Abstract:
:The importance of monoaminergic mechanisms for the regulation of GH-releasing factor (GRF)-stimulated GH secretion was studied in perifused rat anterior pituitaries. Dopamine (greater than 1 microL) reduced GRF-stimulated GH release, but 5-hydroxytryptamine (5-HT; 1 mL) had no effect. The substrates for L-aromatic amino acid decarboxylase, L-5-hydroxy-tryptophan(L-5-HTP; 10 microM) L-dihydroxyphenylalanine; (1 mM), D,L-o-tyrosine (2 mM), and D,L-m-tyrosine (2 mM), all reduced GRF-stimulated GH release. Inhibition of the L-aromatic amino acid decarboxylase by benserazide (0.1 mM), carbidopa (0.1 mM), or alpha-monofluoromethyldopa (0.1 mM) did not reduce the effect of the decarboxylase substrates on GH secretion. The enzyme inhibitors had no influence on hormone secretion per se. The findings indicate that dopamine may inhibit GRF-induced GH release at the pituitary level and that the precursor amino acids inhibit GH secretion independently of the formation of the corresponding amines.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Lindström P,Ohlsson Ldoi
10.1210/endo-120-2-780subject
Has Abstractpub_date
1987-02-01 00:00:00pages
780-4issue
2eissn
0013-7227issn
1945-7170journal_volume
120pub_type
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