Overexpression of adiponectin targeted to adipose tissue in transgenic mice: impaired adipocyte differentiation.

abstract：:The androgen receptor (AR) from calf uterine cytosol has been studied in terms of steroid-binding affinity, hormone dissociation kinetics, and DNA-cellulose-binding capacity. The binding affinity for three androgens, analyzed under conditions where binding to progesterone receptor did not occur, decreased in the order...

journal_title：Endocrinology

authors： de Boer W,Lindh M,Bolt J,Brinkmann A,Mulder E

更新日期：1986-02-01 00:00:00

abstract：:Specific triiodothyronine receptor activity has been detected in rat lung nuclei isolated by Triton X-100, which was sensitive to pH and exhibited temperature-dependent association kinetics. This activity represented a single order of high affinity binding sites, with an apparent dissociation constant for 3,3',5-triio...

journal_title：Endocrinology

authors： Morishige WK,Guernsey DL

更新日期：1978-05-01 00:00:00

abstract：:A transient increase in serum progesterone concentrations (to 1 ng/ml for 1-2 days) is observed in the majority of ewes before the first estrous cycle of the breeding season. To determine whether such a brief antecedent rise in progesterone ensures initiation of a full-length cycle by the next LH surge, synthetic GnRH...

journal_title：Endocrinology

authors： Legan SJ,I'Anson H,Fitzgerald BP,Akaydin MS Jr

更新日期：1985-10-01 00:00:00

abstract：:The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the ...

journal_title：Endocrinology

authors： Konkle AT,McCarthy MM

更新日期：2011-01-01 00:00:00

abstract：:The antigenic epitopes of human GH (hGH) have been investigated using monoclonal antibodies (Mabs) to hGH. A panel of 12 Mabs was incorporated into two-site binding assays in order to investigate the antigenic surface of hGH. Nine reaction patterns were observed. The Mabs were further characterized in terms of their c...

journal_title：Endocrinology

authors： Strasburger CJ,Kostyo J,Vogel T,Barnard GJ,Kohen F

更新日期：1989-03-01 00:00:00

abstract：:A study was conducted to determine the influence of conditions known to alter ACTH secretion on prolactin release by the pituitary. Dexamethasone or 0.9% NaCl was injected subcutaneously into intact male rats 4 hr before a 2-min ether stress. Other rats were submitted to the ether stress 2 weeks following adrenalectom...

journal_title：Endocrinology

authors： Harms PG,Langlier P,McCann SM

更新日期：1975-02-01 00:00:00

abstract：:Prior published reports have demonstrated that glucose-oxidized low-density lipoproteins (g-OxLDL) enhance the proliferative response of vascular smooth muscle cells (SMC) to IGF-I. Our previous studies have determined that the regulation of cleavage of integrin-associated protein (IAP) by matrix-metalloprotease-2 (MM...

journal_title：Endocrinology

authors： Allen LB,Capps BE,Miller EC,Clemmons DR,Maile LA

更新日期：2009-03-01 00:00:00

abstract：:Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to ...

journal_title：Endocrinology

authors： Thaler JP,Schwartz MW

更新日期：2010-09-01 00:00:00

abstract：:We have recently demonstrated that GnRH-stimulated gonadotropin secretion is augmented by coadministration with neuropeptide-Y (NPY) in anterior pituitaries removed in the afternoon from proestrous, but not metestrous, rats. To test the hypothesis that these effects of NPY are due to an interaction with progesterone (...

journal_title：Endocrinology

authors： Knox KL,Bauer-Dantoin AC,Levine JE,Schwartz NB

更新日期：1995-01-01 00:00:00

abstract：:Implantation of an embryo induces rapid proliferation and differentiation of uterine stromal cells, forming a new structure, the decidua. One salient feature of decidua formation is a marked increase in maternal angiogenesis. Vascular endothelial growth factor (VEGF)-dependent pathways are active in the ovary, uterus,...

journal_title：Endocrinology

authors： Douglas NC,Tang H,Gomez R,Pytowski B,Hicklin DJ,Sauer CM,Kitajewski J,Sauer MV,Zimmermann RC

更新日期：2009-08-01 00:00:00

abstract：:Testosterone treatment induces erythrocytosis that could potentially affect blood viscosity and cardiovascular risk. We thus investigated the effects of testosterone administration on blood viscosity and erythrocyte deformability using mouse models. Blood viscosity, erythrocyte deformability, and hematocrits were meas...

journal_title：Endocrinology

authors： Guo W,Bachman E,Vogel J,Li M,Peng L,Pencina K,Serra C,Sandor NL,Jasuja R,Montano M,Basaria S,Gassmann M,Bhasin S

更新日期：2015-05-01 00:00:00

abstract：:In dairy goats, treatments associating a progestogen and the equine chorionic gonadotropin (eCG) are the easiest way to induce and synchronize estrus and ovulation and to permit artificial insemination (AI) and/or out of season breeding. From the first treatment, the injection of eCG induces, in some females, the prod...

journal_title：Endocrinology

authors： Hervé V,Roy F,Bertin J,Guillou F,Maurel MC

更新日期：2004-01-01 00:00:00

abstract：:Previously, we demonstrated that excision of the GnRH first intron (intron A) was largely attenuated in non-GnRH-producing tissues but accelerated in GnRH neurons. In the present study, we examined the splicing rate of GnRH pre-mRNA in developing normal mice and adult hypogonadal mice. The preoptic area and cerebral c...

journal_title：Endocrinology

authors： Seong JY,Kim BW,Park S,Son GH,Kim K

更新日期：2001-10-01 00:00:00

abstract：:Obesity and insulin resistance-related proteinuria is associated with oxidative stress and impaired tissue bioavailable nitric oxide. Recent data suggest that nicotinamide adenine dinucleotide phosphate oxidase-mediated oxidative injury to the proximal tubule, like that seen in the glomerulus, contributes to proteinur...

journal_title：Endocrinology

authors： Habibi J,Hayden MR,Sowers JR,Pulakat L,Tilmon RD,Manrique C,Lastra G,Demarco VG,Whaley-Connell A

更新日期：2011-02-01 00:00:00

abstract：:Neonatal thymectomy at 3 days of age in mice results in ovarian dysgenesis, characterized by early follicular and oocyte loss, followed by a high incidence of ovarian tumorigenesis. Thymectomized animals with dysgenetic ovaries had extremely high levels of circulating PRL and gonadotropins before the appearance of the...

journal_title：Endocrinology

authors： Michael SD,Taguchi O,Nishizuka Y

更新日期：1981-06-01 00:00:00

abstract：:Estradiol (E(2)) rapidly and strongly induces vascular endothelial growth factor (VEGF) transcription in uterine endometrial epithelial cells in vivo. We have shown that this is mediated by both the estrogen receptor-alpha and hypoxia-inducible factor (HIF)-1alpha. By contrast, E(2) induces little or no VEGF expressio...

journal_title：Endocrinology

authors： Molitoris KH,Kazi AA,Koos RD

更新日期：2009-12-01 00:00:00

abstract：:The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the secretory pathway and is the site where protein folding and quality control are initiated. The storage and release of Ca2+ are critical physiological functions of the ER. Disrupted ER homeostasis activates the unfolded protein respo...

journal_title：Endocrinology

authors： Zhang IX,Raghavan M,Satin LS

更新日期：2020-02-01 00:00:00

abstract：:We and others have recently shown that 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] significantly inhibits cell proliferation and increases secretion of prostate-specific antigen (PSA) in LNCaP cells, an androgen-responsive human prostate cancer cell line. The present study was designed to investigate the possible int...

journal_title：Endocrinology

authors： Zhao XY,Ly LH,Peehl DM,Feldman D

更新日期：1997-08-01 00:00:00

abstract：:In previous studies, we have shown that calcitonin gene-related peptide (CGRP) acutely inhibits 45Ca2+ uptake in osteoblastic UMR106 cells, and we have proposed that ATP-sensitive potassium (K(ATP)) channels are involved in mediating this action of CGRP. To directly test this proposed mechanism, we have now examined t...

journal_title：Endocrinology

authors： Kawase T,Burns DM

更新日期：1998-08-01 00:00:00

abstract：:In the gonads and adrenal glands, the transient increase in steroidogenesis after hormonal stimulation requires modulation of steroidogenic acute regulatory protein (Star) expression and activity in a tightly regulated process involving cAMP and Ca(2+). In Leydig cells, the cAMP and Ca(2+) pathways account for most if...

journal_title：Endocrinology

authors： Abdou HS,Villeneuve G,Tremblay JJ

更新日期：2013-01-01 00:00:00

abstract：:GH and insulin-like growth factor (IGF)-I are important components of the growth axis. We undertook to determine how plasma levels of these hormones altered with different seasonal and nutritional states in young male red deer to provide an insight into how the growth axis changes under these conditions. Growth rate a...

journal_title：Endocrinology

authors： Webster JR,Corson ID,Littlejohn RP,Stuart SK,Suttie JM

更新日期：1996-02-01 00:00:00

abstract：:Osteoclast precursors have not been well characterized because there are no known markers that can detect them. We have used osteoclast-like cells formed in vitro to develop a panel of specific antibodies that react with mature osteoclasts, osteoclast precursors, and other cells in the osteoclast lineage. Monoclonal a...

journal_title：Endocrinology

authors： Kukita T,Roodman GD

更新日期：1989-08-01 00:00:00

abstract：:The marked up-regulation of oxytocin (OT) receptors in rabbit amnion at term was reproduced in cultured amnion cells by raising intracellular cAMP levels. (Bu)2AMP, forskolin, or cholera toxin caused 2- to 8-fold increases in specific binding of iodinated OT antagonist. The rise in OT receptors involves activation of ...

journal_title：Endocrinology

authors： Hinko A,Soloff MS

更新日期：1993-01-01 00:00:00

abstract：:The placenta is the primary source of estrogens and progesterone during pregnancy. Because pregnant diabetic women are reported to have lower serum estrogen and higher progesterone levels than nondiabetic pregnant women, and placental insulin-like growth factor II (IGF-II) production may be elevated during diabetic pr...

journal_title：Endocrinology

authors： Nestler JE

更新日期：1990-11-01 00:00:00

abstract：:Aging of the female reproductive system in rats is marked by discrete stages in the disappearance of regular estrous cyclicity. We determined at which point in the transition to acyclicity changes in the LH pulse generator could be detected by comparing pulsatile LH release in ovariectomized young rats to three groups...

journal_title：Endocrinology

authors： Scarbrough K,Wise PM

更新日期：1990-02-01 00:00:00

abstract：:To study the localization of PRL in mammary epithelial cells (MEC) and to characterize PRL forms in serum, milk, and mammary tissue, two groups of lactating rats, a control group and a bromocriptine-treated group, were compared. In serum and milk from control rats, two forms of PRL (25 and 23 kDa) were detected by imm...

journal_title：Endocrinology

authors： Lkhider M,Delpal S,Bousquet MO

更新日期：1996-11-01 00:00:00

abstract：:We have used immunohistochemistry to define the cellular distribution of GH receptors in the gastrointestinal tract (GIT) and its derivatives. Immunohistochemistry was performed in the adult rat GIT with a panel of characterized monoclonal antibodies to the GH receptor. The most intense and heterogeneous immunoreactiv...

journal_title：Endocrinology

authors： Lobie PE,Breipohl W,Waters MJ

更新日期：1990-01-01 00:00:00

abstract：:Spontaneously hypertensive (SH) rats, extensively used as experimental models of essential human hypertension, display important alterations in the neuroendocrine reproductive axis, which manifest as markedly delayed puberty onset in females but whose basis remains largely unknown. We analyze herein in female SH rats:...

journal_title：Endocrinology

authors： Pinilla L,Castellano JM,Romero M,Tena-Sempere M,Gaytán F,Aguilar E

更新日期：2009-06-01 00:00:00

abstract：:The estrogenic and antiestrogenic actions of the geometric isomers of tamoxifen and 4-hydroxytamoxifen were determined in a PRL synthesis assay using primary cultures of dispersed immature rat pituitary gland cells. 4-Hydroxytamoxifen was 100 times more potent as an antiestrogen than tamoxifen. The cis isomer of tamox...

journal_title：Endocrinology

authors： Jordan VC,Koch R,Langan S,McCague R

更新日期：1988-04-01 00:00:00

abstract：:Reduced cellular immune responses and altered cytokine production by cells from mice exposed to thermal injury are minimized if dehydroepiandrosterone (DHEA) is administered after experimental burn injury in mice. An analysis of similar tests of immune function developed by mice given the antiglucocorticoid, 17 beta-h...

journal_title：Endocrinology

authors： Araneo B,Daynes R

更新日期：1995-02-01 00:00:00