Increases in plasma insulin levels in response to electrical stimulation of the dorsal motor nucleus of the vagus nerve.

abstract：:The effects of FFA on circulating LH and GH concentrations in ovariectomized ewe lambs were investigated. Lambs (n = 14) were weaned at 2.5 months, ovariectomized at 6.5 months, and used at 8.5 months of age. From weaning until day 0 of the experiment, lambs were fed to maintain body weights (23 kg). On day 0, serum F...

journal_title：Endocrinology

authors： Estienne MJ,Schillo KK,Hileman SM,Green MA,Hayes SH,Boling JA

更新日期：1990-04-01 00:00:00

abstract：:Ca2+/calmodulin-dependent processes are altered by manipulations of the hypothalamic-pituitary-adrenal axis. In particular, adrenalectomy (ADX) attenuates hippocampal, but not cortical, calmodulin-dependent adenylate cyclase activity measured during the active (waking) phase of rats. The involvement of calmodulin- and...

journal_title：Endocrinology

authors： Gannon MN,Akompong T,Billingsley ML,McEwen BS

更新日期：1994-02-01 00:00:00

abstract：:The effects of increasing concentrations of leucine (0.2, 2.0, and 15.0 mmol/liter) on glucagon secretion from the perfused rat pancreas were examined at various glucose levels (0, 3.3, or 8.3 mmol/liter) and in the absence or presence of either arginine (5.0 mmol/liter) or glutamine (10.0 mmol/liter). At a low glucos...

journal_title：Endocrinology

authors： Leclercq-Meyer V,Marchand J,Woussen-Colle MC,Giroix MH,Malaisse WJ

更新日期：1985-03-01 00:00:00

abstract：:The gonadal steroids have long been known to modulate thyroid function. Most studies suggest that the gonadal steroids act indirectly through the hypothalamic-pituitary axis to modulate thyroid function. The following studies were conducted to determine whether there are receptors for androgens in the thyroid itself. ...

journal_title：Endocrinology

authors： Sheridan PJ,McGill HC Jr,Lissitzky JC,Martin PM

更新日期：1984-12-01 00:00:00

abstract：:A competitive protein-binding (CPB) assay, suitable for measuring corticosterone levels in 20 mul of mouse plasma or 100 mg of brain, is described. The postnatal development of adrenocortical function was determined in C57BL/10 and DBA/1 mice by CPB assay of basal and stressinduced levels of plasma corticosterone and ...

journal_title：Endocrinology

authors： Diez JA,Sze PY,Ginsburg BE

更新日期：1976-06-01 00:00:00

abstract：:Commercially available preparations of natural porcine glucose-dependent insulinotropic polypeptide (GIP) were subjected to reverse phase HPLC. The material was found to give rise to 4 peaks which were characterized by HPLC-retention time and N-terminal sequence analysis. They represented: intact porcine GIP(1-42), 58...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Kümmel H,Gallwitz B,Creutzfeldt W

更新日期：1987-02-01 00:00:00

abstract：:Isolated growth hormone deficiency type II (IGHD2) is mainly caused by heterozygous splice-site mutations in intron 3 of the GH1 gene. A dominant-negative effect of the mutant GH lacking exon 3 on wild-type GH secretion has been proposed; however, the molecular mechanisms involved are elusive. To uncover the molecular...

journal_title：Endocrinology

authors： Ariyasu D,Kubo E,Higa D,Shibata S,Takaoka Y,Sugimoto M,Imaizumi K,Hasegawa T,Araki K

更新日期：2019-11-01 00:00:00

abstract：:Studies were carried out to determine the origin of the immediate increase in plasma calcium following acute calcitonin deficiency in mature rats. Animals were pre-labelled with 45calcium 24 hours and 4 weeks before thyroparathyroidectomy (TPTX) and 1 hour, 24 hours, 2 and 4 weeks before nephrectomy and TPTX and bled ...

journal_title：Endocrinology

authors： Kalu DN,Hadji-Georgopoulos A,Foster GV

更新日期：1976-02-01 00:00:00

abstract：:Analyses of FSH secretion suggest pulsatile, nonpulsatile, or compositely pulsatile and nonpulsatile release modes. This may reflect the reduced signal-to-noise ratio inherent in FSH pulse estimation procedures and/or immunological-biological assay inconsistencies. To address these issues, we sampled cavernous sinus a...

journal_title：Endocrinology

authors： Clarke I,Moore L,Veldhuis J

更新日期：2002-01-01 00:00:00

abstract：:To mimick a state of hyperinsulinemia, normal rats were infused with insulin for 4 days via minipumps, and compared to saline infused rats. At the end of the experimental period, the abundance of mRNA was increased in white adipose tissue (WAT) and decreased in muscles of "insulinized" rats compared to controls. These...

journal_title：Endocrinology

authors： Cusin I,Terrettaz J,Rohner-Jeanrenaud F,Zarjevski N,Assimacopoulos-Jeannet F,Jeanrenaud B

更新日期：1990-12-01 00:00:00

abstract：:Abnormally high GH/IGF-I levels, most often caused by adenomas arising from pituitary somatotrophs, generate deleterious effects. We recently described a targeted secretion inhibitor (SXN101742) comprising a GHRH domain and the endopeptidase domain of botulinum toxin serotype D (GHRH-light chain endopeptidase type D d...

journal_title：Endocrinology

authors： Somm E,Bonnet N,Zizzari P,Tolle V,Toulotte A,Jones R,Epelbaum J,Martinez A,Hüppi PS,Aubert ML

更新日期：2013-11-01 00:00:00

abstract：:Although atrial and brain natriuretic peptides are well known to be involved in the regulation of cardiovascular and endocrine functions as circulating hormones, the roles of the C-type natriuretic peptide (CNP) remain unknown. We examined the effects of CNP on the secretion of aldosterone and cyclic nucleotides from ...

journal_title：Endocrinology

authors： Kawai M,Naruse M,Yoshimoto T,Naruse K,Shionoya K,Tanaka M,Morishita Y,Matsuda Y,Demura R,Demura H

更新日期：1996-01-01 00:00:00

abstract：:Mullerian inhibiting substance (MIS) is a 140-kilodalton homodimeric glycoprotein that causes regression of the Mullerian ducts in male embryos, and may also have a role in both males and females in the regulation of germ cell maturation. We examined the ontogeny of MIS messenger RNA (mRNA) in rat testes from midgesta...

journal_title：Endocrinology

authors： Lee MM,Cate RL,Donahoe PK,Waneck GL

更新日期：1992-02-01 00:00:00

abstract：:To investigate the mechanism of insulin insensitivity during fasting and hyperresponsiveness to insulin after refeeding, insulin binding, 2-deoxyglucose uptake and glucose oxidation were measured in adipocytes from three groups of rats: control, 48 h fasted, and 48 h refed after 48 h fasting. In 48 h fasted rats, fat ...

journal_title：Endocrinology

authors： Kasuga M,Akanuma Y,Iwamoto Y,Kosaka K

更新日期：1977-05-01 00:00:00

abstract：:Studies were carried out to determine the actions of PRL on adrenocortical function in hypophysectomized female rats in the presence and absence of ACTH. PRL administration alone decreased 5 alpha-reductase activity but did not significantly affect the rates of corticosterone secretion or peripheral plasma corticoster...

journal_title：Endocrinology

authors： Colby HD

更新日期：1979-05-01 00:00:00

abstract：:Beta-adrenergic agonists and antagonists are widely used in many clinical situations to regulate beta-adrenergic stimulation. However, responsiveness to beta-stimulation may be reduced by the process of desensitization. We have established an in vivo mammalian model system, the rat lung, to study the cellular and bioc...

journal_title：Endocrinology

authors： Strasser RH,Stiles GL,Lefkowitz RJ

更新日期：1984-10-01 00:00:00

abstract：:Uterine epithelial cells (UEC) isolated from 6-week-old CF-1 mice were immortalized using retroviral-mediated transfection of SV40 large T-antigen. One line, WEG-1, retained epithelial morphology and reacted with antibodies to cytokeratins 18, 19, laminin, fibronectin, and beta-catenin. In addition, WEG-1 cells displa...

journal_title：Endocrinology

authors： Wegner CC,Cherington V,Clemens JW,Jacobs AL,Julian J,Surveyor GA,Bell EC,Carson DD

更新日期：1996-01-01 00:00:00

abstract：:The activity of many endocrine cells is regulated by gamma-aminobutyric acid (GABA). The effects of GABA are mediated by GABAA and/or GABAB receptors. While GABAB receptors in the central nervous system have now been extensively characterized, little is known of the function and pharmacology of GABAB receptors on endo...

journal_title：Endocrinology

authors： De Koning HP,Jenks BG,Roubos EW

更新日期：1993-02-01 00:00:00

abstract：:We and others have recently shown that 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] significantly inhibits cell proliferation and increases secretion of prostate-specific antigen (PSA) in LNCaP cells, an androgen-responsive human prostate cancer cell line. The present study was designed to investigate the possible int...

journal_title：Endocrinology

authors： Zhao XY,Ly LH,Peehl DM,Feldman D

更新日期：1997-08-01 00:00:00

abstract：:Circulating levels of insulin-like growth factor-I (IGF-I) increase during puberty, concurrent with an increase in the levels of GH and the gonadal steroids. The relationship between the changes observed in IGF-I and testosterone (T) levels are not understood. This study was designed to determine whether T has a direc...

journal_title：Endocrinology

authors： Phillip M,Palese T,Hernandez ER,Roberts CT Jr,LeRoith D,Kowarski AA

更新日期：1992-05-01 00:00:00

abstract：:New insulin-secreting cell lines (INS-1 and INS-2) were established from cells isolated from an x-ray-induced rat transplantable insulinoma. The continuous growth of these cells was found to be dependent on the reducing agent 2-mercaptoethanol. Removal of this thiol compound caused a 15-fold drop in total cellular glu...

journal_title：Endocrinology

authors： Asfari M,Janjic D,Meda P,Li G,Halban PA,Wollheim CB

更新日期：1992-01-01 00:00:00

abstract：:The present studies were performed to determine whether the major biologically active metabolite of vitamin D3, 1,25-dihydroxycholecalciferol [1,25(OH)2D3], could influence the activities of rat colonic particulate guanylate cyclase and adenylate cyclase. To address these issues, colonocytes were harvested from Spragu...

journal_title：Endocrinology

authors： Khare S,Wilson DM,Tien XY,Dudeja PK,Wali RK,Sitrin MD,Brasitus TA

更新日期：1993-11-01 00:00:00

abstract：:Estrogen has wide-ranging and complex effects on the reproductive axis, which are often difficult to interpret from in vivo studies. Estrogen negatively regulates tonic GnRH synthesis and also plays a pivotal role in the positive regulation of GnRH necessary for the preovulatory surge. To dissect the mechanisms by whi...

journal_title：Endocrinology

authors： Roy D,Angelini NL,Belsham DD

更新日期：1999-11-01 00:00:00

abstract：:We studied the estrogen-dependent expression of epidermal growth factor (EGF), transforming growth factor (TGF) alpha, and EGF receptor gene transcripts in human fallopian tubes in vivo and in vitro. Competitive polymerase chain reaction (PCR) was performed on the fallopian tube RNA samples from the postmenopausal wom...

journal_title：Endocrinology

authors： Adachi K,Kurachi H,Homma H,Adachi H,Imai T,Sakata M,Higashiguchi O,Yamaguchi M,Morishige K,Sakoyama Y

更新日期：1995-05-01 00:00:00

abstract：:After reproductive senescence or gonadectomy, changes occur in neural gene expression, ultimately altering brain function. The endocrine mechanisms underlying these changes in gene expression beyond immediate hormone loss are poorly understood. To investigate this, we measured changes in gene expression the dorsal str...

journal_title：Endocrinology

authors： Meitzen J,Perry AN,Westenbroek C,Hedges VL,Becker JB,Mermelstein PG

更新日期：2013-05-01 00:00:00

abstract：:We have investigated the possibility that IGF-1 may play a role in the regulation of antler development. Plasma IGF-1 concentrations were measured throughout the first period of development of the pedicle and first antler of red deer (Cervus elaphus) to determine whether a relationship existed between growth of antler...

journal_title：Endocrinology

authors： Suttie JM,Gluckman PD,Butler JH,Fennessy PF,Corson ID,Laas FJ

更新日期：1985-02-01 00:00:00

abstract：:Perifused anterior hemipituitaries from one male and 4 female monkeys released GH and PRL in a pulsatile pattern, with mean +/- SE interpulse intervals of 8.2 +/- 0.4 and 8.5 +/- 0.3 min, as determined by a cycle detection computer algorithm. Mean hormone concentrations in the perifusate fractions collected at 2-min i...

journal_title：Endocrinology

authors： Stewart JK,Clifton DK,Koerker DJ,Rogol AD,Jaffe T,Goodner CJ

更新日期：1985-01-01 00:00:00

abstract：:Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat. In the absence of anesthesia, sodium chloride decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar resul...

journal_title：Endocrinology

authors： Campbell WB,Pettinger WA

更新日期：1975-12-01 00:00:00

abstract：:The expression and functions of receptors for the beta-chemokine, regulated upon activation, normal T cell expressed, and secreted (RANTES)/CCL5, were investigated in osteoblasts. Both primary osteoblasts and the MC3T3-E1 osteoblast cell line express the RANTES receptors, CCR1, 3, 4, and 5 (by RT-PCR), which encode fu...

journal_title：Endocrinology

authors： Yano S,Mentaverri R,Kanuparthi D,Bandyopadhyay S,Rivera A,Brown EM,Chattopadhyay N

更新日期：2005-05-01 00:00:00

abstract：:By acting in the brain, insulin suppresses food intake, whereas neuropeptide Y (NPY) has the opposite effect. Since fasting increases NPY gene expression in the hypothalamic arcuate nucleus (ARC) and also lowers circulating insulin levels, we hypothesized that the anorexiant effect of insulin could result from insulin...

journal_title：Endocrinology

authors： Schwartz MW,Marks JL,Sipols AJ,Baskin DG,Woods SC,Kahn SE,Porte D Jr

更新日期：1991-05-01 00:00:00