Histaminergic activation of the hypothalamic-pituitary-adrenal axis.

abstract：:Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indic...

journal_title：Endocrinology

authors： Williams DL

更新日期：2009-07-01 00:00:00

abstract：:MCF-7 cells migrate through vitronectin-coated filters in response to insulin-like growth factor I (IGF-I); migration is inhibited by the matrix metalloproteinase (MMP) inhibitor BB-94, but not by the serine proteinase inhibitor aprotinin. MMP-9 was identified in the conditioned medium of MCF-7 cells; in addition, flu...

journal_title：Endocrinology

authors： Mira E,Mañes S,Lacalle RA,Márquez G,Martínez-A C

更新日期：1999-04-01 00:00:00

abstract：:Hypothalamic inflammation and gliosis are proposed to participate in the pathogenesis of high-fat diet-induced obesity. Because other factors and nutrients also induce weight gain and adiposity, we analyzed the inflammatory and glial responses to a sucrose (S)-enriched diet. Neonatal overnutrition (NON) exacerbates we...

journal_title：Endocrinology

authors： Fuente-Martín E,García-Cáceres C,Díaz F,Argente-Arizón P,Granado M,Barrios V,Argente J,Chowen JA

更新日期：2013-07-01 00:00:00

abstract：:We have recently found that, in the frog adrenal gland, endozepines are present in chromaffin cells and we have shown that the triakontatetraneuropeptide TTN is a potent stimulator of corticosteroid secretion in vitro. In the present study, we have investigated the transduction mechanisms mediating the corticotropic e...

journal_title：Endocrinology

authors： Lesouhaitier O,Kodjo MK,Cartier F,Contesse V,Yon L,Delarue C,Vaudry H

更新日期：2000-01-01 00:00:00

abstract：:The cell of origin of human null cell pituitary adenomas is disputed. Although these tumors, by definition, do not produce any of the anterior pituitary hormones in vivo, they have been shown to express gonadotropin subunit genes, release gonadotropin hormones in vitro, and express the gonadotroph-associated transcrip...

journal_title：Endocrinology

authors： Kumar TR,Graham KE,Asa SL,Low MJ

更新日期：1998-07-01 00:00:00

abstract：:Pituitary glands from ovariectomized F-344 rats bearing diethylstilbestrol-containing capsules for 70-100 days were dissociated and separated into three size classes by unit gravity sedimentation. The average percentage of large mammotrophs in fraction I was 86 +/- (SE) 2%, the percentage of intermediate-sized mammotr...

journal_title：Endocrinology

authors： Hymer WC,Motter KA

更新日期：1988-05-01 00:00:00

abstract：:In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium. Although FSH ...

journal_title：Endocrinology

authors： Tabraue C,Diaz Peñate R,Gallardo G,Hernandez I,Quintana J,Lopez Blanco F,Gonzalez Reyes J,Fanjul LF,Ruiz de Galarreta CM

更新日期：1997-01-01 00:00:00

abstract：:We studied the direct effects of glucocorticoids on plasminogen activator (PA) production by rat granulosa cells. PA production was assayed by culturing rat granulosa cells on [125I]fibrin plates and determining the extent of fibrinolysis after addition of the specific substrate plasminogen. In granulosa cells from pr...

journal_title：Endocrinology

authors： Wang C,Leung A

更新日期：1989-04-01 00:00:00

abstract：:Mast cells are involved in atopic disorders, often exacerbated by stress, and are located perivascularly close to sympathetic and sensory nerve endings. Mast cells are activated by electrical nerve stimulation and millimolar concentrations of neuropeptides, such as substance P (SP). Moreover, acute psychological stres...

journal_title：Endocrinology

authors： Theoharides TC,Singh LK,Boucher W,Pang X,Letourneau R,Webster E,Chrousos G

更新日期：1998-01-01 00:00:00

abstract：:Lefty/Ebaf polypeptides, novel members of the TGF-beta superfamily, are involved in endometrial differentiation and embryo implantation. Recently, we showed that, during undisturbed estrous cycle, lefty is present in mouse uterine horn primarily in a precursor form. Here, we show that decidual differentiation of endom...

journal_title：Endocrinology

authors： Tang M,Mikhailik A,Pauli I,Giudice LC,Fazelabas AT,Tulac S,Carson DD,Kaufman DG,Barbier C,Creemers JW,Tabibzadeh S

更新日期：2005-12-01 00:00:00

abstract：:The effects of recombinant human insulin-like growth factor I (IGF-I) on both vasoactive intestinal peptide (VIP) and PRL production and gene expression were studied using rat anterior pituitary cell cultures grown in serum-free defined medium. We also examined whether pituitary VIP could be involved in the PRL respon...

journal_title：Endocrinology

authors： Lara JI,Lorenzo MJ,Cacicedo L,Tolón RM,Balsa JA,López-Fernández J,Sánchez-Franco F

更新日期：1994-12-01 00:00:00

abstract：:Early-life experiences, including maternal interaction, profoundly influence hormonal stress responses during adulthood. In rats, daily handling during a critical neonatal period leads to a significant and permanent modulation of key molecules that govern hormonal secretion in response to stress. Thus, hippocampal glu...

journal_title：Endocrinology

authors： Avishai-Eliner S,Eghbal-Ahmadi M,Tabachnik E,Brunson KL,Baram TZ

更新日期：2001-01-01 00:00:00

abstract：:Recent studies suggest that GH may modulate emotion, behavior, or stress response by its direct actions on the brain, and possible expression of the GH gene in the brain has been predicted. In this study we have investigated whether and where the GH gene is expressed in the brain and how it is regulated. Ribonuclease ...

journal_title：Endocrinology

authors： Yoshizato H,Fujikawa T,Soya H,Tanaka M,Nakashima K

更新日期：1998-05-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) inhibits the embryonic migration of GnRH neurons and regulates hypothalamic GnRH release. A subset of GnRH neurons expresses GABA along their migratory route in the nasal compartment before entering the brain, suggesting that GABA produced by GnRH neurons may help regulate the migratory ...

journal_title：Endocrinology

authors： Heger S,Seney M,Bless E,Schwarting GA,Bilger M,Mungenast A,Ojeda SR,Tobet SA

更新日期：2003-06-01 00:00:00

abstract：:Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased t...

journal_title：Endocrinology

authors： Makanji Y,Walton KL,Chan KL,Gregorevic P,Robertson DM,Harrison CA

更新日期：2011-10-01 00:00:00

abstract：:This study was initiated to investigate the significance of uterine cell death and proliferation during the estrous cycle and early pregnancy and their correlation with sex steroids in hamsters where blastocyst implantation occurs in only progesterone-primed uteri. The results obtained in hamsters were also compared w...

journal_title：Endocrinology

authors： Zhang Q,Paria BC

更新日期：2006-05-01 00:00:00

abstract：:In previous studies we have shown that aromatase cytochrome P450 (P450arom) mRNA and protein increase markedly in luteal tissue between days 10-19 of gestation, whereas cholesterol side-chain cleavage cytochrome P450 (P450scc) appears to be constitutively maintained regardless of hormonal changes occurring during preg...

journal_title：Endocrinology

authors： Hickey GJ,Oonk RB,Hall PF,Richards JS

更新日期：1989-09-01 00:00:00

abstract：:For insight into transcriptional mechanisms mediating physiological responses to GH, data mining was performed on a profile of GH-regulated genes induced or inhibited at different times in highly responsive 3T3-F442A adipocytes. Gene set enrichment analysis indicated that GH-regulated genes are enriched in pathways in...

journal_title：Endocrinology

authors： Chen Y,Lin G,Huo JS,Barney D,Wang Z,Livshiz T,States DJ,Qin ZS,Schwartz J

更新日期：2009-08-01 00:00:00

abstract：:Thyroid hormone entry into the thymocyte, a thyroid hormone target, was investigated by incubating the cells with tracer amounts of [125I]L-T3. At 37 C T3 uptake was linear with time up to 2 min, and then approached a plateau. The specific T3 uptake, obtained by subtracting the uptake in the presence of excess unlabel...

journal_title：Endocrinology

authors： Centanni M,Mancini G,Andreoli M

更新日期：1989-05-01 00:00:00

abstract：:ACTH produced a 75% increase in pregnenolone biosynthesis from endogenous precursors in isolated cells prepared from the rat Snell adrenocortical carcinoma 494. On the addition of 24- and 25-hydroxycholesterol to the tumor cells, the rate of pregnenolone synthesis increased 10-fold but was insensitive to the presence ...

journal_title：Endocrinology

authors： Mason JI,Robidoux WF

更新日期：1979-11-01 00:00:00

abstract：:Analogs of the seco-steroid hormone, 1,25-dihydroxyvitamin D3 [1,25-(OH)-2D3] can preferentially stimulate genomic or nongenomic signaling pathways in osteoblasts. In this study, we used 1,25-(OH)2D3 analogs and voltage-sensitive Ca2+ channel (VSCC) ligands, including dihydropyridines (Bay K 8644 and nitrendipine), in...

journal_title：Endocrinology

authors： Khoury R,Ridall AL,Norman AW,Farach-Carson MC

更新日期：1994-12-01 00:00:00

abstract：:GH is a pleiotropic hormone that plays a major role in proliferation, differentiation, and metabolism via its specific receptor. It has been previously suggested that GH signaling pathways are required for normal liver regeneration but the molecular mechanisms involved have yet to be determined. The aim of this study ...

journal_title：Endocrinology

authors： Zerrad-Saadi A,Lambert-Blot M,Mitchell C,Bretes H,Collin de l'Hortet A,Baud V,Chereau F,Sotiropoulos A,Kopchick JJ,Liao L,Xu J,Gilgenkrantz H,Guidotti JE

更新日期：2011-07-01 00:00:00

abstract：:Adrenal secretory rates of catecholamines in response to a repeated stimulus have not been described. We have used repeated small hemorrhages spaced 24 h apart in pentobarbital anesthetized dogs prepared with a chronic adrenal venous catheter to study this question. Our results confirm earlier reports that an initial ...

journal_title：Endocrinology

authors： Lilly MP,Engeland WC,Gann DS

更新日期：1982-12-01 00:00:00

abstract：:Spot 14 (S14) is a protein whose mRNA is rapidly up-regulated by lipogenic stimuli including thyroid hormone and a high-carbohydrate diet. Previous investigation into the role of S14 suggested that it is involved in de novo lipogenesis. Knockout of the gene in mice has given further support to this hypothesis. The lac...

journal_title：Endocrinology

authors： LaFave LT,Augustin LB,Mariash CN

更新日期：2006-09-01 00:00:00

abstract：:GnRH was first identified as the hypothalamic decapeptide that promotes gonadotropin release from pituitary gonadotropes. Thereafter, direct stimulatory and inhibitory effects of GnRH on cell proliferation were demonstrated in a number of types of primary cultured cells and established cell lines. Recently, the effect...

journal_title：Endocrinology

authors： Enomoto M,Utsumi M,Park MK

更新日期：2006-01-01 00:00:00

abstract：:Angiotensin II (AII) receptors in adrenal glomerulosa cells are coupled to adenylate cyclase inhibition. We investigated the importance of cyclase inhibition in adrenal steroidogenesis by treating adrenal glomerulosa cells with the toxin of Bordetella pertussis (20 ng/ml) for 3 and 18 h. This treatment prevented inhib...

journal_title：Endocrinology

authors： Woodcock EA,McLeod JK

更新日期：1986-10-01 00:00:00

abstract：:The hormonal requirements for lactogenesis were investigated using explant cultures of mammary tissue obtained from cows at 30-40 days prepartum. Hormones used were insulin, hydrocortisone, and prolactin, and parameters examined were radioactive acetate incorporation into fatty acids, secretory response ratings, and h...

journal_title：Endocrinology

authors： Collier RJ,Bauman DE,Hays RL

更新日期：1977-04-01 00:00:00

abstract：:We used autoradiography to test the hypothesis that a major function of thyroid hormone-binding proteins in plasma is to ensure uniform distribution of thyroid hormones among cells of a given tissue. The distribution of [125I]T4 within rat hepatic lobules was determined after its single pass perfusion through the port...

journal_title：Endocrinology

authors： Mendel CM,Weisiger RA,Jones AL,Cavalieri RR

更新日期：1987-05-01 00:00:00

abstract：:Cultures of Sertoli cells were treated with freshly isolated, intact germ cells to determine if germ cells were capable of influencing Sertoli cell function. By using two-dimensional polyacrylamide gel electrophoresis and autoradiography, germ cells were found to increase several-fold the incorporation of [32P]orthoph...

journal_title：Endocrinology

authors： Ireland ME,Welsh MJ

更新日期：1987-04-01 00:00:00

abstract：:T3 is required for normal skeletal development, but its cellular targets in bone are unknown. T3 regulates target gene transcription via a specific nuclear receptor (T3R), which can heterodimerize with 9-cis-retinoic acid, 1 alpha, 25-dihydroxyvitamin D3, or retinoic acid receptors to modify T3 responsiveness. Serum-f...

journal_title：Endocrinology

authors： Williams GR,Bland R,Sheppard MC

更新日期：1994-12-01 00:00:00