Abstract:
:Angiotensin II (AII) receptors in adrenal glomerulosa cells are coupled to adenylate cyclase inhibition. We investigated the importance of cyclase inhibition in adrenal steroidogenesis by treating adrenal glomerulosa cells with the toxin of Bordetella pertussis (20 ng/ml) for 3 and 18 h. This treatment prevented inhibition of forskolin-stimulated adenylate cyclase by AII. However, the aldosterone response to AII was not altered by toxin treatment. These results strongly suggest that adenylate cyclase inhibition is not directly involved in mediating the adrenal actions of AII. In addition, ACTH-induced steroidogenesis also was unaffected by toxin treatment demonstrating that cyclase inhibition is not involved in suppressing steroidogenesis via the cAMP pathway.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Woodcock EA,McLeod JKdoi
10.1210/endo-119-4-1697subject
Has Abstractpub_date
1986-10-01 00:00:00pages
1697-702issue
4eissn
0013-7227issn
1945-7170journal_volume
119pub_type
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