Effects of Acupuncture, RU-486 on the Hypothalamic-Pituitary-Adrenal Axis in Chronically Stressed Adult Male Rats.

abstract：:Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results...

journal_title：Endocrinology

authors： Rebourcet D,Darbey A,Monteiro A,Soffientini U,Tsai YT,Handel I,Pitetti JL,Nef S,Smith LB,O'Shaughnessy PJ

更新日期：2017-09-01 00:00:00

abstract：:11 beta-Hydroxysteroid dehydrogenase (11 beta HSI) is an enzyme complex responsible for the conversion of hormonally active cortisol to inactive cortisone; two isoforms of the enzyme have been cloned and characterized. Clinical observations from patients with the hypertensive syndrome apparent mineralocorticoid excess...

journal_title：Endocrinology

authors： Shimojo M,Ricketts ML,Petrelli MD,Moradi P,Johnson GD,Bradwell AR,Hewison M,Howie AJ,Stewart PM

更新日期：1997-03-01 00:00:00

abstract：:Although renal hypertrophy occurs rapidly after uninephrectomy, restoring the majority of renal excretory function, it remains unknown whether similar compensatory mechanisms maintain 1,25-dihydroxyvitamin D production (and calcium homeostasis). To address this issue we compared plasma calcitriol levels and renal 25-h...

journal_title：Endocrinology

authors： Almond JR,Bales CW,Lobaugh B,Klotman PE,Drezner MK

更新日期：1989-05-01 00:00:00

abstract：:Osteoclast-like multinucleated giant cells are induced in bone marrow cultures by 1,25-dihydroxyvitamin D3 and other agents. These cells resemble osteoclasts in their morphology, their ability to resorb bone, and the possession of calcitonin receptors. We report here a biphasic effect of transforming growth factor-bet...

journal_title：Endocrinology

authors： Shinar DM,Rodan GA

更新日期：1990-06-01 00:00:00

abstract：:To determine the relative role of the androgenic and/or estrogenic components of the action of dehydroepiandrosterone (DHEA) on the histomorphology and structure of the rat mammary gland, ovariectomized (OVX) female animals received DHEA administered alone or in combination with the pure antiandrogen flutamide or the ...

journal_title：Endocrinology

authors： Sourla A,Martel C,Labrie C,Labrie F

更新日期：1998-02-01 00:00:00

abstract：:Mutations in the GnRH receptor gene (GNRHR) can result in hypogonadotropic hypogonadism in humans. Unlike most mammals, mice lack a second form of GnRH (GnRH2) and a type 2 GnRH receptor. To determine whether the GnRH receptor is critical at all stages of reproduction and whether this receptor has additional physiolog...

journal_title：Endocrinology

authors： Wu S,Wilson MD,Busby ER,Isaac ER,Sherwood NM

更新日期：2010-03-01 00:00:00

abstract：:Whole saliva collected from rat, mouse, and human sources was found to contain high concentrations of transforming growth factor-alpha (TGF alpha) when analyzed by RIA. The concentrations of TGF alpha in unstimulated human saliva (age, 30-45 yr; n = 10; 1.5 +/- 3.1 nM) was reduced with age (age, 55-70 yr; n = 10; 0.4 ...

journal_title：Endocrinology

authors： Humphreys-Beher MG,Macauley SP,Chegini N,van Setten G,Purushotham K,Stewart C,Wheeler TT,Schultz GS

更新日期：1994-02-01 00:00:00

abstract：:Ghrelin was recently identified as an endogenous ligand of the GH secretagogue receptor. The novel peptide hormone is produced by gastric A-like cells, and circulating levels rise before feeding, suggestive of ghrelin as an endogenous hunger factor. ghrelin stimulates food intake and promotes adiposity after periphera...

journal_title：Endocrinology

authors： Tang-Christensen M,Vrang N,Ortmann S,Bidlingmaier M,Horvath TL,Tschöp M

更新日期：2004-10-01 00:00:00

abstract：:The present work extends our previous report that the intracerebroventricular (i.c.v.) injection of interleukin-1beta(IL-1beta, 80 ng) significantly blunted the testosterone response to 1 U/kg human CG (hCG), an effect that we attributed to the stimulation of inhibitory pathways connecting the hypothalamus to the test...

journal_title：Endocrinology

authors： Ogilvie K,Rivier C

更新日期：1998-07-01 00:00:00

abstract：:LA-PTH is a long-acting parathyroid hormone (PTH) peptide analogue in preclinical development for hypoparathyroidism (HP). Like native PTH, LA-PTH contains a methionine at position 8 (Met8) that is predicted to be critical for function. We assessed the impact of Met oxidation on the functional properties of LA-PTH and...

journal_title：Endocrinology

authors： Daley EJ,Khatri A,Dean T,Vilardaga JP,Zaidi SA,Katritch V,Gardella TJ

更新日期：2021-02-01 00:00:00

abstract：:Recent work in sheep has identified a neuronal subpopulation in the arcuate nucleus that coexpresses kisspeptin, neurokinin B, and dynorphin (referred to here as KNDy cells) and that mediate the negative feedback influence of progesterone on GnRH secretion. We hypothesized that sex differences in progesterone negative...

journal_title：Endocrinology

authors： Cheng G,Coolen LM,Padmanabhan V,Goodman RL,Lehman MN

更新日期：2010-01-01 00:00:00

abstract：:Angiotensin II and extracellular potassium stimulate aldosterone production in adrenal glomerulosa cells by mobilizing the calcium messenger system. This response requires calcium influx across the plasma membrane, followed by calcium uptake into the mitochondria. It has been proposed that calcium is transported to th...

journal_title：Endocrinology

authors： Lalevée N,Resin V,Arnaudeau S,Demaurex N,Rossier MF

更新日期：2003-10-01 00:00:00

abstract：:7B2 is a novel neuroendocrine polypeptide which belongs to an entirely new superfamily of proteins. In extension of previous reports on 7B2, these studies concern its expression in endocrine pancreatic tissue. They have been performed using specific antibodies prepared against two distinct synthetic fragments of 7B2 c...

journal_title：Endocrinology

authors： Benjannet S,Marcinkiewicz M,Falgueyret JP,Johnson DE,Seidah NG,Chrétien M

更新日期：1988-08-01 00:00:00

abstract：:Spinal cord hemisection between T2 and T3 inhibits compensatory adrenal growth when the contralateral but not the ipsilateral adrenal is removed (p less than 0.01). Pretreatment of left adrenals with 1 or 2% lidocaine, but not with saline, before removal inhibits compensatory right adrenal growth that is normally obse...

journal_title：Endocrinology

authors： Engeland WC,Dallman MF

更新日期：1976-12-01 00:00:00

abstract：:Graves' hyperthyroidism is an organ-specific autoimmune disease mediated by stimulatory autoantibodies against the TSH receptor (TSHR; thyroid-stimulating antibodies), causing thyroid hyperplasia and hyperthyroidism. Development of this ailment is well known to be under polygenic and environmental control. For example...

journal_title：Endocrinology

authors： Nagayama Y,McLachlan SM,Rapoport B,Oishi K

更新日期：2004-11-01 00:00:00

abstract：:The occurrence of the thyroid hormone-binding plasma protein transthyretin in the bloodstream was investigated for four American marsupial species. Serum samples were analyzed by incubation with radioactive T4, followed by electrophoresis, then autoradiography, and Western blotting. Transthyretin was found in serum fr...

journal_title：Endocrinology

authors： Richardson SJ,Wettenhall RE,Schreiber G

更新日期：1996-08-01 00:00:00

abstract：:The major changes in pancreatic islet function during pregnancy and after exposure to lactogens are an increase in beta-cell proliferation and enhanced insulin secretion. In this study we examined INS-1 cells as a potential model for further inquiry into PRL signaling in beta-cells. Proliferation of beta-cells, insuli...

journal_title：Endocrinology

authors： Stout LE,Svensson AM,Sorenson RL

更新日期：1997-04-01 00:00:00

abstract：:Previous studies from this laboratory have demonstrated the presence of two populations of rat Leydig cells (I and II), which differ in their capacity for hCG- or cAMP-stimulated testosterone production. In the present study, we examined the metabolism of 25-hydroxycholesterol in primary cultures of both populations o...

journal_title：Endocrinology

authors： Georgiou M,Payne AH

更新日期：1985-09-01 00:00:00

abstract：:MCF-7 cells migrate through vitronectin-coated filters in response to insulin-like growth factor I (IGF-I); migration is inhibited by the matrix metalloproteinase (MMP) inhibitor BB-94, but not by the serine proteinase inhibitor aprotinin. MMP-9 was identified in the conditioned medium of MCF-7 cells; in addition, flu...

journal_title：Endocrinology

authors： Mira E,Mañes S,Lacalle RA,Márquez G,Martínez-A C

更新日期：1999-04-01 00:00:00

abstract：:Estrogens play a central role in regulating female reproduction throughout the reproductive axis, and the pituitary is one of the major targets of estrogen action. We hypothesized that estrogen receptor alpha (ERalpha) mediates estrogen action in the pituitary gonadotroph. To test this hypothesis, we generated a mouse...

journal_title：Endocrinology

authors： Gieske MC,Kim HJ,Legan SJ,Koo Y,Krust A,Chambon P,Ko C

更新日期：2008-01-01 00:00:00

abstract：:Cushing's disease (CD) is a rare condition in which hypercortisolemia is secondary to excessive ACTH release from a pituitary corticotroph adenoma. CD is associated with significant morbidity and mortality, and a safe therapy that effectively targets the pituitary tumor is still lacking. Retinoic acid (RA) and dopamin...

journal_title：Endocrinology

authors： Occhi G,Regazzo D,Albiger NM,Ceccato F,Ferasin S,Scanarini M,Denaro L,Cosma C,Plebani M,Cassarino MF,Mantovani G,Stalla GK,Pecori Giraldi F,Paez-Pareda M,Scaroni C

更新日期：2014-09-01 00:00:00

abstract：:Recent evidence suggests that growth hormone-releasing peptides (GHRPs) mimic an unidentified native GH-releasing hormone (GHRH)-amplifying hormone. GHRH has been shown to stimulate food intake acting on the central nervous system. The present studies were conducted to test the hypothesis that GHRPs may also potentiat...

journal_title：Endocrinology

authors： Okada K,Ishii S,Minami S,Sugihara H,Shibasaki T,Wakabayashi I

更新日期：1996-11-01 00:00:00

abstract：:Glucocorticoid hormones act in the nucleus of the cell to alter expression of specific genes and change cell metabolism. In liver, these hormones have been reported to increase mitochondrial respiratory activity, which is regulated by both nuclear and mitochondrial gene products. We examined the effects of the synthet...

journal_title：Endocrinology

authors： Van Itallie CM

更新日期：1992-02-01 00:00:00

abstract：:The inhibitor of apoptosis proteins (IAPs) constitutes a family of highly conserved apoptosis suppressor proteins that were originally identified in baculoviruses. Although IAP homologs have recently been demonstrated to suppress apoptosis in mammalian cells, their expression and role in human ovarian epithelial cance...

journal_title：Endocrinology

authors： Li J,Feng Q,Kim JM,Schneiderman D,Liston P,Li M,Vanderhyden B,Faught W,Fung MF,Senterman M,Korneluk RG,Tsang BK

更新日期：2001-01-01 00:00:00

abstract：:The glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors (LXRs) are nuclear receptors that play an important role in the regulation of the metabolic gene linked to carbohydrate...

journal_title：Endocrinology

authors： Liu Y,Yan C,Wang Y,Nakagawa Y,Nerio N,Anghel A,Lutfy K,Friedman TC

更新日期：2006-11-01 00:00:00

abstract：:Gonadal differentiation is dependent upon a cascade of molecular and morphological events. Steroidogenic factor 1 (SF-1) and DAX-1 have been implicated in this process. A SF-1 binding site has been reported to be present on the DAX-1 gene. We therefore used immunocytochemistry to determine whether these two transcript...

journal_title：Endocrinology

authors： Majdic G,Saunders PT

更新日期：1996-08-01 00:00:00

abstract：:IGF binding protein-2 (IGFBP-2) has been implicated in the development and spread of a number of tumor types, and its abrogation in experimental models of cancer is associated with decreased tumor growth. This suggests that targeted inhibition of IGFBP-2 expression in some cancers may have therapeutic benefit. In this...

journal_title：Endocrinology

authors： Martin JL,Baxter RC

更新日期：2007-05-01 00:00:00

abstract：:To examine the physiological effects of norepinephrine (NE) in the paraventricular nucleus of the hypothalamus (PVH) on CRF gene expression and CRF release, NE was microinjected bilaterally into the PVH of conscious rats, and kinetic studies were performed on the levels of POMC messenger RNA (mRNA) in the anterior pit...

journal_title：Endocrinology

authors： Itoi K,Suda T,Tozawa F,Dobashi I,Ohmori N,Sakai Y,Abe K,Demura H

更新日期：1994-11-01 00:00:00

abstract：:Progesterone has the capacity to suppress hypothalamic dopaminergic neuronal activity on proestrous afternoon and prolong or amplify the preovulatory prolactin surge in rats. In the present study, we examined enzyme activity and phosphorylation state of tyrosine hydroxylase (TH) in the stalk-median eminence of cycling...

journal_title：Endocrinology

authors： Liu B,Arbogast LA

更新日期：2008-04-01 00:00:00

abstract：:The paucity of clinical and preclinical studies investigating sex differences in sleep has resulted in mixed findings as to the exact nature of these differences. Although gonadal steroids are known to modulate sleep in females, less is known about males. Moreover, little evidence exists concerning the origin of these...

journal_title：Endocrinology

authors： Cusmano DM,Hadjimarkou MM,Mong JA

更新日期：2014-01-01 00:00:00