Estrogen receptors in rat uterine cell cultures: effects of medium on receptor concentration.

abstract：:This study analyzes the role of the autonomic nervous system, the pituitary gland, ACTH, dexamethasone (DEX), and thyroid hormones in the regulation of 5'deiodinase (5'D) in the hypothalamus (HP) and adrenal gland (AG) of the rat. 5'D activity was analyzed in rats under basal conditions (22 C) and during cold exposure...

journal_title：Endocrinology

authors： Anguiano B,Quintanar A,Luna M,Navarro L,Ramírez del Angel A,Pacheco P,Valverde C

更新日期：1995-08-01 00:00:00

abstract：:GH promotes not only longitudinal growth in children but is active throughout life in protein, fat, and carbohydrate metabolism. The multiple actions of GH start when GH binds to the cell surface-expressed GH receptor. Effectiveness of the hormone depends both on its presence in the circulation and the availability of...

journal_title：Endocrinology

authors： van Kerkhof P,Smeets M,Strous GJ

更新日期：2002-04-01 00:00:00

abstract：:Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...

journal_title：Endocrinology

authors： Leech CA,Holz GG 4th,Habener JF

更新日期：1994-07-01 00:00:00

abstract：:Vascularly perfused duodenal loops from normal vitamin D-replete chicks were used to obtain insight with regards to the possible mechanism(s) by which 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] rapidly stimulates intestinal Ca2+ transport (transcaltachia). The phorbol ester, 12-o-tetradecanoyl phorbol-13 acetate (TPA) (1...

journal_title：Endocrinology

authors： de Boland AR,Norman A

更新日期：1990-07-01 00:00:00

abstract：:Vitamin D deficiency is associated with a range of muscle disorders, including myalgia, muscle weakness, and falls. In humans, polymorphisms of the vitamin D receptor (VDR) gene are associated with variations in muscle strength, and in mice, genetic ablation of VDR results in muscle fiber atrophy and motor deficits. H...

journal_title：Endocrinology

authors： Girgis CM,Mokbel N,Cha KM,Houweling PJ,Abboud M,Fraser DR,Mason RS,Clifton-Bligh RJ,Gunton JE

更新日期：2014-09-01 00:00:00

abstract：:cAMP has been shown to mediate the response of the parathyroid gland to a number of agonists and appears to take part in the regulation of this gland by divalent cations as well. We have studied the effects of the concentrations of free magnesium (Mg+2) and ionic calcium (Ca+2) on the kinetic properties of normal porc...

journal_title：Endocrinology

authors： Oldham SB,Rude RK,Molloy CT,Lipson LG

更新日期：1984-11-01 00:00:00

abstract：:The androgen receptor (AR) in Sertoli cells mediates the actions of testosterone on spermatogenesis. However, the transcription factors responsible for AR gene regulation in Sertoli cells remain unknown. In this study, we determined that nuclear factor-kappaB (NF-kappaB) regulates transcription of AR in primary cultur...

journal_title：Endocrinology

authors： Zhang L,Charron M,Wright WW,Chatterjee B,Song CS,Roy AK,Brown TR

更新日期：2004-02-01 00:00:00

abstract：:Although it is known that LH secretion starts at 17 days of gestation in the fetal rat and that this first LH release is most likely driven by hypothalamic GnRH, an earlier role for GnRH during fetal life has been postulated with the observation that presence of GnRH is important before day 13 of gestation for the dif...

journal_title：Endocrinology

authors： Aubert ML,Begeot M,Winiger BP,Morel G,Sizonenko PC,Dubois PM

更新日期：1985-04-01 00:00:00

abstract：:The intraislet insulin hypothesis has been proposed to explain absent glucagon responses to hypoglycemia. Recently we directly confirmed this hypothesis by restoring glucagon secretion via provision of a pancreatic artery insulin infusion, which was switched off at the time of hypoglycemia in Wistar rats made diabetic...

journal_title：Endocrinology

authors： Zhou H,Zhang T,Oseid E,Harmon J,Tonooka N,Robertson RP

更新日期：2007-06-01 00:00:00

abstract：:We have examined expression of the chicken PRL receptor (cPRLR) gene in different tissues of the chicken by Northern blot analysis. Most tissues examined (ovary, testis, oviduct, kidney, and fat) possess a prominent full-length (4.6-kb) cPRLR transcript. A larger (11.7-kb) transcript is also detected in ovary, oviduct...

journal_title：Endocrinology

authors： Mao JN,Burnside J,Li L,Tang J,Davolos C,Cogburn LA

更新日期：1999-03-01 00:00:00

abstract：:In situ hybridization detected a transient, sex-specific transcription of somatostatin gene in the central part of the rat medial preoptic nucleus, which coincides with the sexually dimorphic nucleus of the preoptic area (SDN-POA), during, but not after, the establishment of sex difference. On postnatal d 1 (day of bi...

journal_title：Endocrinology

authors： Orikasa C,Kondo Y,Sakuma Y

更新日期：2007-03-01 00:00:00

abstract：:Early-life experiences, including maternal interaction, profoundly influence hormonal stress responses during adulthood. In rats, daily handling during a critical neonatal period leads to a significant and permanent modulation of key molecules that govern hormonal secretion in response to stress. Thus, hippocampal glu...

journal_title：Endocrinology

authors： Avishai-Eliner S,Eghbal-Ahmadi M,Tabachnik E,Brunson KL,Baram TZ

更新日期：2001-01-01 00:00:00

abstract：:The Src homology 2-containing tyrosine phosphatase, Shp-2, is a crucial enzyme that mediates intracellular signaling and is implicated in cell proliferation and differentiation. Here we investigated the involvement of the Shp-2 tyrosine phosphatase in determining the downstream signaling pathways initiated by the Ret ...

journal_title：Endocrinology

authors： D'Alessio A,Califano D,Incoronato M,Santelli G,Florio T,Schettini G,Carlomagno MS,Cerchia L,de Franciscis V

更新日期：2003-10-01 00:00:00

abstract：:We recently described a novel GnRH receptor signaling pathway mediated by the prostaglandins (PGs) F(2alpha) and PGI(2), which acts through an autocrine/paracrine modality to limit autoregulation of the GnRH receptor and inhibit LH but not FSH release. Here we further explore the cross talk between GnRH and the PG rec...

journal_title：Endocrinology

authors： Naidich M,Shterntal B,Furman R,Pawson AJ,Jabbour HN,Morgan K,Millar RP,Jia J,Tomic M,Stojilkovic S,Stern N,Naor Z

更新日期：2010-06-01 00:00:00

abstract：:Split hand/foot malformation (SHFM) is syndromic ectrodactyly often associated with mental retardation and/or craniofacial defects. Several clinical reports previously described urogenital dysplasia such as micropenis, hypospadias, and small testis in SHFM patients. Genetic lesions in the Dlx5 and Dlx6 (Dlx5/6) locus ...

journal_title：Endocrinology

authors： Nishida H,Miyagawa S,Vieux-Rochas M,Morini M,Ogino Y,Suzuki K,Nakagata N,Choi HS,Levi G,Yamada G

更新日期：2008-05-01 00:00:00

abstract：:Estrogen increases the alpha 1-adrenergic contractile sensitivity of the rabbit uterus. Since estrogen treatment increases prostaglandin (PG) production by the perfused rabbit uterus, and PGs contribute to the alpha 1-adrenergic contractile response, we postulated that estrogen's effects on PG production or response m...

journal_title：Endocrinology

authors： Hurd WW,Riemer RK,Goldfien A,Roberts JM

更新日期：1991-09-01 00:00:00

abstract：:Recent studies using twins and inbred strains of mice reveal evidence for genetic mechanisms contributing to variation in circulating levels of IGF-I, IGF-II, and IGF binding protein (IGFBP)-3. To examine the hypothesis that serum IGFBP-5 levels have a strong heritable component, we intercrossed two inbred strains of ...

journal_title：Endocrinology

authors： Mohan S,Masinde G,Li X,Baylink DJ

更新日期：2003-08-01 00:00:00

abstract：:The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Fur...

journal_title：Endocrinology

authors： Vendrell J,El Bekay R,Peral B,García-Fuentes E,Megia A,Macias-Gonzalez M,Fernández Real J,Jimenez-Gomez Y,Escoté X,Pachón G,Simó R,Selva DM,Malagón MM,Tinahones FJ

更新日期：2011-11-01 00:00:00

abstract：:The anterior pituitary (AP) is made of five different cell types. The relative abundance and phenotype of AP cells may change in different physiological situations as an expression of pituitary plasticity. Here, we analyze in detail the phenotype of mouse corticotropes and the effects of acute cold stress on AP cell p...

journal_title：Endocrinology

authors： Senovilla L,Núñez L,Villalobos C,García-Sancho J

更新日期：2008-05-01 00:00:00

abstract：:Chronic exposure to stressors impairs the function of multiple organ systems and has been implicated in increased disease risk. In the rodent, the chronic variable stress (CVS) paradigm has successfully modeled several stress-related illnesses. Despite striking disparities between men and women in the prevalence and e...

journal_title：Endocrinology

authors： Borrow AP,Bales NJ,Stover SA,Handa RJ

更新日期：2018-07-01 00:00:00

abstract：:Pituitary glands from ovariectomized F-344 rats bearing diethylstilbestrol-containing capsules for 70-100 days were dissociated and separated into three size classes by unit gravity sedimentation. The average percentage of large mammotrophs in fraction I was 86 +/- (SE) 2%, the percentage of intermediate-sized mammotr...

journal_title：Endocrinology

authors： Hymer WC,Motter KA

更新日期：1988-05-01 00:00:00

abstract：:Previous studies established a positive relationship between oocyte competence and follistatin mRNA abundance. Herein, we used the bovine model to test the hypothesis that follistatin plays a functional role in regulation of early embryogenesis. Treatment of early embryos with follistatin during in vitro culture (befo...

journal_title：Endocrinology

authors： Lee KB,Bettegowda A,Wee G,Ireland JJ,Smith GW

更新日期：2009-05-01 00:00:00

abstract：:Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues b...

journal_title：Endocrinology

authors： Karpuzoglu E,Fenaux JB,Phillips RA,Lengi AJ,Elvinger F,Ansar Ahmed S

更新日期：2006-02-01 00:00:00

abstract：:Beta-adrenergic agonists and antagonists are widely used in many clinical situations to regulate beta-adrenergic stimulation. However, responsiveness to beta-stimulation may be reduced by the process of desensitization. We have established an in vivo mammalian model system, the rat lung, to study the cellular and bioc...

journal_title：Endocrinology

authors： Strasser RH,Stiles GL,Lefkowitz RJ

更新日期：1984-10-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may be having its long-term pleiotropic effects through a hitherto unknow...

journal_title：Endocrinology

authors： Wang X,Cahill CM,Piñeyro MA,Zhou J,Doyle ME,Egan JM

更新日期：1999-10-01 00:00:00

abstract：:Recent work has implicated stimulatory kisspeptin neurons in the arcuate nucleus (ARC) as important for seasonal changes in reproductive function in sheep, but earlier studies support a role for inhibitory A15 dopaminergic (DA) neurons in the suppression of GnRH (and LH) pulse frequency in the nonbreeding (anestrous) ...

journal_title：Endocrinology

authors： Goodman RL,Maltby MJ,Millar RP,Hileman SM,Nestor CC,Whited B,Tseng AS,Coolen LM,Lehman MN

更新日期：2012-12-01 00:00:00

abstract：:In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium. Although FSH ...

journal_title：Endocrinology

authors： Tabraue C,Diaz Peñate R,Gallardo G,Hernandez I,Quintana J,Lopez Blanco F,Gonzalez Reyes J,Fanjul LF,Ruiz de Galarreta CM

更新日期：1997-01-01 00:00:00

abstract：:Glucocorticoids induce tyrosine aminotransferase (TAT) in hepatoma cells. We have previously shown that both the concentration of the agonist dexamethasone (Dex) required for half-maximal induction (EC50) and the amount of agonist activity produced by the antagonist dexamethasone 21-mesylate (Dex-Mes), expressed as a ...

journal_title：Endocrinology

authors： Oshima H,Simons SS Jr

更新日期：1992-04-01 00:00:00

abstract：:cAMP is involved in the regulation of secretory activity in lactotrope, thyrotrope, and gonadotrope cells. The present study examined whether pulsatile or intermittent changes in cAMP are more effective than a continuous stimulation in increasing pituitary hormone gene expression. Pituitaries from adult female rats we...

journal_title：Endocrinology

authors： Haisenleder DJ,Yasin M,Marshall JC

更新日期：1992-12-01 00:00:00

abstract：:Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites. We investigated the effects of dexamethasone on the biosynthesis and ...

journal_title：Endocrinology

authors： de Nadai F,Rovere C,Bidard JN,Laur J,Martinez J,Cuber JC,Kitabgi P

更新日期：1993-04-01 00:00:00