The inhibitory effect of acute administration of excess iodide on the formation of adenosine 3', 5'-monophosphate induced by thyrotropin in mouse thyroid lobes.

abstract：:We previously reported that TNF-alpha-induced apoptosis of lactotropes is estrogen dependent and predominant at proestrus. Here we observed that TNF-alpha (50 ng/ml) failed to induce apoptosis of anterior pituitary cells from ovariectomized rats cultured in the presence of progesterone (10(-6) m). However, progesteron...

journal_title：Endocrinology

authors： Candolfi M,Jaita G,Zaldivar V,Zárate S,Ferrari L,Pisera D,Castro MG,Seilicovich A

更新日期：2005-02-01 00:00:00

abstract：:The GH/IGF-I axis has both pre- and postpubertal metabolic effects. However, the differential effects of GH and/or IGF-I on animal physiology or the plasma proteome are still being unraveled. In this report, we analyzed several physiological effects along with the plasma proteome after treatment of mice with recombina...

journal_title：Endocrinology

authors： Ding J,List EO,Bower BD,Kopchick JJ

更新日期：2011-10-01 00:00:00

abstract：:Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...

journal_title：Endocrinology

authors： Akhter N,Odle AK,Allensworth-James ML,Haney AC,Syed MM,Cozart MA,Chua S,Kineman R,Childs GV

更新日期：2012-10-01 00:00:00

abstract：:The lactogen-dependent rat Nb2 lymphoma is a useful model to investigate PRL signaling pathways that lead to regulation of gene transcription. A primary mechanism coupled to PRL receptor (PRLR) activation in Nb2 cells involves phosphorylation by Jak-family tyrosine kinases of one or more signal transducers and activat...

journal_title：Endocrinology

authors： Borg KE,Zhang M,Hegge D,Stephen RL,Buckley DJ,Magnuson NS,Buckley AR

更新日期：1999-12-01 00:00:00

abstract：:We have investigated the ability of fetal rat skin to heal an excisional wound in vitro. Skin from the backs of E17-E19 rats was wounded using a 1-mm diameter cutting needle and suspended in culture on a 6-pin cradle for 72 h. Neither contraction nor epithelial closure was observed within wounds created in skin from E...

journal_title：Endocrinology

authors： Belford DA

更新日期：1997-09-01 00:00:00

abstract：:The metabolic consequences of visceral obesity have been associated with amplification of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in adipose tissue. This study aimed to assess in a rat model of diet-induced obesity the effects of pharmacological 11beta-HSD1 inhibition on the m...

journal_title：Endocrinology

authors： Berthiaume M,Laplante M,Festuccia W,Gélinas Y,Poulin S,Lalonde J,Joanisse DR,Thieringer R,Deshaies Y

更新日期：2007-05-01 00:00:00

abstract：:Calcitonin (CT) and related peptides, such as CT gene-related peptide and salmon CT (sCT)-like peptide, are present in the rat nervous system and the pituitary gland, and sCT markedly inhibits basal and TRH-stimulated PRL release from anterior pituitary (AP) cells. Because TRH-induced PRL release is known to involve i...

journal_title：Endocrinology

authors： Shah GV,Kennedy D,Dockter ME,Crowley WR

更新日期：1990-08-01 00:00:00

abstract：:Pulsatile release of GnRH-1 is critical to stimulate gonadotropes of the anterior pituitary. This secretory pattern seems to be inherent to GnRH-1 neurons, however, the mechanisms underlying such episodical release remain unknown. In monkey nasal explants, the GnRH-1 population exhibits synchronized calcium events wit...

journal_title：Endocrinology

authors： Constantin S,Caraty A,Wray S,Duittoz AH

更新日期：2009-07-01 00:00:00

abstract：:Dysregulation of the hypothalamic-pituitary-adrenocortical axis has been theoretically linked to the processes of aging for decades. To investigate the effects of age on high frequency rhythms of plasma ACTH at the time of circadian activation, integrated 2-min blood samples were collected over 4 h in 10 young and 14 ...

journal_title：Endocrinology

authors： Carnes M,Goodman BM,Lent SJ,Vo H

更新日期：1993-08-01 00:00:00

abstract：:Obesity and its associated comorbidities are of major worldwide concern. It is now recognized that there are a number of metabolically distinct pathways of obesity development. The present paper investigates the effect of moderate daily exercise on the underlying mechanisms of one such pathway to obesity, through inte...

journal_title：Endocrinology

authors： Miles JL,Huber K,Thompson NM,Davison M,Breier BH

更新日期：2009-01-01 00:00:00

abstract：:Centrally administered histamine (HA) stimulates the secretion of adenohypophysial POMC-derived peptides, which subsequently cause release of corticosterone. The effect of HA on POMC-derived peptide release is indirect, and it is possible that hypothalamic neurons containing corticotropin-releasing hormone (CRH), argi...

journal_title：Endocrinology

authors： Kjaer A,Larsen PJ,Knigge U,Warberg J

更新日期：1994-09-01 00:00:00

abstract：:An in vitro system which uses perifused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 x 10-7M) had no effect on basal gastrin levels but ...

journal_title：Endocrinology

authors： Hayes JR,Johnson DG,Koerker D,Williams RH

更新日期：1975-06-01 00:00:00

abstract：:The rate at which the estrogen receptor (ER) is synthesized and degraded (turns over) in target cells is a major factor regulating the levels of ER and cell sensitivity to estrogen. We have used the ability of tamoxifen aziridine [(TAZ)(Z)-1-[4-(2-[N-aziridinyl]ethoxy)phenyl]1,2-diphenyl-1-buten e] to affinity label t...

journal_title：Endocrinology

authors： Nardulli AM,Katzenellenbogen BS

更新日期：1986-11-01 00:00:00

abstract：:The endocrine-disrupting chemical bisphenol A (BPA) increases adipose tissue mass in vivo and promotes adipogenesis in vitro; however, mechanisms explaining BPA's obesogenic effect remain unknown. We investigated the effects of gestational BPA and its analog, bisphenol S (BPS), exposure on the adipogenic differentiati...

journal_title：Endocrinology

authors： Pu Y,Gingrich JD,Steibel JP,Veiga-Lopez A

更新日期：2017-11-01 00:00:00

abstract：:The developmental appearance and regulation of hypothalamic vasopressin (prepropressophysin) mRNA was studied using quantitated in situ hybridization techniques. Vasopressin mRNA levels in the supraoptic nuclei were reliably detected on day 16 of gestation, while mRNA in the suprachiasmatic nuclei (SCN) was detectable...

journal_title：Endocrinology

authors： Reppert SM,Uhl GR

更新日期：1987-06-01 00:00:00

abstract：:In the spiny dogfish (Squalus acanthias), germ cells and adjacent steroidogenic elements are topographically segregated within the testis according to stage of development. In the experiments reported here, we have taken advantage of this favorable anatomical arrangement to demonstrate stage-specific variations in ste...

journal_title：Endocrinology

authors： Callard GV,Pudney JA,Mak P,Canick JA

更新日期：1985-10-01 00:00:00

abstract：:The main objectives of the present study were to investigate the effects of 6-n-propyl-2-thiouracil (PTU) on Sertoli cell proliferation, germ cell number, and testis size in Nile tilapias (Oreochromis niloticus). In this regard, young fish (approximately 1 g BW and approximately 3.5 cm total in length) were treated fo...

journal_title：Endocrinology

authors： Matta SL,Vilela DA,Godinho HP,França LR

更新日期：2002-03-01 00:00:00

abstract：:Cortisol in concentrations similar to the unbound levels of the hormone in human plasma can reverse the inhibition of vascular reactivity produced by prolactin. In the rat mesenteric vascular bed, cortisol alone in similar concentrations had no significant effect on the pressor responses to norepinephrine: the action ...

journal_title：Endocrinology

authors： Horrobin DF,Mtabaji JP,Manku MS

更新日期：1976-08-01 00:00:00

abstract：:Although leptin is a hormone mainly produced by the adipose tissue, it is also produced by the gastric mucosa and the mammary epithelium and is present in maternal milk. The effects of milk leptin on the neonate are not known. The purpose of the investigation was to evaluate the short-term effects of the administratio...

journal_title：Endocrinology

authors： Sánchez J,Oliver P,Miralles O,Ceresi E,Picó C,Palou A

更新日期：2005-06-01 00:00:00

abstract：:Childhood obesity increases the risk of adult obesity and diabetes, suggesting that early overnutrition permanently programs altered energy and glucose homeostasis. In the present studies, we used a mouse model to investigate whether early overnutrition increases susceptibility to obesity and insulin resistance in res...

journal_title：Endocrinology

authors： Glavas MM,Kirigiti MA,Xiao XQ,Enriori PJ,Fisher SK,Evans AE,Grayson BE,Cowley MA,Smith MS,Grove KL

更新日期：2010-04-01 00:00:00

abstract：:Chronically elevated circulating glucocorticoid levels are although to enhance vulnerability to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge in the...

journal_title：Endocrinology

authors： Sarabdjitsingh RA,Isenia S,Polman A,Mijalkovic J,Lachize S,Datson N,de Kloet ER,Meijer OC

更新日期：2010-03-01 00:00:00

abstract：:During the third week of postnatal life, dramatic ontogenic changes occur in the morphology and enzymology of the small intestine of the infant rat, enabling the animal to make the transition from milk to solid food. To investigate the roles of T4 and GH in regulation of these changes, infant rats were hypophysectomiz...

journal_title：Endocrinology

authors： Castillo RO,Glasscock GF,Noren KM,Reisenauer AM

更新日期：1991-09-01 00:00:00

abstract：:Dispersed Leydig cells were prepared from pig testes and purified in a discontinuous Percoll gradient. About 95% of these cells stained for 3 beta-hydroxysteroid dehydrogenase. The cells were cultured in a chemically defined medium. Testosterone production was low (2 +/- 0.4 ng/10(6) cells/day) under basal conditions,...

journal_title：Endocrinology

authors： Benahmed M,Reventos J,Saez JM

更新日期：1983-06-01 00:00:00

abstract：:The mechanism of mitogen-activated protein kinase (MAPK, ERK) stimulation by the GnRH analog [D-Trp6]GnRH (GnRH-a) was investigated in the gonadotroph-derived alphaT3-1 cell line. GnRH-a as well as the protein kinase C (PKC) activator 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated a sustained response of MAPK ...

journal_title：Endocrinology

authors： Reiss N,Llevi LN,Shacham S,Harris D,Seger R,Naor Z

更新日期：1997-04-01 00:00:00

abstract：:Heart failure is a leading cause of death, especially in the elderly or obese and diabetic populations. Various remodeling events have been characterized, which collectively contribute to the progression of heart failure. Of particular interest, autophagy has recently emerged as an important determinant of cardiac rem...

journal_title：Endocrinology

authors： Jahng JW,Turdi S,Kovacevic V,Dadson K,Li RK,Sweeney G

更新日期：2015-07-01 00:00:00

abstract：:The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...

journal_title：Endocrinology

authors： Weisinger RS,Blair-West JR,Burns P,Denton DA,Purcell B,Vale W,Rivier J,Weisinger HS,May CN

更新日期：2004-12-01 00:00:00

abstract：:Both the estrogen responsiveness and -binding capacity of cultured rat uterine cells were decreased dramatically when the medium was not changed at 24-h intervals. Treatment of cells for 24 h with 1 nM 17 beta-estradiol in fresh medium led to a 3-fold increase in progesterone receptor concentration, but without fresh ...

journal_title：Endocrinology

authors： Kassis JA,Walent JH,Gorski J

更新日期：1984-08-01 00:00:00

abstract：:The aim of this study was to determine whether bisphenol A (BPA) has adverse effects on cardiovascular functions in CD-1 mice and define sex-specific modes of BPA action in the heart. Dams and analyzed progeny were maintained on a defined diet containing BPA (0.03, 0.3, 3, 30, or 300 ppm) that resulted in BPA exposure...

journal_title：Endocrinology

authors： Belcher SM,Gear RB,Kendig EL

更新日期：2015-03-01 00:00:00

abstract：:Angiogenic factors, including vascular endothelial growth factor (VEGF), are expressed during follicular development. Our objective was to investigate the role of VEGF in the early follicular phase to test whether early cyclic follicle development and selection are angiogenesis-dependent processes. After documentation...

journal_title：Endocrinology

authors： Zimmermann RC,Xiao E,Bohlen P,Ferin M

更新日期：2002-07-01 00:00:00

abstract：:Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses. The expression of functional leptin receptors (OB-Rb) was detected in vascular smooth muscle cells (VSMCs) from adult W...

journal_title：Endocrinology

authors： Fortuño A,Rodríguez A,Gómez-Ambrosi J,Muñiz P,Salvador J,Díez J,Frühbeck G

更新日期：2002-09-01 00:00:00