Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system.

abstract：:Male Siberian hamsters undergo physiological weight change in changing photoperiod. Weight loss was induced by food restriction in long days to mimic short-day weight loss, or by food restriction superimposed on short-day weight loss, to test the hypothesis that the hypothalamus differentiates between weight change in...

journal_title：Endocrinology

authors： Mercer JG,Moar KM,Logie TJ,Findlay PA,Adam CL,Morgan PJ

更新日期：2001-10-01 00:00:00

abstract：:An assay was developed to detect tritium-labeled ovine FSH beta-subunit [( 3H]oFSH beta) secreted from primary ovine pituitary cultures. This procedure used affinity-enriched antibodies raised against reduced and carbamylmethylated oFSH beta (RCM-oFSH beta) in a two-cycle immunoextraction procedure. A discrete species...

journal_title：Endocrinology

authors： Whitfield GK,Miller WL

更新日期：1984-07-01 00:00:00

abstract：:To examine the possibility that the prepubertal hiatus in gonadotropin secretion in primates is occasioned by an endogenous opioid peptide (EOP)-dependent suppression of pulsatile GnRH release, the ability of an EOP receptor antagonist, naloxone (NAL), to elicit GnRH release was examined indirectly in the rhesus monke...

journal_title：Endocrinology

authors： Medhamurthy R,Gay VL,Plant TM

更新日期：1990-02-01 00:00:00

abstract：:The effects of epidermal growth factor (EGF) on glycogen metabolism and the binding of [125I]iodo-EGF to receptors in fetal rat hepatocytes have been examined. The actions of EGF have been compared with those of insulin-like growth factor I (IGF-I) and insulin. EGF (0.1-45 nM) stimulated dose-dependent increases in [1...

journal_title：Endocrinology

authors： Freemark M

更新日期：1986-08-01 00:00:00

abstract：:Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...

journal_title：Endocrinology

authors： Sanders TR,Kim DW,Glendining KA,Jasoni CL

更新日期：2014-07-01 00:00:00

abstract：:Antisera were raised against synthetic replicates of the carboxyl-terminal (C-terminal) fragment of the precursor to human GH-releasing factor (GRF) (pre-proGRF) whose structure was predicted from the complementary DNA cloned from a pancreatic tumor. These antisera were used along with antisera to human GRF itself to ...

journal_title：Endocrinology

authors： Bloch B,Baird A,Ling N,Guillemin R

更新日期：1986-01-01 00:00:00

abstract：:Young, unilaterally nephrectomized, female Sprague-Dawley rats were given daily sc injections of 19-nor-deoxycorticosterone acetate (19-nor-DOCA) in oil at a dosage of 100 micrograms/day for 21 days and twice that amount for a further 11 days. One group drank distilled water and another drank 1% NaCl solution. Compara...

journal_title：Endocrinology

authors： Hall CE,Gomez-Sanchez CE,Holland OB,Nasseth D

更新日期：1979-09-01 00:00:00

abstract：:We compared the somatomedin (SM) activity of perfusates of livers from normal and hypophysectomized (hypox) rats with and without the addition of growth hormone (GH) to the perfusions. Livers were perfused for a total of 3 hours, with a change of Waymouth's medium MB 752/l every 30 min, in a continously recirculating ...

journal_title：Endocrinology

authors： Phillips LS,Herington AC,Karl IE,Daughaday WH

更新日期：1976-03-01 00:00:00

abstract：:For successful human placentation, invasion of trophoblast cells into the uterus and its associated vasculature is essential, and the regulation of this process is controlled by many factors at the fetal-maternal interface. N-acetylglucosaminyltransferase V (GnT-V) is a key enzyme that catalyzes beta1, 6-N-acetylgluco...

journal_title：Endocrinology

authors： Yamamoto E,Ino K,Miyoshi E,Inamori K,Abe A,Sumigama S,Iwase A,Kajiyama H,Shibata K,Nawa A,Kikkawa F

更新日期：2009-02-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase 2 (11 beta-HSD2) protects mineralocorticoid receptors from high circulating levels of glucocorticoids and cDNAs for 11 beta-HSD2 from human and sheep have been recently cloned. We have isolated the gene for mouse 11 beta-HSD2, which spans 7 kilobases and is composed of 5 exons. In ...

journal_title：Endocrinology

authors： Cole TJ

更新日期：1995-10-01 00:00:00

abstract：:Human osteoblast-like cells (HOB) produce vascular endothelial growth factor (VEGF), the steady state level of which is stimulated by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. As osteoblasts and endothelial cells are proximally located in skeletal tissue, we investigated the anabolic effects of 1,25-(OH)2D3 and VEGF on...

journal_title：Endocrinology

authors： Wang DS,Miura M,Demura H,Sato K

更新日期：1997-07-01 00:00:00

abstract：:Previous studies from our laboratory demonstrated that daily afternoon melatonin injections from 20-40 days of age inhibited sexual development of young male rats, whereas in adult animals, similar injections had no effect. The present study was designed to determine more precisely the critical age period during which...

journal_title：Endocrinology

authors： Lang U,Aubert ML,Rivest RW,Vinas-Bradtke JC,Sizonenko PC

更新日期：1984-12-01 00:00:00

abstract：:For centuries our image of the skeleton has been one of an inert structure playing a supporting role for muscles and a protective role for inner organs like the brain. Cell biology and physiology modified this view in the 20st century by defining the constant interplay between bone-forming and bone resorbing cells tha...

journal_title：Endocrinology

authors： Ducy P

更新日期：2020-10-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), the principal IGF in adult rat serum, occurs complexed to specific binding proteins. After fractionation of serum on Sephadex G-200 at neutral pH, 62% of the immunoreactive IGF-I is recovered in the 150K region, 38% in the 40K region, and none is present as free 7.5K IGF-I. Adult ...

journal_title：Endocrinology

authors： Yang YW,Wang JF,Orlowski CC,Nissley SP,Rechler MM

更新日期：1989-09-01 00:00:00

abstract：:Under acute stress conditions in the rat, there is rapid and transient increase in circulating prolactin (PRL). This leads to an elevated expression of the long form of PRLR (PRLR-L) first in the hypothalamus and the choroid plexus. This increase in PRL is involved in the inhibition of stress-induced hypocalcemia and ...

journal_title：Endocrinology

authors： Fujikawa T,Tamura K,Kawase T,Mori Y,Sakai RR,Sakuma K,Yamaguch A,Ogata M,Soya H,Nakashima K

更新日期：2005-08-01 00:00:00

abstract：:The effects of FFA on circulating LH and GH concentrations in ovariectomized ewe lambs were investigated. Lambs (n = 14) were weaned at 2.5 months, ovariectomized at 6.5 months, and used at 8.5 months of age. From weaning until day 0 of the experiment, lambs were fed to maintain body weights (23 kg). On day 0, serum F...

journal_title：Endocrinology

authors： Estienne MJ,Schillo KK,Hileman SM,Green MA,Hayes SH,Boling JA

更新日期：1990-04-01 00:00:00

abstract：:Inflammatory mediators, such as cytokines and prostaglandins, play a fundamental role in estrogen-dependent breast cancer through their ability to up-regulate aromatase expression and subsequent local production of estrogens in the breast. To study the link between estrogens and inflammation further, we examined the r...

journal_title：Endocrinology

authors： Frasor J,Weaver AE,Pradhan M,Mehta K

更新日期：2008-12-01 00:00:00

abstract：:We recently described a novel GnRH receptor signaling pathway mediated by the prostaglandins (PGs) F(2alpha) and PGI(2), which acts through an autocrine/paracrine modality to limit autoregulation of the GnRH receptor and inhibit LH but not FSH release. Here we further explore the cross talk between GnRH and the PG rec...

journal_title：Endocrinology

authors： Naidich M,Shterntal B,Furman R,Pawson AJ,Jabbour HN,Morgan K,Millar RP,Jia J,Tomic M,Stojilkovic S,Stern N,Naor Z

更新日期：2010-06-01 00:00:00

abstract：:Ovarian cancer in women is a complex and deadly disease, where the molecular events that initiate and control tumor formation remain poorly defined. Therefore, mouse models provide one approach for determining the mechanisms by which specific oncogenic factors cause ovarian surface epithelial cell and granulosa cell t...

journal_title：Endocrinology

authors： Mullany LK,Richards JS

更新日期：2012-04-01 00:00:00

abstract：:Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat. In the absence of anesthesia, sodium chloride decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar resul...

journal_title：Endocrinology

authors： Campbell WB,Pettinger WA

更新日期：1975-12-01 00:00:00

abstract：:In this study, we investigated the hypothalamic regulatory role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the control of LH and PRL secretion. Overiectomized ewes were surgically prepared with bilateral guide tubes directed at the preoptic area (POA) or medial basal hypothalamus (MBH). After rec...

journal_title：Endocrinology

authors： Anderson ST,Sawangjaroen K,Curlewis JD

更新日期：1996-08-01 00:00:00

abstract：:Levels of bovine placental lactogen (bPL) have been measured in the serum of dairy and beef cattle and in the milk and amniotic fluid of pregnant animals with a highly specific radioimmunoassay. In both dairy and beef cows, serum bPL levels remain low (less than 50 ng/ml) during the first two trimesters and then rise ...

journal_title：Endocrinology

authors： Bolander FF,Ulberg LC,Fellows RE

更新日期：1976-11-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00

abstract：:Ghrelin has emerged as putative regulator of an array of endocrine and nonendocrine functions, including cell proliferation. Recently, we provided evidence for the expression of ghrelin in mature, but not in undifferentiated, Leydig cells of rat and human testis. Yet testicular actions of ghrelin, other than modulatio...

journal_title：Endocrinology

authors： Barreiro ML,Gaytan F,Castellano JM,Suominen JS,Roa J,Gaytan M,Aguilar E,Dieguez C,Toppari J,Tena-Sempere M

更新日期：2004-11-01 00:00:00

abstract：:Studies in the rat and rabbit indicate that facilitatory effects of neuropeptide Y (NPY) as well as norepinephrine (NE) on LH and LHRH release are dependent on the presence of the ovarian steroid estrogen. However, we have previously found the NE and an alpha-1-adrenergic agonist are both stimulatory to pulsatile LHRH...

journal_title：Endocrinology

authors： Woller MJ,Terasawa E

更新日期：1991-02-01 00:00:00

abstract：:The hormonal control of the adipose conversion of 3T3 L1 cells was studied in a chemically defined medium and compared to that under serum-containing conditions. Addition of insulin to a chemically defined medium (Dulbecco's Modified Eagle's Medium-Ham's F-12, 1:1) resulted in a dose-dependent increase in glycero-3-ph...

journal_title：Endocrinology

authors： Hauner H

更新日期：1990-08-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) is a neuropeptide related to vasoactive intestinal peptide-secretin-glucagon which stimulates adenylate cyclase in cultured rat pituitary cells and stimulates LH and FSH release in vitro and in vivo. Because the cAMP-protein kinase-A pathway regulates the...

journal_title：Endocrinology

authors： Tsujii T,Ishizaka K,Winters SJ

更新日期：1994-09-01 00:00:00

abstract：:We have previously shown that repeated antenatal synthetic glucocorticoid exposure has sex-specific effects on hypothalamic-pituitary-adrenal development in the fetal and adult guinea pig. However, little is known about the mechanisms that underlie these sex-specific outcomes. In the current study we demonstrated that...

journal_title：Endocrinology

authors： Owen D,Matthews SG

更新日期：2003-07-01 00:00:00

abstract：:Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating d...

journal_title：Endocrinology

authors： Warden SJ,Robling AG,Sanders MS,Bliziotes MM,Turner CH

更新日期：2005-02-01 00:00:00

abstract：:Parathyroid hormone (PTH) secretion rate was measured in seven calves by using a technique which involved RIA of parathyroid venous blood collected during timed intervals and measured volumetrically. Infusion of solutions of NA2EDTA and MgCl2 into the jugular vein was used to alter plasma calcium and magnesium concent...

journal_title：Endocrinology

authors： Mayer GP,Hurst JG

更新日期：1978-06-01 00:00:00