Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.

abstract：:Addition of somatostatin-14 (SRIF) inhibits corticotropin releasing factor (CRF) and forskolin-stimulated cyclic AMP formation and ACTH release from tumor cells of the mouse anterior pituitary (AtT-20/D16-16). After long-term pretreatment of these cells with SRIF, the ability of SRIF to inhibit CRF and forskolin-stimu...

journal_title：Endocrinology

authors： Reisine T,Axelrod J

更新日期：1983-08-01 00:00:00

abstract：:Hypoxia and biological responses to hypoxia are commonly encountered in both normal and pathologic cellular processes. Here we report that extracellular superoxide dismutase (EC-SOD) plays a major role in regulating the magnitude of hypoxia-induced erythropoietin (Epo) gene expression, thus implicating superoxide as a...

journal_title：Endocrinology

authors： Zelko IN,Folz RJ

更新日期：2005-01-01 00:00:00

abstract：:Primary kidney cell cultures from normal rhesus monkeys were used to study the regulation of 24,25-dihydroxyvitamin D3 production. Kidney cells were grown to confluency in the modified National Cancer Institute Medium NCTC 135 with 2% fetal calf serum and then maintained in a serum-free medium (2% bovine serum albumin...

journal_title：Endocrinology

authors： Juan D,DeLUCA HF

更新日期：1977-10-01 00:00:00

abstract：:This study was undertaken to identify uterine insulin-like growth factor-I (IGF-I) receptors and examine the regulation of these receptors throughout the estrous cycle and after 17 beta-estradiol (E2) administration to immature rats. We have demonstrated type I IGF receptors in crude uterine membranes by binding and c...

journal_title：Endocrinology

authors： Ghahary A,Murphy LJ

更新日期：1989-08-01 00:00:00

abstract：:To test the hypothesis that angiotensin (Ang) II induces profibrotic gene expression through endogenous aldosterone, we measured the effect of 4 h infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-...

journal_title：Endocrinology

authors： Luther JM,Wang Z,Ma J,Makhanova N,Kim HS,Brown NJ

更新日期：2009-05-01 00:00:00

abstract：:During luteinization of bovine granulosa cells in vitro in the presence of insulin, or insulin plus forskolin, there is a massive upregulation not only of progesterone production, but also of the gene for the peptide hormone oxytocin, with secretion of the peptide into the medium. By using the progesterone receptor an...

journal_title：Endocrinology

authors： Lioutas C,Einspanier A,Kascheike B,Walther N,Ivell R

更新日期：1997-11-01 00:00:00

abstract：:Maintenance of male golden hamsters on short photoperiod leads to testicular regression due to pineal gland-mediated inhibition of the hypothalamo-hypophyseal reproductive system. This study clarifies the dynamics of the action of GnRH at the pituitary level after short photoperiod-induced gonadal regression. In Exp 1...

journal_title：Endocrinology

authors： Pieper DR

更新日期：1984-11-01 00:00:00

abstract：:Plasma concentrations of IGF-1 decrease markedly during starvation secondary to a reduction in somatotropic receptors in the liver. We investigated whether IGF-1 administration during starvation in mice inhibits the catabolic state normally observed. Plasma concentrations of IGF-1 in starved mice receiving IGF-1 thera...

journal_title：Endocrinology

authors： O'Sullivan U,Gluckman PD,Breier BH,Woodall S,Siddiqui RA,McCutcheon SN

更新日期：1989-11-01 00:00:00

abstract：:It has previously only been possible to assess osteoclastic bone resorption in intact bone, where other cell types may modify or mediate osteoclastic responses to environmental agents. We have recently developed techniques which enable us to measure bone resorption by osteoclasts extracted from bone and have used thes...

journal_title：Endocrinology

authors： Chambers TJ,McSheehy PM,Thomson BM,Fuller K

更新日期：1985-01-01 00:00:00

abstract：:Sex differences in liver gene expression are determined by pituitary growth hormone secretion patterns, which regulate sex-dependent liver transcription factors and establish sex-specific chromatin states. Hypophysectomy (hypox) identifies two major classes of liver sex-biased genes, defined by their sex-dependent pos...

journal_title：Endocrinology

authors： Melia T,Waxman DJ

更新日期：2019-05-01 00:00:00

abstract：:We have examined the effects of a new synthetic inhibitor of mammalian tissue collagenase, CI-1 (N-[3-N-(benzyloxycarbonyl)amino-1-(R)carboxypropyl]L-leucyl-O-methyl-L- tyrosine N-methylamide; G. D. Searle SC 40827), and a general metalloproteinase inhibitor, 1,10-phenanthroline, on ovulation, as judged by the observa...

journal_title：Endocrinology

authors： Brännström M,Woessner JF Jr,Koos RD,Sear CH,LeMaire WJ

更新日期：1988-05-01 00:00:00

abstract：:Premature overexposure to thyroid hormone causes profound effects on testis growth, spermatogenesis, and male fertility. We used genetic mouse models of type 3 deiodinase (DIO3) deficiency to determine the genetic programs affected by premature thyroid hormone action and to define the role of DIO3 in regulating thyroi...

journal_title：Endocrinology

authors： Martinez ME,Lary CW,Karaczyn AA,Griswold MD,Hernandez A

更新日期：2019-12-01 00:00:00

abstract：:It is well established that sexually dimorphic neural regions are organized by steroid hormones during development. In many species, neonatal males are exposed to more testosterone than their female littermates, and ultimately it is the estradiol, produced by aromatization of testosterone, that affects sexual differen...

journal_title：Endocrinology

authors： Bodo C,Rissman EF

更新日期：2008-08-01 00:00:00

abstract：:Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects, including proliferation, migration, survival, epithelial-to-mesenchymal transition, and angiogenesis, to regulate embryogenesis, tissue homeostasis, and tumorigenesis. Those cell behaviors are also associated with implantation of ...

journal_title：Endocrinology

authors： Gershon E,Hadas R,Elbaz M,Booker E,Muchnik M,Kleinjan-Elazary A,Karasenti S,Genin O,Cinnamon Y,Gray PC

更新日期：2018-04-01 00:00:00

abstract：:The androgen receptor (AR) in Sertoli cells mediates the actions of testosterone on spermatogenesis. However, the transcription factors responsible for AR gene regulation in Sertoli cells remain unknown. In this study, we determined that nuclear factor-kappaB (NF-kappaB) regulates transcription of AR in primary cultur...

journal_title：Endocrinology

authors： Zhang L,Charron M,Wright WW,Chatterjee B,Song CS,Roy AK,Brown TR

更新日期：2004-02-01 00:00:00

abstract：:LH treatment of isolated medium (3- to 7-mm) follicles from porcine ovaries stimulated pregnenolone synthesis by mitochondria isolated from these tissues. This LH stimulation of pregnenolone synthesis was observed regardless of whether exogenous cholesterol was added to the mitochondrial assay system, suggesting that ...

journal_title：Endocrinology

authors： Neymark MA,Bieszczad RR,Dimino MJ

更新日期：1984-02-01 00:00:00

abstract：:The previously reported synchronous oscillations in plasma glucose and insulin levels have been further studied to determine whether the phenomenon can be attributed to cyclic secretion or degradation of the hormone. Plasma C-peptide concentrations were measured and found to cycle with the same period as plasma insuli...

journal_title：Endocrinology

authors： Koerker DJ,Goodner CJ,Hansen BW,Brown AC,Rubenstein AH

更新日期：1978-05-01 00:00:00

abstract：:Carbohydrate metabolism in pregnancy reflects the balance between counterregulatory hormones, which induce insulin resistance, and lactogenic hormones, which stimulate beta-cell proliferation and insulin production. Here we explored the interactions of prolactin (PRL) and glucocorticoids in the regulation of beta-cell...

journal_title：Endocrinology

authors： Arumugam R,Horowitz E,Lu D,Collier JJ,Ronnebaum S,Fleenor D,Freemark M

更新日期：2008-11-01 00:00:00

abstract：:Benzodiazepines (BZs) have been shown to modulate voltage-sensitive Ca2+ channels in a number of neuronal and nonneuronal cell types and to competitively antagonize TRH binding to receptors on cells of the nervous system and anterior pituitary gland. Because interaction of TRH with its receptor is known to cause enhan...

journal_title：Endocrinology

authors： Gershengorn MC,Thaw CN,Geras-Raaka E

更新日期：1988-07-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from ge...

journal_title：Endocrinology

authors： Lv F,Wan Y,Chen Y,Pei L,Luo D,Fan G,Luo M,Xu D,Wang H

更新日期：2018-03-01 00:00:00

abstract：:The concentration-activity profiles for insulin and insulin-like growth factor I (IGF-I; in the presence of and insulin-like growth factor I (IGF-I; in the presence of hydrocortisone and PRL) have been compared in terms of the accumulation of beta-casein mRNA, total casein synthesis, and alpha-lactalbumin and basal ca...

journal_title：Endocrinology

authors： Prosser CG,Sankaran L,Hennighausen L,Topper YJ

更新日期：1987-04-01 00:00:00

abstract：:Several studies have revealed a variety of interactions between PTH and ACTH. The existence of a significant area of homology in the bioactive regions of the two molecules has been proposed as a possible reason for such interactions. To clarify the relationship, corticosteroidogenic and cAMP accumulative effects of bo...

journal_title：Endocrinology

authors： Rafferty B,Zanelli JM,Rosenblatt M,Schulster D

更新日期：1983-09-01 00:00:00

abstract：:We tested the hypothesis that chronic maternal GH administration would increase fetal substrate supply, increase maternal and fetal insulin-like growth factor I (IGF-I) concentrations, and therefore enhance growth in the late gestation fetal sheep. Eleven ewes received bovine GH 0.1 mg/kg twice daily for 10 days, wher...

journal_title：Endocrinology

authors： Harding JE,Evans PC,Gluckman PD

更新日期：1997-12-01 00:00:00

abstract：:We studied the effects of 17 beta-estradiol (E2) and PTH on alkaline phosphatase activity in SaOS-2 cells that had been passaged and grown continually in the presence (SaOS + Dex) or absence (SaOS - Dex) of 10(-8) M dexamethasone (Dex). We showed that the more differentiated SaOS + Dex cells had higher alkaline phosph...

journal_title：Endocrinology

authors： Rao LG,Wylie JN,Sutherland MS,Murray TM

更新日期：1994-02-01 00:00:00

abstract：:Type 1 diabetes is caused by autoimmune destruction of β-cells. Although immunotherapy can restore self-tolerance thereby halting continued immune-mediated β-cell loss, residual β-cell mass and function is often insufficient for normoglycemia. Using a growth factor to boost β-cell mass can potentially overcome this ba...

journal_title：Endocrinology

authors： Hyslop CM,Tsai S,Shrivastava V,Santamaria P,Huang C

更新日期：2016-01-01 00:00:00

abstract：:Loss of circulating 17β-estradiol (E2) that occurs during menopause can have detrimental effects on cognitive function. The efficacy of hormone replacement therapy declines as women become farther removed from the menopausal transition, yet the molecular mechanisms underlying this age-related switch in E2 efficacy are...

journal_title：Endocrinology

authors： Shults CL,Pinceti E,Rao YS,Pak TR

更新日期：2015-11-01 00:00:00

abstract：:Dog thyroid slices released in their incubation medium prostaglandins E2 (PGE2), F2 alpha (PGF2 alpha), 15-keto-13,14-dihydro-F2 alpha, and thromboxane B2 (TxB2), as measured by direct RIA. This release could be inhibited by indomethacin and naproxen, indicating that it corresponded to a neosynthesis. Carbamylcholine ...

journal_title：Endocrinology

authors： Boeynaems JM,Waelbroeck M,Dumont JE

更新日期：1979-10-01 00:00:00

abstract：:Elucidation of the role of Ca2+ in the secretion of insulin and glucagon is complicated by the presence of different types of cells in the pancreatic islets. Visualization of calcium in sections of guinea pig pancreas with the histochemical reagent glyoxal bis-2-hydroxyanil revealed the most intense staining in the en...

journal_title：Endocrinology

authors： Berggren PO,Ostenson CG,Petersson B,Hellman B

更新日期：1979-12-01 00:00:00

abstract：:The comparative effectiveness of vitamin D3 and its derivatives in curing hyperparathyroidism and osteodystrophic bone lesions was examined in a laboratory model of renal osteodystrophy associated with marked secondary hyperparathyroidism in rats. The experimental model was prepared by a single injection of homologous...

journal_title：Endocrinology

authors： Fukushima M,Niki R,Ohkawa H,Shimizu T,Matsunaga I,Nakano H,Takagaki Y,Nishii Y,Okano K,Suda T

更新日期：1980-07-01 00:00:00

abstract：:The purpose of these experiments was to test the hypothesis that estrogen has an anabolic effect on cancellous bone formation in long bones of growing rats. In the present studies, estrogen decreased measurements related to cancellous bone formation, including osteoblast number, fluorochrome-labeled bone perimeter, an...

journal_title：Endocrinology

authors： Westerlind KC,Wakley GK,Evans GL,Turner RT

更新日期：1993-12-01 00:00:00