Leptin Controls Glutamatergic Synaptogenesis and NMDA-Receptor Trafficking via Fyn Kinase Regulation of NR2B.

abstract：:T(4) must be activated by its monodeiodination to T(3) by type 1 or 2 iodothyronine deiodinase (D1 and D2). Recent studies show that despite an approximately 2000-fold higher Michaelis constant (K(m); T(4)) for D1 than for D2 using dithiothreitol (DTT) as cofactor, D1 expressed in intact cells produces T(3) at free T(...

journal_title：Endocrinology

authors： Goemann IM,Gereben B,Harney JW,Zhu B,Maia AL,Larsen PR

更新日期：2010-02-01 00:00:00

abstract：:The metabolism of [3H]progesterone by the fetal calf adrenal was examined in homogenates and microsomal fractions of adrenals obtained from mid- or late gestational fetal calves. Throughout the course of gestation, there was no detectable difference in the formation of corticosterone from progesterone by adrenal homog...

journal_title：Endocrinology

authors： Kan KW,Baird A,Solomon S

更新日期：1983-09-01 00:00:00

abstract：:Characterization of glycoconjugates synthesized by polarized immature rabbit uterine epithelial (UE) cells in vitro, their vectorial patterns of secretion, and regulation by ovarian steroid hormones are reported. Large (mol wt, greater than 230 kDa) sialomucoglycoproteins and hyaluronate were primarily (86-96%) secret...

journal_title：Endocrinology

authors： Mani SK,Carson DD,Glasser SR

更新日期：1992-01-01 00:00:00

abstract：:To determine if oxytocin (OT) is present in cynomolgus monkey corpus luteum, OT was measured by a specific and sensitive RIA in 13 corpora lutea, ovarian venous plasma on the ipsilateral side and peripheral venous plasma at different stages of the luteal phase. Serial dilution of acetic acid extract of the corpus lute...

journal_title：Endocrinology

authors： Khan-Dawood FS,Marut EL,Dawood MY

更新日期：1984-08-01 00:00:00

abstract：:To identify genes involved in regulated insulin secretion, we have established and characterized two sublines derived from the mouse pancreatic beta-cell line MIN6, designated B1 and C3. They have a similar insulin content, but differ in their secretory properties. B1 responded to glucose in a concentration- and cell ...

journal_title：Endocrinology

authors： Lilla V,Webb G,Rickenbach K,Maturana A,Steiner DF,Halban PA,Irminger JC

更新日期：2003-04-01 00:00:00

abstract：:An increased activity of the hypothalamo-pituitary-adrenal axis resulting in exaggerated glucocorticoid secretion has been repeatedly described in patients with diabetes mellitus and in animal models of this disease. However, it has been pointed out that experimental diabetes is accompanied by a decreased glucocortico...

journal_title：Endocrinology

authors： Repetto EM,Sanchez R,Cipelli J,Astort F,Calejman CM,Piroli GG,Arias P,Cymeryng CB

更新日期：2010-01-01 00:00:00

abstract：:The master circadian clock located within the hypothalamic suprachiasmatic nucleus (SCN) is necessary for the circadian rhythm of glucocorticoid (GC) release. The pathways by which the SCN sustains rhythmic GC release remain unclear. We studied the circadian regulation of cortisol release in the behaviorally split gol...

journal_title：Endocrinology

authors： Lilley TR,Wotus C,Taylor D,Lee JM,de la Iglesia HO

更新日期：2012-02-01 00:00:00

abstract：:Control of trabecular bone volume is mediated by local events. Recently, it has been shown that the cytokines interleukin-1 (IL-1), tumor necrosis factor alpha (TNF alpha), and TNF beta [also called lymphotoxin (LT)] produced by immune cells all stimulate osteoclast activity, whereas the lymphokine interferon-gamma (I...

journal_title：Endocrinology

authors： Smith DD,Gowen M,Mundy GR

更新日期：1987-06-01 00:00:00

abstract：:In amphibians, the secretion of alpha-MSH by melanotrope cells is stimulated by TRH and inhibited by NPY. We have previously shown that NPY abrogates the stimulatory effect of TRH on alpha-MSH secretion. The aim of the present study was to characterize the receptor subtypes mediating the action of NPY and to investiga...

journal_title：Endocrinology

authors： Galas L,Tonon MC,Beaujean D,Fredriksson R,Larhammar D,Lihrmann I,Jegou S,Fournier A,Chartrel N,Vaudry H

更新日期：2002-05-01 00:00:00

abstract：:Human pituitary prolactin (hPRL) contains a single major component. Upon iodination by a lactoperoxidase procedure approximately 50% of this component remains ulaltered in molecular size and net charge by the criteria of quantitative polyacrylamide gel electrophoresis (PAGE). Aminiotic fluid hPRL contains two componen...

journal_title：Endocrinology

authors： Rogol AD,Chrambach A

更新日期：1975-08-01 00:00:00

abstract：:Sodium butyrate (NaB), a dietary micronutrient, is a potent growth inhibitor that initiates cell differentiation in many cell types, including prostate cancer cells. The molecular mechanisms by which these effects occur remain largely unknown. In this study, we investigated the effects of NaB on the expression of IGF ...

journal_title：Endocrinology

authors： Tsubaki J,Hwa V,Twigg SM,Rosenfeld RG

更新日期：2002-05-01 00:00:00

abstract：:This work examines the cellular pathophysiology associated with the weakened bone matrix found in a murine model of osteogenesis imperfecta murine (oim). Histomorphometric analysis of oim/oim bone showed significantly diminished bone mass, and the osteoblast and osteoclast histomorphometric parameters were increased i...

journal_title：Endocrinology

authors： Kalajzic I,Terzic J,Rumboldt Z,Mack K,Naprta A,Ledgard F,Gronowicz G,Clark SH,Rowe DW

更新日期：2002-05-01 00:00:00

abstract：:Methylamine and monensin are two agents known to interfere with the recycling of membrane receptors. In the present investigation, we studied their effects on the binding, intracellular distribution, and action of insulin in isolated pancreatic acini prepared from diabetic mice. These drugs had several similar effects...

journal_title：Endocrinology

authors： Potau N,Bailey AC,Roach E,Williams JA,Goldfine ID

更新日期：1984-07-01 00:00:00

abstract：:Circulating insulin-like growth factor (IGF) bioactivity is reduced in animals and patients with diabetes mellitus. We sought to determine whether the availability and levels of specific IGF binding proteins (BPs) are altered in animals with experimental diabetes, and might contribute to changes in circulating IGF bio...

journal_title：Endocrinology

authors： Unterman TG,Patel K,Mahathre VK,Rajamohan G,Oehler DT,Becker RE

更新日期：1990-05-01 00:00:00

abstract：:The control of ACTH secretion by opiates seems to involve stimulatory and inhibitory pathways, since opiate agonists and antagonists are capable of releasing ACTH in conscious rats. To elucidate the role of different opiate receptors in the control of ACTH release, rats were treated with receptor-selective opiate agon...

journal_title：Endocrinology

authors： Pfeiffer A,Herz A,Loriaux DL,Pfeiffer DG

更新日期：1985-06-01 00:00:00

abstract：:Hamsters injected sc with 50 mug estradiol cyclopentylpropionate (ECP) at 0900 h on day 1 (metestrus) of the cycle show the normal "postovulatory" vaginal discharge 4 days later but do not resume ovulation until 14--18 days later. After ECP injection ovarian histology reveals that the follicles normally destined to ov...

journal_title：Endocrinology

authors： Greenwald GS

更新日期：1975-10-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF alpha), a product of activated monocytes, induces tissue wasting in certain solid tumors in vivo and in in vitro model systems. Recent studies indicate that TNF alpha also regulates cell replication and expression of differentiated function in a variety of nonneoplastic cell systems. S...

journal_title：Endocrinology

authors： Centrella M,McCarthy TL,Canalis E

更新日期：1988-09-01 00:00:00

abstract：:Glucocorticoids induce tyrosine aminotransferase (TAT) in hepatoma cells. We have previously shown that both the concentration of the agonist dexamethasone (Dex) required for half-maximal induction (EC50) and the amount of agonist activity produced by the antagonist dexamethasone 21-mesylate (Dex-Mes), expressed as a ...

journal_title：Endocrinology

authors： Oshima H,Simons SS Jr

更新日期：1992-04-01 00:00:00

abstract：:Although acute leptin administration in the hypothalamus decreases food intake and increases peripheral energy metabolism, the peripheral actions of central chronic leptin administration are less understood. In this study, we investigated what effects chronic (7 d) intracerebroventricular (ICV) administration of lepti...

journal_title：Endocrinology

authors： Keung W,Palaniyappan A,Lopaschuk GD

更新日期：2011-11-01 00:00:00

abstract：:In an attempt to purify the thyroid receptor for TSH and to study interaction with the thyroid-stimulating antibody (TSAb) of graves' disease, we used both bovine and human thyroid glands. With either tissue, the 10,000 X g pellet of homogenized material was solubilized with 0.5% Triton N-101; excess Triton was remove...

journal_title：Endocrinology

authors： Koizumi Y,Zakarija M,McKenzie JM

更新日期：1982-04-01 00:00:00

abstract：:Neurotensin (NT) is a peptide expressed in the brain and in the gastrointestinal tract. Brain NT inhibits food intake, but the effects of peripheral NT are less investigated. In this study, peripheral NT decreased food intake in both mice and rats, which was abolished by a NT antagonist. Using c-Fos immunohistochemist...

journal_title：Endocrinology

authors： Ratner C,Skov LJ,Raida Z,Bächler T,Bellmann-Sickert K,Le Foll C,Sivertsen B,Dalbøge LS,Hartmann B,Beck-Sickinger AG,Madsen AN,Jelsing J,Holst JJ,Lutz TA,Andrews ZB,Holst B

更新日期：2016-09-01 00:00:00

abstract：:This study investigates the signaling pathways that lead to acute augmentation of secretagogue-induced LH secretion, the physiologically relevant manifestation of which is LHRH self-potentiation. The consequence of LHRH self-potentiation is an augmented LH secretory response to subsequent exposure to the peptide. Alth...

journal_title：Endocrinology

authors： Waring DW,Turgeon JL

更新日期：1992-06-01 00:00:00

abstract：:In this study on highly enriched populations of cultured rat corticotropes, Ca2+ channel inhibitors were used to identify subtypes of the high threshold Ca2+ channel current under voltage clamp conditions. From a holding potential (-50 mV) that eliminated the low threshold T-type current, 52 +/- 4% of the total curren...

journal_title：Endocrinology

authors： Kuryshev YA,Childs GV,Ritchie AK

更新日期：1995-09-01 00:00:00

abstract：:Induction of cyclin proteins is required for progression of cells through the G(1)-S and G(2)-M cell cycle checkpoints and is a primary mechanism by which mitogens regulate cell cycle progression. IGF-I and the epidermal growth factor (EGF)-related ligands are mitogens for mammary epithelial cells in vitro and are ess...

journal_title：Endocrinology

authors： Stull MA,Richert MM,Loladze AV,Wood TL

更新日期：2002-05-01 00:00:00

abstract：:Angiotensin II receptors regulate muscle microvascular recruitment and the delivery of nutrients, oxygen, and insulin to muscle. Although angiotensin type 1 receptor antagonism increases muscle microvascular perfusion and insulin action, angiotensin type 2 receptor blockade markedly restricts muscle microvascular bloo...

journal_title：Endocrinology

authors： Yan F,Yuan Z,Wang N,Carey RM,Aylor KW,Chen L,Zhou X,Liu Z

更新日期：2018-02-01 00:00:00

abstract：:Pheochromocytomas (PCCs) are tumors arising from neural crest-derived chromaffin cells. There are currently few animal models of PCC that recapitulate the key features of human tumors. Because such models may be useful for investigations of molecular pathomechanisms and development of novel therapeutic interventions, ...

journal_title：Endocrinology

authors： Wiedemann T,Peitzsch M,Qin N,Neff F,Ehrhart-Bornstein M,Eisenhofer G,Pellegata NS

更新日期：2016-08-01 00:00:00

abstract：:In previous studies, we have shown that calcitonin gene-related peptide (CGRP) acutely inhibits 45Ca2+ uptake in osteoblastic UMR106 cells, and we have proposed that ATP-sensitive potassium (K(ATP)) channels are involved in mediating this action of CGRP. To directly test this proposed mechanism, we have now examined t...

journal_title：Endocrinology

authors： Kawase T,Burns DM

更新日期：1998-08-01 00:00:00

abstract：:Pure porcine cholecystokinin-33 [the triacontatriapeptide form of cholecystokinin (CCK-33)], gastric inhibitory polypeptide (GIP), and secretin were infused in rats in doses of 1, 10 and 1000 pmol/kg . min. The peptides were administered alone or in combination with glucose (40 mg/kg . min) or arginine (50 mg/kg . min...

journal_title：Endocrinology

authors： Szecówka J,Lins PE,Efendić S

更新日期：1982-04-01 00:00:00

abstract：:The activity of many endocrine cells is regulated by gamma-aminobutyric acid (GABA). The effects of GABA are mediated by GABAA and/or GABAB receptors. While GABAB receptors in the central nervous system have now been extensively characterized, little is known of the function and pharmacology of GABAB receptors on endo...

journal_title：Endocrinology

authors： De Koning HP,Jenks BG,Roubos EW

更新日期：1993-02-01 00:00:00

abstract：:To ascertain if reductions in fetal plasma cortisol cause increases in fetal plasma ACTH, we treated pregnant ewes or their fetuses with aminoglutethimide (10 mg/kg BW) and metyrapone (20 mg/kg BW) and measured the hormonal responses with RIAs. When given to fetuses (n = 9) at 0.90 +/- 0.01 gestation (term-145 days), ...

journal_title：Endocrinology

authors： Rose JC,Turner CS,Ray D,Rawashdeh N

更新日期：1988-09-01 00:00:00