The orphan nuclear estrogen receptor-related receptor-alpha regulates cartilage formation in vitro: implication of Sox9.

abstract：:The sympathetic nervous system is a physiological regulator of bone homeostasis. Autonomic nerves are indeed present in bone, bone cells express the β2-adrenergic receptors (β2AR), and pharmacological or genetic disruption of sympathetic outflow to bone induces bone gain in rodents. These recent findings implied that ...

journal_title：Endocrinology

authors： Ma Y,Nyman JS,Tao H,Moss HH,Yang X,Elefteriou F

更新日期：2011-04-01 00:00:00

abstract：:Ghrelin, a novel GH-releasing acylated peptide, was recently isolated from rat stomach. It stimulated the release of GH from the anterior pituitary through the GH secretagogue receptor (GHS-R). Ghrelin messenger RNA and the peptide are present in rat stomach, but its cellular source has yet to be determined. Using two...

journal_title：Endocrinology

authors： Date Y,Kojima M,Hosoda H,Sawaguchi A,Mondal MS,Suganuma T,Matsukura S,Kangawa K,Nakazato M

更新日期：2000-11-01 00:00:00

abstract：:The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bmal1 can disrupt adrenal clock function. The requirement of the adrenal...

journal_title：Endocrinology

authors： Engeland WC,Massman L,Mishra S,Yoder JM,Leng S,Pignatti E,Piper ME,Carlone DL,Breault DT,Kofuji P

更新日期：2018-12-01 00:00:00

abstract：:We used the library subtraction technique to identify genes specifically expressed in the rat uterus during early pregnancy. One such gene was that for stathmin, a factor that is associated with tubulin binding and the destabilization of microtubules. Stathmin was expressed at higher levels in implantation sites than ...

journal_title：Endocrinology

authors： Tamura K,Hara T,Yoshie M,Irie S,Sobel A,Kogo H

更新日期：2003-04-01 00:00:00

abstract：:The production of hydrogen peroxide (H2O2) as an essential process for iodide organification is a key reaction in TSH-induced thyroid hormone synthesis. Here we characterize the signal transduction pathway involved in TSH-induced H2O2 production in FRTL-5 thyroid cells. At higher than 1 nM TSH, N6-(L-2-phenylisopropyl...

journal_title：Endocrinology

authors： Kimura T,Okajima F,Sho K,Kobayashi I,Kondo Y

更新日期：1995-01-01 00:00:00

abstract：:A single injection of either natural (cortisol, corticosterone) or synthetic [dexamethasone (DEX), triamcinolone acetonide] glucocorticosteroids to estradiol-primed, withdrawn chicks, resulted in a dose-dependent increase in the relative rates of ovalbumin and conalbumin synthesis. The simultaneous injection of equal ...

journal_title：Endocrinology

authors： Le Bouc Y,Groyer A,Cadepond F,Groyer-Schweizer G,Robel P,Baulieu EE

更新日期：1985-06-01 00:00:00

abstract：:The anterior pituitary (AP) is made of five different cell types. The relative abundance and phenotype of AP cells may change in different physiological situations as an expression of pituitary plasticity. Here, we analyze in detail the phenotype of mouse corticotropes and the effects of acute cold stress on AP cell p...

journal_title：Endocrinology

authors： Senovilla L,Núñez L,Villalobos C,García-Sancho J

更新日期：2008-05-01 00:00:00

abstract：:The effects of hypophysectomy and GH on blood pressure and renin secretion were studied. Within 2 weeks after removal of the pituitary gland of rats, mean arterial blood pressure declined 30%, and heart rate fell 50%. No significant effect of hypophysectomy on blood volume or hematocrit was noted. Within 2 h after the...

journal_title：Endocrinology

authors： Honeyman TW,Goodman HM,Fray JC

更新日期：1983-05-01 00:00:00

abstract：:Perturbing the endoplasmic reticulum homeostasis of thyroid cell lines with thapsigargin, a specific inhibitor of the sarcoendoplasmic reticulum Ca(2+) adenosine triphosphatases, and tunicamycin, an inhibitor of the N-linked glycosylation, blocked Tg in the endoplasmic reticulum. This event was signaled outside the en...

journal_title：Endocrinology

authors： Leonardi A,Vito P,Mauro C,Pacifico F,Ulianich L,Consiglio E,Formisano S,Di Jeso B

更新日期：2002-06-01 00:00:00

abstract：:The present study was designed to analyze in detail the effects of L-glutamate (L-Glu) and its agonists on the release of LHRH from arcuate nucleus-median eminence (AN-ME) fragments in vitro. Fragments from adult male rats were incubated in Krebs-Ringer bicarbonate buffer in the presence of different concentrations of...

journal_title：Endocrinology

authors： Donoso AO,López FJ,Negro-Vilar A

更新日期：1990-01-01 00:00:00

abstract：:The occurrence of the thyroid hormone-binding plasma protein transthyretin in the bloodstream was investigated for four American marsupial species. Serum samples were analyzed by incubation with radioactive T4, followed by electrophoresis, then autoradiography, and Western blotting. Transthyretin was found in serum fr...

journal_title：Endocrinology

authors： Richardson SJ,Wettenhall RE,Schreiber G

更新日期：1996-08-01 00:00:00

abstract：:To study possible mechanisms controlling diurnal changes in corticosterone (CORT) levels, we tested the CORT responses to ACTH in the morning (AM) and evening (PM) in male Wistar and Sprague-Dawley rats. Rat ACTH-(1-39) or human ACTH-(1-24) (3.75-15 ng/rat) was given as an iv bolus or an intraarterial infusion to (un)...

journal_title：Endocrinology

authors： Dijkstra I,Binnekade R,Tilders FJ

更新日期：1996-02-01 00:00:00

abstract：:Neuropeptide Y (NPY) readily stimulates the release of hypothalamic LHRH and pituitary LH release in intact and gonadal steroid-primed gonadectomized rats. We have now tested the hypothesis that the release and synthesis of hypothalamic NPY may be regulated by gonadal steroids. To measure the effects of gonadal hormon...

journal_title：Endocrinology

authors： Sahu A,Phelps CP,White JD,Crowley WR,Kalra SP,Kalra PS

更新日期：1992-06-01 00:00:00

abstract：:The administration of testosterone via Silastic capsules has been shown previously to maintain advanced spermatid number quantitatively in intact rats in which LH but not FSH was suppressed, but not in hypophysectomized rats, indicating that pituitary factors in addition to LH are required for the quantitative mainten...

journal_title：Endocrinology

authors： Awoniyi CA,Zirkin BR,Chandrashekar V,Schlaff WD

更新日期：1992-06-01 00:00:00

abstract：:Although cells of the osteoblast lineage express functional ERs, direct effects of estrogen on bone formation remain obscure. In the present study, we have investigated estrogen effects on osteoblastic and adipocytic differentiation from a mouse bone marrow stromal cell line, ST-2, which had been manipulated to overex...

journal_title：Endocrinology

authors： Okazaki R,Inoue D,Shibata M,Saika M,Kido S,Ooka H,Tomiyama H,Sakamoto Y,Matsumoto T

更新日期：2002-06-01 00:00:00

abstract：:The product of the ob/ob gene, leptin, is known to be able to exert a modulator, role on HPA axis function. The aim of the present study was to determine whether endogenous ACTH and glucocorticoids exert any regulatory effect on leptin secretion. For this purpose bilaterally adrenalectomized (ADX) or sham operated (Sh...

journal_title：Endocrinology

authors： Spinedi E,Gaillard RC

更新日期：1998-09-01 00:00:00

abstract：:In contrast to other systems in which angiotensin-II (AII) inhibits adenylyl cyclase, in fetal skin fibroblasts the peptide stimulates cAMP accumulation. The mechanism of this novel effect was studied by analysis of the actions of AII and other regulators on the adenylyl cyclase system in cultured cells. In the presen...

journal_title：Endocrinology

authors： Johnson MC,Aguilera G

更新日期：1992-11-01 00:00:00

abstract：:Parathyroid tissue from patients with hyperparathyroidism (HPT) exhibited reduced immunohistochemical reactivity with monoclonal antiparathyroid antibodies, previously shown to stain intensely the surface of normal human parathyroid cells and to interfere with a receptor mechanism of these cells which is involved in t...

journal_title：Endocrinology

authors： Juhlin C,Klareskog L,Nygren P,Ljunghall S,Gylfe E,Rastad J,Akerström G

更新日期：1988-06-01 00:00:00

abstract：:Hyp mice, the murine homolog of human X-linked hypophosphatemia (XLH), are characterized in part by elevated renal loss of phosphate (Pi) and hypophosphatemia. The lesion responsible for this syndrome is believed to be defective Na+ gradient-dependent phosphate transport across renal brush border membranes (BBM). It h...

journal_title：Endocrinology

authors： Kiebzak GM,Dousa TP

更新日期：1985-08-01 00:00:00

abstract：:We used autoradiography to test the hypothesis that a major function of thyroid hormone-binding proteins in plasma is to ensure uniform distribution of thyroid hormones among cells of a given tissue. The distribution of [125I]T4 within rat hepatic lobules was determined after its single pass perfusion through the port...

journal_title：Endocrinology

authors： Mendel CM,Weisiger RA,Jones AL,Cavalieri RR

更新日期：1987-05-01 00:00:00

abstract：:Male and female Wistar-Furth rats bearing the pituitary tumor MtT/W15 had serum GH and PRL levels several hundred-fold higher, and immunoreactive somatomedin levels 3-fold higher, than those of controls. The presence of tumor appeared to have no effect on specific binding of radioiodinated bovine GH to liver microsoma...

journal_title：Endocrinology

authors： Baxter RC,Zaltsman Z,Turtle JR

更新日期：1982-09-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from ge...

journal_title：Endocrinology

authors： Lv F,Wan Y,Chen Y,Pei L,Luo D,Fan G,Luo M,Xu D,Wang H

更新日期：2018-03-01 00:00:00

abstract：:Human pituitary prolactin (hPRL) contains a single major component. Upon iodination by a lactoperoxidase procedure approximately 50% of this component remains ulaltered in molecular size and net charge by the criteria of quantitative polyacrylamide gel electrophoresis (PAGE). Aminiotic fluid hPRL contains two componen...

journal_title：Endocrinology

authors： Rogol AD,Chrambach A

更新日期：1975-08-01 00:00:00

abstract：:It is well established that sexually dimorphic neural regions are organized by steroid hormones during development. In many species, neonatal males are exposed to more testosterone than their female littermates, and ultimately it is the estradiol, produced by aromatization of testosterone, that affects sexual differen...

journal_title：Endocrinology

authors： Bodo C,Rissman EF

更新日期：2008-08-01 00:00:00

abstract：:Owing to the prevalence of depression during childbearing, mothers can be prescribed multiple antidepressants; however, little is known about the risk and consequences to the offspring or subsequent generations. Fluoxetine (FLX) is usually the first-line of pharmacological treatment for affective disorders in pregnant...

journal_title：Endocrinology

authors： Vera-Chang MN,Moon TW,Trudeau VL

更新日期：2019-09-01 00:00:00

abstract：:Ghrelin was recently identified as an endogenous ligand of the GH secretagogue receptor. The novel peptide hormone is produced by gastric A-like cells, and circulating levels rise before feeding, suggestive of ghrelin as an endogenous hunger factor. ghrelin stimulates food intake and promotes adiposity after periphera...

journal_title：Endocrinology

authors： Tang-Christensen M,Vrang N,Ortmann S,Bidlingmaier M,Horvath TL,Tschöp M

更新日期：2004-10-01 00:00:00

abstract：:Oral ketoconazole has been demonstrated to lower plasma testosterone in man. Measurement of blood precursors of testosterone suggest that ketoconazole may have its effect inhibiting the 17,20-desmolase enzyme within the testis. To substantiate this, a series of in vitro experiments was conducted using the rat testis t...

journal_title：Endocrinology

authors： Sikka SC,Swerdloff RS,Rajfer J

更新日期：1985-05-01 00:00:00

abstract：:Studying the mechanisms for the complex pathogenesis of polycystic ovary syndrome (PCOS) requires animal models with endocrine, reproductive, and metabolic features of the syndrome. Hyperandrogenism seems to be a central factor in PCOS, leading to anovulation and insulin resistance. In female rats, continuous administ...

journal_title：Endocrinology

authors： Maliqueo M,Sun M,Johansson J,Benrick A,Labrie F,Svensson H,Lönn M,Duleba AJ,Stener-Victorin E

更新日期：2013-01-01 00:00:00

abstract：:Rabbit hearts perfused by the Langendorff technique were studied. The addition of ovine prolactin (NIH-P-S-10) to the perfusate in a concentration of 50 ng/ml produced rapid increases in both the amplitude and rate of contraction in 33 adult male hearts studied in winter. Prepubertal male animals showed no response, a...

journal_title：Endocrinology

authors： Nassar BA,Horrobin DF,Tynan M,Manku MS,Davies PA

更新日期：1975-10-01 00:00:00

abstract：:We have used immunohistochemistry to define the cellular distribution of GH receptors in the gastrointestinal tract (GIT) and its derivatives. Immunohistochemistry was performed in the adult rat GIT with a panel of characterized monoclonal antibodies to the GH receptor. The most intense and heterogeneous immunoreactiv...

journal_title：Endocrinology

authors： Lobie PE,Breipohl W,Waters MJ

更新日期：1990-01-01 00:00:00