Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells.

abstract：:Pheochromocytomas (PCCs) are tumors arising from neural crest-derived chromaffin cells. There are currently few animal models of PCC that recapitulate the key features of human tumors. Because such models may be useful for investigations of molecular pathomechanisms and development of novel therapeutic interventions, ...

journal_title：Endocrinology

authors： Wiedemann T,Peitzsch M,Qin N,Neff F,Ehrhart-Bornstein M,Eisenhofer G,Pellegata NS

更新日期：2016-08-01 00:00:00

abstract：:To study conversion of 3,5,3'-triiodothyroinine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (T2) in vitro, T3 or rT3 was incubated at pH 7.35 with homogenates of several rat tissues (liver, kidney, muscle, heart, ling, spleen, intestines, and brain) for 15 min at 37 C. The T2 generated during incub...

journal_title：Endocrinology

authors： Chopra IJ,Wu SY,Nakamura Y,Solomon DH

更新日期：1978-04-01 00:00:00

abstract：:Diabetics have at least twice the risk of stroke and may show performance deficit in a wide range of cognitive domains. The mechanisms underlying this gradually developing end-organ damage may involve both vascular changes and direct damage to neuronal cells as a result of overproduction of superoxide by the respirato...

journal_title：Endocrinology

authors： Aragno M,Mastrocola R,Medana C,Restivo F,Catalano MG,Pons N,Danni O,Boccuzzi G

更新日期：2005-12-01 00:00:00

abstract：:The influences of mating on serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were evaluated in 4-day cyclic proestrous rats of the Wistar strain. Blood samples were collected via guillotine from mated and unmated controls at 1900-2000 h or 2100--2200 h. Serum LH levels were determined by tw...

journal_title：Endocrinology

authors： Moss RL,Dudley CA,Schwartz NB

更新日期：1977-02-01 00:00:00

abstract：:The secretion of neurohypophyseal hormone and ACTH in the rat has been shown to exhibit circadian rhythms, with high values during the day and low values throughout the night. The neurohypophyseal hormone daily rhythm is altered by exposure to constant light and by pinealectomy. It was, thus, proposed that the observe...

journal_title：Endocrinology

authors： Yasin SA,Costa A,Besser GM,Hucks D,Grossman A,Forsling ML

更新日期：1993-03-01 00:00:00

abstract：:There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. ...

journal_title：Endocrinology

authors： França LR,Suescun MO,Miranda JR,Giovambattista A,Perello M,Spinedi E,Calandra RS

更新日期：2006-03-01 00:00:00

abstract：:Brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are present in brain regions regulating LH secretion. Similarities in the molecular structure of these peptides suggest similar physiological function within the brain. This study examined the effects of centrally administered BNP and ANP on LH secre...

journal_title：Endocrinology

authors： Zhang J,Yuen BH,Currie WD,Leung PC

更新日期：1991-08-01 00:00:00

abstract：:Testosterone propionate causes a striking increase in in vivo uptake of 2-deoxyglucose by the levator ani muscle of immature male rats. Autoradiography showed the labeled 2-deoxyglucose to be uniformly distributed over the entire muscle. Liquid scintillation counting of whole muscles allowed quantification of 2-deoxyg...

journal_title：Endocrinology

authors： Max SR,Toop J

更新日期：1983-07-01 00:00:00

abstract：:The crystal structure of human CG reveals that each subunit is a member of the superfamily of cystine-knot growth factors. Although the distribution of the cysteine residues in all the beta-subunits is conserved, the conformation of the human FSH dimer differs from that of the CG/LH dimers. This suggests that the func...

journal_title：Endocrinology

authors： Hiro'oka T,Maassen D,Berger P,Boime I

更新日期：2000-12-01 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha) and IL-1 beta bind to either the p80 type I IL-1 receptor (IL-1RI) or the p68 type II IL-1R (IL-1RII) on both T and B lymphocytes. We and others have previously shown that the anterior pituitary gland also has specific high affinity binding sites for IL-1 alpha (Kd = approximately 1 nM...

journal_title：Endocrinology

authors： French RA,Zachary JF,Dantzer R,Frawley LS,Chizzonite R,Parnet P,Kelley KW

更新日期：1996-09-01 00:00:00

abstract：:Estradiol (E(2)) rapidly and strongly induces vascular endothelial growth factor (VEGF) transcription in uterine endometrial epithelial cells in vivo. We have shown that this is mediated by both the estrogen receptor-alpha and hypoxia-inducible factor (HIF)-1alpha. By contrast, E(2) induces little or no VEGF expressio...

journal_title：Endocrinology

authors： Molitoris KH,Kazi AA,Koos RD

更新日期：2009-12-01 00:00:00

abstract：:Limited proteolysis in vivo of insulin-like growth factor-binding protein-3 (IGFBP-3) by as yet unidentified serine proteases plays a key role in controlling the bioavailability of IGFBP-3-associated insulin-like growth factors (IGFs). Both the IGF system and the system of plasminogen activators (PAs) and their inhibi...

journal_title：Endocrinology

authors： Lalou C,Silve C,Rosato R,Segovia B,Binoux M

更新日期：1994-12-01 00:00:00

abstract：:In a previous paper, we demonstrated that an inhibitory action of excess iodide on thyrotropin-induced thyroid hormone secretion occurs at a site subsequent to the generation of cyclic AMP. In the present study, however, we have found that thyroidal cyclic AMP formation induced by thyrotropin in vitro was markedly inh...

journal_title：Endocrinology

authors： Hashizume K,Akasu F,Takazawa K,Endo W,Onaya T

更新日期：1976-12-01 00:00:00

abstract：:Anandamide and 2-arachidonoylglycerol (2-AG), two endogenous ligands of the CB1 and CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast cancer cells (HBCCs) through down-regulation of the long form of the PRL receptor (PRLr). Here we report that 1) anandamide and 2-AG inhibit th...

journal_title：Endocrinology

authors： Melck D,De Petrocellis L,Orlando P,Bisogno T,Laezza C,Bifulco M,Di Marzo V

更新日期：2000-01-01 00:00:00

abstract：:IGF-I mediates growth-promoting actions of GH. In the present study we investigated whether the somatostatin analog octreotide blunts the stimulatory effects of GH and/or IGF-I on bone growth in hypophysectomized rats infused for 6 d with vehicle, GH, or IGF-I. We found that octreotide significantly suppressed the GH-...

journal_title：Endocrinology

authors： Zapf J,Gosteli-Peter M,Weckbecker G,Hunziker EB,Reinecke M

更新日期：2002-08-01 00:00:00

abstract：:Little is known about the mechanisms of action of polypeptide hormones on chromatin structure and nuclear function. We have employed micrococcal nuclease to examine the effect of TSH on the accessibility of DNA in thyroid nuclei. Brief digestion of nuclear suspensions with 0.05-0.2 U/ml micrococcal nuclease at 26-28 C...

journal_title：Endocrinology

authors： Abe Y,Cooper E,Spaulding SW

更新日期：1982-06-01 00:00:00

abstract：:The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the f...

journal_title：Endocrinology

authors： Lippert RN,Ellacott KL,Cone RD

更新日期：2014-05-01 00:00:00

abstract：:Recently, we demonstrated that estradiol (E(2)) modulates cross-talk between protein tyrosine kinases and norepinephrine (NE) receptor signaling in the hypothalamus (HYP) and preoptic area (POA), brain areas that govern female reproductive function. We are now investigating the identity of protein tyrosine kinase(s) t...

journal_title：Endocrinology

authors： Quesada A,Etgen AM

更新日期：2001-02-01 00:00:00

abstract：:The uterotropic response of the uterus to 17β-estradiol (E2) is genetically controlled, with marked variation observed depending on the mouse strain studied. Previous genetic studies from our laboratory using inbred mice that are high (C57BL6/J; B6) or low (C3H/HeJ; C3H) responders to E2 led to the identification of q...

journal_title：Endocrinology

authors： Wall EH,Case LK,Hewitt SC,Nguyen-Vu T,Candelaria NR,Teuscher C,Lin CY

更新日期：2014-08-01 00:00:00

abstract：:The influence of periparturient secretion of PRL on cytological differentiation of mammary epithelial cells was studied in 17 multiparous, monotocous Holstein cows. Mammary tissue was obtained 10 days prepartum and 10 days postpartum from untreated cows and from cows treated with CB154 (2-Br-alpha-ergokryptin) or CB15...

journal_title：Endocrinology

authors： Akers RM,Bauman DE,Goodman GT,Capuco AV,Tucker HA

更新日期：1981-07-01 00:00:00

abstract：:Both somatostatin (SRIF) and urotensin II, a dodecapeptide from the teleost caudal neurosecretory system, inhibit PRL release from the organ-cultured rostral pars distalis of the tilapia, Sarotherodon mossambicus, in a dose-related manner. The inhibitory action of SRIF on PRL release was completely prevented by the pr...

journal_title：Endocrinology

authors： Grau EG,Nishioka RS,Bern HA

更新日期：1982-03-01 00:00:00

abstract：:Estrogen unresponsiveness among primate species can result from overexpression of a heterogeneous nuclear ribonucleoprotein (hnRNP) that competes with estrogen receptor (ER) for binding to the estrogen-response element (ERE). This hnRNP has been coined the "ERE-binding protein" (ERE-BP). The ERE-BP is a member of the ...

journal_title：Endocrinology

authors： Chen H,Stuart W,Hu B,Nguyen L,Huang G,Clemens TL,Adams JS

更新日期：2005-10-01 00:00:00

abstract：:Bovine parathyroid organoids were maintained for up to 12 days of culture in the presence or absence of insulin. Insulin-treated organoids secreted more PTH and secretory protein-I (SP-I) than did untreated organoids at both 1.4 and 1.8 mM Ca, concentrations chosen to promote partially elevated and suppressed secretio...

journal_title：Endocrinology

authors： Hinton DA,MacGregor RR

更新日期：1991-01-01 00:00:00

abstract：:Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo; however, the nature of these effects and whether glucocorticoids act directly on cardiomyocytes are poorly understood. To explore the role of glucocorticoid signaling in the heart, we used rat embryonic H9C2 cardiomyocytes and...

journal_title：Endocrinology

authors： Ren R,Oakley RH,Cruz-Topete D,Cidlowski JA

更新日期：2012-11-01 00:00:00

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00

abstract：:T4 dynamically regulates the levels of type II iodothyronine 5'-deiodinase in the brain. Using an astrocyte cell culture model, we have shown that thyroxine increases inactivation of this enzyme through a mechanism using the actin cytoskeleton. In the absence of T4, the filamentous actin (F-actin) stress fibers are ab...

journal_title：Endocrinology

authors： Farwell AP,Leonard JL

更新日期：1992-08-01 00:00:00

abstract：:Isoproterenol, phenylephrine, and salbutamol (all 100 microM) induced the activity of tyrosine aminotransferase (TAT; EC 2.6.1.5) by 109%, 72%, and 141%, respectively, in organ culture of fetal human liver. Propranolol (100 microM) inhibited the effects of isoproterenol and phenylephrine. In organ culture of fetal rat...

journal_title：Endocrinology

authors： Andersson SM

更新日期：1983-02-01 00:00:00

abstract：:In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits and are insensitive to bicuculline. However, molecular and functional evidence for the presence of GABA(C) receptors outside...

journal_title：Endocrinology

authors： Boue-Grabot E,Taupignon A,Tramu G,Garret M

更新日期：2000-05-01 00:00:00

abstract：:The DHCR24 gene encodes an enzyme catalyzing the last step of cholesterol biosynthesis, the conversion of desmosterol to cholesterol. To elucidate the physiological significance of cholesterol biosynthesis in mammalian cells, we investigated proliferation of mouse embryonic fibroblasts (MEFs) prepared from DHCR24(-/-)...

journal_title：Endocrinology

authors： Lu X,Kambe F,Cao X,Yoshida T,Ohmori S,Murakami K,Kaji T,Ishii T,Zadworny D,Seo H

更新日期：2006-06-01 00:00:00

abstract：:Angiotensin II binds to the angiotensin II receptors type 1 (AT1 receptors) in adrenocortical cells and triggers an intracellular signaling cascade leading to changes in the gene expression pattern. Here, we show that stimulation with angiotensin II induces the expression of biologically active early growth response (...

journal_title：Endocrinology

authors： Thiel G,Rössler OG

更新日期：2011-11-01 00:00:00