Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells.

abstract：:The formation of ovarian follicles and subsequent development after birth are critical processes for female reproduction, and inappropriate coordination of these processes contributes to ovarian pathologies, such as premature ovarian failure and infertility. Identification and functional investigation of the factors i...

journal_title：Endocrinology

authors： Wang N,Zhang P,Guo X,Zhou Z,Sha J

更新日期：2011-03-01 00:00:00

abstract：:The effects of GH and PTH on cancellous histomorphometry were determined in the proximal tibial metaphysis of hypophysectomized (HYPOX) sexually mature female rats. HYPOX resulted in uterine atrophy and a loss in body weight. Longitudinal bone growth ceased and bone formation was greatly reduced. There were decreases ...

journal_title：Endocrinology

authors： Schmidt IU,Dobnig H,Turner RT

更新日期：1995-11-01 00:00:00

abstract：:Male and female Wistar-Furth rats bearing the pituitary tumor MtT/W15 had serum GH and PRL levels several hundred-fold higher, and immunoreactive somatomedin levels 3-fold higher, than those of controls. The presence of tumor appeared to have no effect on specific binding of radioiodinated bovine GH to liver microsoma...

journal_title：Endocrinology

authors： Baxter RC,Zaltsman Z,Turtle JR

更新日期：1982-09-01 00:00:00

abstract：:When colonic crypt cells isolated from intact rats are incubated with [3H]corticosterone specific nuclear binding is displaced by neither aldosterone nor the antiglucocorticoid RU38486, suggesting that [3H]corticosterone is binding to a site distinct from classical mineralocorticoid and glucocorticoid receptors. TLC r...

journal_title：Endocrinology

authors： Sheppard KE,Funder JW

更新日期：1996-08-01 00:00:00

abstract：:In mammals, skeletal muscle mass is negatively regulated by a muscle-derived growth/differentiating factor named myostatin (MSTN) that belongs to the transforming growth factor-beta superfamily. Although putative MSTN homologs have been identified from several vertebrates, nonmammalian orthologs remained poorly define...

journal_title：Endocrinology

authors： Rodgers BD,Weber GM,Sullivan CV,Levine MA

更新日期：2001-04-01 00:00:00

abstract：:The electrical responses of rat islet cells maintained in culture with varying levels of glucose were determined. After culture with 2.8 or 4.2 mM glucose, the beta-cells did not respond electrically to 27.8 mM glucose. However, after culture in 5.6 mM glucose, the cells responded to 27.8 mM glucose in short term expe...

journal_title：Endocrinology

authors： Pace CS,Conant S,Lacy PE

更新日期：1978-05-01 00:00:00

abstract：:Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...

journal_title：Endocrinology

authors： Tanaka T,Aoyagi C,Mukai K,Nishimoto K,Kodama S,Yanase T

更新日期：2020-03-01 00:00:00

abstract：:PTH-related protein (PTHrP) is the principle mediator of the syndrome of humoral hypercalcemia of malignancy and has potential paracrine actions on smooth muscle, epithelial cell growth, and placental calcium transport. The human PTHrP gene is complex: a combination of three promoters, one 5' alternative splicing even...

journal_title：Endocrinology

authors： Southby J,Murphy LM,Martin TJ,Gillespie MT

更新日期：1996-04-01 00:00:00

abstract：:Intravenous (i.v.) administration of TRF (1 mg/kg) increases the LD50 of pentobarbital (PB) by 25% while the same dose of somatostatin results in a 30% reduction in PB LD50. A similar increase of PB LD50 by TRF was observed in hypophysectomized rats. Mortality was completely abolished in rats receiving TRF (1 mg/kg) t...

journal_title：Endocrinology

authors： Brown M,Vale W

更新日期：1975-05-01 00:00:00

abstract：:Human thyroperoxidase (hTPO), a type I transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis and plays a major role in thyroid autoimmunity. Whereas hormonosynthesis occurs at the apical membrane of thyroid cells, TPO localizes mainly in the perinuclear membrane and ...

journal_title：Endocrinology

authors： Fayadat L,Niccoli-Sire P,Lanet J,Franc JL

更新日期：1998-10-01 00:00:00

abstract：:Hypothalamic peninsulae, posteriorly continuous with the brain stem, were produced in ovariectomized rhesus monkeys by aspiration of the cerebral hemispheres and all brain structures anterior and dorsal to the optic chiasm. These preparations were sustained for 52 to 60 h postoperatively by maintaining blood gases and...

journal_title：Endocrinology

authors： Hess DL,Wilkins RH,Moossy J,Chang JL,Plant TM,McCormack JT,Nakai Y,Knobil E

更新日期：1977-10-01 00:00:00

abstract：:The influence of development and estrogen, thyroid hormone, corticosteroid, and fibrate administration on apolipoprotein (apo) A-IV mRNA levels in the liver and intestine and on serum or plasma concentrations of apo A-IV was studied in the rat. Treatment of ovariectomized rats with ethinyl estradiol provoked a dose-de...

journal_title：Endocrinology

authors： Staels B,van Tol A,Verhoeven G,Auwerx J

更新日期：1990-04-01 00:00:00

abstract：:We previously reported that cAMP inhibits autocrine IGF-I gene expression in rat C6 glioma cells. In this study we examined the influence of cAMP on IGF-binding protein gene expression in C6 cells. cAMP potently inhibited IGF-binding protein-3 mRNA and, to a lesser extent, IGF-binding protein-4 mRNA and transiently st...

journal_title：Endocrinology

authors： Wang L,Ma X,Yeh LC,Adamo ML

更新日期：2001-09-01 00:00:00

abstract：:PTH increased PG synthase-2 transcription in osteoblastic MC3T3-E1 cells at 30 min, as assessed by nuclear run-on assays. To determine the signaling pathways used by PTH, the activity of a construct containing the PG synthase-2 gene between nucleotides -963 and +70 linked to a luciferase reporter was analyzed in stabl...

journal_title：Endocrinology

authors： Tetradis S,Pilbeam CC,Liu Y,Herschman HR,Kream BE

更新日期：1997-09-01 00:00:00

abstract：:CRF dose-dependently enhanced corticosterone (B) secretion by rat adrenal slices including both cortex and medulla. Conversely, CRF did not exert any B response by fragments of adrenocortical autotransplants, which are completely deprived of chromaffin tissue. However, autotransplant quarters exhibited a dose-dependen...

journal_title：Endocrinology

authors： Andreis PG,Neri G,Mazzocchi G,Musajo F,Nussdorfer GG

更新日期：1992-07-01 00:00:00

abstract：:Kisspeptins are hypothalamic neuropeptides encoded by KISS1 and recently described as major regulators of GnRH release from hypothalamic neurons. Although 17beta-estradiol (E2)-induced up-regulation of KISS1 expression has been documented in anteroventral periventricular nucleus neurons, E2 down-regulates KISS1 expres...

journal_title：Endocrinology

authors： Huijbregts L,de Roux N

更新日期：2010-08-01 00:00:00

abstract：:The proglucagon gene (glu) encodes the incretin hormone glucagon-like peptide-1 (GLP-1), produced in the intestinal endocrine L cells. We found previously that the bipartite transcription factor beta-catenin/T cell factor (cat/TCF), the major effector of the canonical Wnt signaling pathway, activates intestinal glu ex...

journal_title：Endocrinology

authors： Yi F,Sun J,Lim GE,Fantus IG,Brubaker PL,Jin T

更新日期：2008-05-01 00:00:00

abstract：:LH and FSH are composed of a common alpha-subunit and a noncovalently associated hormone-specific beta-subunit. Unassociated beta LH and beta FSH can be retained in the cisternae of endoplasmic reticulum (ER). This phenomenon is particularly evident in gonadotropes of castrated animals where beta-subunits are expresse...

journal_title：Endocrinology

authors： Bassetti M,Pasini DL,Rosa P

更新日期：1995-03-01 00:00:00

abstract：:The predisposition of the testis and ovary to primarily synthesize testosterone (T) and estradiol (E2), respectively, is due to gonadal-specific cell types that differentially express the various hydroxysteroid (17beta) dehydrogenase (HSD17B) isoforms. In testes, Leydig cells rely on LH stimulation to maintain express...

journal_title：Endocrinology

authors： Couse JF,Yates MM,Rodriguez KF,Johnson JA,Poirier D,Korach KS

更新日期：2006-08-01 00:00:00

abstract：:α7-Nicotinic acetylcholine receptor (α7nAChR) agonists confer protection against a wide variety of cytotoxic insults and suppress oxidative stress and apoptosis in various cell systems, including hepatocytes. We recently demonstrated that nicotine, when combined with a high-fat diet (HFD), triggers oxidative stress, a...

journal_title：Endocrinology

authors： Hasan MK,Friedman TC,Sims C,Lee DL,Espinoza-Derout J,Ume A,Chalfant V,Lee ML,Sinha-Hikim I,Lutfy K,Liu Y,Mahata SK,Sinha-Hikim AP

更新日期：2018-02-01 00:00:00

abstract：:Our previous studies have identified a role for annexin 1 (also called lipocortin 1) in the regulatory actions of glucocorticoids (GCs) on the release of PRL from the rat anterior pituitary gland. In the present study we used antisense and immunoneutralization strategies to extend this work. Exposure of rat anterior p...

journal_title：Endocrinology

authors： Taylor AD,Philip JG,John CD,Cover PO,Morris JF,Flower RJ,Buckingham JC

更新日期：2000-06-01 00:00:00

abstract：:Ovarian cancer in women is a complex and deadly disease, where the molecular events that initiate and control tumor formation remain poorly defined. Therefore, mouse models provide one approach for determining the mechanisms by which specific oncogenic factors cause ovarian surface epithelial cell and granulosa cell t...

journal_title：Endocrinology

authors： Mullany LK,Richards JS

更新日期：2012-04-01 00:00:00

abstract：:There is growing international interest in how environmental conditions experienced during development can shape adult phenotypes and the extent to which such induced changes are adaptive. One physiological system that links an individual to changes in environmental circumstances during development is the hypothalamic...

journal_title：Endocrinology

authors： Spencer KA,Evans NP,Monaghan P

更新日期：2009-04-01 00:00:00

abstract：:The effects of rat CRF, arginine vasopressin (VP), oxytocin (OXY), and isoproterenol (ISO) on the biosynthesis and release of pro-ACTH/endorphin-derived peptides by monolayer cultures of rat anterior pituitary cells in complete serum-free medium (CSFM) were studied. When cells were exposed to hormone for 3 h, CRF, VP,...

journal_title：Endocrinology

authors： Wand GS,Eipper BA

更新日期：1987-03-01 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1), the primary substrate for the insulin receptor tyrosine kinase in most cells and tissues, is a key component of the insulin signaling network. Numerous studies have documented the trafficking of IRS-1 from the cell membrane to intracellular, extranuclear compartments. During the c...

journal_title：Endocrinology

authors： Boylan JM,Gruppuso PA

更新日期：2002-11-01 00:00:00

abstract：:Due to increased numbers of young cancer patients and improved survival, the impact of anticancer treatments on fertility has become a major health concern. Despite mounting research on ovarian toxicity, there is paucity of data regarding reliable biomarkers of testicular toxicity. Our aim was to evaluate anti-Mülleri...

journal_title：Endocrinology

authors： Levi M,Hasky N,Stemmer SM,Shalgi R,Ben-Aharon I

更新日期：2015-10-01 00:00:00

abstract：:During the preovulatory and estradiol-progesterone-induced GnRH-LH surge, a subpopulation of GnRH neurons transiently expresses the transcription factor c-fos, which is a useful marker of cell activation. To further characterize this subpopulation of GnRH neurons, multiple immunohistochemical procedures were applied t...

journal_title：Endocrinology

authors： Eyigor O,Jennes L

更新日期：2000-02-01 00:00:00

abstract：:The ovulatory LH surge results in follicular inflammation with an increase in cytokines and PGs. Reactive oxygen species (ROS) are also produced during inflammatory processes. To study ROS generation during the ovulatory cascade, preovulatory follicles were dissected from immature female rats primed with PMSG. Follicl...

journal_title：Endocrinology

authors： Kodaman PH,Behrman HR

更新日期：2001-02-01 00:00:00

abstract：:Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues b...

journal_title：Endocrinology

authors： Karpuzoglu E,Fenaux JB,Phillips RA,Lengi AJ,Elvinger F,Ansar Ahmed S

更新日期：2006-02-01 00:00:00

abstract：:Vascular smooth muscle cells (SMC) are major constituents of the medial layer of blood vessels and are involved in the development of atherosclerotic plaque. SMC secrete copious IL-6 under basal conditions that can be increased by cytokines such as tumor necrosis factor-alpha and interleukin-1beta (IL-1beta). The goal...

journal_title：Endocrinology

authors： Maret A,Clamens S,Delrieu I,Elhage R,Arnal JF,Bayard F

更新日期：1999-06-01 00:00:00