1alpha,25-dihydroxyvitamin D3 actions in LNCaP human prostate cancer cells are androgen-dependent.

abstract：:Interleukin-1 (IL-1), one of the mediators of the interaction between the immune and the neuroendocrine system, is well known to modulate anterior pituitary hormone secretion. As IL-1 influences growth of various cell types, we investigated whether IL-1 is also a growth factor of pituitary cells. We demonstrate that I...

journal_title：Endocrinology

authors： Renner U,Newton CJ,Pagotto U,Sauer J,Arzt E,Stalla GK

更新日期：1995-08-01 00:00:00

abstract：:Inhibin was first characterized in mammals as a gonadal dimeric protein that inhibited pituitary follicle-stimulating hormone (FSH) secretion. As in mammals, the inhibin-specific α subunit (INHA/Inha/inha) has also been characterized in teleosts; however, its functions and physiological importance in fish reproduction...

journal_title：Endocrinology

authors： Lu H,Zhao C,Zhu B,Zhang Z,Ge W

更新日期：2020-12-01 00:00:00

abstract：:P19 EPI-7, a differentiated murine embryonal carcinoma cell line with an epithelioid morphology, does not require external growth factors for proliferation under clonal and subconfluent conditions. At saturation density, however, cells become quiescent in the G1/G0 phase of the cell cycle from which they can be restim...

journal_title：Endocrinology

authors： van Zoelen EJ,Koornneef I,Holthuis JC,Ward-van Oostwaard TM,Feijen A,de Poorter TL,Mummery CL,van Buul-Offers SC

更新日期：1989-04-01 00:00:00

abstract：:Properties of cyclic 3',5'-nucleotide phosphodiesterase in the 100,500 X g supernatant of the bovine thyroid were investigated. The enzyme activity was measured by a radioisotopic method using an anionic-exchange resin, and it was found that the activity was stimulated by Mg2+. Sephadex G-200 gel filtration separated ...

journal_title：Endocrinology

authors： Yagura T,Azuma Y,Akazawa Y,Nagata I,Uchino H

更新日期：1978-11-01 00:00:00

abstract：:Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secre...

journal_title：Endocrinology

authors： Señarís RM,Lago F,Coya R,Pineda J,Diéguez C

更新日期：1996-12-01 00:00:00

abstract：:Basal serum gonadotropin levels were monitored weekly in female hamsters from birth to 10 weeks of age. Hamsters raised on three different photoperiods presented uniform pre- and postpubertal patterns of serum LH and FSH, suggesting that gonadotropin release in the young hamster occurs independently of ambient photope...

journal_title：Endocrinology

authors： Smith SG 3rd,Matt KS,Prestowitz WF,Stetson MH

更新日期：1982-04-01 00:00:00

abstract：:Mice deficient in the thyroid hormone (TH) transporter Mct8 (Mct8KO) have increased 5'-deiodination and impaired TH secretion and excretion. These and other unknown mechanisms result in the low-serum T(4), high T(3), and low rT(3) levels characteristic of Mct8 defects. We investigated to what extent each of the 5'-dei...

journal_title：Endocrinology

authors： Liao XH,Di Cosmo C,Dumitrescu AM,Hernandez A,Van Sande J,St Germain DL,Weiss RE,Galton VA,Refetoff S

更新日期：2011-03-01 00:00:00

abstract：:Impaired regulation of hepatic glucose production is a characteristic feature of the metabolic syndrome, a cluster of diseases that includes obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. It has been proposed that sustained endoplasmic reticulum stress, which appears to occur in obesity and ...

journal_title：Endocrinology

authors： Wang D,Wei Y,Schmoll D,Maclean KN,Pagliassotti MJ

更新日期：2006-01-01 00:00:00

abstract：:Benzodiazepines (BZs) have been shown to modulate voltage-sensitive Ca2+ channels in a number of neuronal and nonneuronal cell types and to competitively antagonize TRH binding to receptors on cells of the nervous system and anterior pituitary gland. Because interaction of TRH with its receptor is known to cause enhan...

journal_title：Endocrinology

authors： Gershengorn MC,Thaw CN,Geras-Raaka E

更新日期：1988-07-01 00:00:00

abstract：:Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in mammalian serum, but the source of the circulating enzyme is unknown. Pancreatic islets have been reported to contain and secrete GPI-PLD. In this report we examined the regulation of GPI-PLD secretion from beta TC3 cells, a mouse insulinom...

journal_title：Endocrinology

authors： Deeg MA,Verchere CB

更新日期：1997-02-01 00:00:00

abstract：:In adult male rhesus monkeys, 1 day of fasting leads to a profound suppression of LH secretion that is rapidly reversed with refeeding. To test the hypothesis that changes in insulin secretion during fasting and refeeding mediate the changes in LH secretion, blood samples for LH measurement were obtained between 0900-...

journal_title：Endocrinology

authors： Williams NI,Lancas MJ,Cameron JL

更新日期：1996-06-01 00:00:00

abstract：:To understand the physiological role of ghrelin, it is crucial to study both the actions of ghrelin and the regulation of ghrelin secretion. Although ghrelin actions have been extensively revealed, the direct factors regulating ghrelin secretion by ghrelin-producing cells (X/A-like cells), however, is not fully unders...

journal_title：Endocrinology

authors： Iwakura H,Ariyasu H,Hosoda H,Yamada G,Hosoda K,Nakao K,Kangawa K,Akamizu T

更新日期：2011-07-01 00:00:00

abstract：:The formation of ovarian follicles and subsequent development after birth are critical processes for female reproduction, and inappropriate coordination of these processes contributes to ovarian pathologies, such as premature ovarian failure and infertility. Identification and functional investigation of the factors i...

journal_title：Endocrinology

authors： Wang N,Zhang P,Guo X,Zhou Z,Sha J

更新日期：2011-03-01 00:00:00

abstract：:This report describes properties of highly purified cathepsin-B and an additional cysteine proteinase, designated cysteine proteinase I, obtained from human thyroids. Both enzymes are localized to lysosomes. The activity profile of cysteine proteinase I combined with its sensitivity to the active site inhibitor Z-Phe-...

journal_title：Endocrinology

authors： Dunn AD,Dunn JT

更新日期：1988-08-01 00:00:00

abstract：:The castration-induced regression and testosterone stimulated regrowth of the vasculature in the rat ventral prostate lobe were studied using stereological techniques. Seven days after castration, the endothelial cell proliferation rate (bromodeoxyuridine labeling index); the total weights of blood vessel walls, blood...

journal_title：Endocrinology

authors： Franck-Lissbrant I,Häggström S,Damber JE,Bergh A

更新日期：1998-02-01 00:00:00

abstract：:The aim of the present study was to investigate the presence and localization of the main G protein alpha-subunits in the human fetal adrenal gland during the second trimester of gestation. Immunofluorescence studies conducted on sections from frozen glands obtained immediately after therapeutic abortion indicated tha...

journal_title：Endocrinology

authors： Breault L,Chamoux E,Lehoux JG,Gallo-Payet N

更新日期：2000-12-01 00:00:00

abstract：:The control of ACTH secretion by opiates seems to involve stimulatory and inhibitory pathways, since opiate agonists and antagonists are capable of releasing ACTH in conscious rats. To elucidate the role of different opiate receptors in the control of ACTH release, rats were treated with receptor-selective opiate agon...

journal_title：Endocrinology

authors： Pfeiffer A,Herz A,Loriaux DL,Pfeiffer DG

更新日期：1985-06-01 00:00:00

abstract：:To determine if CRH and glucocorticoids are respectively required for hypophagia and catabolism in malnutrition, we have subjected wild-type (WT) and CRH knockout (KO) mice to dietary protein deprivation. Compared with WT mice, CRH KO mice exhibited greater decreases in food intake and negligible change in plasma cort...

journal_title：Endocrinology

authors： Jacobson L

更新日期：1999-08-01 00:00:00

abstract：:Abnormally high GH/IGF-I levels, most often caused by adenomas arising from pituitary somatotrophs, generate deleterious effects. We recently described a targeted secretion inhibitor (SXN101742) comprising a GHRH domain and the endopeptidase domain of botulinum toxin serotype D (GHRH-light chain endopeptidase type D d...

journal_title：Endocrinology

authors： Somm E,Bonnet N,Zizzari P,Tolle V,Toulotte A,Jones R,Epelbaum J,Martinez A,Hüppi PS,Aubert ML

更新日期：2013-11-01 00:00:00

abstract：:The antiestrogen ICI 164,384 (ICI) binds the estrogen receptor (ER) with approximately 20% the affinity of estradiol, but without the partial agonistic effects caused by tamoxifen. Investigations into the mechanism of ICI action have used ER molecules expressed in vitro to examine the binding of ER to ICI and the capa...

journal_title：Endocrinology

authors： Gibson MK,Nemmers LA,Beckman WC Jr,Davis VL,Curtis SW,Korach KS

更新日期：1991-10-01 00:00:00

abstract：:Task3 K(+) channels are highly expressed in the adrenal cortex and contribute to the angiotensin II and K(+) sensitivity of aldosterone-producing glomerulosa cells. Adult Task3(-/-) mice display a partially autonomous aldosterone secretion, subclinical hyperaldosteronism, and salt-sensitive hypertension. Here, we inve...

journal_title：Endocrinology

authors： Bandulik S,Tauber P,Penton D,Schweda F,Tegtmeier I,Sterner C,Lalli E,Lesage F,Hartmann M,Barhanin J,Warth R

更新日期：2013-08-01 00:00:00

abstract：:The osteoclast is known to be derived from the hemopoietic stem cell, but its lineage and the mechanisms by which its differentiation is regulated are largely unknown. There is evidence that osteoclastic differentiation is induced through a contact-dependent interaction between bone marrow stromal cells and hemopoieti...

journal_title：Endocrinology

authors： Hattersley G,Kerby JA,Chambers TJ

更新日期：1991-01-01 00:00:00

abstract：:The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies...

journal_title：Endocrinology

authors： Jamaluddin MFB,Ko YA,Kumar M,Brown Y,Bajwa P,Nagendra PB,Skerrett-Byrne DA,Hondermarck H,Baker MA,Dun MD,Scott RJ,Nahar P,Tanwar PS

更新日期：2018-02-01 00:00:00

abstract：:The monocarboxylate transporter Mct10 (Slc16a10; T-type amino acid transporter) facilitates the cellular transport of thyroid hormone (TH) and shows an overlapping expression with the well-established TH transporter Mct8. Because Mct8 deficiency is associated with distinct tissue-specific alterations in TH transport a...

journal_title：Endocrinology

authors： Müller J,Mayerl S,Visser TJ,Darras VM,Boelen A,Frappart L,Mariotta L,Verrey F,Heuer H

更新日期：2014-01-01 00:00:00

abstract：:The neuronal growth-associated protein (GAP)-43 has been localized in both long fibers and punctate clusters by immunocytochemistry within the rat anterior pituitary (AP). After adrenalectomy (ADX), GAP-43 immunoreactivity (GAP-43-ir) is greatly increased and is associated with corticotrophs at the light microscopic l...

journal_title：Endocrinology

authors： Paden CM,Watt JA,Selong TH,Paterson CL,Cranston HJ

更新日期：2006-02-01 00:00:00

abstract：:Open pig thyroid follicles in which the apical surface of the follicle cells is in direct contact with the incubation medium were used to study the effect of stimulated exocytosis and stimulated H2O2 generation on the iodination of protein in the incubation medium. In previous studies on this system of follicles we ha...

journal_title：Endocrinology

authors： Björkman U,Ekholm R

更新日期：1988-02-01 00:00:00

abstract：:Although the pituitary-grafted rat is a classic model of chronic PRL excess, the presence of somatotropes in grafted pituitary tissue indicates a potential for GH secretion. The current study was designed to investigate GH-releasing hormone (GRH)-induced GH secretion and beta-adrenergic inhibition of GH release in ani...

journal_title：Endocrinology

authors： Krieg RJ Jr,Johnson JH,Adler RA

更新日期：1989-11-01 00:00:00

abstract：:Administration of dehydroepiandrosterone (DHA) to immature female rats on day 27 for 3 days resulted in an increase in uterine weight within 6 h of injection and a surge of FSH, LH and prolactin occurred on day 30 resulting in premature ovulation. Increase in ovarian weight and vaginal patency also occurred on day 30....

journal_title：Endocrinology

authors： Knudsen JF,Mahesh VB

更新日期：1975-08-01 00:00:00

abstract：:The interaction of alloxan and cyclic AMP on glucose-induced insulin secretion was studied with the use of isolated rat islet perifusion. Simultaneous perifusion with cyclic AMP and alloxan did not protect the islets against the effect of alloxan. However, addition of dibutyryl cyclic AMP to the alloxan solution produ...

journal_title：Endocrinology

authors： Tomita T,Scarpelli DG

更新日期：1977-05-01 00:00:00

abstract：:Oxytocin (OT) has a dual action in the uterus: a uterotonic action on myometrial cells and a prostaglandin (PG)-releasing action on endometrial/decidual cells. It had not been determined whether the OT-binding sites or receptors on the myometrial and the endometrial/decidual membranes are of the same type or may repre...

journal_title：Endocrinology

authors： Chan WY,Chen DL,Manning M

更新日期：1993-03-01 00:00:00