Heterogeneity in mammotrophs prepared from diethylstilbestrol-induced prolactinomas.

abstract：:Transforming growth factor-alpha (TGF alpha) has been localized to the anterior pituitary, specifically to the lactotroph and somatotroph cell populations, by our previous studies. Since pituitary lactotrophs are known to undergo growth in response to estrogens, we have used an estradiol-induced pituitary hyperplasia/...

journal_title：Endocrinology

authors： Borgundvaag B,Kudlow JE,Mueller SG,George SR

更新日期：1992-06-01 00:00:00

abstract：:The antithyroid drug 6-propylthiouracil (PTU) was previously shown in our laboratory to have an unexpectedly prolonged inhibitory effect on iodination in the thyroid glands of rats. Eighteen hours after injection of a relatively small dose, iodination in the thyroid remained inhibited by more than 90%. We previously s...

journal_title：Endocrinology

authors： Taurog A,Dorris ML

更新日期：1989-06-01 00:00:00

abstract：:Remodeling of maternal spiral arteries during pregnancy requires a subpopulation of extravillous cytotrophoblasts (EVTs) to differentiate into endovascular EVTs. Activin A, which is abundantly expressed at the maternal-fetal interface, has been shown to promote trophoblast invasion, but its role in endovascular differ...

journal_title：Endocrinology

authors： Li Y,Zhu H,Klausen C,Peng B,Leung PC

更新日期：2015-11-01 00:00:00

abstract：:Loss of circulating 17β-estradiol (E2) that occurs during menopause can have detrimental effects on cognitive function. The efficacy of hormone replacement therapy declines as women become farther removed from the menopausal transition, yet the molecular mechanisms underlying this age-related switch in E2 efficacy are...

journal_title：Endocrinology

authors： Shults CL,Pinceti E,Rao YS,Pak TR

更新日期：2015-11-01 00:00:00

abstract：:The structural requirements for the inhibition of net bone collagen synthesis by parathyroid hormone (PTH) in vitro have been examined by study of the effects of selected fragments and analogs of bovine PTH (bPTH) upon the incorporation of [3H]proline into collagenase-digestible and -nondigestible proteins by neonatal...

journal_title：Endocrinology

authors： Bringhurst FR,Potts JT Jr

更新日期：1981-01-01 00:00:00

abstract：:GH secretion is altered by exercise in humans. In an attempt to investigate the underlying mechanisms, we developed a rodent model. GH secretion was assayed in male and female rats that were sedentary (not exercised), acutely exercised, and chronically exercised. Sedentary males showed typical pulsatile GH secretion. ...

journal_title：Endocrinology

authors： Butkus JA,Brogan RS,Giustina A,Kastello G,Sothmann M,Wehrenberg WB

更新日期：1995-06-01 00:00:00

abstract：:The levels of beta 1- and beta 3-adrenoreceptor mRNAs in several rat tissues were determined simultaneously with a sensitive nuclease protection assay. The beta 1-receptor gene was expressed to varying degrees in most tissues examined. By contrast, high levels of beta 3-receptor mRNA were only found in brown and white...

journal_title：Endocrinology

authors： Granneman JG,Lahners KN

更新日期：1992-01-01 00:00:00

abstract：:To understand the physiological role of ghrelin, it is crucial to study both the actions of ghrelin and the regulation of ghrelin secretion. Although ghrelin actions have been extensively revealed, the direct factors regulating ghrelin secretion by ghrelin-producing cells (X/A-like cells), however, is not fully unders...

journal_title：Endocrinology

authors： Iwakura H,Ariyasu H,Hosoda H,Yamada G,Hosoda K,Nakao K,Kangawa K,Akamizu T

更新日期：2011-07-01 00:00:00

abstract：:Alpha-calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. Despite well-documented pharmacological effects, its primary physiological role has thus far remained obscure. Increased lipid content, particularly in skeletal muscle and liver, is ...

journal_title：Endocrinology

authors： Danaher RN,Loomes KM,Leonard BL,Whiting L,Hay DL,Xu LY,Kraegen EW,Phillips AR,Cooper GJ

更新日期：2008-01-01 00:00:00

abstract：:Maintenance of cell polarity is essential for Sertoli cell and blood-testis barrier (BTB) function and spermatogenesis; however, the signaling mechanisms that regulate the integrity of the cytoskeleton and polarity of Sertoli cells are not fully understood. Here, we demonstrate that rapamycin-insensitive component of ...

journal_title：Endocrinology

authors： Dong H,Chen Z,Wang C,Xiong Z,Zhao W,Jia C,Lin J,Lin Y,Yuan W,Zhao AZ,Bai X

更新日期：2015-11-01 00:00:00

abstract：:A sensitive radioimmunoassay is described for the measurement of plasma concentrations of canine growth hormone (cGH) as low as 0.25 ng/ml. The assay utilizes enzymatically iodinated cGH and the double antibody technique. The mean plasma concentration of growth hormone in the normal dog after overnight fast is 1.75 pl...

journal_title：Endocrinology

authors： Hampshire J,Altszuler N,Steele R,Greene LJ

更新日期：1975-03-01 00:00:00

abstract：:Nitric oxide (NO) is a free radical produced by the action of NO synthases (NOS) and is known to be involved in the regulation of many reproductive events that occur in the oviducts. The oviducts are highly specialized organs that play crucial roles in reproduction by providing an optimal environment for the final mat...

journal_title：Endocrinology

authors： Lapointe J,Roy M,St-Pierre I,Kimmins S,Gauvreau D,MacLaren LA,Bilodeau JF

更新日期：2006-12-01 00:00:00

abstract：:Clinically, approximately 30% of women who receive synthetic glucocorticoids (sGC) for risk of preterm labor carry to term. In vitro studies have shown that sGC acutely regulate the placental system A amino acid transporter, but there are no comparable data in vivo. Hence, the objective of our study was to examine the...

journal_title：Endocrinology

authors： Audette MC,Challis JR,Jones RL,Sibley CP,Matthews SG

更新日期：2011-09-01 00:00:00

abstract：:The developmental appearance and regulation of hypothalamic vasopressin (prepropressophysin) mRNA was studied using quantitated in situ hybridization techniques. Vasopressin mRNA levels in the supraoptic nuclei were reliably detected on day 16 of gestation, while mRNA in the suprachiasmatic nuclei (SCN) was detectable...

journal_title：Endocrinology

authors： Reppert SM,Uhl GR

更新日期：1987-06-01 00:00:00

abstract：:We report here the effects of antibodies to estrogen receptor (ER) on the binding of tritiated 5 alpha-androstane-3 beta-17 beta-diol and antiestrogens to receptor in calf uterine cytosol. The antibodies, prepared from a rabbit immunized with purified estradiol-receptor complex from calf uterine nuclei, were found to ...

journal_title：Endocrinology

authors： Garcia M,Greene G,Rochefort H,Jensen EV

更新日期：1982-04-01 00:00:00

abstract：:Acute leptin increase as well as endogenous hyperleptinemia evoked by high-fat diets (HF) activate fatty acid metabolism in nonadipose tissues. This supports the notion that hyperleptinemia is pivotal to prevent/delay steatosis during periods of positive energy balance. We have previously shown that long-term HF spare...

journal_title：Endocrinology

authors： Guzmán-Ruiz R,Somoza B,Gil-Ortega M,Merino B,Cano V,Attané C,Castan-Laurell I,Valet P,Fernández-Alfonso MS,Ruiz-Gayo M

更新日期：2010-03-01 00:00:00

abstract：:Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results...

journal_title：Endocrinology

authors： Rebourcet D,Darbey A,Monteiro A,Soffientini U,Tsai YT,Handel I,Pitetti JL,Nef S,Smith LB,O'Shaughnessy PJ

更新日期：2017-09-01 00:00:00

abstract：:We reported previously that chromogranin A (Chga) knockout (KO) mice are hypertensive and hyperadrenergic. Here we sought to determine the basis of such alterations by probing physiological, biochemical, and pharmacological responses to perturbations of the autonomic nervous system. In the conscious state, KO mice had...

journal_title：Endocrinology

authors： Gayen JR,Gu Y,O'Connor DT,Mahata SK

更新日期：2009-11-01 00:00:00

abstract：:In humans, there is a significant decrease in serum T(3) and increase in rT(3) at different time points after myocardial infarction, whereas serum TSH and T(4) remain unaltered. We report here a time course study of pituitary-thyroid function and thyroid hormone metabolism in rats subjected to myocardial infarction by...

journal_title：Endocrinology

authors： Olivares EL,Marassi MP,Fortunato RS,da Silva AC,Costa-e-Sousa RH,Araújo IG,Mattos EC,Masuda MO,Mulcahey MA,Huang SA,Bianco AC,Carvalho DP

更新日期：2007-10-01 00:00:00

abstract：:Activin, a member of the transforming growth factor-beta superfamily, binds to two classes of cell surface receptors. These receptors, designated type I and type II, are structurally related members of transmembrane serine kinase superfamily. Antibodies specific for either type I or type II activin receptor can coprec...

journal_title：Endocrinology

authors： Tsuchida K,Vaughan JM,Wiater E,Gaddy-Kurten D,Vale WW

更新日期：1995-12-01 00:00:00

abstract：:Seven adult female rhesus monkeys were laparotomized at days 22, 42, and 157 of pregnancy and blood was collected from the uterine vein and peripheral circulation. Plasma samples were analyzed for monkey chorionic gonadotropin (mCG), monkey chorionic somatomammotropin (mCS), and prolactin by radioimmunoassay. Levels o...

journal_title：Endocrinology

authors： Walsh SW,Wolf RC,Meyer RK,Aubert ML,Friesen HG

更新日期：1977-03-01 00:00:00

abstract：:We investigated the effect of epidermal growth factor (EGF) on collagen and protein synthesis in clone MC3T30-E1, a cell line which retains osteoblast-like characteristics. EGF at concentrations of 2-50 ng/ml significantly the hydroxyproline content of the cell layer. These effects were completely abolished by the add...

journal_title：Endocrinology

authors： Hiramatsu M,Kumegawa M,Hatakeyama K,Yajima T,Minami N,Kodama H

更新日期：1982-12-01 00:00:00

abstract：:Specialized metabolic sensors in the hypothalamus regulate blood glucose levels by influencing hepatic glucose output and hypoglycemic counterregulatory responses. Hypothalamic reactive oxygen species (ROS) may act as a metabolic signal-mediating responses to changes in glucose, other substrates and hormones. The role...

journal_title：Endocrinology

authors： Pauliina Markkula S,Lyons D,Yueh CY,Riches C,Hurst P,Fielding B,Heisler LK,Evans ML

更新日期：2016-12-01 00:00:00

abstract：:Lefty/Ebaf polypeptides, novel members of the TGF-beta superfamily, are involved in endometrial differentiation and embryo implantation. Recently, we showed that, during undisturbed estrous cycle, lefty is present in mouse uterine horn primarily in a precursor form. Here, we show that decidual differentiation of endom...

journal_title：Endocrinology

authors： Tang M,Mikhailik A,Pauli I,Giudice LC,Fazelabas AT,Tulac S,Carson DD,Kaufman DG,Barbier C,Creemers JW,Tabibzadeh S

更新日期：2005-12-01 00:00:00

abstract：:Angiotensin II binds to the angiotensin II receptors type 1 (AT1 receptors) in adrenocortical cells and triggers an intracellular signaling cascade leading to changes in the gene expression pattern. Here, we show that stimulation with angiotensin II induces the expression of biologically active early growth response (...

journal_title：Endocrinology

authors： Thiel G,Rössler OG

更新日期：2011-11-01 00:00:00

abstract：:Subcellular preparations from rat liver, brain, and kidney and from human liver were tested for their ability to desulfate T3 sulfate (T3SO4). Activity was found associated with the microsomal fraction: rat liver was the most active, hydrolyzing 76 pmol/min.mg protein of T3SO4 while preparations from rat kidney and br...

journal_title：Endocrinology

authors： Kung MP,Spaulding SW,Roth JA

更新日期：1988-04-01 00:00:00

abstract：:The purpose of these studies was to determine whether changes in FSH receptors correlated with FSH-induced attenuation of FSH-responsive adenylyl cyclase in immature porcine granulosa cells. Cells were incubated with FSH (1-1000 ng/ml) for up to 24 h, treated with acidified medium (pH 3.5) to remove FSH bound to cells...

journal_title：Endocrinology

authors： Ford KA,LaBarbera AR

更新日期：1988-11-01 00:00:00

abstract：:A RIA for mouse placental lactogen-I (mPL-I) was developed using recombinant mPL-I as the standard, radioligand, and antigen for antiserum production. Displacement curves for dilutions of serum and placental extracts from pregnant mice were parallel to the recombinant mPL-I standard curve. Serum from male and nonpregn...

journal_title：Endocrinology

authors： Ogren L,Southard JN,Colosi P,Linzer DI,Talamantes F

更新日期：1989-11-01 00:00:00

abstract：:3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone (TH)-derived metabolite that induces severe hypothermia in mice after systemic administration; however, the underlying mechanisms have remained enigmatic. We show here that the rapid 3-T1AM-induced loss in body temperature is a consequence of peripheral vasod...

journal_title：Endocrinology

authors： Gachkar S,Oelkrug R,Martinez-Sanchez N,Rial-Pensado E,Warner A,Hoefig CS,López M,Mittag J

更新日期：2017-06-01 00:00:00

abstract：:Previous studies showed that noncalcemic 20(OH)D3, a product of CYP11A1 action on vitamin D3, has antifibrotic activity in human dermal fibroblasts and in a bleomycin mouse model of scleroderma. In this study, we tested the role of retinoic acid-related orphan receptor γ (RORγ), which is expressed in skin, in the acti...

journal_title：Endocrinology

authors： Janjetovic Z,Postlethwaite A,Kang HS,Kim TK,Tuckey RC,Crossman DK,Qayyum S,Jetten AM,Slominski AT

更新日期：2021-01-01 00:00:00