Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts.

abstract：:Quantitative thyroid cell transplantation was used to evaluate the reestablishment of thyroid function in surgically thyroidectomized rats. Donor thyroid glands were enzymatically dispersed, and the cells were quantified, serially diluted, and inoculated into the sc fat pads of syngeneic recipient rats 1 day after sur...

journal_title：Endocrinology

authors： Domann FE,Mitchen JM,Clifton KH

更新日期：1990-12-01 00:00:00

abstract：:Newly discovered kisspeptin (metastin), encoded by the Kiss1/KISS1 gene, is considered as a major gatekeeper of puberty through the regulation of GnRH. In the present study, we cloned a novel kisspeptin gene (kiss2) in the zebrafish Danio rerio and the medaka Oryzias latipes, which encodes a sequence of 125 and 115 am...

journal_title：Endocrinology

authors： Kitahashi T,Ogawa S,Parhar IS

更新日期：2009-02-01 00:00:00

abstract：:The recently discovered estrogen receptor-beta (ERbeta) is expressed in rodent and human testes. To obtain insight in the physiological role of ERbeta we have investigated the cell type-specific expression pattern of ERbeta messenger RNA (mRNA) and protein in the testis of rats of various ages by in situ hybridization...

journal_title：Endocrinology

authors： van Pelt AM,de Rooij DG,van der Burg B,van der Saag PT,Gustafsson JA,Kuiper GG

更新日期：1999-01-01 00:00:00

abstract：:Immunosympathectomy produced by treatment of newborn rats with antibodies to nerve growth factor (NGF) delays ovarian development and disrupts estrous cyclicity. While these alterations have been ascribed to loss of sympathetic neurons innervating the ovary, the treatment also causes partial loss of ovarian sensory in...

journal_title：Endocrinology

authors： Lara HE,McDonald JK,Ahmed CE,Ojeda SR

更新日期：1990-11-01 00:00:00

abstract：:There is now general agreement that neurokinin B (NKB) acts via neurokinin-3-receptor (NK3R) to stimulate secretion of GnRH and LH in several species, including rats, mice, sheep, and humans. However, the roles of two other tachykinins, substance P (SP) and neurokinin A, which act primarily via NK1R and NK2R, respecti...

journal_title：Endocrinology

authors： Fergani C,Mazzella L,Coolen LM,McCosh RB,Hardy SL,Newcomb N,Grachev P,Lehman MN,Goodman RL

更新日期：2016-12-01 00:00:00

abstract：:The control of ACTH secretion by opiates seems to involve stimulatory and inhibitory pathways, since opiate agonists and antagonists are capable of releasing ACTH in conscious rats. To elucidate the role of different opiate receptors in the control of ACTH release, rats were treated with receptor-selective opiate agon...

journal_title：Endocrinology

authors： Pfeiffer A,Herz A,Loriaux DL,Pfeiffer DG

更新日期：1985-06-01 00:00:00

abstract：:Endometriosis-associated infertility has a multifactorial etiology. We tested the hypothesis that the endometrial response to the early embryonic signal, human chorionic gonadotropin (hCG), alters over time in a nonhuman primate model of endometriosis. Animals with experimental or spontaneous endometriosis were treate...

journal_title：Endocrinology

authors： Sherwin JR,Hastings JM,Jackson KS,Mavrogianis PA,Sharkey AM,Fazleabas AT

更新日期：2010-10-01 00:00:00

abstract：:The classical model for the mechanism of action of steroids holds that unbound receptors for steroids reside exclusively in the cytoplasmic compartment and that they undergo translocation to the nucleus when bound to steroids in a process which is temperature sensitive. We have in the past proposed that unbound recept...

journal_title：Endocrinology

authors： Sheridan PJ,Buchanan JM,Anselmo VC,Martin PM

更新日期：1981-04-01 00:00:00

abstract：:Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical. Developmental exposure produces changes in behavior and gene expression in the brain. Here, we examined social recognition behaviors in mice from the third familial generation (F3) after exposure to gestational BPA. Second-generation mice were bred in on...

journal_title：Endocrinology

authors： Wolstenholme JT,Drobná Z,Henriksen AD,Goldsby JA,Stevenson R,Irvin JW,Flaws JA,Rissman EF

更新日期：2019-08-01 00:00:00

abstract：:Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo; however, the nature of these effects and whether glucocorticoids act directly on cardiomyocytes are poorly understood. To explore the role of glucocorticoid signaling in the heart, we used rat embryonic H9C2 cardiomyocytes and...

journal_title：Endocrinology

authors： Ren R,Oakley RH,Cruz-Topete D,Cidlowski JA

更新日期：2012-11-01 00:00:00

abstract：:Circulating insulin-like growth factor (IGF) bioactivity is reduced in animals and patients with diabetes mellitus. We sought to determine whether the availability and levels of specific IGF binding proteins (BPs) are altered in animals with experimental diabetes, and might contribute to changes in circulating IGF bio...

journal_title：Endocrinology

authors： Unterman TG,Patel K,Mahathre VK,Rajamohan G,Oehler DT,Becker RE

更新日期：1990-05-01 00:00:00

abstract：:In an attempt to purify the thyroid receptor for TSH and to study interaction with the thyroid-stimulating antibody (TSAb) of graves' disease, we used both bovine and human thyroid glands. With either tissue, the 10,000 X g pellet of homogenized material was solubilized with 0.5% Triton N-101; excess Triton was remove...

journal_title：Endocrinology

authors： Koizumi Y,Zakarija M,McKenzie JM

更新日期：1982-04-01 00:00:00

abstract：:SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a 5'-lipid phosphatase hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P(3) to PI(3,4)P(2) in the regulation of insulin signaling, and is shown to be increased in peripheral tissues of diabetic C57BL/KSJ-db/db mice. To clarify the impact of SHIP2 ...

journal_title：Endocrinology

authors： Kagawa S,Soeda Y,Ishihara H,Oya T,Sasahara M,Yaguchi S,Oshita R,Wada T,Tsuneki H,Sasaoka T

更新日期：2008-02-01 00:00:00

abstract：:Ovarian surface epithelium (OSE) is the most conceivable cell origin of epithelial ovarian carcinomas. Unlike many other epithelial tumors, the precancerous lesion acquires expression of epithelial markers, e.g. E-cadherin and claudins, suggesting that OSE cells undergo mesenchymal to epithelial transition (MET) durin...

journal_title：Endocrinology

authors： Zhu Y,Nilsson M,Sundfeldt K

更新日期：2010-11-01 00:00:00

abstract：:A novel class of targeted chemotherapeutic agents based on cytotoxic compounds linked to LHRH analogs was tested in a long term superfusion system in order to determine their effects on different types of rat pituitary cells. The compounds investigated included two cytotoxic LHRH agonists, T-98 ([D-Lys6]LHRH coupled t...

journal_title：Endocrinology

authors： Rékási Z,Szöke B,Nagy A,Groot K,Rékási ES,Schally AV

更新日期：1993-05-01 00:00:00

abstract：:We have recently demonstrated that fibroblast growth factor (FGF)-2 promotes neuroblastoma cell differentiation and overrides their mitogenic response to IGF-I. However, the mechanisms involved are unknown. SK-N-MC cells were cultured with FGF-2 (50 ng/ml) and/or IGF-I (100 ng/ml) up to 48 h. Fluorescence-activated ce...

journal_title：Endocrinology

authors： Higgins S,Wong SH,Richner M,Rowe CL,Newgreen DF,Werther GA,Russo VC

更新日期：2009-09-01 00:00:00

abstract：:Pineal denervation by superior cervical ganglionectomy (Gx) decreased high affinity binding of estradiol (E2) to the pineal cytosol of female rats and of testosterone to the cytosol of male rats by 40 and 26% and by 75 and 80%, 5 and 14 days after sugery; hormone binding remained unchanged up to 24 h after surgery. Bi...

journal_title：Endocrinology

authors： Cardinali DP,Gómez E,Rosner JM

更新日期：1976-04-01 00:00:00

abstract：:A1/A2 noradrenergic neurons in the medulla oblongata are well known to mediate stress signals in the central nervous system. Stress activates A1/A2 noradrenergic neurons, and then noradrenaline (NA) stimulates ACTH secretion through hypothalamic CRH. On the other hand, PRL-releasing peptide (PrRP) was recently isolate...

journal_title：Endocrinology

authors： Maruyama M,Matsumoto H,Fujiwara K,Noguchi J,Kitada C,Fujino M,Inoue K

更新日期：2001-05-01 00:00:00

abstract：:Compelling evidence indicates a crucial role of prostaglandin F2α (PGF2α) in parturition. Both the maternal and fetal sides of the fetal membranes synthesize PGF2α, which exerts effects via the prostaglandin F2α receptor (FP) that is coupled to the activation of protein kinase C (PKC). Cyclooxygenase-2 (COX-2) catalyz...

journal_title：Endocrinology

authors： Guo CM,Kasaraneni N,Sun K,Myatt L

更新日期：2012-10-01 00:00:00

abstract：:PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand. We used the PTHrP and PTH/PTHrP receptor gene knock-out models to investigate whether this receptor mediates...

journal_title：Endocrinology

authors： Lanske B,Divieti P,Kovacs CS,Pirro A,Landis WJ,Krane SM,Bringhurst FR,Kronenberg HM

更新日期：1998-12-01 00:00:00

abstract：:Steroid hormones can differentially modify gonadotropin release stimulated by GnRH. Decreased GnRH-mediated gonadotropin release has been observed in vitro after pretreatment with androgens or glucocorticoids. In this study, we tested this phenomenon further with the use of a new cytochemical stain for a potent biotin...

journal_title：Endocrinology

authors： Tibolt RE,Childs GV

更新日期：1985-07-01 00:00:00

abstract：:Intestinal calcium and phosphate transport was studied in normal and hypophosphatemic mice fed a variety of dietary regimens with and without vitamin D. Regardless of dietary phosphorus levels, the genetic hypophosphatemic mice had drastically reduced levels of serum inorganic phosphate and intestinal phosphate transp...

journal_title：Endocrinology

authors： O'Doherty PJ,DeLuca HF,Eicher EM

更新日期：1977-10-01 00:00:00

abstract：:Three distinct receptor types for natriuretic peptides (NP) have been identified in human tissue. "A" and "B" receptors initiate biological actions, whereas the "C" receptor has a clearance function. It has been proposed that the natural ligand for the B receptor is c-type natriuretic peptide (CNP), rather than atrial...

journal_title：Endocrinology

authors： Canaan-Kühl S,Jamison RL,Myers BD,Pratt RE

更新日期：1992-01-01 00:00:00

abstract：:IGF binding protein (IGFBP)-3 is an important regulator of mammary epithelial cell (MEC) growth and can enhance the ability of both IGF-I and epidermal growth factor ligands such as TGFalpha to stimulate MEC proliferation. Here we investigate the role of the phosphatidylinositol-3 kinase (PI3K) and MAPK pathways in th...

journal_title：Endocrinology

authors： Sivaprasad U,Fleming J,Verma PS,Hogan KA,Desury G,Cohick WS

更新日期：2004-09-01 00:00:00

abstract：:The uptake of [125I]triiodothyroacetic acid ([125I]Triac) in anterior pituitary cells was investigated and compared with that of [125I]T3. Furthermore, the effects of Triac, T3, and T4 on TSH release were compared. Cells isolated from adult male Wistar rats were cultured for 3 days in medium with 10% fetal calf serum....

journal_title：Endocrinology

authors： Everts ME,Visser TJ,Moerings EP,Docter R,van Toor H,Tempelaars AM,de Jong M,Krenning EP,Hennemann G

更新日期：1994-12-01 00:00:00

abstract：:Loss of circulating 17β-estradiol (E2) that occurs during menopause can have detrimental effects on cognitive function. The efficacy of hormone replacement therapy declines as women become farther removed from the menopausal transition, yet the molecular mechanisms underlying this age-related switch in E2 efficacy are...

journal_title：Endocrinology

authors： Shults CL,Pinceti E,Rao YS,Pak TR

更新日期：2015-11-01 00:00:00

abstract：:The effects of electrical and chemical stimulations of the hypothalamus on the plasma levels of glucagon, insulin, and glucose were studied in undisturbed and free-moving rabbits. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH) caused a marked increase in the circulating level of glucagon coincid...

journal_title：Endocrinology

authors： Shimazu T,Ishikawa K

更新日期：1981-02-01 00:00:00

abstract：:Functional disruption of either MC3R or MC4R results in obesity, implicating both in the control of energy homeostasis. The ligands for these receptors are derived from the prohormone proopiomelancortin (POMC), which is posttranslationally processed to produce a set of melanocortin peptides with a range of activities ...

journal_title：Endocrinology

authors： Tung YC,Piper SJ,Yeung D,O'Rahilly S,Coll AP

更新日期：2006-12-01 00:00:00

abstract：:We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance. Here we delineated whether increased glucose flux through the hexosamine biosynthesis pathway (HBP) ca...

journal_title：Endocrinology

authors： Bhonagiri P,Pattar GR,Horvath EM,Habegger KM,McCarthy AM,Elmendorf JS

更新日期：2009-04-01 00:00:00

abstract：:Dynamic bone histomorphometry, [3H]thymidine radioautography, and Northern analysis for bone matrix proteins and insulin-like growth factor-I (IGF-I) were performed in calvariae of ovariectomized (OVX) and estrogen-treated OVX rats. Treatment of OVX rats with diethylstilbestrol (DES) for 2 weeks reduced the periosteal...

journal_title：Endocrinology

authors： Turner RT,Backup P,Sherman PJ,Hill E,Evans GL,Spelsberg TC

更新日期：1992-08-01 00:00:00