Down-regulation of hypothalamic corticotropin-releasing hormone messenger ribonucleic acid (mRNA) precedes early-life experience-induced changes in hippocampal glucocorticoid receptor mRNA.

abstract：:Although implantation of GH3 pituitary epithelial cells has been shown to reverse thymic aging in rats, the differentiation pattern of T-lymphocytes within the reconstituted thymus glands has not been investigated. Syngeneic GH3 cells were implanted into 22-month-old female (old) Wistar-Furth rats. Eight weeks later, ...

journal_title：Endocrinology

authors： Li YM,Brunke DL,Dantzer R,Kelley KW

更新日期：1992-05-01 00:00:00

abstract：:To determine the effect of aromatase inhibitors on peripheral aromatization, male rhesus monkeys were infused with [7-3H]androstenedione and [4-14C]estrone before and during treatment with 4-hdyroxy-androstene-3,17-dione (50 mg/kg each; four monkeys) or 4-acetoxy-androstene-3,17-dione (700 mg each; two monkeys). In al...

journal_title：Endocrinology

authors： Brodie AM,Longcope C

更新日期：1980-01-01 00:00:00

abstract：:Ghrelin has emerged as putative regulator of an array of endocrine and nonendocrine functions, including cell proliferation. Recently, we provided evidence for the expression of ghrelin in mature, but not in undifferentiated, Leydig cells of rat and human testis. Yet testicular actions of ghrelin, other than modulatio...

journal_title：Endocrinology

authors： Barreiro ML,Gaytan F,Castellano JM,Suominen JS,Roa J,Gaytan M,Aguilar E,Dieguez C,Toppari J,Tena-Sempere M

更新日期：2004-11-01 00:00:00

abstract：:Because of the importance of estrogen in osteoporosis, the effects of decreased estrogen production using sensitive measurements of bone mineral metabolism were studied in oophorectomized rats. Serum levels of ionized calcium, bone gla protein (BGP), vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin...

journal_title：Endocrinology

authors： Ismail F,Epstein S,Fallon MD,Thomas SB,Reinhardt TA

更新日期：1988-02-01 00:00:00

abstract：:Within the preoptic region, nitric oxide (NO) production varies during the ovarian cycle and has the ability to impact hypothalamic reproductive function. One mechanism for the regulation of NO release mediated by estrogens during the estrous cycle includes physical association of the calcium-activated neuronal NO syn...

journal_title：Endocrinology

authors： Parkash J,d'Anglemont de Tassigny X,Bellefontaine N,Campagne C,Mazure D,Buée-Scherrer V,Prevot V

更新日期：2010-06-01 00:00:00

abstract：:Modulation of activin and other TGF beta superfamily signaling is the primary mechanism of action for both follistatin (FS) and FS-like 3 (FSTL-3). However, most studies of these ligands use activin A due to its wide availability. We have now tested the ability of FS288 and FSTL-3 to bind and neutralize activin B rela...

journal_title：Endocrinology

authors： Schneyer A,Schoen A,Quigg A,Sidis Y

更新日期：2003-05-01 00:00:00

abstract：:Hypothyroidism is the most frequent and earliest endocrine complication in cystinosis, a multisystemic lysosomal storage disease caused by defective transmembrane cystine transporter, cystinosin (CTNS gene). We recently demonstrated in Ctns(-/-) mice that altered thyroglobulin biosynthesis associated with endoplasmic ...

journal_title：Endocrinology

authors： Gaide Chevronnay HP,Janssens V,Van Der Smissen P,Rocca CJ,Liao XH,Refetoff S,Pierreux CE,Cherqui S,Courtoy PJ

更新日期：2016-04-01 00:00:00

abstract：:In several mammalian species, luteinizing hormone-releasing hormone (LHRH) neurons have been shown to migrate from nasal regions to the brain during early development. Using immunocytochemistry, we have identified LHRH containing neurons in developing chick embryos. In embryonic day 4 (E4) and E5 animals, a small grou...

journal_title：Endocrinology

authors： Norgren RB Jr,Lehman MN

更新日期：1991-03-01 00:00:00

abstract：:Recent evidence indicates that osteopontin (Opn), one of the bone matrix proteins, plays an important role in the attachment of osteoclasts to bone matrix. Besides being elaborated by osteoblasts, this protein is also produced by osteoclasts. The present study was performed to examine the effect of calcitonin (CT) on ...

journal_title：Endocrinology

authors： Kaji H,Sugimoto T,Miyauchi A,Fukase M,Tezuka K,Hakeda Y,Kumegawa M,Chihara K

更新日期：1994-07-01 00:00:00

abstract：:Proteolytic degradation of extracellular matrix components has been suggested to play an essential role in the occurrence of ovulation. Recent studies in our laboratory have indicated that the plasminogen activator and matrix metalloproteinase systems, which were previously believed to be crucial for ovulation, are no...

journal_title：Endocrinology

authors： Wahlberg P,Nylander A,Ahlskog N,Liu K,Ny T

更新日期：2008-10-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) was partially purified from incubation medium of calf fetal testes and injected into a BALB/c mouse, whose splenocytes were fused with Sp2/Ag8 myeloma cells. Hybridomas were screened for specific antibody production by double antibody precipitation of labeled AMH, which was obtained by inc...

journal_title：Endocrinology

authors： Vigier B,Picard JY,Josso N

更新日期：1982-01-01 00:00:00

abstract：:Experimental evidence indicates that the neonatal gonadal steroid environment is an important determinant of the sexual dimorphism of GH secretion and body growth. However, the influence of the sex steroids in GH control during adult life and their mechanism/site of action are largely unknown. In the present study we ...

journal_title：Endocrinology

authors： Painson JC,Thorner MO,Krieg RJ,Tannenbaum GS

更新日期：1992-01-01 00:00:00

abstract：:The possibility that the responsiveness of plasma aldosterone concentration to angiotensin II alters with changes in sodium balance was investigated in male beagle dogs under conditions of controlled sodium and potassium intake. Angiotensin II was infused at four different rates (usually 3, 6, 12, and 24 ng/kg/min), e...

journal_title：Endocrinology

authors： Nicholls MG,Tree M,Brown JJ,Douglas BH,Fraser R,Hay GD,Lever AF,Morton JJ,Robertson JI

更新日期：1978-02-01 00:00:00

abstract：:Endocannabinoids act as a major neuromodulatory system in a variety of physiological and behavioral functions. Three major lines of evidence suggest that the endocannabinoid system interacts with gonadal hormones. First, the endocannabinoid system is implicated in behaviors and physiological functions that are known t...

journal_title：Endocrinology

authors： Gorzalka BB,Dang SS

更新日期：2012-03-01 00:00:00

abstract：:To date, the role of pancreatic hormones in pancreatic islet growth and differentiation is poorly understood. To address this issue, we examined mice with a disruption in the gene encoding prohormone convertase 2 (PC2). These mice are unable to process proglucagon, prosomatostatin, and other neuroendocrine precursors ...

journal_title：Endocrinology

authors： Vincent M,Guz Y,Rozenberg M,Webb G,Furuta M,Steiner D,Teitelman G

更新日期：2003-09-01 00:00:00

abstract：:The role of adrenergic stimulation in the regulation of mitogen-activated protein kinase (MAPK) in rat pinealocytes was investigated by measuring phosphorylated MAPK using Western blot analysis and a MAPK enzymatic assay. Stimulation with the endogenous neurotransmitter, norepinephrine (NE; a mixed alpha- and beta-adr...

journal_title：Endocrinology

authors： Ho AK,Chik CL

更新日期：2000-12-01 00:00:00

abstract：:Increased toxicant exposure and resultant environmentally induced diseases are a tradeoff of industrial productivity. Dioxin [2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD)], a ubiquitous byproduct, is associated with a spectrum of diseases including endometriosis, a common, chronic disease in women. TCDD activates cytoch...

journal_title：Endocrinology

authors： Khan Z,Zheng Y,Jones TL,Delaney AA,Correa LF,Shenoy CC,Khazaie K,Daftary GS

更新日期：2018-01-01 00:00:00

abstract：:Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...

journal_title：Endocrinology

authors： Naulé L,Maione L,Kaiser UB

更新日期：2021-01-01 00:00:00

abstract：:Pancreatic islets express the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system, but its role remains unknown. To address this, we studied the mechanisms of impaired insulin secretion induced by diphenyleneiodium (DPI), an NADPH oxidase inhibitor. We investigated the effects of DP...

journal_title：Endocrinology

authors： Imoto H,Sasaki N,Iwase M,Nakamura U,Oku M,Sonoki K,Uchizono Y,Iida M

更新日期：2008-11-01 00:00:00

abstract：:Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to ...

journal_title：Endocrinology

authors： Thaler JP,Schwartz MW

更新日期：2010-09-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) was measured by RIA in the hypophysial portal blood of rats after total hypophysectomy. The mean (+/- SE) VIP concentrations were 1332 +/- 171 pg/ml (range, 300-3868 pg/ml) under urethane anesthesia and 1735 +/- 707 pg/ml under pentobarbital anesthesia. The concentrations of VIP...

journal_title：Endocrinology

authors： Shimatsu A,Kato Y,Matsushita N,Katakami H,Yanaihara N,Imura H

更新日期：1981-02-01 00:00:00

abstract：:Developmental effects of genistein (Gen) on the mammary gland were investigated using outbred female CD-1 mice treated neonatally on d 1-5 by sc injections at doses of 0.5, 5, or 50 mg/kg.d. Examination of mammary gland whole mounts (no. 4) before puberty (4 wk) revealed no morphological differences in development aft...

journal_title：Endocrinology

authors： Padilla-Banks E,Jefferson WN,Newbold RR

更新日期：2006-10-01 00:00:00

abstract：:Experiments were performed in vitro to examine the possible role of calcium and calmodulin in GRF-induced somatostatin (SRIF) release from the median eminence. Adult male rats were used as tissue donors. The median eminences were first prestimulated in 0.4 ml Krebs Ringer bicarbonate glucose buffer (pH 7.4) containing...

journal_title：Endocrinology

authors： Aguila MC,McCann SM

更新日期：1988-07-01 00:00:00

abstract：:Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...

journal_title：Endocrinology

authors： Akhter N,Odle AK,Allensworth-James ML,Haney AC,Syed MM,Cozart MA,Chua S,Kineman R,Childs GV

更新日期：2012-10-01 00:00:00

abstract：:Phorbol ester receptors in GH4C1 rat pituitary cells have been studied using [3H]phorbol 12,13-dibutyrate (PDBu). Binding to intact cells was of higher affinity at 37 C than at 4 C (Kd, approximately 8 or approximately 34 nM, respectively). The dissociation rate (measured at 4 C) of PDBu from cells equilibrated at 37 ...

journal_title：Endocrinology

authors： Jaken S

更新日期：1985-12-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-1, IGF binding protein (IGFBP)-2, and IGFBP-3 are expressed in the rat brain in regions of neuronal loss by 3 days after hypoxic- ischemic (HI) brain injury and IGF-2 somewhat later. Central administration of rh-IGF-1 after HI injury reduces neuronal loss in vivo. To clarify the mode o...

journal_title：Endocrinology

authors： Guan J,Williams CE,Skinner SJ,Mallard EC,Gluckman PD

更新日期：1996-03-01 00:00:00

abstract：:We examined the effects of the polycationic antibiotic, neomycin, on the function of dispersed bovine parathyroid cells. Neomycin caused a reversible, dose-dependent inhibition of low calcium (Ca++)-stimulated PTH release, with half-maximal inhibition at 30 microM. Maximal inhibition (with 200 microM neomycin) was not...

journal_title：Endocrinology

authors： Brown EM,Butters R,Katz C,Kifor O

更新日期：1991-06-01 00:00:00

abstract：:Like insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-5 forms a ternary complex with insulin-like growth factor (IGF)-I or IGF-II, and the acid-labile subunit (ALS). The study of IGFBP-5/IGFBP-6 chimeric proteins with amino-terminal and middle domain swaps, has revealed the existence of a site in the midd...

journal_title：Endocrinology

authors： Twigg SM,Kiefer MC,Zapf J,Baxter RC

更新日期：2000-01-01 00:00:00

abstract：:Vitamin D receptor (VDR) null mice develop hypocalcemia, hyperparathyroidism, rickets, osteomalacia and alopecia. Normalization of mineral ion homeostasis prevents all of these abnormalities except alopecia. Hair reconstitution assays, performed in athymic nude mice, demonstrate that the lack of VDR in keratinocytes l...

journal_title：Endocrinology

authors： Chen CH,Sakai Y,Demay MB

更新日期：2001-12-01 00:00:00

abstract：:Hormonal induction of steroidogenesis in the adrenal and gonads is dependent on the synthesis and function of the steroidogenic acute regulatory protein (StAR). As a first approach to investigate the role of translation in the control of StAR expression, we examined StAR protein synthesis and steroid production in MA-...

journal_title：Endocrinology

authors： Clark BJ,Combs R,Hales KH,Hales DB,Stocco DM

更新日期：1997-11-01 00:00:00