Reduced behavioral response to gonadal hormones in mice shipped during the peripubertal/adolescent period.

abstract：:We tested further our postulate that enhanced de novo synthesis of phosphatidic acid is responsible for ACTH- and cAMP-induced increases in adrenal phospholipids in the phosphatidate polyphosphoinositide pathway. During incubation of adrenal sections or cells in vitro, ACTH and cAMP increased the concentrations of and...

journal_title：Endocrinology

authors： Farese RV,Sabir MA,Larson RE

更新日期：1981-12-01 00:00:00

abstract：:Artificial copulomimetic cervical stimulation (CS) induces an immediate release of oxytocin (OT) and prolactin (PRL) followed by a daily PRL rhythm characterized by nocturnal and diurnal surges. Although we have shown that the initial release of PRL is induced by the immediate release of OT, we tested whether the PRL ...

journal_title：Endocrinology

authors： Helena CV,McKee DT,Bertram R,Walker AM,Freeman ME

更新日期：2009-07-01 00:00:00

abstract：:We have previously documented that raloxifene enhances the mechanical properties of dog vertebrae independent of changes in bone mass, suggesting a positive effect of raloxifene on material-level mechanical properties. The goal of this study was to determine the separate effects of raloxifene on the material-level mec...

journal_title：Endocrinology

authors： Allen MR,Hogan HA,Hobbs WA,Koivuniemi AS,Koivuniemi MC,Burr DB

更新日期：2007-08-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) play potential roles in chemoprevention of colon cancer and others by inhibiting prostaglandin synthesis. In this report, we used LNCaP cells, an androgen-responsive human prostate carcinoma cell line, to study the effects of two NSAIDs, flufenamic acid (FA) and piroxicam ...

journal_title：Endocrinology

authors： Zhu W,Smith A,Young CY

更新日期：1999-11-01 00:00:00

abstract：:Insulin and protein kinase B (or Akt) play critical roles in cardiomyocytic growth and survival. High concentrations of glucocorticoids antagonize insulin's action. To examine whether endogenous glucocorticoids modulate insulin's effect on Akt signaling in the protein and glycogen synthetic pathways in myocardium, we ...

journal_title：Endocrinology

authors： Wu Y,Barrett EJ,Long W,Liu Z

更新日期：2004-03-01 00:00:00

abstract：:Six pony mares were ovariectomized (OVX) on day 16 of diestrus during June and July, 1972, to study short term changes in plasma luteinizing hormone (LH) concentrations. Plasma LH was higher (P less than .05) 3 days after OVX (1.76 ng/ml) than the day after OVX (1.01 ng/ml), and a gradual increase occurred over the fi...

journal_title：Endocrinology

authors： Garcia MC,Ginther OJ

更新日期：1976-04-01 00:00:00

abstract：:Involvement of ionized cytosolic calcium ([Ca2+]i) and protein kinase-C (PKC) in GnRH-stimulated LH release was assessed by correlating measurable changes in [Ca2+]i and LH release in PKC-depleted and nondepleted gonadotropes. Primary cultures of anterior pituitary cells were loaded with the calcium-sensitive fluoresc...

journal_title：Endocrinology

authors： Waters SB,Conn PM

更新日期：1992-04-01 00:00:00

abstract：:Endotoxin has been shown to stimulate GH secretion in human and sheep. However, changes in hypothalamic neurohormones involved in the GH regulation by endotoxin have never been studied in vivo. In sheep it is possible to collect hypophysial portal blood (HPB) and quantify GH-releasing hormone (GHRH) and somatostatin (...

journal_title：Endocrinology

authors： Briard N,Guillaume V,Frachebois C,Rico-Gomez M,Sauze N,Oliver C,Dutour A

更新日期：1998-06-01 00:00:00

abstract：:Nuclear receptor function on DNA is regulated by the balanced recruitment of coregulatory complexes. Recruited proteins that increase gene expression are called coactivators, and those that decrease gene expression are called corepressors. Little is known about the role of corepressors, such as nuclear receptor corepr...

journal_title：Endocrinology

authors： Jessen HM,Kolodkin MH,Bychowski ME,Auger CJ,Auger AP

更新日期：2010-03-01 00:00:00

abstract：:The calbindins are Ca-binding proteins whose expression is regulated by 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D3. The calbindins are found in high amounts in the proximal intestine (calbindin-D-9k) and the kidney (calbindin-D-28k), and they are thought to play a role in Ca transport by these tissu...

journal_title：Endocrinology

authors： Armbrecht HJ,Boltz M,Strong R,Richardson A,Bruns ME,Christakos S

更新日期：1989-12-01 00:00:00

abstract：:In the present study we used characterized perifusion model for the development of homologous desensitization to GnRH in the pituitary gonadotrope. This system relies on immobilized primary pituitary cultures that are perifused with various pulse patterns and concentrations of GnRH; these patterns and concentrations a...

journal_title：Endocrinology

authors： Janovick JA,Conn PM

更新日期：1996-05-01 00:00:00

abstract：:A [3H]colchicine-binding assay was employed for estimating the relative amounts of soluble and polymerized tubulin present in an individual anterior pituitary lobe. Colchicine binding to these two tubulin pools was time dependent and dose responsive. Scatchard analysis of the binding revealed that [3H]colchicine bound...

journal_title：Endocrinology

authors： Ravindra R,Grosvenor CE

更新日期：1988-01-01 00:00:00

abstract：:At menopause, the dramatic loss of ovarian estradiol (E2) necessitates the adaptation of estrogen-sensitive neurons in the hypothalamus to an estrogen-depleted environment. We developed a rat model to test the "critical window" hypothesis of the effects of timing and duration of E2 treatment after deprivation on the h...

journal_title：Endocrinology

authors： Yin W,Maguire SM,Pham B,Garcia AN,Dang NV,Liang J,Wolfe A,Hofmann HA,Gore AC

更新日期：2015-08-01 00:00:00

abstract：:A method has been developed for the purification of rat placental lactogen employing a specific radioreceptor assay (RRA). The method involves precipitation with ammonium sulfate, gel filtration on Sephadex G-100, ion-exchange chromatography on DEAE-cellulose and CM-Sephadex, and preparative isoelectric focusing. The ...

journal_title：Endocrinology

authors： Roberston MC,Friesen HG

更新日期：1975-09-01 00:00:00

abstract：:The purpose of this study is to establish a primary LHRH cell culture system using embryonic olfactory placode and to examine whether LHRH cells derived from olfactory placode and the migratory pathway of LHRH neurons mature in vitro. Six monkey fetuses at the ages of E34-E36 were delivered surgically and the area inc...

journal_title：Endocrinology

authors： Terasawa E,Quanbeck CD,Schulz CA,Burich AJ,Luchansky LL,Claude P

更新日期：1993-11-01 00:00:00

abstract：:The effects of dopamine on PRL secretion and lysosomal enzyme activity in anterior pituitary tissue from rats selected during various stages of the estrous cycle were examined under in vitro conditions. During the estrous cycle, there was a marked variation in the capacity of dopamine to stimulate the activity of the ...

journal_title：Endocrinology

authors： Nansel DD,Gudelsky GA,Reymond MJ,Porter JC

更新日期：1981-03-01 00:00:00

abstract：:We examined whether mitogen-activated protein (MAP) kinase was activated by stimulation of the cAMP pathway and whether MAP kinase activation was involved in synthesis of PRL and GH in GH(3) cells. Treatment of the cells with a cAMP analog, 8-(4-chlorophenylthio)cAMP (CPT-cAMP), activated MAP kinase and increased PRL ...

journal_title：Endocrinology

authors： Yonehara T,Kanasaki H,Yamamoto H,Fukunaga K,Miyazaki K,Miyamoto E

更新日期：2001-07-01 00:00:00

abstract：:Increasing adiposity predisposes to the development of the metabolic syndrome, in part, through adipose tissue dysregulation and inflammation. In addition, offspring nutrient-restricted (NR) in utero can exhibit an increased risk of early-onset insulin resistance and obesity, although the mechanisms remain unclear. We...

journal_title：Endocrinology

authors： Sharkey D,Symonds ME,Budge H

更新日期：2009-08-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor-gamma (PPARgamma) transcription factor plays a pivotal role in adipocyte differentiation and metabolic regulation. The transcriptional activity of PPARgamma is positively modulated by ligand binding and negatively regulated by phosphorylation mediated by the MEK/ERK signa...

journal_title：Endocrinology

authors： Camp HS,Tafuri SR,Leff T

更新日期：1999-01-01 00:00:00

abstract：:The importance of monoaminergic mechanisms for the regulation of GH-releasing factor (GRF)-stimulated GH secretion was studied in perifused rat anterior pituitaries. Dopamine (greater than 1 microL) reduced GRF-stimulated GH release, but 5-hydroxytryptamine (5-HT; 1 mL) had no effect. The substrates for L-aromatic ami...

journal_title：Endocrinology

authors： Lindström P,Ohlsson L

更新日期：1987-02-01 00:00:00

abstract：:Chorionic gonadotropin (CG) is an early embryo-derived signal that is known to support the corpus luteum. An in vivo baboon model was used to study the direct actions of human CG (hCG) on the endometrium, during the periimplantation period. Endometrial gene expression was analyzed using microarrays. The endometrial bi...

journal_title：Endocrinology

authors： Sherwin JR,Sharkey AM,Cameo P,Mavrogianis PM,Catalano RD,Edassery S,Fazleabas AT

更新日期：2007-02-01 00:00:00

abstract：:Bisphenol A (BPA) is an endocrine-disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts, and many other everyday items and is detectable in human urine and blood. Exposure to BPA during development can disrupt sexual differentiation of some brain regions. Mo...

journal_title：Endocrinology

authors： Goldsby JA,Wolstenholme JT,Rissman EF

更新日期：2017-01-01 00:00:00

abstract：:Orexins/hypocretins heavily innervate the posterior division of the paraventricular nucleus of the thalamus (pPVT), which expresses both orexin receptor types. The pPVT is important for adaptations to repeated stress, particularly the ability to facilitate to novel stress after repeated stress exposure. Here, we exami...

journal_title：Endocrinology

authors： Heydendael W,Sharma K,Iyer V,Luz S,Piel D,Beck S,Bhatnagar S

更新日期：2011-12-01 00:00:00

abstract：:Neurosteroids are steroids that are synthesized de novo in the brain and include some classical (adrenal and gonadal steroids) and some unique brain-specific steroids. Neurosteroids are thought to mediate their action through ion gated channel receptors such as gamma-aminobutyric acid(A) and N-methyl-D-aspartate rathe...

journal_title：Endocrinology

authors： Compagnone NA,Bulfone A,Rubenstein JL,Mellon SH

更新日期：1995-11-01 00:00:00

abstract：:In virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progesterone and pregnenolone in MA-10 cells over a period of 3 h. Steroids were then extracted, separated by...

journal_title：Endocrinology

authors： Rommerts FF,King SR,Span PN

更新日期：2001-12-01 00:00:00

abstract：:Angiotensin II (AII) receptors in adrenal glomerulosa cells are coupled to adenylate cyclase inhibition. We investigated the importance of cyclase inhibition in adrenal steroidogenesis by treating adrenal glomerulosa cells with the toxin of Bordetella pertussis (20 ng/ml) for 3 and 18 h. This treatment prevented inhib...

journal_title：Endocrinology

authors： Woodcock EA,McLeod JK

更新日期：1986-10-01 00:00:00

abstract：:This review describes formation of the islet basement membrane and the function of extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for islet transplantation are discussed. The insulin-producing β-cell is key for maintaining glucose homeostasis. The islet microenvironment greatl...

journal_title：Endocrinology

authors： Townsend SE,Gannon M

更新日期：2019-08-01 00:00:00

abstract：:Immunohistochemical localization of two estrogen receptor (ER) subtypes, ER beta and ER alpha, was performed in neonatal, early postnatal, immature, and adult rats to determine whether ER alpha and ER beta are differentially expressed in the ovary. ER beta and ER alpha were visualized using a polyclonal anti-ER beta a...

journal_title：Endocrinology

authors： Sar M,Welsch F

更新日期：1999-02-01 00:00:00

abstract：:The previously reported synchronous oscillations in plasma glucose and insulin levels have been further studied to determine whether the phenomenon can be attributed to cyclic secretion or degradation of the hormone. Plasma C-peptide concentrations were measured and found to cycle with the same period as plasma insuli...

journal_title：Endocrinology

authors： Koerker DJ,Goodner CJ,Hansen BW,Brown AC,Rubenstein AH

更新日期：1978-05-01 00:00:00

abstract：:The concentration of testosterone (T) and 5alpha-dihydrotestosterone (DHT) in plasma, seminal fluid, and epididymis of male Wistar rats have been determined by radioimmunoassay. The DHT/T ratio rose from 0.1 in blood to 1 in testicular fluid and 4 in epididymal fluid. This ratio is 2 in tissues of "caput" epididymis a...

journal_title：Endocrinology

authors： Pujol A,Bayard F,Louvet JP,Boulard C

更新日期：1976-01-01 00:00:00