Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland.

abstract：:Patients with noninsulin-dependent diabetes mellitus exhibit increased proportions of plasma proinsulin and proinsulin conversion intermediates. We used hyperinsulinemic diabetic and nondiabetic Psammomys obesus to study the possible relationship between steady state pancreatic insulin stores and the proportion of pro...

journal_title：Endocrinology

authors： Gadot M,Leibowitz G,Shafrir E,Cerasi E,Gross DJ,Kaiser N

更新日期：1994-08-01 00:00:00

abstract：:The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies...

journal_title：Endocrinology

authors： Jamaluddin MFB,Ko YA,Kumar M,Brown Y,Bajwa P,Nagendra PB,Skerrett-Byrne DA,Hondermarck H,Baker MA,Dun MD,Scott RJ,Nahar P,Tanwar PS

更新日期：2018-02-01 00:00:00

abstract：:Mouse β-cell-specific reporter lines have played a key role in diabetes research. Although the rat provides several advantages, its use has lagged behind the mouse due to the relative paucity of genetic models. In this report we describe the generation and characterization of transgenic rats expressing a Renilla lucif...

journal_title：Endocrinology

authors： Ghislain J,Fontés G,Tremblay C,Kebede MA,Poitout V

更新日期：2016-03-01 00:00:00

abstract：:The rat anterior pituitary expresses beta(2)-adrenoceptors (ARs) on somatotrophs, lactotrophs, and corticotrophs. The present study investigates whether beta(1)-ARs exist in the anterior pituitary, in which cell type(s) they are found, and whether they are regulated by glucocorticoids. As determined by quantitative RT...

journal_title：Endocrinology

authors： Janssens K,Krylyshkina O,Hersmus N,Vankelecom H,Denef C

更新日期：2008-05-01 00:00:00

abstract：:In order to elucidate the putative role of inhibin in regulation of spermatogenesis, expression of inhibin subunits was examined at defined stages of the cycle of the rat seminiferous epithelium. Twenty 2-mm segments of seminiferous tubules at stages XIII-I, II-VI, VII-VIII, and IX-XII were dissected using the transil...

journal_title：Endocrinology

authors： Bhasin S,Krummen LA,Swerdloff RS,Morelos BS,Kim WH,diZerega GS,Ling N,Esch F,Shimasaki S,Toppari J

更新日期：1989-02-01 00:00:00

abstract：:Estrogens stimulate cell proliferation in typical estrogen-responsive tissues including the anterior pituitary gland. Here we report that 17-beta estradiol (E2) has estrogen receptor-mediated mitogenic and antimitogenic actions on rat lactotrophs in primary culture, depending on the cell context. E2 did not affect bas...

journal_title：Endocrinology

authors： Kawashima K,Yamakawa K,Takahashi W,Takizawa S,Yin P,Sugiyama N,Kanba S,Arita J

更新日期：2002-07-01 00:00:00

abstract：:Differences in the catalytic activity of the placental and gonadal isozymes of porcine aromatase cytochrome P450 (P450arom) were examined in cell lines exhibiting stable expression of recombinant enzyme. Cell lines were selected that expressed high, but similar, immunodetectable levels of each isozyme based on Western...

journal_title：Endocrinology

authors： Corbin CJ,Trant JM,Walters KW,Conley AJ

更新日期：1999-11-01 00:00:00

abstract：:To date, the role of pancreatic hormones in pancreatic islet growth and differentiation is poorly understood. To address this issue, we examined mice with a disruption in the gene encoding prohormone convertase 2 (PC2). These mice are unable to process proglucagon, prosomatostatin, and other neuroendocrine precursors ...

journal_title：Endocrinology

authors： Vincent M,Guz Y,Rozenberg M,Webb G,Furuta M,Steiner D,Teitelman G

更新日期：2003-09-01 00:00:00

abstract：:In male hamsters, light deprivation was reported to reduce both testis weight and prolactin (PRL) levels. Therefore, we decided to examine the effects of PRL on testicular function in hamsters exposed to short day-length. Adult hamsters were exposed to 5 h of light per day to induce gonadal atrophy, and, starting two ...

journal_title：Endocrinology

authors： Bartke A,Croft BT,Dalterio S

更新日期：1975-12-01 00:00:00

abstract：:The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We used a Pax6-deficient model in rat primary enriched-α cells with specifi...

journal_title：Endocrinology

authors： Gosmain Y,Cheyssac C,Masson MH,Guérardel A,Poisson C,Philippe J

更新日期：2012-09-01 00:00:00

abstract：:We recently reported that aluminum administration to beagles stimulates uncoupled bone formation in the marrow cavity which increases trabecular bone volume and generates new osseous networks within the axial skeleton. To investigate whether this osteogenic process results from direct stimulation of bone cell replicat...

journal_title：Endocrinology

authors： Quarles LD,Wenstrup RJ,Castillo SA,Drezner MK

更新日期：1991-06-01 00:00:00

abstract：:To further our understanding of the role of pituitary gonadotropin secretion in the control of corpus luteum function during the primate menstrual cycle, we have used an experimental model which enables us to directly control pituitary gonadotropin secretion throughout the luteal phase. Specifically, we have asked whe...

journal_title：Endocrinology

authors： Hutchison JS,Zeleznik AJ

更新日期：1985-09-01 00:00:00

abstract：:Previous studies established the existence of an FSH-inducible rat granulosa cell-derived insulin-like growth factor binding protein (IGFBP)-5 endopeptidase. It was the objective of this communication to characterize this activity in some detail. Exposure of [125I]rhIGFBP-5 substrate to media conditioned by FSH-treate...

journal_title：Endocrinology

authors： Resnick CE,Fielder PJ,Rosenfeld RG,Adashi EY

更新日期：1998-03-01 00:00:00

abstract：:Free radical production and lipid peroxidation are potentially important mediators in testicular physiology and toxicology. The cytochrome P450 enzymes of the steroidogenic pathway are known to produce free radicals. The present study was conducted to elucidate in vivo the gonadotropin regulation of free radical-media...

journal_title：Endocrinology

authors： Peltola V,Huhtaniemi I,Metsa-Ketela T,Ahotupa M

更新日期：1996-01-01 00:00:00

abstract：:Steroid receptors, including estrogen receptor (ER) and progesterone receptors (PR), form associations with heat shock proteins (Hsps). Dissociation of Hsps activates PR, whereas retention of Hsp90 in vitro stimulates ER. Progesterone and estrogen, interacting with their receptors, regulate myometrial contractility th...

journal_title：Endocrinology

authors： Wu WX,Derks JB,Zhang Q,Nathanielsz PW

更新日期：1996-12-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is expressed in many neuronal and non-neuronal tissues during development as well as in adult animals. GDNF signaling is mediated through a two-component system consisting of the so called GDNF receptor-alfa (GFRalpha1) which binds to GDNF. Thereafter this complex bin...

journal_title：Endocrinology

authors： Urbano AG,Suárez-Peñaranda JM,Diéguez C,Alvarez CV

更新日期：2000-05-01 00:00:00

abstract：:We have investigated the production and actions of a growth regulatory protein, insulin-like growth factor binding protein (IGFBP)-3, in the androgen-responsive prostate carcinoma cell line LNCaP. Confluent monolayers of cells secreted approximately 0.7 ng/ml IGFBP-3 over 24 h. Dihydrotestosterone (DHT, 10 nM) and 1,2...

journal_title：Endocrinology

authors： Martin JL,Pattison SL

更新日期：2000-07-01 00:00:00

abstract：:The conceptus and endometrium secrete large amounts of prostaglandin E₂ (PGE₂) into the porcine uterine lumen during the periimplantation period. We hypothesized that PGE₂ acts on conceptus/trophoblast cells through auto- and paracrine mechanisms. Real-time RT-PCR analysis revealed that PGE₂ receptor (PTGER)2 mRNA was...

journal_title：Endocrinology

authors： Waclawik A,Kaczynski P,Jabbour HN

更新日期：2013-10-01 00:00:00

abstract：:The signals that regulate cardiac myocyte maturation in the neonatal heart are not completely understood. In our study we examined the effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] on primary cultures of ventricular myocytes isolated from neonatal rat hearts. Our data show that 1,25-(OH)2D3 inhibited an increase ...

journal_title：Endocrinology

authors： O'Connell TD,Giacherio DA,Jarvis AK,Simpson RU

更新日期：1995-02-01 00:00:00

abstract：:Treatment of isolated rat adipocytes with epinephrine or isoproterenol caused a time- and concentration-dependent increase in phospholipid methyltransferase (PLMT) activity that was blocked by propranolol and unaffected by phentolamine. Forskolin mimicked the stimulatory effect on PLMT, and insulin inhibited this effe...

journal_title：Endocrinology

authors： Kelly KL,Wong EH

更新日期：1987-06-01 00:00:00

abstract：:We have studied regulation of the glucose transporter by thyroid hormone in ARL 15 cells, a thyroid hormone-responsive cell line derived from rat liver, T3 treatment (5 x 10(-8) M for 48 h) of confluent cell monolayers grown in thyroid hormone-deficient medium increased the rate of uptake of [3H] 2-deoxyglucose by 2.3...

journal_title：Endocrinology

authors： Weinstein SP,Watts J,Graves PN,Haber RS

更新日期：1990-03-01 00:00:00

abstract：:Studies were carried out to determine the regional central nervous system and species specificity of the previously observed [125I]iodoavian pancreatic polypeptide ( [125I]iodo-APP) specific binding to chick brain membranes. The avian species examined were chicken, pigeon, duck, quail, chukar, and pheasant. In all spe...

journal_title：Endocrinology

authors： Adamo ML,Hazelwood RL

更新日期：1984-03-01 00:00:00

abstract：:Based on the finding that retinoic acid (RA) increases 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] receptor number in ROS 17/2 cells, we investigated the effects of RA on the ability of 1,25-(OH)2D3 to regulate alkaline phosphatase activity and PTH-responsive adenylate cyclase in these cells. A maximally effective dose of...

journal_title：Endocrinology

authors： Grigoriadis AE,Petkovich PM,Rosenthal EE,Heersche JN

更新日期：1986-08-01 00:00:00

abstract：:A subline of an x-ray-induced transplantable rat insulinoma has been studied in vivo and in vitro. Tumors grew rapidly after sc transplantation and were rich in insulin, but contained only small amounts of glucagon and somatostatin. Despite marked basal hyperinsulinemia, iv glucose administration caused a further incr...

journal_title：Endocrinology

authors： Masiello P,Wollheim CB,Janjic D,Gjinovci A,Blondel B,Praz GA,Renold AE

更新日期：1982-12-01 00:00:00

abstract：:Alpha-calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. Despite well-documented pharmacological effects, its primary physiological role has thus far remained obscure. Increased lipid content, particularly in skeletal muscle and liver, is ...

journal_title：Endocrinology

authors： Danaher RN,Loomes KM,Leonard BL,Whiting L,Hay DL,Xu LY,Kraegen EW,Phillips AR,Cooper GJ

更新日期：2008-01-01 00:00:00

abstract：:Adiponectin (ApN) is an adipokine whose expression and plasma levels are inversely related to obesity and insulin-resistant states. Chronic repercussions of ApN treatment or overexpression on adiposity and body weight are still controversial. Here, we generated a transgenic (Tg) mouse model allowing persistent and mod...

journal_title：Endocrinology

authors： Bauche IB,El Mkadem SA,Pottier AM,Senou M,Many MC,Rezsohazy R,Penicaud L,Maeda N,Funahashi T,Brichard SM

更新日期：2007-04-01 00:00:00

abstract：:The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bmal1 can disrupt adrenal clock function. The requirement of the adrenal...

journal_title：Endocrinology

authors： Engeland WC,Massman L,Mishra S,Yoder JM,Leng S,Pignatti E,Piper ME,Carlone DL,Breault DT,Kofuji P

更新日期：2018-12-01 00:00:00

abstract：:The purpose of the present study was to further examine the hypothesis that activation of G protein-coupled receptor 54 (GPR54) signaling at the end of the juvenile phase of primate development is responsible for initiation of gonadarche and the onset of puberty. Accordingly, we determined whether repetitive iv admini...

journal_title：Endocrinology

authors： Plant TM,Ramaswamy S,Dipietro MJ

更新日期：2006-02-01 00:00:00

abstract：:PTH-related protein (PTHrP) and its receptor are expressed in vascular smooth muscle cells and are believed to participate in the local regulation of vascular tone. To explore the function of locally produced PTHrP in vascular smooth muscle in vivo, we developed transgenic mice that overexpress PTHrP in smooth muscle ...

journal_title：Endocrinology

authors： Maeda S,Sutliff RL,Qian J,Lorenz JN,Wang J,Tang H,Nakayama T,Weber C,Witte D,Strauch AR,Paul RJ,Fagin JA,Clemens TL

更新日期：1999-04-01 00:00:00

abstract：:In higher primates, FSH secretion appears to be regulated by a control system consistent with that described by the classical inhibin hypothesis. The purpose of the present experiment was to examine the time course of inhibin's action to suppress FSH secretion in the intact adult male rhesus monkey. To this end, five ...

journal_title：Endocrinology

authors： Ramaswamy S,Pohl CR,McNeilly AS,Winters SJ,Plant TM

更新日期：1998-08-01 00:00:00