Abstract:
:Exposure of FRTL-5 cells to iodide (I-) in excess of 3 microM suppresses the concentrative uptake of I-. The depression of I- uptake measured at the steady state is due to decrease in the rate of I- influx and not to an effect on I- efflux. Exposure to NaI is associated with decreased T4 secretion and also depressed Na+-dependent amino acid accumulation. The depression in I- and amino acid transports increases proportionately with the duration of exposure and concentration of I- used but is not associated with alterations in FRTL-5 cell cAMP levels. The I- suppression effect is blocked, however, when methimazole is present during the incubation with NaI. In agreement with studies in vivo, I- suppression in FRTL-5 cells appears to depend on an intermediate in the organification process and to be independent of a TSH-induced cAMP-mediated action.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Grollman EF,Smolar A,Ommaya A,Tombaccini D,Santisteban Pdoi
10.1210/endo-118-6-2477subject
Has Abstractpub_date
1986-06-01 00:00:00pages
2477-82issue
6eissn
0013-7227issn
1945-7170journal_volume
118pub_type
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