Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice.

abstract：:Glucose stimulation of pancreatic beta-cells triggers electrical activity (slow waves of membrane potential with superimposed spikes) that is best monitored with intracellular microelectrodes. Closure of ATP-sensitive K+ channels underlies the depolarization to the threshold potential and participates in the increase ...

journal_title：Endocrinology

authors： Henquin JC

更新日期：1998-03-01 00:00:00

abstract：:Homogenates from male ddy mouse sublingual glands were incubated with 100 nM [125I]rT3 in the presence of 2 mM dithiothreitol (DTT). Metabolites were analyzed by HPLC or Dowex-50 minicolumn assay. 3,3'-Diiodothyronine and I- were the only appreciable products. Iodide release from rT3 was compatible with the enzymatic ...

journal_title：Endocrinology

authors： Tanaka K,Imura H

更新日期：1993-03-01 00:00:00

abstract：:We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after ons...

journal_title：Endocrinology

authors： Eshkevari L,Mulroney SE,Egan R,Lao L

更新日期：2015-10-01 00:00:00

abstract：:Angiotensin II binds to the angiotensin II receptors type 1 (AT1 receptors) in adrenocortical cells and triggers an intracellular signaling cascade leading to changes in the gene expression pattern. Here, we show that stimulation with angiotensin II induces the expression of biologically active early growth response (...

journal_title：Endocrinology

authors： Thiel G,Rössler OG

更新日期：2011-11-01 00:00:00

abstract：:In vitro addition of rat insulin (200, 400 or 800 muU/ml) to collagenase-isolated pancreatic islets of adult rats diminished glucose (3 mg/ml)-induced insulin release which was correlated with a decrease of the ratio of total NADPH/NADP and inhibition of glucose oxidation via the pentose phosphate shunt (PPS). NADH an...

journal_title：Endocrinology

authors： Ammon HP,Verspohl E

更新日期：1976-12-01 00:00:00

abstract：:Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of transcription) proteins, and mitogen-activated protein kinase, and to stimulate the DNA-binding activity of STAT3 in mouse hypothalamus. In this study, the activation of ...

journal_title：Endocrinology

authors： McCowen KC,Chow JC,Smith RJ

更新日期：1998-11-01 00:00:00

abstract：:The existence of a vasoactive molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human chorionic gonadotropin (hCG) mediator. This study was conducted...

journal_title：Endocrinology

authors： Gómez R,Simón C,Remohí J,Pellicer A

更新日期：2002-11-01 00:00:00

abstract：:The neuroendocrine basis for short-day induced testicular regression was studied in Syrian hamsters of the LSH/Ss Lak strain. Adult animals were maintained either under long or short days (14:10D or 6L:18D, respectively) and given single, daily ip injections of N-methyl-D-aspartate (NMDA) (25 mg/kg BW); control animal...

journal_title：Endocrinology

authors： Urbanski HF

更新日期：1990-11-01 00:00:00

abstract：:Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects, including proliferation, migration, survival, epithelial-to-mesenchymal transition, and angiogenesis, to regulate embryogenesis, tissue homeostasis, and tumorigenesis. Those cell behaviors are also associated with implantation of ...

journal_title：Endocrinology

authors： Gershon E,Hadas R,Elbaz M,Booker E,Muchnik M,Kleinjan-Elazary A,Karasenti S,Genin O,Cinnamon Y,Gray PC

更新日期：2018-04-01 00:00:00

abstract：:Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and low T levels. In utero expos...

journal_title：Endocrinology

authors： Martinez-Arguelles DB,Papadopoulos V

更新日期：2015-01-01 00:00:00

abstract：:Hyp mice, the murine homolog of human X-linked hypophosphatemia (XLH), are characterized in part by elevated renal loss of phosphate (Pi) and hypophosphatemia. The lesion responsible for this syndrome is believed to be defective Na+ gradient-dependent phosphate transport across renal brush border membranes (BBM). It h...

journal_title：Endocrinology

authors： Kiebzak GM,Dousa TP

更新日期：1985-08-01 00:00:00

abstract：:The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve. Both chromosomal and serial duplications have been suggested as mechanisms for the expansion of this gene family. We have identified and annotated IGFBP sequences from a wide selection of vertebrate species as well as Branchios...

journal_title：Endocrinology

authors： Daza DO,Sundström G,Bergqvist CA,Duan C,Larhammar D

更新日期：2011-06-01 00:00:00

abstract：:To assess a potential underlying rhythm in the sensitivity of the pregnant primate myometrium to oxytocin we infused five pregnant rhesus monkeys (gestational age, 121-142 days) with oxytocin at three different periods of the 24-h day, in the order night, afternoon, and morning, via the maternal inferior vena cava. Ox...

journal_title：Endocrinology

authors： Honnebier MB,Myers T,Figueroa JP,Nathanielsz PW

更新日期：1989-09-01 00:00:00

abstract：:Activin A is a dimeric protein hormone that regulates numerous cellular functions. A clear physiological role for this molecule in pregnancy is suggested by previous studies in the human, wherein activin A rises dramatically as women approach parturition. To determine whether the rodent is a suitable animal model for ...

journal_title：Endocrinology

authors： Draper LB,Chong H,Wang E,Woodruff TK

更新日期：1997-07-01 00:00:00

abstract：:A central feature of glucocorticoid (GC)-induced osteoporosis is decreased bone formation, secondary to decreased numbers of functional osteoblasts. We find that ERK activity is essential for serum-induced osteoblast proliferation in vitro because inhibition of MAPK/ERK kinase activity by U0126 completely abolished bo...

journal_title：Endocrinology

authors： Engelbrecht Y,de Wet H,Horsch K,Langeveldt CR,Hough FS,Hulley PA

更新日期：2003-02-01 00:00:00

abstract：:Pure porcine cholecystokinin-33 [the triacontatriapeptide form of cholecystokinin (CCK-33)], gastric inhibitory polypeptide (GIP), and secretin were infused in rats in doses of 1, 10 and 1000 pmol/kg . min. The peptides were administered alone or in combination with glucose (40 mg/kg . min) or arginine (50 mg/kg . min...

journal_title：Endocrinology

authors： Szecówka J,Lins PE,Efendić S

更新日期：1982-04-01 00:00:00

abstract：:The hormonal requirements for lactogenesis were investigated using explant cultures of mammary tissue obtained from cows at 30-40 days prepartum. Hormones used were insulin, hydrocortisone, and prolactin, and parameters examined were radioactive acetate incorporation into fatty acids, secretory response ratings, and h...

journal_title：Endocrinology

authors： Collier RJ,Bauman DE,Hays RL

更新日期：1977-04-01 00:00:00

abstract：:Food deprivation in laboratory rats induces profound changes in the neuroendocrine system. We have investigated the hypothalamic and pituitary responses of the hypothalamo-pituitary thyroid axis to 48-h food deprivation in Sprague-Dawley rats. Peripheral T3 and hypophysial portal TRH were measured by RIA, and TSH beta...

journal_title：Endocrinology

authors： Blake NG,Eckland DJ,Foster OJ,Lightman SL

更新日期：1991-11-01 00:00:00

abstract：:The effects of estrogens, androgens, and glucocorticoids on bone resorption were compared in organ culture. At a concentration of 10(-5) M, corticosterone, testosterone, dihydrotestosterone, dehydroepiandosterone, estradiol, ethinyl estradiol and estrone did not inhibit the release of 45Ca from 19-day fetal rat long b...

journal_title：Endocrinology

authors： Caputo CB,Meadows D,Raisz LG

更新日期：1976-04-01 00:00:00

abstract：:The antigenic epitopes of human GH (hGH) have been investigated using monoclonal antibodies (Mabs) to hGH. A panel of 12 Mabs was incorporated into two-site binding assays in order to investigate the antigenic surface of hGH. Nine reaction patterns were observed. The Mabs were further characterized in terms of their c...

journal_title：Endocrinology

authors： Strasburger CJ,Kostyo J,Vogel T,Barnard GJ,Kohen F

更新日期：1989-03-01 00:00:00

abstract：:In the kidney, 11 beta-dehydrogenase (11 beta-DH) converts the active steroid cortisol to inactive cortisone (corticosterone to 11-dehydrocorticosterone in the rat). In man, congenital and acquired deficiency of 11 beta-dehydrogenase are rare causes of hypertension in which cortisol acts as a potent mineralocorticoid....

journal_title：Endocrinology

authors： Stewart PM,Whorwood CB,Barber P,Gregory J,Monder C,Franklyn JA,Sheppard MC

更新日期：1991-04-01 00:00:00

abstract：:As4.1 cells are derived from a renin-expressing kidney tumor induced by tissue-specific oncogene-mediated tumorigenesis in transgenic mice. These cells express high levels of renin messenger RNA (mRNA) and synthesize prorenin and renin; they were therefore used as a model to further investigate the molecular biology o...

journal_title：Endocrinology

authors： Thompson HA,Burson JM,Lang JA,Gross KW,Sigmund CD

更新日期：1995-07-01 00:00:00

abstract：:The effects of pentobarbital (Pnt) treatment on the progesterone (P)-induced afternoon increase in the medial basal hypothalamic (MBH) LHRH and serum LH and FSH levels in ovariectomized estradiol benzoate-primed rats were studied. Pnt injection before P blocked the afternoon rise in serum gonadotropins but failed to a...

journal_title：Endocrinology

authors： Kalra SP,Simpkins JW,Kalra PS

更新日期：1981-04-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) stimulates the formation of osteoclast-like tartrate-resistant acid phosphatase-positive multinucleated cells (TRAP + MNC) in vitro. This effect likely results from stimulation of adenylyl cyclase, which is mediated by two PGE2 receptors, designated EP2 and EP4. We used cells from mice in which...

journal_title：Endocrinology

authors： Li X,Okada Y,Pilbeam CC,Lorenzo JA,Kennedy CR,Breyer RM,Raisz LG

更新日期：2000-06-01 00:00:00

abstract：:Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in this region. In the present study, we addressed the hypothesis t...

journal_title：Endocrinology

authors： Molnár CS,Vida B,Sipos MT,Ciofi P,Borsay BÁ,Rácz K,Herczeg L,Bloom SR,Ghatei MA,Dhillo WS,Liposits Z,Hrabovszky E

更新日期：2012-11-01 00:00:00

abstract：:Photoaffinity labeling with underivatized T3 was used to identify T3-binding proteins in the membrane of rat erythrocytes. UV irradiation of ghosts and peripheral protein-depleted membranes in the presence of [125I]T3 resulted in the covalent attachment of 125I to membrane proteins (analyzed by polyacrylamide gel elec...

journal_title：Endocrinology

authors： Samson M,Osty J,Blondeau JP

更新日期：1993-06-01 00:00:00

abstract：:One day of fasting suppresses pulsatile LH secretion in adult male rhesus monkeys. In the present study, we determined whether the hypothalamic-pituitary-adrenal (HPA) axis is activated by 1 day of fasting, and if there is any evidence that an increase in the activity of the HPA axis causes the fasting-induced suppres...

journal_title：Endocrinology

authors： Helmreich DL,Mattern LG,Cameron JL

更新日期：1993-06-01 00:00:00

abstract：:Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysacc...

journal_title：Endocrinology

authors： Coste SC,Heldwein KA,Stevens SL,Tobar-Dupres E,Stenzel-Poore MP

更新日期：2001-08-01 00:00:00

abstract：:Cholecystokinin (CCK)/gastrin receptors were characterized in calf pancreatic plasma membranes from newborns, 28- and 119-day-old milk-fed preruminants, and 119-day-old weaned ruminants. Scatchard analysis of [125I]Bolton-Hunter reagent-[Thr28,Nle31]CCK-(25-33) binding indicated two classes of binding sites: high affi...

journal_title：Endocrinology

authors： Le Meuth V,Philouze-Rome V,Le Huerou-Luron I,Formal M,Vaysse N,Gespach C,Guilloteau P,Fourmy D

更新日期：1993-09-01 00:00:00

abstract：:The distribution pattern of messenger RNAs (mRNAs) for insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor and the detection of IGF-binding sites in sections of ovine ovary were demonstrated using in situ hybridization and autoradiography. Ovaries were collected from 30 ewes at time points throug...

journal_title：Endocrinology

authors： Perks CM,Denning-Kendall PA,Gilmour RS,Wathes DC

更新日期：1995-12-01 00:00:00