Abstract:
:Intravenous (i.v.) administration of TRF (1 mg/kg) increases the LD50 of pentobarbital (PB) by 25% while the same dose of somatostatin results in a 30% reduction in PB LD50. A similar increase of PB LD50 by TRF was observed in hypophysectomized rats. Mortality was completely abolished in rats receiving TRF (1 mg/kg) ten minutes after a lethal dose of PB (120 mg/kg). Somatostatin (1 mg/kg) decreases strychnine-induced seizure duration and increases strychnine LD50 by 21% while TRF lowers the strychnine LD50 by 28%. These observations are consistent with central nervous system sites of action for TRF and somatostatin.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Brown M,Vale Wdoi
10.1210/endo-96-5-1333subject
Has Abstractpub_date
1975-05-01 00:00:00pages
1333-6issue
5eissn
0013-7227issn
1945-7170journal_volume
96pub_type
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