Abstract:
:The comparative effectiveness of vitamin D3 and its derivatives in curing hyperparathyroidism and osteodystrophic bone lesions was examined in a laboratory model of renal osteodystrophy associated with marked secondary hyperparathyroidism in rats. The experimental model was prepared by a single injection of homologous glycopeptide. Plasma levels of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] appeared to decrease in the rats receiving glycopeptide. Various doses of vitamin D3 derivatives [2 or 10 microgram/kg D3, 2 microgram/kg 25-hydroxyvitamin D3 (25OHD3), 0.1 microgram/kg 1 alpha,25(OH)2D3, and 0.1 or 0.2 microgram/kg 1 alpha-hydroxyvitamin D3 (1 alpha OHD3)] were daily administered orally to the nephritic rats for 23 days before sacrifice. 1 alpha,25(OH)2D3 and 1 alpha OHD3 were much more potent than 25OHD3 and D3 in reducing the hyperplasia of parathyroir glands. The potency of 1 alpha OHD3 in curing the histological changes of osteodystrophy appeared to be greater than that of 1 alpha,25(OH)2D3. The same dose level of 1 alpha OHD3 was more effective than 1 alpha,25(OH)2D3 in enhancing plasma 1 alpha,25(OH)2D3 levels.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Fukushima M,Niki R,Ohkawa H,Shimizu T,Matsunaga I,Nakano H,Takagaki Y,Nishii Y,Okano K,Suda Tdoi
10.1210/endo-107-1-328subject
Has Abstractpub_date
1980-07-01 00:00:00pages
328-33issue
1eissn
0013-7227issn
1945-7170journal_volume
107pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::We examined the levels and stability of glucocorticoid receptor activity in cytosol preparations of rat lung and other tissues. [3H]Dexamethasome binding capacity at 2 C in lung cytosol decreases with a t1/2 of 40 min in the absence of steroid or a sulfhydryl compound. This rapid inactivation of unbound receptor is pr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-100-4-1160
更新日期:1977-04-01 00:00:00
abstract::This study was designed to investigate the role of dopaminergic mechanisms in the control of aldosterone secretion. Six rhesus monkeys received metoclopramide (1.25 mg, iv), with 5% dextrose (vehicle) or with dopamine (4 micrograms/kg . min) infusions begun 60 min before the administration of the dopamine antagonists....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-110-4-1173
更新日期:1982-04-01 00:00:00
abstract::Alpha-calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. Despite well-documented pharmacological effects, its primary physiological role has thus far remained obscure. Increased lipid content, particularly in skeletal muscle and liver, is ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0583
更新日期:2008-01-01 00:00:00
abstract::Thyroid hormones (THs) are charged and iodinated amino acid derivatives that need to pass the cell membrane facilitated by thyroid hormone transmembrane transporters (THTT) to exert their biological function. The importance of functional THTT is affirmed by the devastating effects of mutations in the human monocarboxy...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1933
更新日期:2016-04-01 00:00:00
abstract::Hashimoto thyroiditis can be partially reproduced in mice by immunization with thyroglobulin or, more recently, thyroperoxidase. This experimental autoimmune thyroiditis (EAT) model has been extensively characterized during early disease phases (up to d 35 after immunization). By extending the analysis of EAT to 100 d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0639
更新日期:2009-01-01 00:00:00
abstract::We report for the first time the expression of estrogen receptor-related receptor (ERR)-alpha in fetal and adult rat chondrocytes in growth plate and articular cartilage and the rat chondrogenic cell line C5.18 cells in vitro. ERRalpha mRNA and protein were expressed from proliferating chondrocyte to mature chondrocyt...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0962
更新日期:2007-03-01 00:00:00
abstract::Mitochondrial reactive oxygen species have been implicated in both diabetic complications and the progression of the underlying diabetic state. However, it is not clear whether mitochondria of diabetic origin are intrinsically altered to generate excess reactive oxygen species independent of the surrounding diabetic m...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0404
更新日期:2009-01-01 00:00:00
abstract::We have studied regulation of the glucose transporter by thyroid hormone in ARL 15 cells, a thyroid hormone-responsive cell line derived from rat liver, T3 treatment (5 x 10(-8) M for 48 h) of confluent cell monolayers grown in thyroid hormone-deficient medium increased the rate of uptake of [3H] 2-deoxyglucose by 2.3...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-3-1421
更新日期:1990-03-01 00:00:00
abstract::Mouse fibroblast cell lines which secrete bovine (b) GH have been generated. This was accomplished by cotransforming mouse L cells (thymidine kinase-negative [TK-] and adenine phosphoribosyl transferase-negative [APRT-]) with DNA molecules encoding the Rous sarcoma virus-long-terminal repeat and bGH genes along with t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-4-1489
更新日期:1986-10-01 00:00:00
abstract::There is a growing body of evidence that subtle decreases in maternal thyroid hormone during gestation can impact fetal brain development. The present study examined the impact of graded levels of thyroid hormone insufficiency on brain development in rodents. Maternal thyroid hormone insufficiency was induced by expos...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-1276
更新日期:2007-06-01 00:00:00
abstract::Sclerostin (SOST), a member of the cystine-knot superfamily, is essential for proper skeletogenesis because a loss-of-function mutation in the SOST gene results in sclerosteosis featured with massive bone growth in humans. To understand the function of SOST in developmental skeletal tissue formation, we examined SOST ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1492
更新日期:2004-10-01 00:00:00
abstract::A serum-free, hormone- and factor-supplemented, defined medium was developed which maintains functional activity of primary cultures of adult islet cells and continuous islet cell lines. Medium supplements examined included proteose peptone (PP), transferrin (TrFe), insulin-like growth factor-I (IGF-I), an insulinotro...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-4-1895
更新日期:1990-04-01 00:00:00
abstract::The electrophoretic distribution of the polypeptides synthesized by bovine granulosa cell cultures after metabolic labeling with [35S]methionine has been analyzed by double gel electrophoresis. The fluctuations of 35 polypeptides have been followed as a function of the size of the follicles from which cultures origina...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-6-1798
更新日期:1980-12-01 00:00:00
abstract::Reproductive function is dependent on the interaction between GnRH and its cognate receptor found on gonadotrope cells of the anterior pituitary gland. GnRH activation of the GnRH receptor (GnRHR) is a potent stimulus for increased expression of multiple genes including the gene encoding the GnRHR itself. Thus, homolo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220784
更新日期:2003-03-01 00:00:00
abstract::The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve. Both chromosomal and serial duplications have been suggested as mechanisms for the expansion of this gene family. We have identified and annotated IGFBP sequences from a wide selection of vertebrate species as well as Branchios...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-0047
更新日期:2011-06-01 00:00:00
abstract::Molecular and cellular mechanisms involved in artificially induced ovarian differentiation were analyzed by exposing embryos of medaka (Oryzias latipes) to a potent nonsteroidal estrogen, diethylstilbestrol (DES). Embryos were exposed for short-exposure (SE) [from 0 to 8 d postfertilization (dpf)] and long-exposure (L...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0812
更新日期:2011-02-01 00:00:00
abstract::The regulation of insulin-like growth factor binding protein (IGFBP)-4 proteolytic degradation by insulin-like growth factors (IGFs) has been largely studied in vitro, but not in vivo. The aim of this study was to investigate the involvement of IGFs, IGFBP-2, IGFBP-3, and IGFBP-3 proteolytic fragments in the regulatio...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.9.6979
更新日期:1999-09-01 00:00:00
abstract::Male rats of five different strains (Simonsen albino, Wistar, Long-Evans, Holtzman Sprague-Dawley, and Charles River Sprague-Dawley) were tested for their response to the U.S. Biochemical Corp. Remington low iodine diet containing 15-18 microgram I/kg. Measurements made after the diet had been fed for 28-30 days indic...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-109-2-458
更新日期:1981-08-01 00:00:00
abstract::During the purification of skeletal growth factor/insulin-like growth factor-II and transforming growth factor-beta (TGF beta) from EDTA extracts of bovine bone matrix significant mitogenic activity for cultured osteoblast (Ob)-like cells eluted in fractions that contained a nearly homogeneous peptide with a mol wt of...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-1-404
更新日期:1989-07-01 00:00:00
abstract::RIAs specific for the alpha-subunit of glycoprotein hormones were used to monitor the subunit conformation in ovine FSH and TSH and in recombinants of ovine LH alpha with (ovine and porcine) LH beta and hCG beta. Differences in log-logit slopes of the RIA dilution curves were interpreted to indicate changes, presumabl...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-111-1-95
更新日期:1982-07-01 00:00:00
abstract::The uptake of [125I]T3 in rat skeletal muscle was investigated by incubating intact soleus muscles with a tracer amount of [125I]T3. At 37 C [125I]T3 uptake increased asymptotically; at 60 min the muscle contained 10% of the total [125I]T3 or 0.238 +/- 0.021% per mg wet tissue. At 0 C the [125I]T3 uptake was 1/5 of th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-6-2755
更新日期:1986-12-01 00:00:00
abstract::The quantitative light microscope radioautographic approach was utilized to locate specific binding sites for blood-borne 125I-labeled ACTH1-24 in the rat brain. Specific binding occurred exclusively in the external zone of the median eminence, adjacent to the primary portal plexus, and to a lesser extent in the ventr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-6-2385
更新日期:1981-06-01 00:00:00
abstract::We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats. VDR messenger RNA (mRNA) was assayed by Northern blot, and VDR protein was determined immunocytochemically....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.4.5903
更新日期:1998-04-01 00:00:00
abstract::Using a Leydig tumor cell line (MA-10) transiently transfected with the human lutropin receptor (hLHR) and mutants thereof, we examined the identity of the G proteins activated by the agonist-engaged hLHR-wild type (wt) and by three of its naturally occurring constitutively active mutants. Two of the mutants examined,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0365
更新日期:2003-09-01 00:00:00
abstract::The effects of several compounds which interfere with cellular microfilaments and microtubules on the conversion of proparathyroid hormone (ProPTH) to parathyroid hormone (PTH) were examined in slices of bovine parathyroid slices incubated in vitro with 3H-leucine. Inhibitors of microtubular function, vinblastine and ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-4-903
更新日期:1975-04-01 00:00:00
abstract::Germ cells were isolated from 30-day-old rat testes and purified by a Percoll gradient. Germ cells were cultured for 24 h to eliminate contaminant cells by utilizing the property of many nongerm cells of attaching to plastic surfaces. Germ cells were subsequently seeded on top of 7-day-old Sertoli cell monolayers. RNA...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-5-1796
更新日期:1985-11-01 00:00:00
abstract::We have previously demonstrated that cultured rat thyroid cells do not exhibit constitutive expression of major histocompatibility (MHC) class II antigens. Using reovirus types 1 and 3, we infected 1B-6 cells (a cloned derivative of the Fisher rat cell line FRTL-5), and found a dose-dependent induction of thyroid cell...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-1-543
更新日期:1989-01-01 00:00:00
abstract::We studied the interactions of two natural thyroid hormone receptor (TR) mutants from patients with resistance to thyroid hormone (RTH) and an artificial TR mutant with a nuclear receptor corepressor, N-CoR, and a steroid receptor coactivator, SRC-1. In electrophoretic mobility shift assays, wild-type TRbeta-1 interac...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.10.6218
更新日期:1998-10-01 00:00:00
abstract::The present experiments investigated the time course of maternal modulation of GH secretion and examined the possible role of milk in the regulation of GH secretion in neonatal rats. Serum GH concentrations in neonatal rats were high at birth and declined over time postpartum. Separation of rat pups from their mothers...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-3-1326
更新日期:1989-09-01 00:00:00
abstract::The quantities of estrone and estradiol were determined by radioimmunoassay in maternal and fetal plasma of the rhesus monkey from day 59 to 163 of gestation. A two way analysis of variance of data classified according to fetal sex and 3 pooled gestational ages for each hormone and for mother or fetus (4 analyses) rev...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-2-425
更新日期:1975-08-01 00:00:00