Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice.

abstract：:The response of purified rat testicular peritubular myoid cells (PMC) to platelet-derived growth factor (PDGF) was studied. Freshly isolated PMC were devoid of measurable amounts of PDGF-binding sites. However, after 1 day in culture in serum-free conditions, specific high affinity receptors were detected. The estimat...

journal_title：Endocrinology

authors： Gnessi L,Emidi A,Scarpa S,Palleschi S,Ragano-Caracciolo M,Silvestroni L,Modesti A,Spera G

更新日期：1993-10-01 00:00:00

abstract：:Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an antiadrenergic/nitric oxide-cGMP mediated mechanism. Whether these phenomena are related is unknown. We here investigated whether and to what extent ...

journal_title：Endocrinology

authors： Pasqua T,Corti A,Gentile S,Pochini L,Bianco M,Metz-Boutigue MH,Cerra MC,Tota B,Angelone T

更新日期：2013-09-01 00:00:00

abstract：:The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bmal1 can disrupt adrenal clock function. The requirement of the adrenal...

journal_title：Endocrinology

authors： Engeland WC,Massman L,Mishra S,Yoder JM,Leng S,Pignatti E,Piper ME,Carlone DL,Breault DT,Kofuji P

更新日期：2018-12-01 00:00:00

abstract：:The role of adrenergic stimulation in the regulation of mitogen-activated protein kinase (MAPK) in rat pinealocytes was investigated by measuring phosphorylated MAPK using Western blot analysis and a MAPK enzymatic assay. Stimulation with the endogenous neurotransmitter, norepinephrine (NE; a mixed alpha- and beta-adr...

journal_title：Endocrinology

authors： Ho AK,Chik CL

更新日期：2000-12-01 00:00:00

abstract：:The anterior pituitary (AP) is made of five different cell types. The relative abundance and phenotype of AP cells may change in different physiological situations as an expression of pituitary plasticity. Here, we analyze in detail the phenotype of mouse corticotropes and the effects of acute cold stress on AP cell p...

journal_title：Endocrinology

authors： Senovilla L,Núñez L,Villalobos C,García-Sancho J

更新日期：2008-05-01 00:00:00

abstract：:PTH-related peptide (PTHrP) has been shown to be the major mediator of hypercalcemia of malignancy, but may also exert effects on cell growth and differentiation. The Leydig cell tumor H-500, when implanted in Fischer rats, produces abundant PTHrP and eventually causes the death of the host animal. In the present stud...

journal_title：Endocrinology

authors： Rabbani SA,Gladu J,Liu B,Goltzman D

更新日期：1995-12-01 00:00:00

abstract：:The present studies investigated whether insulin inhibits the stimulatory effect of dexamethasone (DEX) on angiotensinogen (ANG) gene expression and induction of hypertrophy in rat immortalized renal proximal tubular cells (IRPTCs) in a high-glucose milieu. Rat IRPTCs were cultured in monolayer. ANG and ANG mRNA expre...

journal_title：Endocrinology

authors： Zhang SL,Chen X,Wei CC,Filep JG,Tang SS,Ingelfinger JR,Chan JS

更新日期：2002-12-01 00:00:00

abstract：:The present studies examine the initial events in the action of PTH, namely receptor binding and adenylate cyclase activation in the postobstructed canine kidney. Both kidneys were removed from five mongrel dogs 2 h after relief of unilateral ureteral obstruction (UUO) of 42 h duration. Basolateral membranes (BLM) wer...

journal_title：Endocrinology

authors： Stokes TJ,Martin KJ,Klahr S

更新日期：1985-03-01 00:00:00

abstract：:QRFP, an RFamide peptide, was recently identified as an endogenous ligand of an orphan G protein-coupled receptor, GPR103. Recent investigation revealed that acute intracerebroventricular (ICV) administration of QRFP26/P518/26RFa, a constitutive part of QRFP43 (43-amino acid-residue form of QRFP), increases appetite i...

journal_title：Endocrinology

authors： Moriya R,Sano H,Umeda T,Ito M,Takahashi Y,Matsuda M,Ishihara A,Kanatani A,Iwaasa H

更新日期：2006-06-01 00:00:00

abstract：:cAMP has been shown to mediate the response of the parathyroid gland to a number of agonists and appears to take part in the regulation of this gland by divalent cations as well. We have studied the effects of the concentrations of free magnesium (Mg+2) and ionic calcium (Ca+2) on the kinetic properties of normal porc...

journal_title：Endocrinology

authors： Oldham SB,Rude RK,Molloy CT,Lipson LG

更新日期：1984-11-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) has been localized to the anterior pituitary, specifically to the lactotroph and somatotroph cell populations, by our previous studies. Since pituitary lactotrophs are known to undergo growth in response to estrogens, we have used an estradiol-induced pituitary hyperplasia/...

journal_title：Endocrinology

authors： Borgundvaag B,Kudlow JE,Mueller SG,George SR

更新日期：1992-06-01 00:00:00

abstract：:Thyroid hormones (THs) are charged and iodinated amino acid derivatives that need to pass the cell membrane facilitated by thyroid hormone transmembrane transporters (THTT) to exert their biological function. The importance of functional THTT is affirmed by the devastating effects of mutations in the human monocarboxy...

journal_title：Endocrinology

authors： Johannes J,Jayarama-Naidu R,Meyer F,Wirth EK,Schweizer U,Schomburg L,Köhrle J,Renko K

更新日期：2016-04-01 00:00:00

abstract：:We looked for the presence of vitamin D-dependent intestinal calcium binding protein (CaBP), relative molecular mass (mol wt) about 10,000, in kidneys of mammals, birds, and reptiles, and compared the localization of this 10,000 mol wt CaBP with the localization of the 28,000 mol wt vitamin D-dependent CaBP. Antiserum...

journal_title：Endocrinology

authors： Rhoten WB,Bruns ME,Christakos S

更新日期：1985-08-01 00:00:00

abstract：:Estrogen has wide-ranging and complex effects on the reproductive axis, which are often difficult to interpret from in vivo studies. Estrogen negatively regulates tonic GnRH synthesis and also plays a pivotal role in the positive regulation of GnRH necessary for the preovulatory surge. To dissect the mechanisms by whi...

journal_title：Endocrinology

authors： Roy D,Angelini NL,Belsham DD

更新日期：1999-11-01 00:00:00

abstract：:The inhibitory effect of stress on reproductive function is potentially mediated by high concentrations of circulating glucocorticoids (GCs) acting via the GC receptor (GR). Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion. GnIH may mediate stress-induced repro...

journal_title：Endocrinology

authors： Son YL,Ubuka T,Narihiro M,Fukuda Y,Hasunuma I,Yamamoto K,Belsham DD,Tsutsui K

更新日期：2014-05-01 00:00:00

abstract：:Physiological concentrations of L-T4 were found previously to stimulate Ca2+-ATPase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. In these previous studies, preincubation of intact cells or ghosts with testosterone (5 X 10(-11) M) conve...

journal_title：Endocrinology

authors： Lawrence WD,Osawa YM,Davis PJ,Blas SD

更新日期：1986-12-01 00:00:00

abstract：:The rate at which the estrogen receptor (ER) is synthesized and degraded (turns over) in target cells is a major factor regulating the levels of ER and cell sensitivity to estrogen. We have used the ability of tamoxifen aziridine [(TAZ)(Z)-1-[4-(2-[N-aziridinyl]ethoxy)phenyl]1,2-diphenyl-1-buten e] to affinity label t...

journal_title：Endocrinology

authors： Nardulli AM,Katzenellenbogen BS

更新日期：1986-11-01 00:00:00

abstract：:Ghrelin is an acylated peptide recently isolated from rat stomach that potently stimulates GH release in vitro and in vivo in rat and man. Ghrelin specifically activates the receptor for the growth hormone secretagogues (GHS-Rla), and it has been proposed as the endogenous ligand mimicked by these synthetic compounds....

journal_title：Endocrinology

authors： Torsello A,Ghe' C,Bresciani E,Catapano F,Ghigo E,Deghenghi R,Locatelli V,Muccioli G

更新日期：2002-05-01 00:00:00

abstract：:Agouti-related protein (AGRP) is a homologue of the agouti gene product and, when overexpressed, promotes obesity. Like neuropeptide Y (NPY) messenger RNA (mRNA), AGRP mRNA is produced in the hypothalamic arcuate nucleus and is elevated in leptin-deficient ob/ob and leptin-resistant db/db mice. These data suggest that...

journal_title：Endocrinology

authors： Mizuno TM,Mobbs CV

更新日期：1999-02-01 00:00:00

abstract：:Glucose release from the liver is mediated by hypothalamic norepinephrine (NE) neuronal activity, but glucose itself (or a metabolite of it) exerts negative feedback effects on central NE activity. The aim of the present study was to investigate a possible role for insulin in these central glucose homeostatic mechanis...

journal_title：Endocrinology

authors： Smythe GA,Bradshaw JE,Nicholson MV,Grunstein HS,Storlien LH

更新日期：1985-10-01 00:00:00

abstract：:The quantitative light microscope radioautographic approach was utilized to locate specific binding sites for blood-borne 125I-labeled ACTH1-24 in the rat brain. Specific binding occurred exclusively in the external zone of the median eminence, adjacent to the primary portal plexus, and to a lesser extent in the ventr...

journal_title：Endocrinology

authors： van Houten M,Khan MN,Khan RJ,Posner BI

更新日期：1981-06-01 00:00:00

abstract：:A study was conducted to determine the role of the thyroid gland in three neuroendocrine responses to photoperiod; secretion of melatonin, PRL, and LH. Ewes were thyroidectomized (THX) in midsummer or left thyroid intact, and both groups were moved indoors to artificial short days (8 h of light, 16 h of darkness) for ...

journal_title：Endocrinology

authors： Dahl GE,Evans NP,Moenter SM,Karsch FJ

更新日期：1994-07-01 00:00:00

abstract：:The hypothalamic hormone, GnRH, is released and transported to the anterior pituitary in a pulsatile manner, where it binds to specific high-affinity receptors and regulates gonadotropin biosynthesis and secretion. The frequency of GnRH pulses changes under various physiological conditions, and varying GnRH pulse freq...

journal_title：Endocrinology

authors： Kaiser UB,Jakubowiak A,Steinberger A,Chin WW

更新日期：1997-03-01 00:00:00

abstract：:The lipolysis, ketosis and hypertriglyceridemia of fasted rats in late pregnancy may be related to decreased insulin secretion geared to decreased glucose availability. In odd-carbon fatty acid enriched (OCE) rats, the odd-carbon fatty acids (OCFA) mobilized during fasting provide terminal three-carbon residues which ...

journal_title：Endocrinology

authors： Kim S,Pi-Sunyer FX

更新日期：1977-02-01 00:00:00

abstract：:The effect of naloxone (N-allylnoroxymorphone), a narcotic antagonist, on the morphine blockade of ovulation was studied. Female rats were treated with morphine (50 mg/kg) at the critical period, resulting in ovulatory blockade. The administration of naloxone (0.5 mg/kg) effectively reversed the anti-ovulatory effect ...

journal_title：Endocrinology

authors： Packman PM,Rothchild JA

更新日期：1976-07-01 00:00:00

abstract：:Elucidation of the role of Ca2+ in the secretion of insulin and glucagon is complicated by the presence of different types of cells in the pancreatic islets. Visualization of calcium in sections of guinea pig pancreas with the histochemical reagent glyoxal bis-2-hydroxyanil revealed the most intense staining in the en...

journal_title：Endocrinology

authors： Berggren PO,Ostenson CG,Petersson B,Hellman B

更新日期：1979-12-01 00:00:00

abstract：:Cathepsin-D has been previously reported to cleave intact PTH into PTH-(1-34) and -(35-84) in membranous fractions of rat and bovine kidney. Whether PTH degradation occurs by intact kidney cells, however, has not been examined in detail. We have, therefore, examined this possibility using an opossum kidney (OK) cell l...

journal_title：Endocrinology

authors： Yamaguchi T,Fukase M,Nishikawa M,Fujimi T,Fujita T

更新日期：1988-12-01 00:00:00

abstract：:In an attempt to further define the optimum experimental conditions for the in vitro study of PRL endocrinology, the effect of extracellular leucine concentration on PRL secretion was assessed. Rat pituitary cells, maintained in short term monolayer culture, were washed free of serum and placed in Minimum Essential Me...

journal_title：Endocrinology

authors： Cross M,Walker AM

更新日期：1984-01-01 00:00:00

abstract：:Previous studies have provided evidence that tumors associated with humoral hypercalcemia of malignancy produce a factor that shares certain biological properties with, but is not, native PTH. In the present study, media from Xenopus oocytes microinjected with polyadenylated RNA prepared from three human or animal tum...

journal_title：Endocrinology

authors： Broadus AE,Goltzman D,Webb AC,Kronenberg HM

更新日期：1985-10-01 00:00:00

abstract：:Important enzymes for thyroid hormone metabolism, antioxidative defense, and intracellular redox control contain selenocysteine (Sec) in their active centers. Expression of these selenoproteins is tightly controlled, and a sex-specific phenotype is observed on disturbance of selenium (Se) transport in mice. Therefore,...

journal_title：Endocrinology

authors： Riese C,Michaelis M,Mentrup B,Götz F,Köhrle J,Schweizer U,Schomburg L

更新日期：2006-12-01 00:00:00