Abstract:
:Our laboratory has previously reported that physiological levels of progestins stimulate growth of the human breast cancer cell line T47D. We have also determined that the antiprogestin RU486 inhibits this stimulation. Here we present the unexpected finding that RU486 alone also stimulates growth of these breast cancer cells. Thus, RU486 exhibits both antagonist and agonist-like activity, in a manner somewhat reminiscent of the antiestrogen tamoxifen. To our knowledge, this is the first report of stimulation of breast cancer growth by RU486.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Bowden RT,Hissom JR,Moore MRdoi
10.1210/endo-124-5-2642subject
Has Abstractpub_date
1989-05-01 00:00:00pages
2642-4issue
5eissn
0013-7227issn
1945-7170journal_volume
124pub_type
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