Glucocorticoids and sex-dependent development of brain glucocorticoid and mineralocorticoid receptors.

abstract：:One day of fasting suppresses pulsatile LH secretion in adult male rhesus monkeys. In the present study, we determined whether the hypothalamic-pituitary-adrenal (HPA) axis is activated by 1 day of fasting, and if there is any evidence that an increase in the activity of the HPA axis causes the fasting-induced suppres...

journal_title：Endocrinology

authors： Helmreich DL,Mattern LG,Cameron JL

更新日期：1993-06-01 00:00:00

abstract：:Glucocorticoid hormones are involved in functional differentiation of GH-producing somatotrophs. Glucocorticoid treatment prematurely induces GH expression in mammals and birds in a process requiring protein synthesis and Rat sarcoma (Ras) signaling. The objective of this study was to investigate mechanisms through wh...

journal_title：Endocrinology

authors： Ellestad LE,Puckett SA,Porter TE

更新日期：2015-03-01 00:00:00

abstract：:Recent evidence suggests that the aromatization of testosterone to estrogen is important for the organizing effects of neonatal testosterone on neuroendocrine responses to acute challenges. However, the extent to which neonatal inhibition of aromatase alters the stress-induced activation of neural pathways has not bee...

journal_title：Endocrinology

authors： Bingham B,Wang NX,Innala L,Viau V

更新日期：2012-04-01 00:00:00

abstract：:The ABCB1-type multidrug resistance efflux transporter P-glycoprotein (P-gp) has been hypothesized to regulate hypothalamic-pituitary-adrenal axis activity by limiting the access of glucocorticoids to the brain. In vivo systemic administration studies using P-gp-deficient mice have shown increased glucocorticoid entry...

journal_title：Endocrinology

authors： Mason BL,Pariante CM,Thomas SA

更新日期：2008-10-01 00:00:00

abstract：:This study was initiated to investigate the significance of uterine cell death and proliferation during the estrous cycle and early pregnancy and their correlation with sex steroids in hamsters where blastocyst implantation occurs in only progesterone-primed uteri. The results obtained in hamsters were also compared w...

journal_title：Endocrinology

authors： Zhang Q,Paria BC

更新日期：2006-05-01 00:00:00

abstract：:Insulin and protein kinase B (or Akt) play critical roles in cardiomyocytic growth and survival. High concentrations of glucocorticoids antagonize insulin's action. To examine whether endogenous glucocorticoids modulate insulin's effect on Akt signaling in the protein and glycogen synthetic pathways in myocardium, we ...

journal_title：Endocrinology

authors： Wu Y,Barrett EJ,Long W,Liu Z

更新日期：2004-03-01 00:00:00

abstract：:Although Na+/H+ exchange is important to maintenance of pH and volume and thus placental-fetal homeostasis, regulation of the Na+/H+ exchange system is incompletely understood. We previously showed that Na+/H+ exchanger (NHE)1 and -3 and their regulatory factors NHERF1 and -2 were expressed in human and nonhuman prima...

journal_title：Endocrinology

authors： Pepe GJ,Burch MG,Albrecht ED

更新日期：2006-06-01 00:00:00

abstract：:The hypothesis that hydrogen peroxide generation occurs in the corpora lutea of superovulated rats during luteolysis was tested using a peroxide-dependent inhibitor of catalase, 3-amino-1,2,4-triazole (AT). Luteal regression was induced during midpseudopregnancy by injection of 500 micrograms prostaglandin F2 alpha (P...

journal_title：Endocrinology

authors： Riley JC,Behrman HR

更新日期：1991-04-01 00:00:00

abstract：:In the present study, we have investigated the cellular mechanisms of androgen-induced antral follicular growth arrest and the possible involvement of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) in this process, using a chronically androgenized rat model. We hypothesize that hyperandrogenism induces a...

journal_title：Endocrinology

authors： Kim JY,Xue K,Cao M,Wang Q,Liu JY,Leader A,Han JY,Tsang BK

更新日期：2013-08-01 00:00:00

abstract：:Progesterone, which is normally produced in the endoplasmic reticulum, was found to be rapidly degraded in the cytosolic fraction of the guinea pig adrenal cortex in vitro. Assuming this finding reflects what happens in vivo raises a question as to the source of progesterone for interacting with a nuclear progesterone...

journal_title：Endocrinology

authors： Demura T,Driscoll WJ,Strott CA

更新日期：1990-09-01 00:00:00

abstract：:To test the hypothesis that vitamin D-dependent calcium-binding protein (CaBP) and active calcium (Ca) transport in the small intestine of vitamin D-replete lactating rats are regulated by dietary Ca intake, pregnant rats were given a high Ca (1.6% Ca and 1.4% phosphorus) or low Ca (0.1% Ca and 0.4% phosphorus) diet s...

journal_title：Endocrinology

authors： Bruns ME,Boass A,Toverud SU

更新日期：1987-07-01 00:00:00

abstract：:Nicotine is a potent stimulus for the secretion of ACTH, and norepinephrinergic neurons originating in the brainstem are involved. Prior reports using in vivo microdialysis in alert rats have shown that nicotine, administered i.p. or into the fourth ventricle, stimulated the release of norepinephrine (NE) into the hyp...

journal_title：Endocrinology

authors： Fu Y,Matta SG,Valentine JD,Sharp BM

更新日期：1997-05-01 00:00:00

abstract：:Kisspeptin, encoded by the Kiss1 gene, binds to a specific G protein-coupled receptor (kisspeptin1 receptor) to regulate the central reproductive axis. Kisspeptin has also been reported to be expressed in peripheral tissues, including the testes. However, factors regulating testicular kisspeptin and its role in reprod...

journal_title：Endocrinology

authors： Salehi S,Adeshina I,Chen H,Zirkin BR,Hussain MA,Wondisford F,Wolfe A,Radovick S

更新日期：2015-04-01 00:00:00

abstract：:The relationship between progesterone and prostaglandin (PG) secretion in the pseudopregnant rabbit corpus luteum was investigated using isolated in vitro perfused ovaries. Progesterone and PG secretion were measured on days 1, 11, and 18 of hCG-induced pseudopregnancy. The mean progesterone secretion increased signif...

journal_title：Endocrinology

authors： Dharmarajan AM,Sueoka K,Miyazaki T,Atlas SJ,Ghodgaonkar RB,Dubin NH,Zirkin BR,Wallach EE

更新日期：1989-03-01 00:00:00

abstract：:Basal growth hormone (GH) levels are higher in female than male primates, and estradiol (E) treatment of gonadectomized primates increases serum GH. To determine if the effect of E is mediated at the level of the somatotroph, we verified the effect of E-treatment on serum GH in spayed macaques, and then examined the e...

journal_title：Endocrinology

authors： Bethea CL

更新日期：1991-10-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) is a pleiotropic cytokine known to control the proliferation and survival of stem cells including primordial germ cells and gonocytes. This led us to study the origin and regulation of testicular LIF. The LIF transcript was detected in the rat testis by RT-PCR from 13.5 days postcoitum...

journal_title：Endocrinology

authors： Piquet-Pellorce C,Dorval-Coiffec I,Pham MD,Jégou B

更新日期：2000-03-01 00:00:00

abstract：:The ability of ovarian steroids to influence the release of LH was examined after ovariectomy in regularly cycling adult female rats and two types of anovulatory persistent estrous rats: rats treated with 10 mug of testosterone propionate (TP) shortly after birth, and normal rats housed under constant illumination. Tw...

journal_title：Endocrinology

authors： Mennin SP,Gorski RA

更新日期：1975-02-01 00:00:00

abstract：:Hormonal induction of steroidogenesis in the adrenal and gonads is dependent on the synthesis and function of the steroidogenic acute regulatory protein (StAR). As a first approach to investigate the role of translation in the control of StAR expression, we examined StAR protein synthesis and steroid production in MA-...

journal_title：Endocrinology

authors： Clark BJ,Combs R,Hales KH,Hales DB,Stocco DM

更新日期：1997-11-01 00:00:00

abstract：:GnRH neurons are regulated by hypothalamic kisspeptin neurons. Recently, galanin was identified in a subpopulation of kisspeptin neurons. Although the literature thoroughly describes kisspeptin activation of GnRH neurons, little is known about the effects of galanin on GnRH neurons. This study investigated whether gal...

journal_title：Endocrinology

authors： Constantin S,Wray S

更新日期：2016-08-01 00:00:00

abstract：:The preovulatory LH surge in the sheep is accompanied by a massive and sustained surge of GnRH. The objective of this study was to examine the duration of the endogenous GnRH signal required to induce and maintain a LH surge of full amplitude and duration. For this purpose, we assessed the effect of a competitive GnRH...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Caraty A,Padmanabhan V,Thrun LA,Karsch FJ

更新日期：1996-11-01 00:00:00

abstract：:Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and dynorphin acting as start and stop signals, respectively. In this study, we tested this hypothesis...

journal_title：Endocrinology

authors： Goodman RL,Hileman SM,Nestor CC,Porter KL,Connors JM,Hardy SL,Millar RP,Cernea M,Coolen LM,Lehman MN

更新日期：2013-11-01 00:00:00

abstract：:Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein "dilution" has been explained by resource-mediated trade-...

journal_title：Endocrinology

authors： Larson KR,Russo KA,Fang Y,Mohajerani N,Goodson ML,Ryan KK

更新日期：2017-10-01 00:00:00

abstract：:We investigated the effects of intraventricular (ivt) injection of bombesin on the TRH-induced increase in temperature in the midbrain reticular formation (mrf) of the rat brain under pentobarbital anesthesia. Ivt injection of TRH in a dose of 3 nmol significantly antagonized the decrease in brain temperature induced ...

journal_title：Endocrinology

authors： Mori M,Yamaguchi M,Yamada M,Kobayashi I,Kobayashi S,Ishikawa K,Suzuki M

更新日期：1986-10-01 00:00:00

abstract：:Previous studies demonstrated the involvement of transforming growth factor-alpha (TGF alpha), a member of the epidermal growth factor (EGF) family, in the developmental regulation of hypothalamic LHRH release. Although both TGF alpha and EGF stimulate LHRH release, they do not appear to act directly on LHRH neurons, ...

journal_title：Endocrinology

authors： Ma YJ,Berg-von der Emde K,Rage F,Wetsel WC,Ojeda SR

更新日期：1997-01-01 00:00:00

abstract：:The development of androgen responsiveness in the submandibular gland of normal and androgen-resistant (Tfm) mice of different ages was studied after varying hormonal treatments. Total esteroproteolytic (tamase) activity of submandibular gland homogenates was used as a marker for androgen action. Newborn mice of all f...

journal_title：Endocrinology

authors： Dunn JF,Wilson JD

更新日期：1975-06-01 00:00:00

abstract：:The present study was undertaken to determine whether T3 could modify anterior pituitary Ca++ metabolism under basal conditions and in the presence of TRH. Paired hemipituitaries from hypothyroid rats were preincubated with T3 (10(-7) M) for 2 h, allowed to accumulate 45Ca++ for the third hour, and repeatedly washed i...

journal_title：Endocrinology

authors： Schrey MP,Larsen PR

更新日期：1981-05-01 00:00:00

abstract：:Binding of atrial and brain natriuretic peptides to guanylyl cyclase-A/natriuretic peptide receptor-A produces second messenger cGMP, which plays an important role in maintaining renal and cardiovascular homeostasis. Mice carrying a targeted disruption of the Npr1 gene coding for guanylyl cyclase-A/natriuretic peptide...

journal_title：Endocrinology

authors： Das S,Au E,Krazit ST,Pandey KN

更新日期：2010-12-01 00:00:00

abstract：:alpha-Fetoprotein (AFP) is present in high levels in fetal fluids, certain neoplasias, and regenerating liver. Although AFP's physiological role remains an enigma, we have recently demonstrated mitogenic activity for AFP. Using a primary monolayer culture system, we have further investigated the proliferative activity...

journal_title：Endocrinology

authors： Keel BA,Eddy KB,Cho S,May JV

更新日期：1991-07-01 00:00:00

abstract：:The expression and functions of receptors for the beta-chemokine, regulated upon activation, normal T cell expressed, and secreted (RANTES)/CCL5, were investigated in osteoblasts. Both primary osteoblasts and the MC3T3-E1 osteoblast cell line express the RANTES receptors, CCR1, 3, 4, and 5 (by RT-PCR), which encode fu...

journal_title：Endocrinology

authors： Yano S,Mentaverri R,Kanuparthi D,Bandyopadhyay S,Rivera A,Brown EM,Chattopadhyay N

更新日期：2005-05-01 00:00:00

abstract：:Electrical stimulation of the preoptic area resulted in a significant increase in the secretion rate of immunoreactive somatostatin (IRS) and its concentration in the hypophysial portal blood of urethane-anesthetized rats. In contrast, stimulation of the ventromedial nucleus did not cause any changes in portal immunor...

journal_title：Endocrinology

authors： Chihara K,Arimura A,Kubli-Garfias C,Schally AV

更新日期：1979-12-01 00:00:00