Abstract:
:Nucleic acid-based therapies offer great potential for treatment of a variety of diseases including cancer by modulating protein expression with DNA or small interfering RNA. However, realization of their full therapeutic potential is currently limited due to an inability to reach the target site in an active form. Identification of delivery barriers such as stability in circulation, resistance to degradation and entrapment in subcellular vesicles has led to development of sophisticated multifunctional synthetic polymers for forming ionic complexes with nucleic acids and also providing performance-enhancing features. The most promising designs comprise features to help increase stability in circulation and also contain functionality to aid in endosome escape of nucleic acid cargo after cellular internalization.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Christie RJ,Nishiyama N,Kataoka Kdoi
10.1210/en.2009-1045subject
Has Abstractpub_date
2010-02-01 00:00:00pages
466-73issue
2eissn
0013-7227issn
1945-7170pii
en.2009-1045journal_volume
151pub_type
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