Adrenergic regulation of mitogen-activated protein kinase in rat pinealocytes: opposing effects of protein kinase A and protein kinase G.

abstract：:The secretion of LH, PRL, and cortisol was investigated in 4 sexually mature female rhesus macaques with cardiac catheters protected by tethers. Based on endocrine parameters, all 4 of the animals ovulated within 2 months from the time they were tethered, and regular menstrual cycles of 24-34 days were observed. The c...

journal_title：Endocrinology

authors： Norman RL,Lindstrom SA,Bangsberg D,Ellinwood WE,Gliessman P,Spies HG

更新日期：1984-07-01 00:00:00

abstract：:The microenvironment of placental mesenchymal stem cells (PMSCs) is dynamic throughout gestation and determines changes in cell fate. In vivo, PMSCs initially develop in low-oxygen tension and low IGF-I concentrations, and both increase gradually with gestation. The impact of varying concentrations of IGF-I and changi...

journal_title：Endocrinology

authors： Youssef A,Iosef C,Han VK

更新日期：2014-04-01 00:00:00

abstract：:GH secretion is altered by exercise in humans. In an attempt to investigate the underlying mechanisms, we developed a rodent model. GH secretion was assayed in male and female rats that were sedentary (not exercised), acutely exercised, and chronically exercised. Sedentary males showed typical pulsatile GH secretion. ...

journal_title：Endocrinology

authors： Butkus JA,Brogan RS,Giustina A,Kastello G,Sothmann M,Wehrenberg WB

更新日期：1995-06-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) and adrenomedullin (AM) are multifunctional regulatory peptides that are secreted by a variety of normal and malignant cells. The TGFbetas are expressed in developing organs and adults, and their tissue distribution pattern has possible significance for signaling roles in many...

journal_title：Endocrinology

authors： Montuenga LM,Mariano JM,Prentice MA,Cuttitta F,Jakowlew SB

更新日期：1998-09-01 00:00:00

abstract：:Rabbit uterine muscle may contract or relax with adrenergic stimulation depending on the hormonal milieu. This difference in contractile activity has been shown to be due to alteration of adrenergic response between alpha-adrenergic (contraction) and beta-adrenergic (relaxation). When rabbits are treated with estrogen...

journal_title：Endocrinology

authors： Roberts JM,Insel PA,Goldfien RD,Goldfien A

更新日期：1977-12-01 00:00:00

abstract：:Fetal adrenal steroid hydroxylase activity and messenger RNA (mRNA) expression increases concurrent with the preterm rise in fetal plasma cortisol during late gestation in sheep. By placing bilateral lesions of the fetal paraventricular nuclei (PVN) we have previously demonstrated that the fetal PVN is necessary for t...

journal_title：Endocrinology

authors： Myers DA,McDonald TJ,Nathanielsz PW

更新日期：1992-07-01 00:00:00

abstract：:PTH-related protein (PTHrP), the major mediator of hypercalcemia of malignancy, reduces tubular phosphate (Pi) reabsorption through its PTH-like renotropic actions. Another peptide detected in tumoral cells, transforming growth factor-beta (TGF beta), has been shown to considerably suppress the sodium-dependent Pi tra...

journal_title：Endocrinology

authors： Law F,Rizzoli R,Bonjour JP

更新日期：1993-07-01 00:00:00

abstract：:To examine further the relationship between developmental changes in LH release and the onset of puberty, effects of posterior hypothalamic lesions were tested in ovariectomized (OVX), sexually immature female monkeys. In OVX females (n = 3) with sham hypothalamic lesions basal LH levels were suppressed during the pre...

journal_title：Endocrinology

authors： Schultz NJ,Terasawa E

更新日期：1988-07-01 00:00:00

abstract：:Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effe...

journal_title：Endocrinology

authors： Mills TM,Copland JA,Coy DH,Schally AV

更新日期：1983-09-01 00:00:00

abstract：:The influence of periparturient secretion of PRL on cytological differentiation of mammary epithelial cells was studied in 17 multiparous, monotocous Holstein cows. Mammary tissue was obtained 10 days prepartum and 10 days postpartum from untreated cows and from cows treated with CB154 (2-Br-alpha-ergokryptin) or CB15...

journal_title：Endocrinology

authors： Akers RM,Bauman DE,Goodman GT,Capuco AV,Tucker HA

更新日期：1981-07-01 00:00:00

abstract：:The dynamics of dopamine (DA) action on PRL release was studied in superfused rat anterior pituitary cell aggregates, cultured for for 5 days either in conventional or in serum-free defined medium. In aggregates cultured in conventional medium 0.1-1 nM DA applied for 20 min provoked a rapid and concentration-dependent...

journal_title：Endocrinology

authors： Denef C,Baes M,Schramme C

更新日期：1984-04-01 00:00:00

abstract：:The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the ...

journal_title：Endocrinology

authors： Konkle AT,McCarthy MM

更新日期：2011-01-01 00:00:00

abstract：:The expression of cholesterol side-chain cleavage cytochrome P450 (P450scc), 17 alpha-hydroxylase cytochrome P450 (P45017 alpha), and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) was studied in bovine placenta and fetal adrenal glands throughout gestation. The levels of expression of these enzymes were much lower ...

journal_title：Endocrinology

authors： Conley AJ,Head JR,Stirling DT,Mason JI

更新日期：1992-05-01 00:00:00

abstract：:Insulin acts directly as a mitogen on isolated embryonic tissues but has been shown to be inactive at physiological concentrations on several fetal cell types. Since insulin availability is obligatory for optimal fetal growth, we have investigated its mitogenic actions on chondrocytes isolated from the epiphyseal grow...

journal_title：Endocrinology

authors： Hill DJ,de Sousa D

更新日期：1990-05-01 00:00:00

abstract：:PRL levels during the estrous cycle have been reported to be low, with the notable exception of the afternoon proestrous surge. The present study was designed to evaluate the pulsatile pattern of PRL secretion during the low secretory phases of the cycle. Animals were bled at 3-min intervals for 150 min during proestr...

journal_title：Endocrinology

authors： López FJ,Dominguez JR,Sánchez-Criado JE,Negro-Vilar A

更新日期：1989-01-01 00:00:00

abstract：:Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, the protein hypoxia-inducible lipid droplet-associated (HILPDA) was localized to lipid droplets and was suggested to inhibit...

journal_title：Endocrinology

authors： Dijk W,Mattijssen F,de la Rosa Rodriguez M,Loza Valdes A,Loft A,Mandrup S,Kalkhoven E,Qi L,Borst JW,Kersten S

更新日期：2017-05-01 00:00:00

abstract：:Slices of normal mammary tissue from pregnant and lactating mice and slices of neoplastic (MXT) mouse mammary tissue were superfused with estradiol (E2) and estrone (E1) each labeled with a different isotope. Isotope concentrations in tissue and perfusate at the steady state were used to calculate fractions and rates ...

journal_title：Endocrinology

authors： De Ryck LM,Raus JC

更新日期：1983-07-01 00:00:00

abstract：:The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve. Both chromosomal and serial duplications have been suggested as mechanisms for the expansion of this gene family. We have identified and annotated IGFBP sequences from a wide selection of vertebrate species as well as Branchios...

journal_title：Endocrinology

authors： Daza DO,Sundström G,Bergqvist CA,Duan C,Larhammar D

更新日期：2011-06-01 00:00:00

abstract：:Administration of GH increases both the tubular reabsorption of inorganic phosphate (Pi) and the plasma level of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. These two effects could be induced by a common mediator, possibly the GH-generated insulin-like growth factor 1 (IGF-1). In the present work, the influence of recomb...

journal_title：Endocrinology

authors： Caverzasio J,Montessuit C,Bonjour JP

更新日期：1990-07-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) was partially purified from incubation medium of calf fetal testes and injected into a BALB/c mouse, whose splenocytes were fused with Sp2/Ag8 myeloma cells. Hybridomas were screened for specific antibody production by double antibody precipitation of labeled AMH, which was obtained by inc...

journal_title：Endocrinology

authors： Vigier B,Picard JY,Josso N

更新日期：1982-01-01 00:00:00

abstract：:Previous studies indicate that magnesium, like calcium, stimulates the release of calcitonin (CT) from the thyroid gland. On the other hand, C-cell hyperplasia has been noted in magnesium-deficient dogs and rats. To explore further possible interrelationships between magnesium and CT, 21-day-old Sprague-Dawley male ra...

journal_title：Endocrinology

authors： Anast CS,Gardner DW

更新日期：1985-06-01 00:00:00

abstract：:For successful human placentation, invasion of trophoblast cells into the uterus and its associated vasculature is essential, and the regulation of this process is controlled by many factors at the fetal-maternal interface. N-acetylglucosaminyltransferase V (GnT-V) is a key enzyme that catalyzes beta1, 6-N-acetylgluco...

journal_title：Endocrinology

authors： Yamamoto E,Ino K,Miyoshi E,Inamori K,Abe A,Sumigama S,Iwase A,Kajiyama H,Shibata K,Nawa A,Kikkawa F

更新日期：2009-02-01 00:00:00

abstract：:Prolonged exposure to elevated FFA levels has been shown to induce peripheral insulin resistance and to alter the beta-cell secretory response to glucose. To investigate the effects of FFAs on preproinsulin gene expression, we measured insulin release, cell content, and messenger RNA (mRNA) levels in rat islets after ...

journal_title：Endocrinology

authors： Ritz-Laser B,Meda P,Constant I,Klages N,Charollais A,Morales A,Magnan C,Ktorza A,Philippe J

更新日期：1999-09-01 00:00:00

abstract：:Regularly menstruating female rhesus monkeys were implanted sc with Silastic tubing packed with estrone. The implants were replaced every 6-8 months to maintain the serum estrone and estradiol concentrations constantly elevated 1.5-2.5-fold, i.e. in the midfollicular phase range, for 4 yr. Increasing the estrone and e...

journal_title：Endocrinology

authors： Billiar RB,Richardson DW,Little B

更新日期：1989-05-01 00:00:00

abstract：:Orally delivered salt stimulates renal salt excretion more effectively than does iv delivered salt. Although the mechanisms that underlie this "postprandial natriuresis" are poorly understood, the peptide uroguanylin (UGn) is thought to be a key mediator. However, the lack of selective assays for UGn gene products has...

journal_title：Endocrinology

authors： Moss NG,Fellner RC,Qian X,Yu SJ,Li Z,Nakazato M,Goy MF

更新日期：2008-09-01 00:00:00

abstract：:Circulating levels of calcitonin precursors (CTpr), including procalcitonin (ProCT), increase up to several thousand-fold in human sepsis, and immunoneutralization improves survival in two animal models of this disease. Herein, we analyzed inflammation-mediated calcitonin I gene (CALC I) expression in human adipocyte ...

journal_title：Endocrinology

authors： Linscheid P,Seboek D,Nylen ES,Langer I,Schlatter M,Becker KL,Keller U,Müller B

更新日期：2003-12-01 00:00:00

abstract：:Estrogen formation is catalyzed by the aromatase cytochrome P450 (P450AROM) enzyme. Aromatase activity has been detected in several regions in the rat brain. In the present study, we used peptide-generated polyclonal antibodies raised against a 20-amino acid synthetic fragment of the rat P450AROM protein (as deduced f...

journal_title：Endocrinology

authors： Sanghera MK,Simpson ER,McPhaul MJ,Kozlowski G,Conley AJ,Lephart ED

更新日期：1991-12-01 00:00:00

abstract：:We previously described a novel alternatively spliced mRNA transcript of the betacellulin (BTC) gene. This splice isoform, termed BTC-delta4, lacks the C-loop of the epidermal growth factor motif and the transmembrane domain as a result of exon 4 'skipping'. In this study, we expressed BTC-delta4 recombinantly to expl...

journal_title：Endocrinology

authors： Ogata T,Dunbar AJ,Yamamoto Y,Tanaka Y,Seno M,Kojima I

更新日期：2005-11-01 00:00:00

abstract：:GH promptly increases cytosolic free calcium ([Ca2+]i) in freshly isolated rat adipocytes. Adipocytes deprived of GH for 3 h or longer are incapable of increasing [Ca2+]i in response to GH, but instead respond in an insulin-like manner. Insulin blocks the GH-induced increase in [Ca2+]i in GH-replete cells and stimulat...

journal_title：Endocrinology

authors： Gaur S,Yamaguchi H,Goodman HM

更新日期：2000-02-01 00:00:00

abstract：:Effects of thyroidectomy on Fos-like immunoreactivity (IR) in the rat brain were examined using single and double-label immunocytochemical techniques. In particular, the possibility that Fos might be involved in thyroid hormone regulation of thyrotropin releasing hormone (TRH)-containing neurons located in the parvoce...

journal_title：Endocrinology

authors： Koibuchi N,Gibbs RB,Suzuki M,Pfaff DW

更新日期：1991-12-01 00:00:00