dependent insulinotropic peptide (GIP), through which intestinal PGDP secretion is...

journal_title：Endocrinology

authors： Roberge JN,Gronau KA,Brubaker PL

更新日期：1996-06-01 00:00:00

abstract：:Our laboratory has previously reported that physiological levels of progestins stimulate growth of the human breast cancer cell line T47D. We have also determined that the antiprogestin RU486 inhibits this stimulation. Here we present the unexpected finding that RU486 alone also stimulates growth of these breast cance...

journal_title：Endocrinology

authors： Bowden RT,Hissom JR,Moore MR

更新日期：1989-05-01 00:00:00

abstract：:Human myometrium contains hCG/LH receptors. There are fewer of these receptors during labor compared to no labor at preterm or term deliveries. Exogenous hCG can directly inhibit oxytocin-stimulated human myometrial contractions. These findings suggest that hCG may directly maintain myometrial quiescence during pregna...

journal_title：Endocrinology

authors： Ambrus G,Rao CV

更新日期：1994-12-01 00:00:00

abstract：:The sexually dimorphic extrahypothalamic arginine-vasopressin (AVP) projections from the bed nucleus of the stria terminalis to the lateral septum (LS) and lateral habenula (LHb) are denser in males than females and, in rats, require males' perinatal exposure to gonadal hormones but the absence of such exposure in fem...

journal_title：Endocrinology

authors： Lonstein JS,Rood BD,De Vries GJ

更新日期：2005-03-01 00:00:00

abstract：:To assess a potential underlying rhythm in the sensitivity of the pregnant primate myometrium to oxytocin we infused five pregnant rhesus monkeys (gestational age, 121-142 days) with oxytocin at three different periods of the 24-h day, in the order night, afternoon, and morning, via the maternal inferior vena cava. Ox...

journal_title：Endocrinology

authors： Honnebier MB,Myers T,Figueroa JP,Nathanielsz PW

更新日期：1989-09-01 00:00:00

abstract：:A study of the synthesis and migration of thyroglobulin has been carried out by the incubation of calf thyroid slices in the presence of [14C]leucine followed by the separation of intracellular compartments from the colloid by differential and density gradient centrifugation. The effect of inhibitors on these processe...

journal_title：Endocrinology

authors： Spiro MJ,Gorski KM

更新日期：1986-09-01 00:00:00

abstract：:We have tested the hypothesis that basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) regulate the proliferation of osteoblast-like cells. Cells which migrated from central bone explants of fetal calf calvaria expressed markers characteristic of the osteoblast phenotype, including ost...

journal_title：Endocrinology

authors： Globus RK,Patterson-Buckendahl P,Gospodarowicz D

更新日期：1988-07-01 00:00:00

abstract：:Glutamate (Glu) is the most prevalent excitatory neurotransmitter in the brain and has been implicated in the regulation of GnRH secretion in several mammalian species, including the monkey. To investigate the neuroanatomical basis for Glu-GnRH interactions, we performed an immunocytochemical study at both the light a...

journal_title：Endocrinology

authors： Goldsmith PC,Thind KK,Perera AD,Plant TM

更新日期：1994-02-01 00:00:00

abstract：:In vitro addition of rat insulin (200, 400 or 800 muU/ml) to collagenase-isolated pancreatic islets of adult rats diminished glucose (3 mg/ml)-induced insulin release which was correlated with a decrease of the ratio of total NADPH/NADP and inhibition of glucose oxidation via the pentose phosphate shunt (PPS). NADH an...

journal_title：Endocrinology

authors： Ammon HP,Verspohl E

更新日期：1976-12-01 00:00:00

abstract：:Folliculostellate (FS) cells are known to communicate with each other and with endocrine cells via gap junctions in the anterior pituitary. We investigated whether TGFbeta3 and estradiol, known to regulate FS cell production and secretion of basic fibroblast growth factor (bFGF), increases gap junctional communication...

journal_title：Endocrinology

authors： Kabir N,Chaturvedi K,Liu LS,Sarkar DK

更新日期：2005-09-01 00:00:00

abstract：:Thyroid hormones are of considerable importance for vertebrate reproductive function and during development. To further assess the role of these compounds in this capacity, we examined the expression pattern of the type 2 iodothyronine deiodinase (D2), which converts T(4) to the more active hormone T(3), in the rat ut...

journal_title：Endocrinology

authors： Galton VA,Martinez E,Hernandez A,St Germain EA,Bates JM,St Germain DL

更新日期：2001-05-01 00:00:00

abstract：:The effects of FSH, hCG, and PRL on the activity of 20 alpha-hydroxysteroid dehydrogenase (20 alpha-SDH) of separate ovarian components of hypophysectomized, diethylstilbestrol-treated rats were studied. Enzyme activity was found to reside mainly in granulosa cells. FSH induced an increase in enzyme activity. A prepar...

journal_title：Endocrinology

authors： Eckstein B,Nimrod A

更新日期：1979-03-01 00:00:00

abstract：:The inhibitor of apoptosis proteins (IAPs) constitutes a family of highly conserved apoptosis suppressor proteins that were originally identified in baculoviruses. Although IAP homologs have recently been demonstrated to suppress apoptosis in mammalian cells, their expression and role in human ovarian epithelial cance...

journal_title：Endocrinology

authors： Li J,Feng Q,Kim JM,Schneiderman D,Liston P,Li M,Vanderhyden B,Faught W,Fung MF,Senterman M,Korneluk RG,Tsang BK

更新日期：2001-01-01 00:00:00

abstract：:Recent research progress indicates a close link between ghrelin, a natural ligand of GH secretagogues receptor (GHS-R), and both the metabolic balance and body composition. To clarify the involvement of ghrelin and GHS-R in the process of adipogenesis, we measured the expression of GHS-R and peroxisome proliferator-ac...

journal_title：Endocrinology

authors： Choi K,Roh SG,Hong YH,Shrestha YB,Hishikawa D,Chen C,Kojima M,Kangawa K,Sasaki S

更新日期：2003-03-01 00:00:00

abstract：:The possible role of atrial natriuretic factor (ANF) in the regulation of adrenal sensitivity to angiotensin II (AII) was investigated in vivo and in vitro by analyzing the characteristics of the inhibitory effect of ANF on aldosterone production stimulated by AII and other stimuli. In isolated adrenal glomerulosa cel...

journal_title：Endocrinology

authors： Aguilera G

更新日期：1987-01-01 00:00:00

abstract：:Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...

journal_title：Endocrinology

authors： Frolova A,Flessner L,Chi M,Kim ST,Foyouzi-Yousefi N,Moley KH

更新日期：2009-03-01 00:00:00

abstract：:L-Triiodothyronine in vitro increased the uptake of the non-metabolizable amino acid, alpha-aminoisobutyrate, into isolated rat thymocytes. This effect was evident at extracellular free hormone concentrations of 10-7 to 5 times 10-8M and was due to a marked inhibition of amino acid efflux. In contrast, insulin and dib...

journal_title：Endocrinology

authors： Goldfine ID,Simons CG,Ingbar SH

更新日期：1975-03-01 00:00:00

abstract：:The present study investigated whether activation of the hexosamine biosynthesis pathway might mediate at least in part the high glucose effect on angiotensinogen (ANG) gene expression and immortalized renal proximal tubular cell (IRPTC) hypertrophy. IRPTC were cultured in monolayer. ANG, renin, and beta-actin mRNA ex...

journal_title：Endocrinology

authors： Hsieh TJ,Fustier P,Zhang SL,Filep JG,Tang SS,Ingelfinger JR,Fantus IG,Hamet P,Chan JS

更新日期：2003-10-01 00:00:00

abstract：:Depletion of hypothalamic norepinephrine (NE) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular (IVT) angiotensin II (AII) on LH release in ovariectomized rats pretreated with estradiol and progesterone. The increase in blood LH produced by IVT NE or iv L...

journal_title：Endocrinology

authors： Steele MK,Ganong WF

更新日期：1986-12-01 00:00:00

abstract：:Recently, we reported that ovariectomy (OVX)-induced FSH hypersecretion can be elicited in hypophysectomized rats bearing renal pituitary allografts isolated from direct hypothalamic intervention. The possible role of the FSH-stimulating protein, activin-B, in eliciting this response was investigated using passive imm...

journal_title：Endocrinology

authors： DePaolo LV,Bald LN,Fendly BM

更新日期：1992-03-01 00:00:00

abstract：:Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...

journal_title：Endocrinology

authors： Shibata M,Banno R,Sugiyama M,Tominaga T,Onoue T,Tsunekawa T,Azuma Y,Hagiwara D,Lu W,Ito Y,Goto M,Suga H,Sugimura Y,Oiso Y,Arima H

更新日期：2016-04-01 00:00:00

abstract：:The primate brain was thought to contain only the GnRH known as mammalian GnRH (mGnRH). This study investigates whether a second form of GnRH exists within the primate brain. We found that brain extracts from adult stumptail and rhesus monkeys contained two forms of GnRH that were similar to mGnRH and chicken GnRH-II ...

journal_title：Endocrinology

authors： Lescheid DW,Terasawa E,Abler LA,Urbanski HF,Warby CM,Millar RP,Sherwood NM

更新日期：1997-12-01 00:00:00

abstract：:Prenatal stress is associated with altered behavior and hypothalamic-pituitary-adrenal (HPA) axis function postnatally. Recent studies suggest that these outcomes are dependent on the timing of the prenatal stress. The majority of these studies have been carried out in male offspring. We hypothesized that a short peri...

journal_title：Endocrinology

authors： Kapoor A,Matthews SG

更新日期：2008-12-01 00:00:00

abstract：:The 3'5'-cyclic GMP (cGMP) pathway is known to influence ovarian functions, including steroidogenesis, ovulation, and granulosa cell proliferation. We show here that cGMP-phosphodiesterase (PDE) activity increased in a gonadotropin-dependent manner more than 3-fold in the cumulus-oocyte complex (COC) after 24 h in vit...

journal_title：Endocrinology

authors： Sasseville M,Côté N,Gagnon MC,Richard FJ

更新日期：2008-11-01 00:00:00

abstract：:One of the hypotheses attempting to explain the etiology of the human disease X-linked hypophosphatemia (XLH) posits renal hypersensitivity to parathyroid hormone (PTH). These studies were designed to test this hypothesis in vivo, using the hemizygous hypophosphatemic (Hyp/Y) mouse as an animal model for XLH. Vehicle ...

journal_title：Endocrinology

authors： Kiebzak GM,Meyer RA Jr

更新日期：1982-03-01 00:00:00

abstract：:We recently identified a 32 K mol wt insulin-like growth factor (IGF)-binding protein (BP) which is markedly increased in the serum of streptozotocin-diabetic rats and recognized by antiserum against the human amniotic fluid IGFBP (hIGFBP-1). In the present study we sought to confirm that this protein represents the r...

journal_title：Endocrinology

authors： Unterman TG,Oehler DT,Gotway MB,Morris PW

更新日期：1990-08-01 00:00:00

abstract：:A healthy nutritional state is required for all aspects of reproduction and is signaled by the adipokine leptin. Leptin acts in a relatively narrow concentration range: too much or too little will compromise fertility. The leptin signal timing is important to prepubertal development in both sexes. In the brain, leptin...

journal_title：Endocrinology

authors： Childs GV,Odle AK,MacNicol MC,MacNicol AM

更新日期：2021-02-01 00:00:00

abstract：:The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses to CRH. However, it's potential activity in blunting behavioral and endocrine sequelae of stressor exposure has not been assessed. Because antagonism of central CRH by alpha-helical CRH attenuates conditioned fear ...

journal_title：Endocrinology

authors： Deak T,Nguyen KT,Ehrlich AL,Watkins LR,Spencer RL,Maier SF,Licinio J,Wong ML,Chrousos GP,Webster E,Gold PW

更新日期：1999-01-01 00:00:00