In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue.

abstract：:We have investigated the activation of ERK2, a serine/threonine kinase necessary for transmission of mitogenic signals, in cells derived from mouse embryos homozygous for a null mutation of the insulin-like growth factor (IGF)-1R gene (R- cells) and from wild-type littermates (W cells), respectively. Stimulation of qu...

journal_title：Endocrinology

authors： Swantek JL,Baserga R

更新日期：1999-07-01 00:00:00

abstract：:The present study assesses the relationship between G-proteins and protein kinase-C (PKC) in the gonadotrope. Cells were depleted of PKC with 1 microM phorbol 12-myristate 13-acetate for 12 h, followed by medium 199-BSA for 6 h before treatment with vehicle, pertussis toxin (PTX), cholera toxin (CTX), or (Bu)2cAMP (dB...

journal_title：Endocrinology

authors： Barnes SJ,Conn PM

更新日期：1993-12-01 00:00:00

abstract：:Active immunization of male rabbits results in a marked increase in plasma testosterone (T) and in the fraction of T bound to circulating proteins. In order to identify the cause of the increased T levels, the half-life of T after castration, and the metabolic clearance rate (MCR) and production rate (PR) after a sing...

journal_title：Endocrinology

authors： Wickings EJ,Becher A,Nieschlag E

更新日期：1976-05-01 00:00:00

abstract：:Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...

journal_title：Endocrinology

authors： Hashimoto K,Ishida E,Miura A,Ozawa A,Shibusawa N,Satoh T,Okada S,Yamada M,Mori M

更新日期：2013-01-01 00:00:00

abstract：:Exposure of rats to microsomal enzyme inducers perturbs thyroid hormone (TH) homeostasis through a variety of mechanisms. Glucuronidation is an important metabolic pathway for TH and is catalyzed by uridine diphosphate-dibenzo-glucuronosyltransferase (UGT) family proteins. Administration of 2,3,7,8-tetrachlorodibenzo-...

journal_title：Endocrinology

authors： Emi Y,Ikushiro S,Kato Y

更新日期：2007-12-01 00:00:00

abstract：:Nitric oxide is a ubiquitous estrogen-regulated signaling molecule that has been implicated in the regulation of bone maturation and remodeling. To better understand the role that bone-cell-secreted nitric oxide plays in ovariectomy-induced modifications of bone turnover, we examined the expression of endothelial NO s...

journal_title：Endocrinology

authors： Grassi F,Fan X,Rahnert J,Weitzmann MN,Pacifici R,Nanes MS,Rubin J

更新日期：2006-09-01 00:00:00

abstract：:GnRH release in the median eminence (ME) is the central output for control of reproduction. GnRH processes in the preoptic area (POA) also release GnRH. We examined region-specific regulation of GnRH secretion using fast-scan cyclic voltammetry to detect GnRH release in brain slices from adult male mice. Blocking endo...

journal_title：Endocrinology

authors： Glanowska KM,Moenter SM

更新日期：2015-01-01 00:00:00

abstract：:Steroidogenic acute regulatory protein (StAR) synthesis and steroidogenesis are stimulated by activation of divergent signaling pathways in the adrenal cortex. The two major physiological regulators of aldosterone synthesis in the adrenal zona glomerulosa are angiotensin II (AII) and extracellular K+, which both media...

journal_title：Endocrinology

authors： Clark BJ,Combs R

更新日期：1999-10-01 00:00:00

abstract：:Vitamin D deficiency is associated with a range of muscle disorders, including myalgia, muscle weakness, and falls. In humans, polymorphisms of the vitamin D receptor (VDR) gene are associated with variations in muscle strength, and in mice, genetic ablation of VDR results in muscle fiber atrophy and motor deficits. H...

journal_title：Endocrinology

authors： Girgis CM,Mokbel N,Cha KM,Houweling PJ,Abboud M,Fraser DR,Mason RS,Clifton-Bligh RJ,Gunton JE

更新日期：2014-09-01 00:00:00

abstract：:A primary culture system has been established for rainbow trout corpuscles of Stannius (CS). A RIA has also been developed to monitor and characterize the teleocalcin secreted by these cultures. The primary cultured CS cells actively synthesized and secreted teleocalcin for up to 39 days when maintained in amphibian a...

journal_title：Endocrinology

authors： Gellersen B,Wagner GF,Copp DH,Friesen HG

更新日期：1988-08-01 00:00:00

abstract：:We are investigating the mechanisms by which aromatic hydrocarbons, such as 3-methylcholanthrene (MC), suppress hepatic cytochrome P450 2C11 (CYP2C11) gene expression. CYP2C11 is an enzyme expressed in the liver of male rats and is regulated by a pulsatile pattern of GH secretion. We have previously shown that MC atte...

journal_title：Endocrinology

authors： Timsit YE,Riddick DS

更新日期：2002-09-01 00:00:00

abstract：:Testerone (T) concentrations in the plasma, gonads, and adrenals were measured by radioimmunoassay in 188 male and 160 female rabbit fetuses. Determinations were performed daily from the 20th to the 31st day of gestation and were correlated with the maternal plasma concentration of T. The T content of both testes rema...

journal_title：Endocrinology

authors： Veyssiere G,Berger M,Jean-Faucher C,De Turckheim M,Jean C

更新日期：1976-11-01 00:00:00

abstract：:Members of the winged helix transcription factor family are known to regulate epithelial cell differentiation by regulating cell-specific gene expression. rWIN is a newly discovered member of the winged helix family shown to be present in the adult rat testis. In the testis the human homolog of rWIN, HFH-11, was local...

journal_title：Endocrinology

authors： Chaudhary J,Mosher R,Kim G,Skinner MK

更新日期：2000-08-01 00:00:00

abstract：:An immunomodulatory role for LHRH was suggested when we reported the presence of immunoactive and bioactive LHRH and its mRNA in rat splenic and thymic lymphocytes. In this paper we report that human peripheral T-cells as well as its subsets CD4+ and CD8+ contained immunoactive and bioactive LHRH. Furthermore, analysi...

journal_title：Endocrinology

authors： Azad N,La Paglia N,Jurgens KA,Kirsteins L,Emanuele NV,Kelley MR,Lawrence AM,Mohagheghpour N

更新日期：1993-07-01 00:00:00

abstract：:The importance of locally produced insulin-like growth factor-I (IGF-I) in connective tissues has recently been recognized. It has been postulated that the action of anabolic hormones on bone may be mediated through local IGF-I release. However, whether IGF-I can also be modulated by other locally acting cytokines has...

journal_title：Endocrinology

authors： Elford PR,Lamberts SW

更新日期：1990-10-01 00:00:00

abstract：:Uterine epithelial cells (UEC) isolated from 6-week-old CF-1 mice were immortalized using retroviral-mediated transfection of SV40 large T-antigen. One line, WEG-1, retained epithelial morphology and reacted with antibodies to cytokeratins 18, 19, laminin, fibronectin, and beta-catenin. In addition, WEG-1 cells displa...

journal_title：Endocrinology

authors： Wegner CC,Cherington V,Clemens JW,Jacobs AL,Julian J,Surveyor GA,Bell EC,Carson DD

更新日期：1996-01-01 00:00:00

abstract：:Adiposity is regulated in a sexually divergent manner. This is partly due to sex steroids, but the differential effects of androgens in males and females are unclear. We investigated effects of testosterone on energy balance in castrated male (n = 6) and female sheep (n = 4), which received 3 × 200 mg testosterone imp...

journal_title：Endocrinology

authors： Clarke SD,Clarke IJ,Rao A,Cowley MA,Henry BA

更新日期：2012-01-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) has a biphasic clinical phenotype with failure to thrive in the neonatal period followed by hyperphagia and severe obesity commencing in childhood among other endocrinological and neurobehavioral abnormalities. The syndrome results from loss of function of several clustered, paternally expr...

journal_title：Endocrinology

authors： Stefan M,Ji H,Simmons RA,Cummings DE,Ahima RS,Friedman MI,Nicholls RD

更新日期：2005-10-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the spontaneous and TRH-induced TSH release were investigated in vitro on perifused rat pituitaries. The dynamic pattern of TSH release was measured in response to a 6-min pulse of TRH (10 nM) with or without GABA addition. GABA had no effect on spontaneous TSH release ...

journal_title：Endocrinology

authors： Tapia-Arancibia L,Roussel JP,Astier H

更新日期：1987-09-01 00:00:00

abstract：:The administration of testosterone via Silastic capsules has been shown previously to maintain advanced spermatid number quantitatively in intact rats in which LH but not FSH was suppressed, but not in hypophysectomized rats, indicating that pituitary factors in addition to LH are required for the quantitative mainten...

journal_title：Endocrinology

authors： Awoniyi CA,Zirkin BR,Chandrashekar V,Schlaff WD

更新日期：1992-06-01 00:00:00

abstract：:cAMP is involved in the regulation of secretory activity in lactotrope, thyrotrope, and gonadotrope cells. The present study examined whether pulsatile or intermittent changes in cAMP are more effective than a continuous stimulation in increasing pituitary hormone gene expression. Pituitaries from adult female rats we...

journal_title：Endocrinology

authors： Haisenleder DJ,Yasin M,Marshall JC

更新日期：1992-12-01 00:00:00

abstract：:Pituitary growth hormone (GH) content and plasma GH response to pentobarbital (PB) of severely hypothyroid rats are markedly decreased compared with euthyroid rats. Both pituitary and plasma GH may be increased by single ip injections of physiologic doses of thyroxine (T4) (1.75 mug/100g BW) or triiodothyronine (T3) (...

journal_title：Endocrinology

authors： Hervás F,Morreale de Escobar G,Escobar del Rey F

更新日期：1976-01-01 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are polypeptides secreted by skeletal cells and are considered regulators of bone formation. IGF-I and -II were studied for their effects on collagen synthesis and degradation in cultures of intact fetal rat calvariae and on type I collagen transcript levels in oste...

journal_title：Endocrinology

authors： McCarthy TL,Centrella M,Canalis E

更新日期：1989-01-01 00:00:00

abstract：:We have demonstrated TSH binding sites in membranes prepared from guinea pig testis. The binding of TSH to testicular homogenate was localized to the interstitial tissue and showed similar characteristics to the binding of TSH to thyroid membranes with high affinity (Ka = 2.5 X 10(10) M-1) but limited capacity (approx...

journal_title：Endocrinology

authors： Davies TF,Smith BR,Hall R

更新日期：1978-07-01 00:00:00

abstract：:The present study was undertaken to identify the mechanisms underlying the effect of insulin-like growth factor (IGF-I) on LH receptor in rat granulosa cells. Treatment with FSH, as expected, produced a substantial increase in LH receptor messenger RNA (mRNA) level, and concurrent treatment with increasing concentrati...

journal_title：Endocrinology

authors： Hirakawa T,Minegishi T,Abe K,Kishi H,Ibuki Y,Miyamoto K

更新日期：1999-11-01 00:00:00

abstract：:Oxytocin (OT) receptors (OTRs) mediate reproductive functions, including the initiation of labor and milk ejection. OTR messenger RNA levels are highly regulated, reaching the greatest concentration in the uterus at the end of gestation, and in the mammary gland during lactation. Factors directly effecting changes in ...

journal_title：Endocrinology

authors： Hoare S,Copland JA,Wood TG,Jeng YJ,Izban MG,Soloff MS

更新日期：1999-05-01 00:00:00

abstract：:The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the secretory pathway and is the site where protein folding and quality control are initiated. The storage and release of Ca2+ are critical physiological functions of the ER. Disrupted ER homeostasis activates the unfolded protein respo...

journal_title：Endocrinology

authors： Zhang IX,Raghavan M,Satin LS

更新日期：2020-02-01 00:00:00

abstract：:The physicochemical and immunological properties of androgen receptors from kidney and brain of testicular-feminized (Tfm) mutant mice and wild-type mice were compared. Analysis by gel filtration and sucrose density gradients revealed that the mol wt of the mutant receptor was 66K (38A; 3.8S) which was significantly s...

journal_title：Endocrinology

authors： Young CY,Johnson MP,Prescott JL,Tindall DJ

更新日期：1989-02-01 00:00:00

abstract：:Ghrelin has emerged as putative regulator of an array of endocrine and nonendocrine functions, including cell proliferation. Recently, we provided evidence for the expression of ghrelin in mature, but not in undifferentiated, Leydig cells of rat and human testis. Yet testicular actions of ghrelin, other than modulatio...

journal_title：Endocrinology

authors： Barreiro ML,Gaytan F,Castellano JM,Suominen JS,Roa J,Gaytan M,Aguilar E,Dieguez C,Toppari J,Tena-Sempere M

更新日期：2004-11-01 00:00:00

abstract：:The induction of hepatic drug metabolizing enzymes alters not only the metabolism of the xenobiotic substances that induce them but also the metabolism of various endogenous hormones. The xenobiotic receptor constitutive androstane receptor (CAR) (NR1I3) mediates the well-studied induction of CYP2B genes and other dru...

journal_title：Endocrinology

authors： Qatanani M,Zhang J,Moore DD

更新日期：2005-03-01 00:00:00