Brain temperature in the rat midbrain reticular formation is regulated by bombesin and TRH.

abstract：:We have demonstrated previously that both rat and human liver microsomes contain a highly specific binding protein for the anabolic steroids stanozolol (ST) and danazol (DA). In this study we solubilized the male rat liver ST-binding protein (STBP) and investigated the following parameters: 1) pharmacological properti...

journal_title：Endocrinology

authors： Luzardo OP,Machín RP,Díaz-Chico BN,Fernández L

更新日期：2000-09-01 00:00:00

abstract：:In order to investigate the physiological counterpart of the anatomical finding showing that the dorsal motor nucleus of the vagus nerve (DMX) is a source of efferent vagal fibers innervating the pancreas, unilateral electrical stimulation using monopolar electrodes (50 microA, 30 Hz, 0.2 msec) at a glycemia of 150 mg...

journal_title：Endocrinology

authors： Ionescu E,Rohner-Jeanrenaud F,Berthoud HR,Jeanrenaud B

更新日期：1983-03-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) play potential roles in chemoprevention of colon cancer and others by inhibiting prostaglandin synthesis. In this report, we used LNCaP cells, an androgen-responsive human prostate carcinoma cell line, to study the effects of two NSAIDs, flufenamic acid (FA) and piroxicam ...

journal_title：Endocrinology

authors： Zhu W,Smith A,Young CY

更新日期：1999-11-01 00:00:00

abstract：:Pituitary growth hormone (GH) content and plasma GH response to pentobarbital (PB) of severely hypothyroid rats are markedly decreased compared with euthyroid rats. Both pituitary and plasma GH may be increased by single ip injections of physiologic doses of thyroxine (T4) (1.75 mug/100g BW) or triiodothyronine (T3) (...

journal_title：Endocrinology

authors： Hervás F,Morreale de Escobar G,Escobar del Rey F

更新日期：1976-01-01 00:00:00

abstract：:GnRH neurons are central regulators of reproduction and respond to factors affecting fertility, such as stress. Corticotropin-releasing hormone (CRH) is released during stress response. In brain slices from unstressed controls, CRH has opposite, estradiol-dependent effects on GnRH neuron firing depending on the CRH re...

journal_title：Endocrinology

authors： Phumsatitpong C,De Guzman RM,Zuloaga DG,Moenter SM

更新日期：2020-11-01 00:00:00

abstract：:The roles of growth hormone and somatomedin in stimulating muscle cell proliferation were investigated in a series of experiments on myoblast growth in culture. At levels 100 times normal circulating concentrations, neither growth hormone nor insulin stimulated growth of rat muscle cells in serum-free medium. In contr...

journal_title：Endocrinology

authors： Florini JR,Nicholson ML,Dulak NC

更新日期：1977-07-01 00:00:00

abstract：:The adipokine, leptin (LEP), is a hormonal gateway, signaling energy stores to appetite-regulatory neurons, permitting reproduction when stores are sufficient. Dual-labeling for LEP receptors (LEPRs) and gonadotropins or GH revealed a 2-fold increase in LEPR during proestrus, some of which was seen in LH gonadotropes....

journal_title：Endocrinology

authors： Akhter N,CarlLee T,Syed MM,Odle AK,Cozart MA,Haney AC,Allensworth-James ML,Beneš H,Childs GV

更新日期：2014-10-01 00:00:00

abstract：:The present study was designed to evaluate the relative contribution of endogenous excitatory amino acids to the control of the estradiol-induced LH surge using specific blockers for N-methyl-D-aspartic acid (NMDA) and non-NMDA receptor types. Adult female rats ovariectomized for 2-3 weeks were implanted with third ve...

journal_title：Endocrinology

authors： López FJ,Donoso AO,Negro-Vilar A

更新日期：1990-03-01 00:00:00

abstract：:High fat feeding is associated with impaired insulin action, an obese body composition, and down-regulation of glucose transporter-4 (GLUT4) expression in adipocytes. We recently showed that overexpression of GLUT4 selectively in adipocytes of transgenic mice using the aP2 (fatty acid-binding protein) promoter/enhance...

journal_title：Endocrinology

authors： Gnudi L,Tozzo E,Shepherd PR,Bliss JL,Kahn BB

更新日期：1995-03-01 00:00:00

abstract：:UMR106-06 cells predominantly express the C1a isoform of the rat calcitonin (CT) receptor (CTR). We have compared the homologous regulation of the C1a CTR endogenously expressed in UMR106-06 cells with the cloned C1a CTR in transfected HEK 293 cells, in which expression is driven by a heterologous promoter. It was fou...

journal_title：Endocrinology

authors： Findlay DM,Houssami S,Christopoulos G,Sexton PM

更新日期：1996-11-01 00:00:00

abstract：:We examined the levels and stability of glucocorticoid receptor activity in cytosol preparations of rat lung and other tissues. [3H]Dexamethasome binding capacity at 2 C in lung cytosol decreases with a t1/2 of 40 min in the absence of steroid or a sulfhydryl compound. This rapid inactivation of unbound receptor is pr...

journal_title：Endocrinology

authors： Granberg JP,Ballard PL

更新日期：1977-04-01 00:00:00

abstract：:We performed an electrophysiological study to investigate ion transport of pendrin and thereby understand the pathogenesis of Pendred syndrome. Using pendrin-transfected COS-7 cells, we could show that pendrin transports both iodide and chloride measured as voltage-dependent inward and outward membrane currents. Chlor...

journal_title：Endocrinology

authors： Yoshida A,Hisatome I,Taniguchi S,Sasaki N,Yamamoto Y,Miake J,Fukui H,Shimizu H,Okamura T,Okura T,Igawa O,Shigemasa C,Green ED,Kohn LD,Suzuki K

更新日期：2004-09-01 00:00:00

abstract：:In the mouse, there is a large family of paralogous genes closely related to PRL. The objective of this report was to investigate the organization of the mouse PRL gene family locus. PRL family genes reside on chromosome 13 of the mouse genome. The PRL gene family members were localized to a series of overlapping bact...

journal_title：Endocrinology

authors： Wiemers DO,Shao LJ,Ain R,Dai G,Soares MJ

更新日期：2003-01-01 00:00:00

abstract：:We tested further our postulate that enhanced de novo synthesis of phosphatidic acid is responsible for ACTH- and cAMP-induced increases in adrenal phospholipids in the phosphatidate polyphosphoinositide pathway. During incubation of adrenal sections or cells in vitro, ACTH and cAMP increased the concentrations of and...

journal_title：Endocrinology

authors： Farese RV,Sabir MA,Larson RE

更新日期：1981-12-01 00:00:00

abstract：:Galanin-like peptide (GALP), a 29-amino-acid neuropeptide, is located in the hypothalamic arcuate nucleus (ARC), binds to galanin receptor subtype 2, and induces food intake upon intracerebroventricular (icv) injection in rats. However, neural mechanisms underlying its orexigenic action remain unclear. We aimed to ide...

journal_title：Endocrinology

authors： Kuramochi M,Onaka T,Kohno D,Kato S,Yada T

更新日期：2006-04-01 00:00:00

abstract：:Ovarian angiotensin I (Ang I)-converting enzyme (ACE), estimated by the specific binding of the ACE inhibitor [125I]iodo-MK-351A, is localized on multiple ovarian structures, including follicular granulosa cells, corpora lutea, terminal epithelium, and ovarian blood vessels, but total ovarian ACE does not display a cy...

journal_title：Endocrinology

authors： Daud AI,Bumpus FM,Husain A

更新日期：1990-06-01 00:00:00

abstract：:At micromolar (pharmacological) concentrations, the action of tamoxifen on the proliferation of estrogen-dependent cells can be mediated not only by the estrogen receptor (ER), but also by other target molecules, such as protein kinase-C (PKC), which are easily inhibited by antiestrogens in cell-free experiments. By d...

journal_title：Endocrinology

authors： Astruc ME,Chabret C,Bali P,Gagne D,Pons M

更新日期：1995-03-01 00:00:00

abstract：:Although LHRH can stimulate the release of both LH and FSH from the pituitary, there are a number of instances in which the secretion of LH and FSH are divergent. Previous studies from our laboratory have indicated that pulsatile LH and FSH secretion are independently regulated by gonadal factors. We have, therefore, ...

journal_title：Endocrinology

authors： Culler MD,Negro-Vilar A

更新日期：1986-02-01 00:00:00

abstract：:The effect of bovine corneal extracellular matrix (ECM) on gonadotropin-primed rat granulosa cells in vitro was studied by examining the following parameters: 1) rate of cell attachment to culture dishes; 2) modulation of cell morphology; 3) specific binding of [125I]human(h)CG to LH/hCG receptors; 4) cAMP response to...

journal_title：Endocrinology

authors： Furman A,Rotmensch S,Kohen F,Mashiach S,Amsterdam A

更新日期：1986-05-01 00:00:00

abstract：:Insulin receptors were measured in cultured Zajdela rat hepatoma cells (ZHC cells), a stable cell line which presents differentiated hepatic functions. The number of sites was 50,000/cell at 2 C, and the dissociation constant for high affinity binding was 1.6 x 10(-10) M. Down-regulation of receptors occurred rapidly ...

journal_title：Endocrinology

authors： Capeau J,Flaig-Staedel C,Beck JP,Picard J

更新日期：1982-09-01 00:00:00

abstract：:Hyperaldosteronism is linked to the development and progression of several different cardiovascular diseases. Angiotensin (Ang) II increases aldosterone secretion and adrenal blood flow. Ang II peptide fragments are produced by various peptidases, and these Angs have diverse and vital physiologic roles. Due to the unc...

journal_title：Endocrinology

authors： Kopf PG,Campbell WB

更新日期：2013-12-01 00:00:00

abstract：:Methylamine and monensin are two agents known to interfere with the recycling of membrane receptors. In the present investigation, we studied their effects on the binding, intracellular distribution, and action of insulin in isolated pancreatic acini prepared from diabetic mice. These drugs had several similar effects...

journal_title：Endocrinology

authors： Potau N,Bailey AC,Roach E,Williams JA,Goldfine ID

更新日期：1984-07-01 00:00:00

abstract：:This review describes formation of the islet basement membrane and the function of extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for islet transplantation are discussed. The insulin-producing β-cell is key for maintaining glucose homeostasis. The islet microenvironment greatl...

journal_title：Endocrinology

authors： Townsend SE,Gannon M

更新日期：2019-08-01 00:00:00

abstract：:Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating d...

journal_title：Endocrinology

authors： Warden SJ,Robling AG,Sanders MS,Bliziotes MM,Turner CH

更新日期：2005-02-01 00:00:00

abstract：:Brain-derived neurotropic factor (BDNF) is a member of the nerve growth factor family that is important for neuronal survival and plasticity. We recently demonstrated that stress decreases BDNF messenger RNA (mRNA) levels in the hippocampus, which raises the possibility that BDNF may play a role in regulation of the h...

journal_title：Endocrinology

authors： Smith MA,Makino S,Kim SY,Kvetnansky R

更新日期：1995-09-01 00:00:00

abstract：:We analyzed the mechanism by which a Graves' disease-associated C/T polymorphism in the Kozak sequence of CD40 affects CD40 expression. CD40 expression levels on B cells in individuals with CT and TT genotypes were decreased by 13.3 and 39.4%, respectively, compared with the levels in CC genotypes (P = 0.012). Similar...

journal_title：Endocrinology

authors： Jacobson EM,Concepcion E,Oashi T,Tomer Y

更新日期：2005-06-01 00:00:00

abstract：:Estrogen has wide-ranging and complex effects on the reproductive axis, which are often difficult to interpret from in vivo studies. Estrogen negatively regulates tonic GnRH synthesis and also plays a pivotal role in the positive regulation of GnRH necessary for the preovulatory surge. To dissect the mechanisms by whi...

journal_title：Endocrinology

authors： Roy D,Angelini NL,Belsham DD

更新日期：1999-11-01 00:00:00

abstract：:Intestinal calcium and phosphate transport was studied in normal and hypophosphatemic mice fed a variety of dietary regimens with and without vitamin D. Regardless of dietary phosphorus levels, the genetic hypophosphatemic mice had drastically reduced levels of serum inorganic phosphate and intestinal phosphate transp...

journal_title：Endocrinology

authors： O'Doherty PJ,DeLuca HF,Eicher EM

更新日期：1977-10-01 00:00:00

abstract：:The present study determined whether the reduction in serum progesterone (P4) concentrations which follows the administration of the antiestrogen ethamoxytriphetol [1-(rho-2-diethylaminoethoxyphenyl)1-phenyl-2-rho-methoxyphenyl ethanol (MER-25)] to pregnant baboons reflects a decline in placental and/or luteal functio...

journal_title：Endocrinology

authors： Albrecht ED,Pepe GJ

更新日期：1984-11-01 00:00:00

abstract：:We previously examined the segregation patterns of two polymorphic restriction enzyme sites for EcoRI and HindIII in the 3'-flanking region of human CG-alpha gene in placenta and choriocarcinoma. We observed that a unique combination of restriction sites predominates in choriocarcinoma while this pattern was rare in p...

journal_title：Endocrinology

authors： Otani T,Boime I

更新日期：1986-11-01 00:00:00