Inhibition of urokinase activity by the antiangiogenic factor 16K prolactin: activation of plasminogen activator inhibitor 1 expression.

abstract：:The original objective of this study was to use available distribution volume (V) and deca constant (k) estimates for rat LH and FSH to determine the amounts of these hormones synthesized and released during a dynamic secretory event, the postpartum preovulatory surge. The problem was approached by 1) determining the ...

journal_title：Endocrinology

authors： Diebel ND,Bogdanove EM

更新日期：1978-09-01 00:00:00

abstract：:The specific uptake by rat liver of human (hGH) and bovine (bGH) GHs labeled with 125I was studied by an in vivo procedure. A significant reduction of the uptake was observed when labeled hormones were injected together with different amounts of the corresponding native GH. This reduction was dose dependent, and the c...

journal_title：Endocrinology

authors： Turyn D,Dellacha JM

更新日期：1978-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. It is also secreted into hypophyseal portal vessels. The injection of NPY into the third ventricle (3V) lowered plasma GH levels in conscious, freely moving male rats. To determine the physiol...

journal_title：Endocrinology

authors： Rettori V,Milenkovic L,Aguila MC,McCann SM

更新日期：1990-05-01 00:00:00

abstract：:One of the hypotheses attempting to explain the etiology of the human disease X-linked hypophosphatemia (XLH) posits renal hypersensitivity to parathyroid hormone (PTH). These studies were designed to test this hypothesis in vivo, using the hemizygous hypophosphatemic (Hyp/Y) mouse as an animal model for XLH. Vehicle ...

journal_title：Endocrinology

authors： Kiebzak GM,Meyer RA Jr

更新日期：1982-03-01 00:00:00

abstract：:Recent data suggest that proinflammatory cytokines secreted from adipose tissue contribute to the morbidity associated with obesity. However, characterization of the cell types involved in inflammation and how these cells promote insulin resistance in human adipocytes are unclear. We simulated acute inflammation using...

journal_title：Endocrinology

authors： Chung S,Lapoint K,Martinez K,Kennedy A,Boysen Sandberg M,McIntosh MK

更新日期：2006-11-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), the predominant IGF carrier protein in circulation, is posttranslationally modified in vivo by IGFBP-3 protease(s) into a number of fragments. Based on the ascertained and predicted recognition sites for known IGFBP-3 proteases, FLAG-epitope tagged intact I...

journal_title：Endocrinology

authors： Devi GR,Yang DH,Rosenfeld RG,Oh Y

更新日期：2000-11-01 00:00:00

abstract：:Heart failure is a leading cause of death, especially in the elderly or obese and diabetic populations. Various remodeling events have been characterized, which collectively contribute to the progression of heart failure. Of particular interest, autophagy has recently emerged as an important determinant of cardiac rem...

journal_title：Endocrinology

authors： Jahng JW,Turdi S,Kovacevic V,Dadson K,Li RK,Sweeney G

更新日期：2015-07-01 00:00:00

abstract：:Osteoblasts are known to produce osteoclast-stimulating activity (OSA). The aim of the current study was to relate the expression of OSA to the osteoblastic phenotype and examine its regulation by calciotropic hormones. The study was performed with the normal osteoblastic cell clone CRP 10/30 and the preosteoblastic c...

journal_title：Endocrinology

authors： Collin P,Guenther HL,Fleisch H

更新日期：1992-09-01 00:00:00

abstract：:Mouse uterine estrogen receptor (ER) was purified about 11,000-fold from normal mouse uteri by affinity chromatography. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified ER demonstrated a major component of 65,000 mol wt with minor fragments of the 54,000- and 37,000-dalton species, as judged b...

journal_title：Endocrinology

authors： Horigome T,Golding TS,Quarmby VE,Lubahn DB,McCarty K Sr,Korach KS

更新日期：1987-12-01 00:00:00

abstract：:Aging of the female reproductive system in rats is marked by discrete stages in the disappearance of regular estrous cyclicity. We determined at which point in the transition to acyclicity changes in the LH pulse generator could be detected by comparing pulsatile LH release in ovariectomized young rats to three groups...

journal_title：Endocrinology

authors： Scarbrough K,Wise PM

更新日期：1990-02-01 00:00:00

abstract：:Hypophysectomized rats bearing three transplanted pituitaries under the kidney capsule responded to synthetic lysine vasopressin or pitressin with a significant elevation of plasma corticosterone, whereas hypophysectomized rats with no grafts did not. This response was completely abolished by pretreatment of animals w...

journal_title：Endocrinology

authors： Yasuda N,Greer MA,Greer SE,Panton P

更新日期：1978-09-01 00:00:00

abstract：:LH receptor (LHR) expression in the ovary is regulated by the RNA binding protein, (LHR mRNA binding protein [LRBP]), which has been identified as being mevalonate kinase. This study examined the role of microRNA miR-122 in LRBP-mediated LHR mRNA expression. Real-time PCR analysis of ovaries from pregnant mare serum g...

journal_title：Endocrinology

authors： Menon B,Sinden J,Franzo-Romain M,Botta RB,Menon KM

更新日期：2013-12-01 00:00:00

abstract：:Stanniocalcin (STC) is a new mammalian polypeptide hormone and appears to be a regulator of neuronal function. We have already shown that the induction of STC mRNA and protein expression by cAMP is integral to neuroblastoma cell differentiation, particularly neurite outgrowth. In this study, we examined the cAMP pathw...

journal_title：Endocrinology

authors： Yeung HY,Chan DK,Mak NK,Wagner GF,Wong CK

更新日期：2003-10-01 00:00:00

abstract：:Current drug therapies for obesity are ineffective, and existing treatments for lipid disorders can be further improved. Thyroid hormones affect both conditions, although currently available nonselective thyromimetics are not clinically useful for such treatment due to cardiac side effects. Recent studies suggest that...

journal_title：Endocrinology

authors： Grover GJ,Egan DM,Sleph PG,Beehler BC,Chiellini G,Nguyen NH,Baxter JD,Scanlan TS

更新日期：2004-04-01 00:00:00

abstract：:The electrical responses of rat islet cells maintained in culture with varying levels of glucose were determined. After culture with 2.8 or 4.2 mM glucose, the beta-cells did not respond electrically to 27.8 mM glucose. However, after culture in 5.6 mM glucose, the cells responded to 27.8 mM glucose in short term expe...

journal_title：Endocrinology

authors： Pace CS,Conant S,Lacy PE

更新日期：1978-05-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP), via its guanylyl cyclase (GC)-A receptor, plays a key role in the regulation of arterial blood pressure (ABP) and volume. Endothelial-restricted deletion of GC-A in mice [endothelial cell (EC) GC-A knockout (KO)] resulted in hypervolemic hypertension, demonstrating that the endotheliu...

journal_title：Endocrinology

authors： Sabrane K,Kruse MN,Gazinski A,Kuhn M

更新日期：2009-05-01 00:00:00

abstract：:The antithyroid drug 6-propylthiouracil (PTU) was previously shown in our laboratory to have an unexpectedly prolonged inhibitory effect on iodination in the thyroid glands of rats. Eighteen hours after injection of a relatively small dose, iodination in the thyroid remained inhibited by more than 90%. We previously s...

journal_title：Endocrinology

authors： Taurog A,Dorris ML

更新日期：1989-06-01 00:00:00

abstract：:The circadian rhythm of glucocorticoids affects diverse physiological systems, including stress responses and the coordination of rhythmic functions in peripheral and central tissues. Circadian clocks are considered to be important coordinators of glucocorticoid release and loss of the core clock component Brain and m...

journal_title：Endocrinology

authors： Dumbell R,Leliavski A,Matveeva O,Blaum C,Tsang AH,Oster H

更新日期：2016-11-01 00:00:00

abstract：:Hexose-6-phosphate dehydrogenase (EC 1.1.1.47) catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor fo...

journal_title：Endocrinology

authors： Rogoff D,Ryder JW,Black K,Yan Z,Burgess SC,McMillan DR,White PC

更新日期：2007-10-01 00:00:00

abstract：:A number of cytokines have been found to be potent regulators of bone resorption and to share the properties originally attributed to osteoclast-activating factor. One such activity, differentiation-inducing factor (DIF, D-factor) from mouse spleen cells, shares a number of biological and biochemical properties with t...

journal_title：Endocrinology

authors： Reid LR,Lowe C,Cornish J,Skinner SJ,Hilton DJ,Willson TA,Gearing DP,Martin TJ

更新日期：1990-03-01 00:00:00

abstract：:Adipokines, cytokines mainly produced by adipocytes, are active participants in the regulation of inflammation. Administration of zymosan (ZY) was used to investigate the regulation and role of adipokines during peritonitis in mice. Injection of ZY led to a significant increase in leptin levels in both serum and perit...

journal_title：Endocrinology

authors： Pini M,Gove ME,Sennello JA,van Baal JW,Chan L,Fantuzzi G

更新日期：2008-08-01 00:00:00

abstract：:Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...

journal_title：Endocrinology

authors： Tanaka T,Aoyagi C,Mukai K,Nishimoto K,Kodama S,Yanase T

更新日期：2020-03-01 00:00:00

abstract：:Marked development of the mammary parenchyma (ducts, lobules, and alveoli) occurs during the last third of the 115-day gestation period in the gilt. These changes in the mammary gland are temporally correlated with elevated blood levels of relaxin, estrogen, and progesterone. We recently demonstrated that relaxin play...

journal_title：Endocrinology

authors： Winn RJ,Baker MD,Merle CA,Sherwood OD

更新日期：1994-09-01 00:00:00

abstract：:The signals that regulate cardiac myocyte maturation in the neonatal heart are not completely understood. In our study we examined the effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] on primary cultures of ventricular myocytes isolated from neonatal rat hearts. Our data show that 1,25-(OH)2D3 inhibited an increase ...

journal_title：Endocrinology

authors： O'Connell TD,Giacherio DA,Jarvis AK,Simpson RU

更新日期：1995-02-01 00:00:00

abstract：:It is known that the circadian rhythm in hepatic phosphoenolpyruvate carboxykinase expression (a limiting catalytic step of gluconeogenesis) and hepatic glucose production is maintained by both daily oscillation in autonomic inputs to the liver and night feeding behavior. However, increased glycemia and reduced melato...

journal_title：Endocrinology

authors： Nogueira TC,Lellis-Santos C,Jesus DS,Taneda M,Rodrigues SC,Amaral FG,Lopes AM,Cipolla-Neto J,Bordin S,Anhê GF

更新日期：2011-04-01 00:00:00

abstract：:The lipolysis, ketosis and hypertriglyceridemia of fasted rats in late pregnancy may be related to decreased insulin secretion geared to decreased glucose availability. In odd-carbon fatty acid enriched (OCE) rats, the odd-carbon fatty acids (OCFA) mobilized during fasting provide terminal three-carbon residues which ...

journal_title：Endocrinology

authors： Kim S,Pi-Sunyer FX

更新日期：1977-02-01 00:00:00

abstract：:During preimplantation development in the mouse, it is crucial that glucose metabolism not be compromised. Any decrease in glucose uptake at this stage in development can compromise the developing embryo. We have cloned another member of the glucose transporter family, GLUT9, which is expressed embryonically. Three di...

journal_title：Endocrinology

authors： Carayannopoulos MO,Schlein A,Wyman A,Chi M,Keembiyehetty C,Moley KH

更新日期：2004-03-01 00:00:00

abstract：:Many aspects of reproductive function are corrected in hypogonadal mice with preoptic area grafts (HPG/POA). Gonadotropin release and gonadal development are dependent on the presence of GnRH cells within the grafts and GnRH innervation of the median eminence. This study examined the effect of a known modulator of GnR...

journal_title：Endocrinology

authors： Saitoh Y,Silverman AJ,Gibson MJ

更新日期：1991-05-01 00:00:00

abstract：:The induction of hepatic drug metabolizing enzymes alters not only the metabolism of the xenobiotic substances that induce them but also the metabolism of various endogenous hormones. The xenobiotic receptor constitutive androstane receptor (CAR) (NR1I3) mediates the well-studied induction of CYP2B genes and other dru...

journal_title：Endocrinology

authors： Qatanani M,Zhang J,Moore DD

更新日期：2005-03-01 00:00:00

abstract：:The effects of LH on glucose metabolism within cumulus cell-enclosed bovine oocytes were determined. Cumulus cell-enclosed bovine oocytes were matured in vitro (IVM) in control medium alone or supplemented with LH, FSH, or TSH, then individually assayed for the metabolism of D-[5-3H]glucose, D-[1-14C]glucose, D-[6-14C...

journal_title：Endocrinology

authors： Zuelke KA,Brackett BG

更新日期：1992-12-01 00:00:00