Abstract:
:Smoltification is a transformation that occurs in some species of salmon, during which solitary fish in fresh water become schooling fish and migrate to the sea. This process is accompanied by large increases in plasma T4. T4 secretion rate and other parameters of T4 metabolism in juvenile coho salmon were estimated by applying kinetic analyses to measurements of the disappearance of injected T4 radiotracer from plasma. Studies were performed at the beginning (March) and end (May) of the increase in T4 concentration in fresh water and seawater. Early and intensive sampling permitted characterization of a very fast initial component of the T4 disappearance curve when analyses included a zero time datum derived from an independent estimate of plasma volume. The plasma volume, equal to 1.77% of body weight, was obtained by measuring the disappearance of radiolabeled albumin from the plasma in two other groups of animals in fresh water and seawater. There were 3- to 7-fold changes in T4 production, distribution, and metabolism between March and May, whereas environment (fresh water vs. seawater) had relatively minor effects on T4 kinetics. In fresh water, the T4 secretion rate was 4.48 ng/h in March and 1.50 ng/h in May. The total T4 pool size was 37.8 ng in March and 12.2 ng in May. Plasma-tissue T4 fluxes were 3- to 7-fold greater in May. Relatively less T4 was distributed in tissue in May (63% vs. 83%), and T4 spent much less time in tissue in May than in March during each pass through the tissue space (11 min vs. 3.1 h). We propose that the difference in secretion rate and a redistribution of T4 between blood and tissues contribute to both the rise and fall in the plasma T4 concentration between March and May. Changes in T4 kinetics during salmonid smoltification resemble those occurring during amphibian metamorphosis and mammalian gestation and neonatal life, and may reflect an increased requirement and an important role for thyroid hormones during periods of rapid development in vertebrates in general.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Specker JL,DiStefano JJ 3rd,Grau EG,Nishioka RS,Bern HAdoi
10.1210/endo-115-1-399subject
Has Abstractpub_date
1984-07-01 00:00:00pages
399-406issue
1eissn
0013-7227issn
1945-7170journal_volume
115pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Trans-10, cis-12 conjugated linoleic acid (10,12 CLA) is a dietary fatty acid that promotes weight loss and disproportionate fat loss. Obese mice fed a high-fat, high-sucrose (HFHS) diet containing 10,12 CLA are resistant to weight gain and contain markedly reduced subcutaneous fat and adiponectin, with a concurrent l...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00213
更新日期:2017-09-01 00:00:00
abstract::Prolactinomas are the most prevalent functional pituitary adenomas. Dopamine D2 receptor (D2R) agonists, such as bromocriptine are the first line of therapy; however, drug intolerance/resistance to D2R agonists exists. Apart from D2R agonists, there is no established medical therapy for prolactinomas; therefore, ident...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1760
更新日期:2008-08-01 00:00:00
abstract::Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved to be effective in several organisms. In this study, we reported that TALENs can induce somatic mutations in Nile tilapia, an important species for worldwide aquaculture, with reliably high...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1451
更新日期:2013-12-01 00:00:00
abstract::Lanosterol 14alpha-demethylase (CYP51) responds to cholesterol feedback regulation through sterol regulatory element binding proteins (SREBPs). The proximal promoter of CYP51 contains a conserved region with clustered regulatory elements: GC box, cAMP-response elements (CRE-like), and sterol regulatory element (SRE). ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0781
更新日期:2005-12-01 00:00:00
abstract::Humans are routinely exposed to bisphenol A (BPA), an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. BPA binds both classical nuclear estrogen receptors and facilitates membrane-initiated estrogenic effects. Here we explore the ability of en...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0189
更新日期:2006-08-01 00:00:00
abstract::3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone (TH)-derived metabolite that induces severe hypothermia in mice after systemic administration; however, the underlying mechanisms have remained enigmatic. We show here that the rapid 3-T1AM-induced loss in body temperature is a consequence of peripheral vasod...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1951
更新日期:2017-06-01 00:00:00
abstract::The invasion of extravillous cytotrophoblasts (EVT) into the underlying maternal tissues and vasculature is a key step in human placentation. The molecular mechanisms involved in the development of the invasive phenotype of EVT include many that were first discovered for their role in cancer cell metastasis. Previous ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1488
更新日期:2012-02-01 00:00:00
abstract::We have recently demonstrated that GnRH-stimulated gonadotropin secretion is augmented by coadministration with neuropeptide-Y (NPY) in anterior pituitaries removed in the afternoon from proestrous, but not metestrous, rats. To test the hypothesis that these effects of NPY are due to an interaction with progesterone (...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.1.7828530
更新日期:1995-01-01 00:00:00
abstract::Immunoreactive neurophysin (Np) is demonstrated by the immunoperoxidase technique not only within neurones of the classical hypothalamo-neurohypophyseal system, but also in extrahypothalamic perikarya and fibers. Np-positive perikarya are found in the triangular nucleus of the septum. Np fibers join the stria terminal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-102-1-334
更新日期:1978-01-01 00:00:00
abstract::Glutathione (GSH) is the most abundant intracellular thiol and an important regulator of cellular redox status. Mice that lack the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have decreased GSH synthesis. Nicotinamide nucleotide transhydrogenase, an inner mitochondr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-0207
更新日期:2011-07-01 00:00:00
abstract::Testosterone propionate causes a striking increase in in vivo uptake of 2-deoxyglucose by the levator ani muscle of immature male rats. Autoradiography showed the labeled 2-deoxyglucose to be uniformly distributed over the entire muscle. Liquid scintillation counting of whole muscles allowed quantification of 2-deoxyg...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-113-1-119
更新日期:1983-07-01 00:00:00
abstract::Bovine placental lactogen (bPL) was found to be as potent as human GH (hGH) in its ability to bind to soluble full-size recombinant hGH-binding protein (hGHBP) and to membrane-embedded hGH receptor in intact IM-9 human lymphocytes. bPL was also capable of forming a 1:2 complex with hGHBP, although the structure of thi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.3.7867580
更新日期:1995-03-01 00:00:00
abstract::The present study was undertaken to evaluate the efficacy of an estradiol-chemical delivery system (E2-CDS) for the brain vs. estradiol benzoate (E2-BNZ) in suppressing serum testosterone (T) and weights of the ventral prostate and seminal vesicle in male rats. Also, the role of serum T in the weight reduction of andr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-2-726
更新日期:1991-08-01 00:00:00
abstract::Activin, a member of the transforming growth factor-beta superfamily, binds to two classes of cell surface receptors. These receptors, designated type I and type II, are structurally related members of transmembrane serine kinase superfamily. Antibodies specific for either type I or type II activin receptor can coprec...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.12.7588300
更新日期:1995-12-01 00:00:00
abstract::The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Fur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1070
更新日期:2011-11-01 00:00:00
abstract::The effect of progesterone on the secretion of LH was studied in intact and castrated immature female sheep between 12 and 42 weeks of age. (First spontaneous ovulation occurs between 30 and 50 weeks of age.) Progesterone was administered by means of Silastic capsules inserted SC to achieve circulating progesterone co...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-1-1
更新日期:1976-07-01 00:00:00
abstract::Reproductive fitness in females is susceptible to obesogenic diets. Energy balance and reproduction are tightly regulated, in part, by hypothalamic neurons in the arcuate nucleus (ARC), and high-fat diet (HFD) can steadily increase estradiol levels in rodents. Estradiol regulates the reproductive axis via negative fee...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa146
更新日期:2020-10-01 00:00:00
abstract::In the present study, we investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in the control of access of cortisol and corticosterone to the mouse and human brain. [(3)H]Cortisol poorly penetrated the brain of adrenalectomized wild-type mice, but the uptake was 3.5-fo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.6.8213
更新日期:2001-06-01 00:00:00
abstract::Bovine granulosa cells seeded in the presence of serum on extracellular matrix-coated dishes proliferate actively when exposed to serum-free medium supplemented with insulin (2 microgram/ml), fibroblast growth factor (FGF, 100 ng/ml), and high density lipoprotein (HDL, 30 microgram protein/ml). The final density of th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-109-2-409
更新日期:1981-08-01 00:00:00
abstract::Effects of spironolactone, canrenone and canrenoate-K on adrenal cytochrome P450 (P450) and corticosteroid biosynthesis were examined by studying difference spectra, P450 reduction and corticoid hydroxylation in mitochondrial preparations isolated from zona fasciculata and zona glomerulosa of bovine adrenals and from ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-4-1097
更新日期:1976-10-01 00:00:00
abstract::In addition to 17beta-estradiol binding, estrogen receptor (ER) transcriptional activity could be controlled by intracellular kinase signaling pathways activated by growth factors. In this report we present evidence suggesting that glycogen synthase kinase 3 (GSK3), an effector kinase of the phosphatidylinositol 3-kin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-1224
更新日期:2006-06-01 00:00:00
abstract::Resorption of devitalized bone particles by monocytes grown in culture was stimulated by platelet-derived growth factor (PDGF) in a dose-dependent manner. Bone resorption in response to PDGF was time-dependent with a significant increase over control cultures evident by 72 hours. These data are the first to demonstrat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-2-761
更新日期:1983-02-01 00:00:00
abstract::Increased expression of bone morphogenetic proteins (BMPs) in several tissues is associated with inflammation and type 2 diabetes mellitus. BMP2 and BMP4 mRNA expression is increased in pancreatic islets from db/db mice and β-cell proliferation and function are inhibited by BMP4. The effect of BMPs on α-cells is curre...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1163
更新日期:2016-10-01 00:00:00
abstract::The regulation of cholecystokinin octapeptide (CCK-8) secretion was studied using a fetal cerebral cortical cell culture system. After 2-3 weeks in culture, the cells were utilized for short-term release experiments. CCK-8 was measured by RIA and its identity was confirmed by HPLC. Depolarization of the cells with K+ ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-6-3125
更新日期:1991-12-01 00:00:00
abstract::A chemiluminescent dot blot assay has been developed by our laboratory for rapid determinations of IGF-I in serum-free conditioned media (CM) collected from cultured cells. In contrast to IGF-I radioimmunoassays (RIAs), the IGF binding proteins (IGFBPs) did not interfere with the dot blot assay and did not require the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.5.5237
更新日期:1997-05-01 00:00:00
abstract::The effects of L-leucine, D-leucine, and L-isoleucine upon the secretion of glucagon and insulin were investigated using the isolated, perfused rat pancreas. All experiments were conducted in the presence of 5.6 mM D-glucose. Ten-minute perfusions of 2, 5, and 10 mM L-leucine induced the release of glucagon and insuli...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-103-4-1208
更新日期:1978-10-01 00:00:00
abstract::Members of the winged helix transcription factor family are known to regulate epithelial cell differentiation by regulating cell-specific gene expression. rWIN is a newly discovered member of the winged helix family shown to be present in the adult rat testis. In the testis the human homolog of rWIN, HFH-11, was local...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.8.7599
更新日期:2000-08-01 00:00:00
abstract::In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium. Although FSH ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.1.4854
更新日期:1997-01-01 00:00:00
abstract::Hepatic synthesis of alpha 2u-globulin and its mRNA in the male rat is dependent on androgen, glucocorticoid, T4, insulin, and GH. Some of these hormones may act directly on the liver, while others may influence alpha 2u-globulin synthesis through indirect physiological changes. In the present study the specific role ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-5-1814
更新日期:1987-11-01 00:00:00
abstract::Calcium (Ca2+) ionophore A23187 increased the intracellular cAMP content and PRL release in normal rat anterior pituitary cells. Cotreatment with dopamine reduced both control and A23187-stimulated cAMP accumulation and PRL release. The dopamine antagonist spiperone restored the response of cAMP to ionophoric stimulat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-5-1801
更新日期:1983-05-01 00:00:00