Abstract:
:Ghrelin stimulates and leptin inhibits appetite by modulating neuropeptide Y (NPY) signaling in the hypothalamus. Analysis of plasma ghrelin and leptin by sensitive radioimmunoassays showed that the two peripheral hormones are secreted in pulsatile fashion in rats consuming ad libitum rat chow. Fasting augmented all parameters of ghrelin pulsatile secretion and diminished leptin secretion by selectively attenuating the pulse amplitude; concomitantly it produced synchrony in ghrelin and leptin pulse discharge. These studies imply that a synchronous leptin restraint and ghrelin stimulus on NPYergic signaling may underlie robust appetitive drive.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Bagnasco M,Kalra PS,Kalra SPdoi
10.1210/endo.143.2.8743subject
Has Abstractpub_date
2002-02-01 00:00:00pages
726-9issue
2eissn
0013-7227issn
1945-7170journal_volume
143pub_type
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