Full-length human chromogranin-A cardioactivity: myocardial, coronary, and stimulus-induced processing evidence in normotensive and hypertensive male rat hearts.

abstract：:Although the pituitary-grafted rat is a classic model of chronic PRL excess, the presence of somatotropes in grafted pituitary tissue indicates a potential for GH secretion. The current study was designed to investigate GH-releasing hormone (GRH)-induced GH secretion and beta-adrenergic inhibition of GH release in ani...

journal_title：Endocrinology

authors： Krieg RJ Jr,Johnson JH,Adler RA

更新日期：1989-11-01 00:00:00

abstract：:Caveolae and their principal component caveolin have been implicated in playing a major role in G protein-mediated transmembrane signaling. We examined whether caveolin interacts with adenylyl cyclase, an effector of G protein signaling, using a 20-mer peptide derived from the N-terminus scaffolding domain of caveolin...

journal_title：Endocrinology

authors： Toya Y,Schwencke C,Couet J,Lisanti MP,Ishikawa Y

更新日期：1998-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1), a cold-induced protein expressed in brown adipose tissue (BAT), plays a role in adaptive thermogenesis by up-regulating uncoupling proteins (UCP). Here, we explore its relationship to the thermogenic actions of leptin, which also up-regulates UCPs...

journal_title：Endocrinology

authors： Kakuma T,Wang ZW,Pan W,Unger RH,Zhou YT

更新日期：2000-12-01 00:00:00

abstract：:Somatostatin-like immunoreactivity (SRIF-LI) has previously been demonstrated immunohistochemically in rat thyroid parafollicular cells. Studies were therefore performed to determine whether SRIF-LI was present in a transplantable medullary carcinoma of the thyroid (MCT) in the WAG/Rij strain of rat. SRIF-LI was found...

journal_title：Endocrinology

authors： Berelowitz M,Cibelius M,Szabo M,Frohman LA,Epstein S,Bell NH

更新日期：1980-11-01 00:00:00

abstract：:Gene expression of fibroblast growth factor-9 (FGF9) is decreased in granulosa cells (GC) of cystic follicles compared with normal dominant follicles in cattle. The objectives of this study were to investigate the effects of FGF9 on GC steroidogenesis, gene expression, and cell proliferation and to determine the hormo...

journal_title：Endocrinology

authors： Schreiber NB,Spicer LJ

更新日期：2012-09-01 00:00:00

abstract：:Adrenomedullin (AM), a potent and novel vasodilator 52-residue peptide originally isolated from pheochromocytoma, is processed from a precursor molecule (preproAM) in which another unique 20-residue sequence, termed proadrenomedullin N-terminal 20 peptide (PAMP), exists. Using [125I Tyr0] rat PAMP as a radioligand, we...

journal_title：Endocrinology

authors： Iwasaki H,Hirata Y,Iwashina M,Sato K,Marumo F

更新日期：1996-07-01 00:00:00

abstract：:Fibroblasts represent one of the in vivo sites of extrahepatic insulin-like growth factor I (IGF-I) production. In this study, cultured fibroblasts prepared from the skin of neonatal rats were used as a model to assess the role of serum in regulating IGF-I messenger RNA (mRNA) levels. IGF-I mRNA, as demonstrated by No...

journal_title：Endocrinology

authors： Lowe WL Jr,Kummer M,Karpen CW,Wu XD

更新日期：1990-12-01 00:00:00

abstract：:Ghrelin, a novel 28 amino acid peptide found in hypothalamus and stomach, was recently identified as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). We have now found that both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of ghrelin in freely feeding rats stimu...

journal_title：Endocrinology

authors： Wren AM,Small CJ,Ward HL,Murphy KG,Dakin CL,Taheri S,Kennedy AR,Roberts GH,Morgan DG,Ghatei MA,Bloom SR

更新日期：2000-11-01 00:00:00

abstract：:Mammalian ovaries contain sympathetic neurons expressing the low affinity neurotropin receptor (p75NTR). To date neither the role these neurons might play in ovarian physiology nor their embryological origin is known. Immunohistochemistry was used to detect postnatal changes in distribution and number of both p75NTR-p...

journal_title：Endocrinology

authors： Dees WL,Hiney JK,McArthur NH,Johnson GA,Dissen GA,Ojeda SR

更新日期：2006-08-01 00:00:00

abstract：:The human estrogen receptor alpha (ERalpha) and the recently identified ERbeta share a high degree of amino acid homology; however, there are significant differences in regions of these receptors that would be expected to influence transcriptional activity. Consequently, we compared the mechanism(s) by which these rec...

journal_title：Endocrinology

authors： Hall JM,McDonnell DP

更新日期：1999-12-01 00:00:00

abstract：:Glucose-dependent insulinotropic peptide (GIP) is a 42-amino acid peptide synthesized and secreted from endocrine cells in the small intestine. The role of GIP in coupling nutrient intake and insulin secretion, the incretin effect, is well known. We report that GIP receptor messenger RNA and protein are present in nor...

journal_title：Endocrinology

authors： Bollag RJ,Zhong Q,Phillips P,Min L,Zhong L,Cameron R,Mulloy AL,Rasmussen H,Qin F,Ding KH,Isales CM

更新日期：2000-03-01 00:00:00

abstract：:The maternal skeleton resorbs during lactation to provide calcium to milk and the lost mineral content is restored after weaning. The changes are particularly marked in Ctcgrp null mice, which lose 50% of spine mineral content during lactation but restore it fully. The known calciotropic hormones are not required for ...

journal_title：Endocrinology

authors： Collins JN,Kirby BJ,Woodrow JP,Gagel RF,Rosen CJ,Sims NA,Kovacs CS

更新日期：2013-04-01 00:00:00

abstract：:Testicular peritubular cells are myofibroblastic cells, which represent the major cellular components of the wall of the seminiferous tubules. In men their phenotypic characteristics, including possible secretory activity and regulation, are not well known, in neither normal nor pathologically altered testes. Especial...

journal_title：Endocrinology

authors： Schell C,Albrecht M,Mayer C,Schwarzer JU,Frungieri MB,Mayerhofer A

更新日期：2008-04-01 00:00:00

abstract：:A subline of an x-ray-induced transplantable rat insulinoma has been studied in vivo and in vitro. Tumors grew rapidly after sc transplantation and were rich in insulin, but contained only small amounts of glucagon and somatostatin. Despite marked basal hyperinsulinemia, iv glucose administration caused a further incr...

journal_title：Endocrinology

authors： Masiello P,Wollheim CB,Janjic D,Gjinovci A,Blondel B,Praz GA,Renold AE

更新日期：1982-12-01 00:00:00

abstract：:The present studies demonstrate that the murine adrenocortical tumor cell line Y-1 releases a digoxin-like immunoreactive material into both serum-supplemented nutrient medium and minimal Krebs-Ringer bicarbonate medium. Release of pregnenolone into minimal medium from these cells was consistently inhibited by additio...

journal_title：Endocrinology

authors： Doris PA,Kilgore MW,Durham D,Alberts D,Stocco DM

更新日期：1989-11-01 00:00:00

abstract：:Testicular LH receptor occupancy and steroidogenic responses were measured in adult male rats after intracardiac injections of [125I]iodo-hCG (0.5--5 x 10(6) cpm) mixed with known amounts of nonradioactive hCG to yield doses ranging from 10 ng to 300 micrograms. Uptake of the hormone by the testis was measured in the ...

journal_title：Endocrinology

authors： Huhtaniemi IT,Clayton RN,Catt KJ

更新日期：1982-09-01 00:00:00

abstract：:The disappearance of 125-I-ACTH from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. The mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. The higher fetal than mate...

journal_title：Endocrinology

authors： Jones CT,Luther E,Ritchie JW,Worthington D

更新日期：1975-01-01 00:00:00

abstract：:Adult rats which have received monosodium-L-glutamate (MSG, 4 mg/g BW) on alternate days for the first 10 days of life manifest central nervous system lesions largely restricted to the retina and the arcuate nucleus of the hypothalamus in which nearly 90% of the perikarya are destroyed, leaving axons in passage intact...

journal_title：Endocrinology

authors： Greeley GH Jr,Nicholson GF,Nemeroff CB,Youngblood WW,Kizer JS

更新日期：1978-07-01 00:00:00

abstract：:Melatonin receptors in lizard brain were identified and characterized using 125I-labeled melatonin ([125I]MEL) after solubilization with the detergent digitonin. Saturation studies of solubilized material revealed a high affinity binding site, with an apparent equilibrium dissociation constant of 181 +/- 45 pM. Bindin...

journal_title：Endocrinology

authors： Rivkees SA,Conron RW Jr,Reppert SM

更新日期：1990-09-01 00:00:00

abstract：:We previously reported that dexamethasone (DEX) induces dose-dependent biphasic effects on steady state somatostatin (SS) messenger RNA (mRNA) levels in normal rat islet and islet SS-producing tumor cells (1027B2), characterized by stimulation at low doses and marked inhibition at high doses. The stimulatory effect is...

journal_title：Endocrinology

authors： Liu JL,Patel YC

更新日期：1995-06-01 00:00:00

abstract：:Exposure of FRTL-5 thyroid cells to ATP (1 microM to 1 mM) resulted in the stimulation of I- efflux in association with the induction of inositol trisphosphate production and intracellular Ca2+ mobilization. Nonhydrolyzable ATP derivatives, ADP and GTP, were also as effective in magnitude as ATP, whereas neither AMP n...

journal_title：Endocrinology

authors： Okajima F,Sho K,Kondo Y

更新日期：1988-08-01 00:00:00

abstract：:The antitumor properties of antibodies to the beta-subunit of hCG (hCG beta) coupled to tetanus toxoid (tt) were studied in hamsters implanted with the BeWo strain of human choriocarcinoma. After active immunization with hCG beta-tt mixed in complete Freund's adjuvant, hamsters synthesized large quantities of antibodi...

journal_title：Endocrinology

authors： Knecht M

更新日期：1980-01-01 00:00:00

abstract：:Depletion of hypothalamic norepinephrine (NE) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular (IVT) angiotensin II (AII) on LH release in ovariectomized rats pretreated with estradiol and progesterone. The increase in blood LH produced by IVT NE or iv L...

journal_title：Endocrinology

authors： Steele MK,Ganong WF

更新日期：1986-12-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDCs) that interfere with the steroid axis can affect amelogenesis, leading to enamel hypomineralization similar to that of molar incisor hypomineralization, a recently described enamel disease. We investigated the sex steroid receptors that may mediate the effects of EDCs during rat am...

journal_title：Endocrinology

authors： Jedeon K,Loiodice S,Salhi K,Le Normand M,Houari S,Chaloyard J,Berdal A,Babajko S

更新日期：2016-11-01 00:00:00

abstract：:The amount and sources of T3 associated with high affinity, low capacity cellular nuclear receptors in brown adipose tissue (BAT) have been estimated by in vivo pulse-labeling techniques. Maximal binding capacity was measured by in vivo saturation analysis. Nuclear receptor occupancy at endogenous levels of T3 and T4 ...

journal_title：Endocrinology

authors： Bianco AC,Silva JE

更新日期：1987-01-01 00:00:00

abstract：:Thyroid toxicity of iodide excess has been demonstrated in animals fed with an iodide-rich diet; in vitro iodide is cytotoxic, inhibits cell growth, and induces morphological changes in thyroid cells of some species. In this study, we investigated the effect of iodide excess in an immortalized thyroid cell line (TAD-2...

journal_title：Endocrinology

authors： Vitale M,Di Matola T,D'Ascoli F,Salzano S,Bogazzi F,Fenzi G,Martino E,Rossi G

更新日期：2000-02-01 00:00:00

abstract：:IGF-II has been reported to decrease neonatal islet cell apoptosis and in vitro adult islet cell necrosis and apoptosis, but the usefulness of IGF-II in a transplantation setting is unknown. We evaluated the effect of in vitro IGF-II incubations on microencapsulated rat islet survival both in vitro and in minimal mass...

journal_title：Endocrinology

authors： Robitaille R,Dusseault J,Henley N,Rosenberg L,Hallé JP

更新日期：2003-07-01 00:00:00

abstract：:Human livers, obtained from donors at the time of transplant, were homogenized in 0.25 M sucrose and fractionated by differential centrifugation. The specific binding of [125I] human (h) GH to total particulate fractions from 18 livers varied from 0.4-5.1% of the total radioactivity/100 micrograms protein. Binding aff...

journal_title：Endocrinology

authors： Hocquette JF,Postel-Vinay MC,Kayser C,de Hemptinne B,Amar-Costesec A

更新日期：1989-10-01 00:00:00

abstract：:The lipolysis, ketosis and hypertriglyceridemia of fasted rats in late pregnancy may be related to decreased insulin secretion geared to decreased glucose availability. In odd-carbon fatty acid enriched (OCE) rats, the odd-carbon fatty acids (OCFA) mobilized during fasting provide terminal three-carbon residues which ...

journal_title：Endocrinology

authors： Kim S,Pi-Sunyer FX

更新日期：1977-02-01 00:00:00

abstract：:The BB/Wor rat develops spontaneous autoimmune diabetes mellitus and also frequently develops lymphocytic thyroiditis. To clarify the role of T cell lymphopenia and the major histocompatibility complex (MHC) in the development of these autoimmune disorders, we studied back-cross animals between the inbred thyroiditis ...

journal_title：Endocrinology

authors： Awata T,Guberski DL,Like AA

更新日期：1995-12-01 00:00:00