Cloning and expression of kiss2 in the zebrafish and medaka.

abstract：:GnRH release in the median eminence (ME) is the central output for control of reproduction. GnRH processes in the preoptic area (POA) also release GnRH. We examined region-specific regulation of GnRH secretion using fast-scan cyclic voltammetry to detect GnRH release in brain slices from adult male mice. Blocking endo...

journal_title：Endocrinology

authors： Glanowska KM,Moenter SM

更新日期：2015-01-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) plays an important role in development of the central nervous system and is neurotropic for a variety of neurons. In this study, we investigated whether bFGF is neurotropic for GT1 GnRH neuronal cell lines and if these cells express functional FGF receptors (FGFRs). The GT1 cell l...

journal_title：Endocrinology

authors： Tsai PS,Werner S,Weiner RI

更新日期：1995-09-01 00:00:00

abstract：:The electrical responses of rat islet cells maintained in culture with varying levels of glucose were determined. After culture with 2.8 or 4.2 mM glucose, the beta-cells did not respond electrically to 27.8 mM glucose. However, after culture in 5.6 mM glucose, the cells responded to 27.8 mM glucose in short term expe...

journal_title：Endocrinology

authors： Pace CS,Conant S,Lacy PE

更新日期：1978-05-01 00:00:00

abstract：:Atrial Natriuretic Factor (ANF) has been demonstrated within the central nervous system (CNS), where it has been implicated in the regulation of blood pressure, fluid and electrolyte balance. To explore the effect of acute plasma vol expansion on the activation of CNS ANF, changes in ANF levels of CSF drawn from the c...

journal_title：Endocrinology

authors： Cameron VA,Espiner EA

更新日期：1990-11-01 00:00:00

abstract：:Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...

journal_title：Endocrinology

authors： Akhter N,Odle AK,Allensworth-James ML,Haney AC,Syed MM,Cozart MA,Chua S,Kineman R,Childs GV

更新日期：2012-10-01 00:00:00

abstract：:Pure porcine cholecystokinin-33 [the triacontatriapeptide form of cholecystokinin (CCK-33)], gastric inhibitory polypeptide (GIP), and secretin were infused in rats in doses of 1, 10 and 1000 pmol/kg . min. The peptides were administered alone or in combination with glucose (40 mg/kg . min) or arginine (50 mg/kg . min...

journal_title：Endocrinology

authors： Szecówka J,Lins PE,Efendić S

更新日期：1982-04-01 00:00:00

abstract：:Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an antiadrenergic/nitric oxide-cGMP mediated mechanism. Whether these phenomena are related is unknown. We here investigated whether and to what extent ...

journal_title：Endocrinology

authors： Pasqua T,Corti A,Gentile S,Pochini L,Bianco M,Metz-Boutigue MH,Cerra MC,Tota B,Angelone T

更新日期：2013-09-01 00:00:00

abstract：:In the developing follicle, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are the primary stimulators of steroidogenesis in granulosa and theca cells. The steroidogenic actions of both these gonadotropins are largely if not exclusively mediated through cAMP. Previous studies have shown that EGF and T...

journal_title：Endocrinology

authors： Gangrade BK,Davis JS,May JV

更新日期：1991-11-01 00:00:00

abstract：:We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. 7alpha-Hydroxypregnenolone stimulates locomotor activity of male newts. Locomotor activity of male newts increases during the breeding period as in o...

journal_title：Endocrinology

authors： Haraguchi S,Koyama T,Hasunuma I,Vaudry H,Tsutsui K

更新日期：2010-05-01 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1) has an important role as an early intermediary between the insulin and IGF receptors and downstream molecules that participate in insulin and IGF-I signal transduction. Here we employed an antisense oligonucleotide (IRS-1AS) to inhibit whole-body expression of IRS-1 in vivo and eva...

journal_title：Endocrinology

authors： Araújo EP,De Souza CT,Gasparetti AL,Ueno M,Boschero AC,Saad MJ,Velloso LA

更新日期：2005-03-01 00:00:00

abstract：:Recent evidence indicates that osteopontin (Opn), one of the bone matrix proteins, plays an important role in the attachment of osteoclasts to bone matrix. Besides being elaborated by osteoblasts, this protein is also produced by osteoclasts. The present study was performed to examine the effect of calcitonin (CT) on ...

journal_title：Endocrinology

authors： Kaji H,Sugimoto T,Miyauchi A,Fukase M,Tezuka K,Hakeda Y,Kumegawa M,Chihara K

更新日期：1994-07-01 00:00:00

abstract：:Blepharophimosis ptosis epicanthus inversus syndrome (BPES) is a human disorder caused by mutations in the forkhead transcription factor gene FOXL2 and is characterized by facial dysmorphology combined in some cases with ovarian failure. To better understand the role of FOXL2 in the etiology of ovarian failure in BPES...

journal_title：Endocrinology

authors： Loffler KA,Zarkower D,Koopman P

更新日期：2003-07-01 00:00:00

abstract：:Male rats, kept under a lighting condition of 14-h light, 10-h dark, were subjected to scheduled feeding regimens. Food was available either in the early light phase or the early dark phase. The 24-h rhythms of serum corticosterone and of N-acetylserotonin (NAS) and melatonin (MT) in the pineal and serum were determin...

journal_title：Endocrinology

authors： Ho AK,Burns TG,Grota LJ,Brown GM

更新日期：1985-05-01 00:00:00

abstract：:We previously showed that receptor-like protein tyrosine phosphatase (RPTP)-alpha inhibited insulin-increased prolactin gene transcription. Others suggested that RPTPalpha was a key intermediary between integrins and activation of Src. We present evidence that inhibition of insulin-increased prolactin gene transcripti...

journal_title：Endocrinology

authors： Vulin AI,Jacob KK,Stanley FM

更新日期：2005-08-01 00:00:00

abstract：:Clinical studies indicate alternate-day, intermittent fasting (IMF) protocols result in meaningful weight loss in obese individuals. To further understand the mechanisms sustaining weight loss by IMF, we investigated the metabolic and neural alterations of IMF in obese mice. Male C57/BL6 mice were fed a high-fat diet ...

journal_title：Endocrinology

authors： Gotthardt JD,Verpeut JL,Yeomans BL,Yang JA,Yasrebi A,Roepke TA,Bello NT

更新日期：2016-02-01 00:00:00

abstract：:The cytokine interleukin-1 (IL-1) has numerous actions in brain, including pronounced neuroendocrine effects. Recent radioligand binding studies have identified high-affinity binding sites for 125I-recombinant human IL-1 alpha in the hippocampus with characteristics similar to those of IL-1 receptors in immune cells. ...

journal_title：Endocrinology

authors： Cunningham ET Jr,Wada E,Carter DB,Tracey DE,Battey JF,De Souza EB

更新日期：1991-05-01 00:00:00

abstract：:An estrogen-responsive uterine proenzyme of a proteinase in the immature rat uterus has been known for some time. Its mol wt is 77,000, its N-terminal amino acid sequence is the same as prothrombin's for 15 residues, it contains gamma-carboxyl glutamate residues, its biosynthesis is prevented by warfarin, it cross-rea...

journal_title：Endocrinology

authors： Henrikson KP,Jazin EE,Greenwood JA,Dickerman HW

更新日期：1990-01-01 00:00:00

abstract：:Oral ketoconazole has been demonstrated to lower plasma testosterone in man. Measurement of blood precursors of testosterone suggest that ketoconazole may have its effect inhibiting the 17,20-desmolase enzyme within the testis. To substantiate this, a series of in vitro experiments was conducted using the rat testis t...

journal_title：Endocrinology

authors： Sikka SC,Swerdloff RS,Rajfer J

更新日期：1985-05-01 00:00:00

abstract：:Both fructose consumption and increased intracellular glucocorticoid activation have been implicated in the pathogenesis of the metabolic syndrome. Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) depends on hexose-6-phosphate dehydrogenase (H6PD), which physically interacts with 11β-HSD...

journal_title：Endocrinology

authors： Senesi S,Legeza B,Balázs Z,Csala M,Marcolongo P,Kereszturi E,Szelényi P,Egger C,Fulceri R,Mandl J,Giunti R,Odermatt A,Bánhegyi G,Benedetti A

更新日期：2010-10-01 00:00:00

abstract：:In mice, GH levels rise in response to short-term fasting or starvation (food restriction to 40% of ad libitum intake), similar to that which occurs in humans in response to fasting or anorexia. Recent studies using acyl-ghrelin knockout mice have suggested that the rise in GH during food restriction is essential to s...

journal_title：Endocrinology

authors： Gahete MD,Córdoba-Chacón J,Luque RM,Kineman RD

更新日期：2013-01-01 00:00:00

abstract：:While the potential role of insulin-like growth factor (IGF)-I in ovarian physiology has been extensively studied, relatively limited attention has been paid to IGF-II the very presence of which in the mature rat ovary has been questioned. In the present study, we have reevaluated rat ovarian IGF-II gene expression, i...

journal_title：Endocrinology

authors： Hernandez ER,Roberts CT Jr,Hurwitz A,LeRoith D,Adashi EY

更新日期：1990-12-01 00:00:00

abstract：:We have investigated the characteristics and properties of cholesterol esterase (CEase) in the rat adrenal to clarify the mechanism of synthesis of free cholesterol from esterified cholesterol. CEase activity was estimated using substrate vesicles which were sonicated mixtures of cholesteryl oleate and phosphatidylcho...

journal_title：Endocrinology

authors： Nishikawa T,Mikami K,Saito Y,Tamura Y,Kumagai A

更新日期：1981-03-01 00:00:00

abstract：:Activin A is a dimeric protein hormone that regulates numerous cellular functions. A clear physiological role for this molecule in pregnancy is suggested by previous studies in the human, wherein activin A rises dramatically as women approach parturition. To determine whether the rodent is a suitable animal model for ...

journal_title：Endocrinology

authors： Draper LB,Chong H,Wang E,Woodruff TK

更新日期：1997-07-01 00:00:00

abstract：:To examine the role of androgen receptor (AR) in Sertoli cells (SC), we used a SC-specific AR knockout (S-AR-/y) mouse to further evaluate the chronological changes of seminiferous tubules and the molecular mechanisms of SC androgen/AR signals on spermatogenesis. Testes morphology began changing as early as postnatal ...

journal_title：Endocrinology

authors： Wang RS,Yeh S,Chen LM,Lin HY,Zhang C,Ni J,Wu CC,di Sant'Agnese PA,deMesy-Bentley KL,Tzeng CR,Chang C

更新日期：2006-12-01 00:00:00

abstract：:Specific serum binding of 25-hydroxy-cholecalciferol (25-OHD3) was measured by saturation analysis in rats of various ages, and during vitamin D deprivation. The serum binding capacity for 25-OHD3 was observed to increase until age 6-8 weeks, then decline and remain stable thereafter at 3.7 x 10(-6) M. The 25-hydroxyv...

journal_title：Endocrinology

authors： Rojanasathit S,Haddad JG

更新日期：1977-03-01 00:00:00

abstract：:Recent studies suggest that hyperinsulinemia and insulin resistance are linked to Alzheimer's disease (AD). In this study, we used Tg2576 transgenic (Tg) mice, a widely used transgenic mouse model for AD, to explore the relationship between increased amyloid beta-peptide (Abeta) and insulin resistance. When fed a high...

journal_title：Endocrinology

authors： Kohjima M,Sun Y,Chan L

更新日期：2010-04-01 00:00:00

abstract：:Gastrin is natriuretic, but its renal molecular targets and signal transduction pathways are not fully known. In this study, we confirmed the existence of CCKBR (a gastrin receptor) in male human renal proximal tubule cells and discovered that gastrin induced S6 phosphorylation, a downstream component of the phosphati...

journal_title：Endocrinology

authors： Liu T,Jose PA

更新日期：2013-02-01 00:00:00

abstract：:Lanosterol 14alpha-demethylase (CYP51) responds to cholesterol feedback regulation through sterol regulatory element binding proteins (SREBPs). The proximal promoter of CYP51 contains a conserved region with clustered regulatory elements: GC box, cAMP-response elements (CRE-like), and sterol regulatory element (SRE). ...

journal_title：Endocrinology

authors： Fink M,Acimovic J,Rezen T,Tansek N,Rozman D

更新日期：2005-12-01 00:00:00

abstract：:Osteocalcin, a synthetic osteoblast-specific protein, has recently emerged as an important regulator of energy metabolism, but the underlying mechanisms are not fully understood. In the present study, mice fed a high-fat diet and receiving osteocalcin showed reduced body weight gain, less fat pad gain, and improved in...

journal_title：Endocrinology

authors： Zhou B,Li H,Xu L,Zang W,Wu S,Sun H

更新日期：2013-03-01 00:00:00

abstract：:The receptor for the orexigenic peptide, ghrelin, is one of the most constitutively active 7TM receptors known, as demonstrated under in vitro conditions. Change in expression of a constitutively active receptor is associated with change in signaling independent of the endogenous ligand. In the following study, we fou...

journal_title：Endocrinology

authors： Petersen PS,Woldbye DP,Madsen AN,Egerod KL,Jin C,Lang M,Rasmussen M,Beck-Sickinger AG,Holst B

更新日期：2009-11-01 00:00:00