Stimulation of hepatic signal transducer and activator of transcription 5b by GH is not altered by 3-methylcholanthrene.

abstract：:To investigate GH's role in diabetic end organ damage, experimental diabetes was induced with streptozotocin (STZ) in bovine GH (bGH) or bGH antagonist transgenic mice and in their nontransgenic (NTG) litter mates. Body growth, blood glucose, serum insulin-like growth factor-I levels, liver GH receptor (GHR) binding, ...

journal_title：Endocrinology

authors： Chen NY,Chen WY,Bellush L,Yang CW,Striker LJ,Striker GE,Kopchick JJ

更新日期：1995-02-01 00:00:00

abstract：:We have used immunohistochemistry to define the cellular distribution of GH receptors in the gastrointestinal tract (GIT) and its derivatives. Immunohistochemistry was performed in the adult rat GIT with a panel of characterized monoclonal antibodies to the GH receptor. The most intense and heterogeneous immunoreactiv...

journal_title：Endocrinology

authors： Lobie PE,Breipohl W,Waters MJ

更新日期：1990-01-01 00:00:00

abstract：:Prolactin (Prl) secreting cells in a mixed pituitary cell culture form microscopically-identifiable plaques (zones of hemolysis around the lactotropes) when incubated in a monolayer with staphylococcal protein-A-coated ovine erythrocytes in the presence of Prl antiserum and complement. Plaques form first at 15-30 min ...

journal_title：Endocrinology

authors： Neill JD,Frawley LS

更新日期：1983-03-01 00:00:00

abstract：:GH promotes the conversion of cultured preadipose 3T3 cells into adipose cells. The serum of most animals also promotes this differentiation. In order to determine the extent to which GH is responsible for the adipogenic activity of serum, we used a specific antiserum able to suppress completely the adipogenic activit...

journal_title：Endocrinology

authors： Nixon T,Green H

更新日期：1984-02-01 00:00:00

abstract：:T4 dynamically regulates the levels of type II iodothyronine 5'-deiodinase in the brain. Using an astrocyte cell culture model, we have shown that thyroxine increases inactivation of this enzyme through a mechanism using the actin cytoskeleton. In the absence of T4, the filamentous actin (F-actin) stress fibers are ab...

journal_title：Endocrinology

authors： Farwell AP,Leonard JL

更新日期：1992-08-01 00:00:00

abstract：:C-type natriuretic peptide (CNP), found in endothelial cells, chondrocytes, and neurons, binds its cognate transmembrane receptor, natriuretic peptide receptor-B (NPR-B/GC-B), and stimulates the synthesis of the intracellular signaling molecule, cGMP. The known physiologic consequences of this binding event are vasore...

journal_title：Endocrinology

authors： Abbey SE,Potter LR

更新日期：2003-01-01 00:00:00

abstract：:We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...

journal_title：Endocrinology

authors： Shimizu Y,Tanishita T,Minokoshi Y,Shimazu T

更新日期：1997-01-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) is a growth regulatory polypeptide factor that is expressed by several prostatic tumor cell lines. In this investigation, we examined whether TGF alpha is expressed during morphogenesis of the rat prostate gland. We first examined whether the prostate gland expressed TGF al...

journal_title：Endocrinology

authors： Taylor TB,Ramsdell JS

更新日期：1993-09-01 00:00:00

abstract：:The effects of insulin and glucose, alone and combined, on diacylglycerol (DAG), protein kinase-C (PKC), and glucose transport were compared in rat adipocytes and solei incubated in medium containing 0-20 mM glucose. In both tissues insulin rapidly stimulated [3H]DAG production from [3H]glycerol; extracellular glucose...

journal_title：Endocrinology

authors： Hoffman JM,Ishizuka T,Farese RV

更新日期：1991-06-01 00:00:00

abstract：:Daily administration of an inhibitor of 5 alpha-reductase, 17 beta-testosterone carboxylic acid, significantly attenuated the stimulatory effect of testosterone propionate on penile erections displayed by castrated male rats which were restrained in a supine position. This treatment, however, failed to affect mating b...

journal_title：Endocrinology

authors： Bradshaw WG,Baum MJ,Awh CC

更新日期：1981-10-01 00:00:00

abstract：:To obtain large amounts of hTSH and to study the role of the N-linked oligosaccharides for its biological activity, hTSH was produced using recombinant baculovirus containing the human alpha-subunit and a hTSH beta-minigene, respectively, both under the control of the polyhedrin promoter. Expression in insect cells wa...

journal_title：Endocrinology

authors： Grossmann M,Wong R,Teh NG,Tropea JE,East-Palmer J,Weintraub BD,Szkudlinski MW

更新日期：1997-01-01 00:00:00

abstract：:Bovine placental lactogen (bPL) has been isolated from bovine trophoblast and characterized as a 32 K mol wt protein which exists in three different forms which differ in their isoelectric point values and their amino acid compositions. Two of the three forms have been shown to have both bovine GH (bGH)- and bovine PR...

journal_title：Endocrinology

authors： Duello TM,Byatt JC,Bremel RD

更新日期：1986-09-01 00:00:00

abstract：:We previously examined the segregation patterns of two polymorphic restriction enzyme sites for EcoRI and HindIII in the 3'-flanking region of human CG-alpha gene in placenta and choriocarcinoma. We observed that a unique combination of restriction sites predominates in choriocarcinoma while this pattern was rare in p...

journal_title：Endocrinology

authors： Otani T,Boime I

更新日期：1986-11-01 00:00:00

abstract：:The present study examined the effects of FSH and insulin (IN) on 17 beta-estradiol (E2) secretion and granulosa cell proliferation. For these studies, immature rat ovaries were maintained in perifusion culture and continuously exposed to FSH (0-800 ng RP-1 eq/ml) and /or IN (0.2 U/ml). At specific times, the ovaries ...

journal_title：Endocrinology

authors： Peluso JJ,Delidow BC,Lynch J,White BA

更新日期：1991-01-01 00:00:00

abstract：:Angiotensin II (AII) receptors in adrenal glomerulosa cells are coupled to adenylate cyclase inhibition. We investigated the importance of cyclase inhibition in adrenal steroidogenesis by treating adrenal glomerulosa cells with the toxin of Bordetella pertussis (20 ng/ml) for 3 and 18 h. This treatment prevented inhib...

journal_title：Endocrinology

authors： Woodcock EA,McLeod JK

更新日期：1986-10-01 00:00:00

abstract：:Trophoblast hypoxia and injury, key components of placental dysfunction, are associated with fetal growth restriction and other complications of pregnancy. Accumulation of lipid droplets has been found in hypoxic nonplacental cells. Unique to pregnancy, lipid accumulation in the placenta might perturb lipid transport ...

journal_title：Endocrinology

authors： Bildirici I,Schaiff WT,Chen B,Morizane M,Oh SY,O'Brien M,Sonnenberg-Hirche C,Chu T,Barak Y,Nelson DM,Sadovsky Y

更新日期：2018-12-01 00:00:00

abstract：:Around the onset of labor, uterine sensitivity to oxytocin (OT) increases tremendously. Although this is considered to reflect OT receptor (OTR) augmentation in myometrium, neither spatial expression of OTR nor the level of the receptor message during the course of pregnancy have been investigated at the molecular lev...

journal_title：Endocrinology

authors： Kimura T,Takemura M,Nomura S,Nobunaga T,Kubota Y,Inoue T,Hashimoto K,Kumazawa I,Ito Y,Ohashi K,Koyama M,Azuma C,Kitamura Y,Saji F

更新日期：1996-02-01 00:00:00

abstract：:As part of an ongoing investigation of the role of metabolic activation of estrogens in the genesis of cancers such as estrogen-induced renal tumors in hamsters, we have 1) determined steroid-17 beta-oxidoreductase activity of microsomes and cytosol prepared from hamster kidney and liver; 2) compared the rates of 2-, ...

journal_title：Endocrinology

authors： Zhu BT,Bui QD,Weisz J,Liehr JG

更新日期：1994-11-01 00:00:00

abstract：:Acylation-stimulating protein (ASP) is a potent lipogenic protein produced by adipocytes. In vitro studies have shown that ASP increases triglyceride synthesis and glucose transport in both murine and human adipocytes. Our initial study indicated that complement C3-deficient (-/-) mice (and, therefore, ASP deficient) ...

journal_title：Endocrinology

authors： Murray I,Havel PJ,Sniderman AD,Cianflone K

更新日期：2000-03-01 00:00:00

abstract：:High fat feeding is associated with impaired insulin action, an obese body composition, and down-regulation of glucose transporter-4 (GLUT4) expression in adipocytes. We recently showed that overexpression of GLUT4 selectively in adipocytes of transgenic mice using the aP2 (fatty acid-binding protein) promoter/enhance...

journal_title：Endocrinology

authors： Gnudi L,Tozzo E,Shepherd PR,Bliss JL,Kahn BB

更新日期：1995-03-01 00:00:00

abstract：:The maternal skeleton resorbs during lactation to provide calcium to milk and the lost mineral content is restored after weaning. The changes are particularly marked in Ctcgrp null mice, which lose 50% of spine mineral content during lactation but restore it fully. The known calciotropic hormones are not required for ...

journal_title：Endocrinology

authors： Collins JN,Kirby BJ,Woodrow JP,Gagel RF,Rosen CJ,Sims NA,Kovacs CS

更新日期：2013-04-01 00:00:00

abstract：:Hashimoto thyroiditis can be partially reproduced in mice by immunization with thyroglobulin or, more recently, thyroperoxidase. This experimental autoimmune thyroiditis (EAT) model has been extensively characterized during early disease phases (up to d 35 after immunization). By extending the analysis of EAT to 100 d...

journal_title：Endocrinology

authors： Chen CY,Kimura H,Landek-Salgado MA,Hagedorn J,Kimura M,Suzuki K,Westra W,Rose NR,Caturegli P

更新日期：2009-01-01 00:00:00

abstract：:Leucine-rich repeat-containing G protein-coupled receptor (LGR)-5 is a recently identified marker of stem cells in adult intestinal epithelium and hair follicles. Because of this characteristic, we studied the status of Lgr5 expression in the mouse uterus under various conditions. Lgr5 is highly expressed in the uteri...

journal_title：Endocrinology

authors： Sun X,Jackson L,Dey SK,Daikoku T

更新日期：2009-11-01 00:00:00

abstract：:The observation that angiotensin III is present in the circulation of the rat in amounts similar to those of angiotensin II has led to the notion that it may, in part, be formed by the action of converting enzyme on des-Asp-angiotensin I without the prior formation of angiotensin II. This possibility was studied in co...

journal_title：Endocrinology

authors： Garcia Del Rio C,Smellie WS,Morton JJ

更新日期：1981-02-01 00:00:00

abstract：:Recent evidence suggests that the aromatization of testosterone to estrogen is important for the organizing effects of neonatal testosterone on neuroendocrine responses to acute challenges. However, the extent to which neonatal inhibition of aromatase alters the stress-induced activation of neural pathways has not bee...

journal_title：Endocrinology

authors： Bingham B,Wang NX,Innala L,Viau V

更新日期：2012-04-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00

abstract：:The contributions of estradiol and testosterone to atherosclerotic lesion progression are not entirely understood. Cross-sex hormone therapy (XHT) for transgender individuals dramatically alters estrogen and testosterone levels and consequently could have widespread consequences for cardiovascular health. Yet, no prec...

journal_title：Endocrinology

authors： Goetz TG,Mamillapalli R,Sahin C,Majidi-Zolbin M,Ge G,Mani A,Taylor HS

更新日期：2018-02-01 00:00:00

abstract：:The injection of chlorpropamide into Brattleboro homozygous rats (di/di) has previously been shown to result in enhanced activation of renal medullary adenylate cyclase activity and increased renal medullary content of cAMP in response to 1-desamino-8-D-arginine vasopressin (dDAVP). In contrast, in vivo chlorpropamide...

journal_title：Endocrinology

authors： Moses AM,Fenner R,Schroeder ET,Coulson R

更新日期：1982-12-01 00:00:00

abstract：:Tear fluid is known to contain many different hormones with relevance for ocular surface homeostasis. We studied the presence and functional role of insulin-like factor 3 (INSL3) and its cognate receptor RXFP2 (relaxin/insulin-like family peptide receptor 2) at the ocular surface and in tears. Expression of human INSL...

journal_title：Endocrinology

authors： Hampel U,Klonisch T,Sel S,Schulze U,Garreis F,Seitmann H,Zouboulis CC,Paulsen FP

更新日期：2013-06-01 00:00:00

abstract：:Insulin stimulation of glucose transport involves the translocation of vesicles containing the glucose transporter Glut 4 to the plasma membrane. Since low mol wt GTP-binding proteins (LMW-GTP-binding proteins) have been implicated in the regulation of vesicular trafficking, we have analyzed these proteins in adipocyt...

journal_title：Endocrinology

authors： Cormont M,Tanti JF,Grémeaux T,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1991-12-01 00:00:00