Hyperparathyroidism is associated with reduced expression of a parathyroid calcium receptor mechanism defined by monoclonal antiparathyroid antibodies.

abstract：:During the preovulatory and estradiol-progesterone-induced GnRH-LH surge, a subpopulation of GnRH neurons transiently expresses the transcription factor c-fos, which is a useful marker of cell activation. To further characterize this subpopulation of GnRH neurons, multiple immunohistochemical procedures were applied t...

journal_title：Endocrinology

authors： Eyigor O,Jennes L

更新日期：2000-02-01 00:00:00

abstract：:Perturbing the endoplasmic reticulum homeostasis of thyroid cell lines with thapsigargin, a specific inhibitor of the sarcoendoplasmic reticulum Ca(2+) adenosine triphosphatases, and tunicamycin, an inhibitor of the N-linked glycosylation, blocked Tg in the endoplasmic reticulum. This event was signaled outside the en...

journal_title：Endocrinology

authors： Leonardi A,Vito P,Mauro C,Pacifico F,Ulianich L,Consiglio E,Formisano S,Di Jeso B

更新日期：2002-06-01 00:00:00

abstract：:Previous studies have established the presence of an extrahypothalamic GnRH in a variety of tissues. GnRH receptor is known to be present in the placenta, which produces and secretes the decapeptide from the very early stages of placentation. We hypothesized that GnRH may play a role in the preimplantation development...

journal_title：Endocrinology

authors： Raga F,Casañ EM,Kruessel J,Wen Y,Bonilla-Musoles F,Polan ML

更新日期：1999-08-01 00:00:00

abstract：:The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses to CRH. However, it's potential activity in blunting behavioral and endocrine sequelae of stressor exposure has not been assessed. Because antagonism of central CRH by alpha-helical CRH attenuates conditioned fear ...

journal_title：Endocrinology

authors： Deak T,Nguyen KT,Ehrlich AL,Watkins LR,Spencer RL,Maier SF,Licinio J,Wong ML,Chrousos GP,Webster E,Gold PW

更新日期：1999-01-01 00:00:00

abstract：:The possibility that the responsiveness of plasma aldosterone concentration to angiotensin II alters with changes in sodium balance was investigated in male beagle dogs under conditions of controlled sodium and potassium intake. Angiotensin II was infused at four different rates (usually 3, 6, 12, and 24 ng/kg/min), e...

journal_title：Endocrinology

authors： Nicholls MG,Tree M,Brown JJ,Douglas BH,Fraser R,Hay GD,Lever AF,Morton JJ,Robertson JI

更新日期：1978-02-01 00:00:00

abstract：:19-Nor progesterone (19-nor P) has previously been shown to have a approximately 3-fold higher affinity for mineralocorticoid receptors than progesterone (P), its C-19 methylated parent steroid; in contrast, 19-nor aldosterone has less than 1% the mineralocorticoid receptor affinity of aldosterone. In the present stud...

journal_title：Endocrinology

authors： Funder JW,Adam WR

更新日期：1981-07-01 00:00:00

abstract：:An estrogen-responsive uterine proenzyme of a proteinase in the immature rat uterus has been known for some time. Its mol wt is 77,000, its N-terminal amino acid sequence is the same as prothrombin's for 15 residues, it contains gamma-carboxyl glutamate residues, its biosynthesis is prevented by warfarin, it cross-rea...

journal_title：Endocrinology

authors： Henrikson KP,Jazin EE,Greenwood JA,Dickerman HW

更新日期：1990-01-01 00:00:00

abstract：:Leukemia Inhibitory Factor (LIF) and its receptors in human and mouse pituicytes are expressed abundantly in corticotrophs and somatotrophs. As LIF induces POMC transcription and LPS-mediated stress also induces hypothalamic and pituitary LIF expression, we studied ACTH secretion in LIF knockout (LIF KO) mice. Basal A...

journal_title：Endocrinology

authors： Akita S,Malkin J,Melmed S

更新日期：1996-07-01 00:00:00

abstract：:To assess the consequences of prolonged exposure to elevated levels of LH/human chorionic gonadotropin (hCG) in the female, we developed a transgenic (TG) mouse model (hCGbeta+) that overexpresses the hCGbeta-subunit cDNA. Because of the promoter used, ubiquitin C, the transgene is expressed in multiple tissues, inclu...

journal_title：Endocrinology

authors： Rulli SB,Kuorelahti A,Karaer O,Pelliniemi LJ,Poutanen M,Huhtaniemi I

更新日期：2002-10-01 00:00:00

abstract：:Exposure of FRTL-5 cells to iodide (I-) in excess of 3 microM suppresses the concentrative uptake of I-. The depression of I- uptake measured at the steady state is due to decrease in the rate of I- influx and not to an effect on I- efflux. Exposure to NaI is associated with decreased T4 secretion and also depressed N...

journal_title：Endocrinology

authors： Grollman EF,Smolar A,Ommaya A,Tombaccini D,Santisteban P

更新日期：1986-06-01 00:00:00

abstract：:Impaired regulation of hepatic glucose production is a characteristic feature of the metabolic syndrome, a cluster of diseases that includes obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. It has been proposed that sustained endoplasmic reticulum stress, which appears to occur in obesity and ...

journal_title：Endocrinology

authors： Wang D,Wei Y,Schmoll D,Maclean KN,Pagliassotti MJ

更新日期：2006-01-01 00:00:00

abstract：:The present studies were designed to evaluate the binding characteristics of arginine vasopressin (AVP), using rat anterior pituitary dispersed cells, in correlation with the biological activity of the peptide. Synthetic AVP released ACTH from dispersed anterior pituitary cells in a concentration-dependent fashion, wi...

journal_title：Endocrinology

authors： Spinedi E,Negro-Vilar A

更新日期：1984-06-01 00:00:00

abstract：:Mice bearing IL-1beta-secreting tumor were used to study the chronic effect of IL-1beta on glucose metabolism. Mice were injected with syngeneic tumor cells transduced with the human IL-1beta gene. Serum IL-1beta levels increased exponentially with time. Secretion of IL-1beta from the developed tumors was associated w...

journal_title：Endocrinology

authors： Metzger S,Nusair S,Planer D,Barash V,Pappo O,Shilyansky J,Chajek-Shaul T

更新日期：2004-11-01 00:00:00

abstract：:The binding properties of the gamma-emitting 125I-labeled 11 beta-methoxy analog of 16 alpha-iodoestradiol, 11 beta-methoxy-16 alpha-iodoestradiol (MIE2), were characterized for its use in vivo as a ligand for the measurement and localization of estrogen-binding sites. In binding displacement studies, MIE2 bound to ra...

journal_title：Endocrinology

authors： Brown TJ,MacLusky NJ,Toran-Allerand CD,Zielinski JE,Hochberg RB

更新日期：1989-05-01 00:00:00

abstract：:Tunicamycin, an inhibitor of glycosylation, was incubated with ovine thyroid cells in culture to determine the role of glycosylation in the subsequent processing of thyroglobulin to form thyroid hormone. After a 6-h preincubation with tunicamycin (1 microgram/ml), mannose incorporation into glycoproteins in the cell l...

journal_title：Endocrinology

authors： Eggo MC,Burrow GN

更新日期：1983-11-01 00:00:00

abstract：:Renal prostaglandin E2 (PGE2) synthesis is enhanced by exogenous vasopressin (AVP). To determine whether the pressor or the antidiuretic activities of AVP are related to its effect on PGE2 synthesis, AVP and the nonpressor analog, 1-deamino-8-D-arginine vasopressin (dD'AVP), were administered to the isolated perfused ...

journal_title：Endocrinology

authors： Zipser RD,Myers SI,Needleman P

更新日期：1981-02-01 00:00:00

abstract：:The inhibitory effect of stress on reproductive function is potentially mediated by high concentrations of circulating glucocorticoids (GCs) acting via the GC receptor (GR). Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion. GnIH may mediate stress-induced repro...

journal_title：Endocrinology

authors： Son YL,Ubuka T,Narihiro M,Fukuda Y,Hasunuma I,Yamamoto K,Belsham DD,Tsutsui K

更新日期：2014-05-01 00:00:00

abstract：:The occupancy of atrial natriuretic peptide (ANP) receptors of the ANPA type in human neuroblastoma NB-OK-1 cells elevates cGMP. In this study, ANP concentrations of 10 nM or more increased total K+ uptake. Data obtained in the presence of bumetanide and/or ouabain demonstrated that 1 microM ANP induced a primary stim...

journal_title：Endocrinology

authors： Delporte C,Winand J,Poloczek P,Christophe J

更新日期：1993-07-01 00:00:00

abstract：:In muscle, physiologic hyperinsulinemia, presumably acting on endothelial cells (ECs), dilates arterioles and regulates both total blood flow and capillary recruitment, which in turn influences glucose disposal. In cultured ECs, however, supraphysiological (e.g. >or=10 nM) insulin concentrations are typically used to ...

journal_title：Endocrinology

authors： Li G,Barrett EJ,Wang H,Chai W,Liu Z

更新日期：2005-11-01 00:00:00

abstract：:In young adult female rats, the patterns of inhibin subunit mRNA expression during the estrous cycle are regulated by cyclic changes in gonadotropin secretion and follicular development. Since there are distinct alterations in profiles of both hormone secretion and folliculogenesis during the reproductive lifespan of ...

journal_title：Endocrinology

authors： Jih MH,Lu JK,Wan YJ,Wu TC

更新日期：1993-01-01 00:00:00

abstract：:Up to now, no relevant tumor antigen has been identified in medullary thyroid carcinoma (MTC). The aim of the present study was to prove the concept of an immunization with an amino acid-modified calcitonin (CT) for the treatment of MTC in a transgenic mouse model. Amino acid-modified (human) CT has been chosen for va...

journal_title：Endocrinology

authors： Wuttke M,Papewalis C,Meyer Y,Kessler C,Jacobs B,Willenberg HS,Schinner S,Kouatchoua C,Baehring T,Scherbaum WA,Schott M

更新日期：2008-11-01 00:00:00

abstract：:Acromegaly is associated with an increased incidence of cardiovascular disease. Transgenic mice expressing bovine GH (bGH) gene have previously been used to examine the effects of chronic GH stimulation on cardiovascular function. Results concerning systolic blood pressure (SBP) in bGH mice are conflicting. We hypothe...

journal_title：Endocrinology

authors： Jara A,Benner CM,Sim D,Liu X,List EO,Householder LA,Berryman DE,Kopchick JJ

更新日期：2014-03-01 00:00:00

abstract：:Retinoid X receptor (RXR) occupies a central position within the nuclear receptor superfamily, serving as an obligatory partner to numerous other nuclear receptors, including vitamin D receptor (VDR). In the current study, we examined whether phosphorylation of RXRα at serine 260 affects VDR/RXR and VDR interacting pr...

journal_title：Endocrinology

authors： Jusu S,Presley JF,Williams C,Das SK,Jean-Claude B,Kremer R

更新日期：2018-03-01 00:00:00

abstract：:Loss-of-function mutations in the X-linked immunoglobulin superfamily, member 1 (IGSF1) gene cause central hypothyroidism. IGSF1 is a transmembrane glycoprotein of unknown function expressed in thyrotropin (TSH)-producing thyrotrope cells of the anterior pituitary gland. The protein is cotranslationally cleaved, with ...

journal_title：Endocrinology

authors： Turgeon MO,Silander TL,Doycheva D,Liao XH,Rigden M,Ongaro L,Zhou X,Joustra SD,Wit JM,Wade MG,Heuer H,Refetoff S,Bernard DJ

更新日期：2017-04-01 00:00:00

abstract：:The metabolic consequences of visceral obesity have been associated with amplification of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in adipose tissue. This study aimed to assess in a rat model of diet-induced obesity the effects of pharmacological 11beta-HSD1 inhibition on the m...

journal_title：Endocrinology

authors： Berthiaume M,Laplante M,Festuccia W,Gélinas Y,Poulin S,Lalonde J,Joanisse DR,Thieringer R,Deshaies Y

更新日期：2007-05-01 00:00:00

abstract：:A single injection of either natural (cortisol, corticosterone) or synthetic [dexamethasone (DEX), triamcinolone acetonide] glucocorticosteroids to estradiol-primed, withdrawn chicks, resulted in a dose-dependent increase in the relative rates of ovalbumin and conalbumin synthesis. The simultaneous injection of equal ...

journal_title：Endocrinology

authors： Le Bouc Y,Groyer A,Cadepond F,Groyer-Schweizer G,Robel P,Baulieu EE

更新日期：1985-06-01 00:00:00

abstract：:Thyroid hormone is essential for normal proliferation and differentiation of chondrocytes. Thus, untreated congenital hypothyroidism is marked by severe short stature. The monocarboxylate transporter 8 (MCT8) is a highly specific transporter for thyroid hormone. The hallmarks of Allan-Herndon-Dudley syndrome, caused b...

journal_title：Endocrinology

authors： Abe S,Namba N,Abe M,Fujiwara M,Aikawa T,Kogo M,Ozono K

更新日期：2012-08-01 00:00:00

abstract：:Nuclear entry of proteins the size of the glucocorticoid and thyroid hormone receptors appears to be mediated by an interaction of nuclear localization signals (NLSs) within the proteins and specific NLS-binding proteins. NLSs have been identified in the hinge region of both receptors. We have identified the cellular ...

journal_title：Endocrinology

authors： LaCasse EC,Lochnan HA,Walker P,Lefebvre YA

更新日期：1993-03-01 00:00:00

abstract：:Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses. The expression of functional leptin receptors (OB-Rb) was detected in vascular smooth muscle cells (VSMCs) from adult W...

journal_title：Endocrinology

authors： Fortuño A,Rodríguez A,Gómez-Ambrosi J,Muñiz P,Salvador J,Díez J,Frühbeck G

更新日期：2002-09-01 00:00:00

abstract：:Prolactinomas are the most prevalent functional pituitary adenomas. Dopamine D2 receptor (D2R) agonists, such as bromocriptine are the first line of therapy; however, drug intolerance/resistance to D2R agonists exists. Apart from D2R agonists, there is no established medical therapy for prolactinomas; therefore, ident...

journal_title：Endocrinology

authors： Miller M,Chen S,Woodliff J,Kansra S

更新日期：2008-08-01 00:00:00