Abstract:
:Functional disruption of either MC3R or MC4R results in obesity, implicating both in the control of energy homeostasis. The ligands for these receptors are derived from the prohormone proopiomelancortin (POMC), which is posttranslationally processed to produce a set of melanocortin peptides with a range of activities at the MC3R and MC4R. The relative importance of each of these peptides alpha-MSH, gamma3-MSH, gamma2-MSH, gamma-lipotropin (gamma-LPH) and, in man but not in rodents, beta-MSH] in the maintenance of energy homeostasis is, as yet, unclear. To investigate this further, equimolar amounts (2 nmol) of each peptide were centrally administered to freely feeding, corticosterone-supplemented, Pomc null (Pomc-/-) mice. After a single dose at the onset of the dark cycle, alpha-MSH had the most potent anorexigenic effect, reducing food intake to 35% of sham-treated animals. beta-MSH, gamma-LPH, and gamma3- and gamma2-MSH all reduced food intake but to a lesser degree. The effects of peptide administration over 3 d were also assessed. Only alpha-MSH significantly reduced body weight, affecting both fat and lean mass. Other peptides had no significant effect on body weight. Pair-feeding of sham-treated mice to those treated with alpha-MSH resulted in identical changes in total weight, fat and lean mass indicating that the effects of alpha-MSH were primarily due to reduced food intake rather than increased energy expenditure. Although other melanocortins can reduce food intake in the short-term, only alpha-MSH can reduce the excess fat and lean mass found in Pomc-/- mice, mediated largely through an effect on food intake.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Tung YC,Piper SJ,Yeung D,O'Rahilly S,Coll APdoi
10.1210/en.2006-0866subject
Has Abstractpub_date
2006-12-01 00:00:00pages
5940-7issue
12eissn
0013-7227issn
1945-7170pii
en.2006-0866journal_volume
147pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::To address the neural mediation of the eating-inhibitory effect of circulating glucagon-like peptide-1 (GLP-1), we investigated the effects of 1) intra-fourth ventricular infusion of the GLP-1 receptor antagonist exendin-9 or 2) area postrema lesion on the eating-inhibitory effect of intrameal hepatic portal vein (HPV...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1447
更新日期:2014-05-01 00:00:00
abstract::The experimental induction of puberty by GnRH administration to prepubertal lambs increases serum bioactive FSH (B-FSH) as measured in the rat Sertoli cell aromatase induction bioassay. Serum immunoreactive FSH (I-FSH) levels are unchanged. The increase in serum B-FSH is associated with an increase in the proportion o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.4.8462450
更新日期:1993-04-01 00:00:00
abstract::The level of fructose 2,6-bisphosphate (F2,6P2), a potent stimulator of 6-phosphofructo-1-kinase and inhibitor of fructose 1,6-bisphosphatase, was measured in three different muscle types (tensor fascia latae, biceps femoris, and soleus) and in the liver of normal and diabetic rats. The mean (+/- SEM) content of F2,6P...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-1-108
更新日期:1986-01-01 00:00:00
abstract::Activation of the leptin receptor, LepRb, by the adipocytokine/neurotrophic factor leptin in the central nervous system has procognitive and antidepressive effects. Leptin has been shown to increase glutamatergic synaptogenesis in multiple brain regions. In contrast, mice that have a mutation in the LepRb gene show ab...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqz030
更新日期:2020-02-01 00:00:00
abstract::Tumoral insulin-producing cells of the RINm5F line display a poor secretory response to D-glucose. Relative to basal insulin output, which corresponds to a fractional release of stored hormone close to 25%/90 min, the glucose-induced increment in insulin release does not exceed 28 +/- 7%. The low efficiency of D-gluco...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-4-1443
更新日期:1988-04-01 00:00:00
abstract::Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In vitro studies investigated the capacity of differentiated C2 murine muscle cell...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2245
更新日期:2013-09-01 00:00:00
abstract::Transforming growth factor-alpha (TGF alpha) is a growth regulatory polypeptide factor that is expressed by several prostatic tumor cell lines. In this investigation, we examined whether TGF alpha is expressed during morphogenesis of the rat prostate gland. We first examined whether the prostate gland expressed TGF al...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.3.8103450
更新日期:1993-09-01 00:00:00
abstract::A monoclonal antibody which recognizes the [125I]human GH ([125I]hGH)-binding proteins of rabbit liver has been produced using hybridoma technology. A CB6F1/J mouse was immunized over a period of 82 days with a partially purified GH receptor (GHr) preparation. On the 83rd day, spleen cells from the mouse were fused wi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-6-2137
更新日期:1983-06-01 00:00:00
abstract::A proteinaceous secretion from phagocytizing polymorphonuclear leukocytes, termed "leukocytic endogenous mediator" (LEM), has been shown to have marked effects on hepatic amino acid transport and RNA and protein synthesis. A single injection of LEM results in a marked accumulation of labeled nonmetabolizable model ami...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-3-651
更新日期:1975-03-01 00:00:00
abstract::We have studied regulation of the glucose transporter by thyroid hormone in ARL 15 cells, a thyroid hormone-responsive cell line derived from rat liver, T3 treatment (5 x 10(-8) M for 48 h) of confluent cell monolayers grown in thyroid hormone-deficient medium increased the rate of uptake of [3H] 2-deoxyglucose by 2.3...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-3-1421
更新日期:1990-03-01 00:00:00
abstract::Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in ad...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1595
更新日期:2009-05-01 00:00:00
abstract::Studies in mice have identified the ob gene product, leptin, as a signaling factor regulating body weight homeostasis and energy balance. Defective production of the encoded protein may be one of the causes for the development of obesity. Using a high affinity antibody, that in immunohistochemical studies specifically...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.4.8625930
更新日期:1996-04-01 00:00:00
abstract::We recently reported that aluminum administration to beagles stimulates uncoupled bone formation in the marrow cavity which increases trabecular bone volume and generates new osseous networks within the axial skeleton. To investigate whether this osteogenic process results from direct stimulation of bone cell replicat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-128-6-3144
更新日期:1991-06-01 00:00:00
abstract::Adipose tissue secretes a variety of bioactive signaling molecules, termed adipokines, which regulate numerous biological functions including appetite, energy balance, glucose homeostasis, and inflammation. Chemerin is a novel adipokine that regulates adipocyte differentiation and metabolism by binding to and activati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1490
更新日期:2012-02-01 00:00:00
abstract::Previous studies have demonstrated that uterine progesterone (P) receptor is under dual hormonal control; estradiol (E2) induces the synthesis of cytosolic P receptor, and P induces the loss of its own receptor and antagonizes E2-induced P receptor replenishment. The objective of this study was to examine the contribu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-6-2488
更新日期:1986-06-01 00:00:00
abstract::Bisphenol-A (BPA) is a component of polycarbonate and other plastics to which humans are regularly exposed at low levels. BPA is characterized as an endocrine disruptor because of observations of its estrogenic activity in various experimental models. We have previously shown evidence of disrupted hypothalamic feeding...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1718
更新日期:2017-04-01 00:00:00
abstract::Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). We studied a young Saudi Arabian girl who exhibited the typical clinical features of HVDRR, but without alopecia. Analysis of her VDR gene revealed a homozygous T to C mutation in exon ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0080
更新日期:2004-11-01 00:00:00
abstract::Androgen signaling in prostate smooth muscle cells (pSMCs) is critical for the maintenance of prostate homeostasis, the alterations of which are a central aspect in the development of pathological conditions. Testosterone can act through the classic androgen receptor (AR) in the cytoplasm, eliciting genomic signaling,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00718
更新日期:2018-02-01 00:00:00
abstract::Attempts to assess human placental GH variant (hGH-V) and chorionic somatomammotropin (hCS) RNA in choriocarcinoma cell lines have been hampered by low levels of expression and limited sensitivity of RNA blotting analysis. We examined human choriocarcinoma BeWo, JAR, and JEG-3 cell lines as well as samples of complete...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.6.7515000
更新日期:1994-06-01 00:00:00
abstract::Atrial, brain-type, and C-type natriuretic peptides (ANP, BNP, and CNP) act via receptors with intrinsic guanylate cyclase activity. The A-type and B-type ANP receptors are selectively activated by ANP and CNP, respectively. The anterior pituitary is a site of ANP production and action, suggesting a local regulatory f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.5.7682940
更新日期:1993-05-01 00:00:00
abstract::The possible role of the pentose phosphate shunt in thyroid hormone secretion was investigated in vivo and in vitro with mouse thyroid glands. Thyroidal endocytosis in response to TSH, a step of thyroid hormone secretion, was evaluated for its dependency upon the pentose phosphate shunt by using 6-aminonicotinamide (6...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-4-962
更新日期:1975-10-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF) is expressed in many neuronal and non-neuronal tissues during development as well as in adult animals. GDNF signaling is mediated through a two-component system consisting of the so called GDNF receptor-alfa (GFRalpha1) which binds to GDNF. Thereafter this complex bin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.5.7548
更新日期:2000-05-01 00:00:00
abstract::Disruption of the pituitary adenylate cyclase-activating polypeptide (PACAP) gene in mice has demonstrated a role for this highly conserved neuropeptide in the regulation of metabolism and temperature control. Localization of PACAP neurons within hypothalamic nuclei that regulate appetite suggest PACAP may affect feed...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0515
更新日期:2008-04-01 00:00:00
abstract::Treatment of 5-day cyclic rats with 10 or 100 microgram estradiol benzoate on the day of estrus induced a luteal phase in all animals studied. On the other hand, an injection with 1 microgram estradiol benzoate given on the same day failed to induce pseudopregnancy. When 10 mg progesterone were injected on the day of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-105-1-195
更新日期:1979-07-01 00:00:00
abstract::Previously, a human CYP3A4-transgenic (Tg-CYP3A4) mouse line was reported to exhibit enhanced metabolism of midazolam by cytochrome P450 3A4 (CYP3A4) expressed in small intestine. Here we show that expression of CYP3A4 and murine cyp3a and cyp2b was both age and sex dependent. CYP3A4 was expressed in the livers of mal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-1248
更新日期:2005-07-01 00:00:00
abstract::Pure porcine cholecystokinin-33 [the triacontatriapeptide form of cholecystokinin (CCK-33)], gastric inhibitory polypeptide (GIP), and secretin were infused in rats in doses of 1, 10 and 1000 pmol/kg . min. The peptides were administered alone or in combination with glucose (40 mg/kg . min) or arginine (50 mg/kg . min...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-110-4-1268
更新日期:1982-04-01 00:00:00
abstract::Although the main role of prolactin (PRL) in pregnant rodents is to sustain progesterone production by the corpus luteum, progesterone treatment of PRL or PRL receptor (PRL-R) null mice is unable to prevent fetal loss. We have previously shown that the rat decidua is a site of PRL production and action. In this report...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-1643
更新日期:2007-05-01 00:00:00
abstract::Bovine granulosa cells seeded in the presence of serum on extracellular matrix-coated dishes proliferate actively when exposed to serum-free medium supplemented with insulin (2 microgram/ml), fibroblast growth factor (FGF, 100 ng/ml), and high density lipoprotein (HDL, 30 microgram protein/ml). The final density of th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-109-2-409
更新日期:1981-08-01 00:00:00
abstract::Blepharophimosis ptosis epicanthus inversus syndrome (BPES) is a human disorder caused by mutations in the forkhead transcription factor gene FOXL2 and is characterized by facial dysmorphology combined in some cases with ovarian failure. To better understand the role of FOXL2 in the etiology of ovarian failure in BPES...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-0095
更新日期:2003-07-01 00:00:00
abstract::Early postnatal exposures to sex steroids have been well recognized to modulate predisposition to diseases of adulthood. There is a complex interplay between timing, duration and dose of endocrine exposures through environmental or dietary sources that may alter the sensitivity of target tissues to the exogenous stimu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/EN.2015-1117
更新日期:2015-10-01 00:00:00