Extrahypothalamic neurophysin-containing perikarya, fiber pathways and fiber clusters in the rat brain.

abstract：:Nucleic acid-based therapies offer great potential for treatment of a variety of diseases including cancer by modulating protein expression with DNA or small interfering RNA. However, realization of their full therapeutic potential is currently limited due to an inability to reach the target site in an active form. Id...

journal_title：Endocrinology

authors： Christie RJ,Nishiyama N,Kataoka K

更新日期：2010-02-01 00:00:00

abstract：:The gastrointestinal tract of the pig undergoes enhanced growth as well as morphological and functional differentiation during the perinatal period. Concurrently, porcine neonates ingest physiologically significant amounts of insulin-like growth factor-I (IGF-I) via colostrum and milk. The objectives of this study wer...

journal_title：Endocrinology

authors： Schober DA,Simmen FA,Hadsell DL,Baumrucker CR

更新日期：1990-02-01 00:00:00

abstract：:The rapid, nongenomic effects of estrogen are increasingly recognized as playing an important role in several aspects of estrogen action. Rapid activation of the mitogen-activated protein kinase (MAPK) signaling pathway by estrogen is among the more recently identified of these effects. To explore the role of estrogen...

journal_title：Endocrinology

authors： Wade CB,Robinson S,Shapiro RA,Dorsa DM

更新日期：2001-06-01 00:00:00

abstract：:G proteins were quantitated by immunoblot in normal rat anterior pituitary, an estrone-induced pituitary adenoma, and in two transplantable pituitary tumors resistant to dopamine, 7315a and MtTW15. Antisera specific for the alpha o and beta subunits or the alpha i subunit of G proteins were tested with all preparation...

journal_title：Endocrinology

authors： Collu R,Bouvier C,Lagacé G,Unson CG,Milligan G,Goldsmith P,Spiegel AM

更新日期：1988-03-01 00:00:00

abstract：:The presence of estrogen receptors (ERs) in nonneural cells in brain, including glia, ependyma, and endothelia, has not previously been documented with electron microscopy. This study employed immunocytochemistry to investigate whether ER immunoreactivity (ER-ir) is present in glial, ependymal, or endothelial cells in...

journal_title：Endocrinology

authors： Langub MC Jr,Watson RE Jr

更新日期：1992-01-01 00:00:00

abstract：:Mature male rat liver cytosol contains a moderate affinity and capacity estrogen-binding protein in at least a 200-fold higher level than mature female or immature male rat liver cytosol. Binding of estradiol to this protein is very rapid, is stabilized by EDTA, and is inhibited by divalent cations. This is the major ...

journal_title：Endocrinology

authors： Dickson RB,Aten RF,Eisenfeld AJ

更新日期：1978-11-01 00:00:00

abstract：:Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating d...

journal_title：Endocrinology

authors： Warden SJ,Robling AG,Sanders MS,Bliziotes MM,Turner CH

更新日期：2005-02-01 00:00:00

abstract：:T4-binding globulin (TBG), the principal carrier of thyroid hormone in serum, is a glycoprotein containing 20% carbohydrate. The importance of the carbohydrate moiety has been previously studied by enzymatic deglycosylation, which showed that deglycosylated TBG retains its original immunological an T4-binding properti...

journal_title：Endocrinology

authors： Murata Y,Magner JA,Refetoff S

更新日期：1986-04-01 00:00:00

abstract：:The interaction of alloxan and cyclic AMP on glucose-induced insulin secretion was studied with the use of isolated rat islet perifusion. Simultaneous perifusion with cyclic AMP and alloxan did not protect the islets against the effect of alloxan. However, addition of dibutyryl cyclic AMP to the alloxan solution produ...

journal_title：Endocrinology

authors： Tomita T,Scarpelli DG

更新日期：1977-05-01 00:00:00

abstract：:The ontogeny of expression of the CRF gene in the paraventricular hypothalamic nucleus and POMC gene in the pituitary was studied in rats using in situ hybridization histochemistry and Northern blotting techniques, respectively. CRF mRNA was first detected on day 17 of gestation (E17) in the paraventricular nucleus of...

journal_title：Endocrinology

authors： Grino M,Young WS 3rd,Burgunder JM

更新日期：1989-01-01 00:00:00

abstract：:Estradiol-17beta (E2) is suspected to exert a role in the regulation of testicular activity. Using a nonmammalian vertebrate model (the frog, Rana esculenta), we have investigated whether c-fos activity is detectable in the testis during the annual sexual cycle and whether E2 exerts a regulatory role on spermatogenesi...

journal_title：Endocrinology

authors： Cobellis G,Pierantoni R,Minucci S,Pernas-Alonso R,Meccariello R,Fasano S

更新日期：1999-07-01 00:00:00

abstract：:Previous studies from this laboratory have demonstrated the presence of two populations of rat Leydig cells (I and II), which differ in their capacity for hCG- or cAMP-stimulated testosterone production. In the present study, we examined the metabolism of 25-hydroxycholesterol in primary cultures of both populations o...

journal_title：Endocrinology

authors： Georgiou M,Payne AH

更新日期：1985-09-01 00:00:00

abstract：:Glucose release from the liver is mediated by hypothalamic norepinephrine (NE) neuronal activity, but glucose itself (or a metabolite of it) exerts negative feedback effects on central NE activity. The aim of the present study was to investigate a possible role for insulin in these central glucose homeostatic mechanis...

journal_title：Endocrinology

authors： Smythe GA,Bradshaw JE,Nicholson MV,Grunstein HS,Storlien LH

更新日期：1985-10-01 00:00:00

abstract：:Epidemiological evidence indicates that phytoestrogens inhibit cancer formation and growth, reduce cholesterol levels, and show benefits in treating osteoporosis. At least some of these activities are mediated through the interaction of phytoestrogens with estrogen receptors alpha and beta (ERalpha and ERbeta). Resver...

journal_title：Endocrinology

authors： Bowers JL,Tyulmenkov VV,Jernigan SC,Klinge CM

更新日期：2000-10-01 00:00:00

abstract：:Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effe...

journal_title：Endocrinology

authors： Mills TM,Copland JA,Coy DH,Schally AV

更新日期：1983-09-01 00:00:00

abstract：:As we showed previously, the extracellular matrix (ECM) derived from rat bladder carcinoma cells (804G-ECM) has positive effects on rat primary beta-cell function and survival in vitro. The aim of this study was to define beta-cell genes induced by this ECM with a specific focus on cytokines. Analysis of differential ...

journal_title：Endocrinology

authors： Ribaux P,Ehses JA,Lin-Marq N,Carrozzino F,Böni-Schnetzler M,Hammar E,Irminger JC,Donath MY,Halban PA

更新日期：2007-11-01 00:00:00

abstract：:We have studied the changes in thyroid hormone economy that occur in normal pregnant rats between 17-22 days of gestation. T4 and T3 decreased in all extrathyroidal tissues studied, namely plasma, liver, kidney, lung, heart, and skeletal muscle. The exception is the concentration of T3 in cerebral cortex, which remain...

journal_title：Endocrinology

authors： Calvo R,Obregon MJ,Ruiz de Oña C,Ferreiro B,Escobar Del Rey E,Morreale de Escobar G

更新日期：1990-07-01 00:00:00

abstract：:Aside from studies of a possible synergism between T3 and glucocorticoids in regulating GH mRNA, there have been few previous studies of the modulation by hormones and other factors of glucocorticoid hormone regulation of pituitary cell GH gene expression. We have employed a serum-free medium containing no exogenously...

journal_title：Endocrinology

authors： Gick GG,Bancroft C

更新日期：1987-05-01 00:00:00

abstract：:Ghrelin is more effective than GHRH in stimulating GH release in normal adult humans and monkeys in vivo. This robust effect of ghrelin has been largely attributed to regulation of hypothalamic input, whereas the direct effect of ghrelin on pituitary GH release has been minimized by the observation that ghrelin has on...

journal_title：Endocrinology

authors： Kineman RD,Luque RM

更新日期：2007-09-01 00:00:00

abstract：:Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates a strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) to increase the bioavailability of glucagon-like peptide-1 is an emerging therapy for control of glycemia in type 2 diabetes patien...

journal_title：Endocrinology

authors： Aroor AR,Sowers JR,Bender SB,Nistala R,Garro M,Mugerfeld I,Hayden MR,Johnson MS,Salam M,Whaley-Connell A,Demarco VG

更新日期：2013-07-01 00:00:00

abstract：:The influences of mating on serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were evaluated in 4-day cyclic proestrous rats of the Wistar strain. Blood samples were collected via guillotine from mated and unmated controls at 1900-2000 h or 2100--2200 h. Serum LH levels were determined by tw...

journal_title：Endocrinology

authors： Moss RL,Dudley CA,Schwartz NB

更新日期：1977-02-01 00:00:00

abstract：:Thyroid hormones (THs) are charged and iodinated amino acid derivatives that need to pass the cell membrane facilitated by thyroid hormone transmembrane transporters (THTT) to exert their biological function. The importance of functional THTT is affirmed by the devastating effects of mutations in the human monocarboxy...

journal_title：Endocrinology

authors： Johannes J,Jayarama-Naidu R,Meyer F,Wirth EK,Schweizer U,Schomburg L,Köhrle J,Renko K

更新日期：2016-04-01 00:00:00

abstract：:In previous studies we found that plasma angiotensinogen levels were reduced by lesions of the hypothalamic paraventricular nuclei. To determine if the decrease was caused by decreased secretion of hormones that normally stimulate angiotensinogen secretion by the liver, we correlated the changes in plasma angiotensino...

journal_title：Endocrinology

authors： Kjos T,Gotoh E,Tkacs N,Shackelford R,Ganong WF

更新日期：1991-08-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase activity and reductase mRNA level were determined in adrenals from hamsters treated with ACTH, with or without cycloheximide or aminoglutethimide. Both reductase activity and reductase mRNA level were similarly enhanced by ACTH administration compared to levels...

journal_title：Endocrinology

authors： Lehoux JG,Lefebvre A,De Médicis E,Bélisle S,Bellabarba D

更新日期：1989-07-01 00:00:00

abstract：:Monolayer cultures of mouse adrenal tumor cell line Y-1 have been used to investigate the effects of glucocorticoid on cell replication, [3H]thymidine incorporation into the trichloroacetic acid-precipitated cell fraction, steroidogenesis, and the ACTH receptors of adrenocortical cells. Corticosterone at a concentrati...

journal_title：Endocrinology

authors： Saito E,Mukai M,Muraki T,Ichikawa Y,Homma M

更新日期：1979-02-01 00:00:00

abstract：:In addition to mineralocorticoid and glucocorticoid receptors, the kidney contains a third high affinity binding site for endogenous glucocorticoids, the type III receptor. These binding sites have been localized to the collecting duct, but their biological function has not yet been identified. We have used immunodiss...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Rusvai E,Fejes-Tóth G

更新日期：1994-04-01 00:00:00

abstract：:Characterization of glycoconjugates synthesized by polarized immature rabbit uterine epithelial (UE) cells in vitro, their vectorial patterns of secretion, and regulation by ovarian steroid hormones are reported. Large (mol wt, greater than 230 kDa) sialomucoglycoproteins and hyaluronate were primarily (86-96%) secret...

journal_title：Endocrinology

authors： Mani SK,Carson DD,Glasser SR

更新日期：1992-01-01 00:00:00

abstract：:The secretion of neurohypophyseal hormone and ACTH in the rat has been shown to exhibit circadian rhythms, with high values during the day and low values throughout the night. The neurohypophyseal hormone daily rhythm is altered by exposure to constant light and by pinealectomy. It was, thus, proposed that the observe...

journal_title：Endocrinology

authors： Yasin SA,Costa A,Besser GM,Hucks D,Grossman A,Forsling ML

更新日期：1993-03-01 00:00:00

abstract：:Ghrelin is a gastric peptide that regulates appetite and GH secretion. Circulating ghrelin levels are elevated by fasting and suppressed postprandially. However, the mechanisms regulating circulating ghrelin levels are unclear. Oxyntomodulin is an anorexic peptide hormone released from L cells in the gut. We investiga...

journal_title：Endocrinology

authors： Patterson M,Murphy KG,Patel SR,Patel NA,Greenwood HC,Cooke JH,Campbell D,Bewick GA,Ghatei MA,Bloom SR

更新日期：2009-08-01 00:00:00

abstract：:Chronically elevated circulating glucocorticoid levels are although to enhance vulnerability to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge in the...

journal_title：Endocrinology

authors： Sarabdjitsingh RA,Isenia S,Polman A,Mijalkovic J,Lachize S,Datson N,de Kloet ER,Meijer OC

更新日期：2010-03-01 00:00:00