PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia.

abstract：:The gene encoding the human TNF alpha receptor (TNFR) 2 contains polymorphisms in the 3' untranslated region (UTR). Previous studies have shown that some variant alleles in this region are associated with obesity and insulin resistance. However, the effect of these polymorphisms on the expression of TNFR2 has not been...

journal_title：Endocrinology

authors： Puga I,Lainez B,Fernández-Real JM,Buxadé M,Broch M,Vendrell J,Espel E

更新日期：2005-05-01 00:00:00

abstract：:Protein kinase-C (PKC) has been suggested as a possible mediator of the antigonadotropic action of prostaglandin F2 alpha (PGF2 alpha) in luteal cells. To examine this possibility, we evaluated the effects of phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA)] in relation to those of PGF2 alpha on cAMP accumula...

journal_title：Endocrinology

authors： Musicki B,Aten RF,Behrman HR

更新日期：1990-03-01 00:00:00

abstract：:Control of trabecular bone volume is mediated by local events. Recently, it has been shown that the cytokines interleukin-1 (IL-1), tumor necrosis factor alpha (TNF alpha), and TNF beta [also called lymphotoxin (LT)] produced by immune cells all stimulate osteoclast activity, whereas the lymphokine interferon-gamma (I...

journal_title：Endocrinology

authors： Smith DD,Gowen M,Mundy GR

更新日期：1987-06-01 00:00:00

abstract：:We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...

journal_title：Endocrinology

authors： Shimizu Y,Tanishita T,Minokoshi Y,Shimazu T

更新日期：1997-01-01 00:00:00

abstract：:At micromolar (pharmacological) concentrations, the action of tamoxifen on the proliferation of estrogen-dependent cells can be mediated not only by the estrogen receptor (ER), but also by other target molecules, such as protein kinase-C (PKC), which are easily inhibited by antiestrogens in cell-free experiments. By d...

journal_title：Endocrinology

authors： Astruc ME,Chabret C,Bali P,Gagne D,Pons M

更新日期：1995-03-01 00:00:00

abstract：:We have recently reported that a subpopulation of galanin (GAL)-immunoreactive perikarya in the preoptic area near the organum vasculosum of the lamina terminalis (OVLT) has morphological characteristics similar to those of LHRH-containing neurons. In fact, both peptides are colocalized in those neurons in the male ra...

journal_title：Endocrinology

authors： Merchenthaler I,López FJ,Lennard DE,Negro-Vilar A

更新日期：1991-10-01 00:00:00

abstract：:We have previously demonstrated in vitro that 1alpha,25-dihydroxyvitamin D3 (calcitriol) treatment increases p27 expression and decreases cell proliferation in cultured thyroid carcinoma cell lines. We hypothesized that in vivo treatment with calcitriol would have a beneficial effect on thyroid carcinoma growth and pr...

journal_title：Endocrinology

authors： Dackiw AP,Ezzat S,Huang P,Liu W,Asa SL

更新日期：2004-12-01 00:00:00

abstract：:Insulin and insulin-like growth factors (IGFs) stimulate responses in skeletal muscle that include effects on carbohydrate and fat metabolism, protein turnover, growth, and differentiation. To gain insight into the relative importance of insulin and IGFs at different stages of development, the expression of their spec...

journal_title：Endocrinology

authors： Alexandrides T,Moses AC,Smith RJ

更新日期：1989-02-01 00:00:00

abstract：:In vertebrates, activation of the GnRH receptor is necessary to initiate the reproductive cascade. However, little is known about the characteristics of GnRH receptors before the vertebrates evolved. Recently genome sequencing was completed for amphioxus, Branchiostoma floridae. To understand the GnRH receptors (GnRHR...

journal_title：Endocrinology

authors： Tello JA,Sherwood NM

更新日期：2009-06-01 00:00:00

abstract：:Proxyfan is a histamine H3 receptor protean agonist that can produce a spectrum of pharmacological effects including agonist, inverse agonist, and antagonist. We have discovered that proxyfan (10 mg/kg orally) significantly improved glucose excursion after an ip glucose tolerance test in either lean or high-fat/choles...

journal_title：Endocrinology

authors： Henry MB,Zheng S,Duan C,Patel B,Vassileva G,Sondey C,Lachowicz J,Hwa JJ

更新日期：2011-03-01 00:00:00

abstract：:The insulin-like growth factor-binding proteins (IGFBPs) comprise at least six distinct species that may modulate the action of IGFs. IGFs are important regulators of fetal growth and differentiation. To define sites of IGFBP mRNA synthesis, we have used in situ hybridization techniques in mouse conceptuses of differe...

journal_title：Endocrinology

authors： Schuller AG,Zwarthoff EC,Drop SL

更新日期：1993-06-01 00:00:00

abstract：:The ability of FSH to stimulate the activity of ornithine decarboxylase (ODC) in the ovary of the immature rat and cycling hamster has been examined using specific antisera to gonadotropins. The stimulatory effect of FSH on ODC activity in the ovary of the immature rat was abolished when LH antiserum was administered ...

journal_title：Endocrinology

authors： Sheela Rani CS,Moudgal NR

更新日期：1979-05-01 00:00:00

abstract：:Cultures of Sertoli cells were treated with freshly isolated, intact germ cells to determine if germ cells were capable of influencing Sertoli cell function. By using two-dimensional polyacrylamide gel electrophoresis and autoradiography, germ cells were found to increase several-fold the incorporation of [32P]orthoph...

journal_title：Endocrinology

authors： Ireland ME,Welsh MJ

更新日期：1987-04-01 00:00:00

abstract：:Interferon-tau (IFNtau) is the embryonic signal responsible for pregnancy recognition in ruminants. The primary action of IFNtau is believed to be mediated through inhibition of prostaglandin F(2alpha) (PGF(2alpha)) released from the endometrial epithelial cells in response to oxytocin (OT). Our working hypothesis was...

journal_title：Endocrinology

authors： Krishnaswamy N,Danyod G,Chapdelaine P,Fortier MA

更新日期：2009-02-01 00:00:00

abstract：:The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Fur...

journal_title：Endocrinology

authors： Vendrell J,El Bekay R,Peral B,García-Fuentes E,Megia A,Macias-Gonzalez M,Fernández Real J,Jimenez-Gomez Y,Escoté X,Pachón G,Simó R,Selva DM,Malagón MM,Tinahones FJ

更新日期：2011-11-01 00:00:00

abstract：:Maternal nutrient restriction at specific stages of gestation has differential effects on fetal development such that the offspring are programmed to be at increased risk of adult disease. We investigated the effect of gestational age and maternal nutrition on the maternal plasma concentration of leptin and cortisol t...

journal_title：Endocrinology

authors： Bispham J,Gopalakrishnan GS,Dandrea J,Wilson V,Budge H,Keisler DH,Broughton Pipkin F,Stephenson T,Symonds ME

更新日期：2003-08-01 00:00:00

abstract：:We have investigated the interaction of estrogen with GnRH on the regulation of LH subunit mRNA in female hypogonadal (hpg) mice receiving constant frequency and amplitude pulsatile GnRH treatment for up to 18 days. The level of cytosolic common alpha mRNA in female hpg mouse pituitaries was 45 +/- 6% of normal female...

journal_title：Endocrinology

authors： Saade G,London DR,Clayton RN

更新日期：1989-04-01 00:00:00

abstract：:We have studied the relationship between the levels of the alpha and beta subunit of TSH and alpha and TSH-beta mRNA content in pituitaries from euthyroid, short-term, and long-term hypothyroid mice and in various mouse TSH-secreting tumors. TSH, alpha, and TSH-beta were determined by specific radioimmunoassay. alpha ...

journal_title：Endocrinology

authors： Gurr JA,Kourides IA

更新日期：1984-08-01 00:00:00

abstract：:Defining the molecular genetics of diabetes gives new insight into the underlying etiology and so should help improve treatment. The genetic etiology is now known for most patients with beta-cell monogenic diabetes, allowing genetic classification. We review how this genetic knowledge alters treatment. Patients with a...

journal_title：Endocrinology

authors： Hattersley AT,Pearson ER

更新日期：2006-06-01 00:00:00

abstract：:We previously reported that hormones important for the normal growth and function of FRTL-5 rat thyroid cells, TSH, or its cAMP signal plus insulin or IGF-I, could transcriptionally suppress constitutive and gamma-interferon (IFN)-increased synthesis of the 90K protein (also known as Mac-2BP). Here we cloned the 5'-fl...

journal_title：Endocrinology

authors： Grassadonia A,Tinari N,Fiorentino B,Nakazato M,Chung HK,Giuliani C,Napolitano G,Iacobelli S,Howcroft TK,Singer DS,Kohn LD,Consorzio Interuniversitario Nazionale per la Bioncologia.

更新日期：2007-07-01 00:00:00

abstract：:The influence of development and estrogen, thyroid hormone, corticosteroid, and fibrate administration on apolipoprotein (apo) A-IV mRNA levels in the liver and intestine and on serum or plasma concentrations of apo A-IV was studied in the rat. Treatment of ovariectomized rats with ethinyl estradiol provoked a dose-de...

journal_title：Endocrinology

authors： Staels B,van Tol A,Verhoeven G,Auwerx J

更新日期：1990-04-01 00:00:00

abstract：:Oxytocin plays a pivotal role in rat parturition, acting within the brain to facilitate its own release in the supraoptic nucleus (SON) and paraventricular nucleus, and to stimulate maternal behavior. We investigated oxytocin receptor (OTR) expression and activation perinatally. Using a (35)S-labeled riboprobe complem...

journal_title：Endocrinology

authors： Meddle SL,Bishop VR,Gkoumassi E,van Leeuwen FW,Douglas AJ

更新日期：2007-10-01 00:00:00

abstract：:Five studies are reported which were designed to define the effects of an estrogen and a progestogen, alone and in combination, on tissue concentrations (heart, kidney, and liver) of two trace metals (zinc, copper) and four bulk cations (sodium, potassium, calcium, magnesium). Male rats received Premarin (0.08 mg) and...

journal_title：Endocrinology

authors： Yunice AA,Lindeman RD

更新日期：1975-11-01 00:00:00

abstract：:The majority of ovarian follicles undergo atresia through a mechanism involving apoptotic cell death. Although GnRH and its agonists have been shown to suppress ovarian growth and differentiation in hypophysectomized rats, studies on the induction of follicle atresia by GnRH are contradictory. In the present study, th...

journal_title：Endocrinology

authors： Billig H,Furuta I,Hsueh AJ

更新日期：1994-01-01 00:00:00

abstract：:Atrial, brain-type, and C-type natriuretic peptides (ANP, BNP, and CNP) act via receptors with intrinsic guanylate cyclase activity. The A-type and B-type ANP receptors are selectively activated by ANP and CNP, respectively. The anterior pituitary is a site of ANP production and action, suggesting a local regulatory f...

journal_title：Endocrinology

authors： McArdle CA,Poch A,Käppler K

更新日期：1993-05-01 00:00:00

abstract：:To determine the basis for the marked daily variability in circulating luteinizing hormone (LH) in the female lamb shortly after birth and to determine whether circulating follicle-stimulating hormone (FSH) exhibits similar variability during this period of life, serum levels of both gonadotropins were monitored frequ...

journal_title：Endocrinology

authors： Foster DL,Jaffe RB,Niswender GD

更新日期：1975-01-01 00:00:00

abstract：:TSH initiates its action by binding to specific membrane receptors' thyroid cells and induces activation of the adenylate cyclase-cAMP cascade. The factors involved in the regulation of TSH receptors are poorly known, except for the TSH dose-dependent regulatory effect. The fact that the thyroid gland of Graves' patie...

journal_title：Endocrinology

authors： Denereaz N,Lemarchand-Beraud T

更新日期：1995-04-01 00:00:00

abstract：:The involvement of IGF-I in mammary carcinogenesis is well established, but the role of GH, as an autocrine growth factor for breast cancers is poorly understood. The goal of our study was to investigate whether antagonists of GHRH can interfere with the effects of GH and IGF-I in MXT mouse mammary cancers. GHRH antag...

journal_title：Endocrinology

authors： Szepeshazi K,Schally AV,Armatis P,Groot K,Hebert F,Feil A,Varga JL,Halmos G

更新日期：2001-10-01 00:00:00

abstract：:GH3 cells are a PRL-secreting adenoma cell line derived from pituitary lactotropes. These cells have been stably transfected with rat GnRH receptor complementary DNA to produce four cell lines: GGH(3)1', GGH(3)2', GGH(3)6', and GGH(3)12'. In response to either GnRH or Buserelin (a metabolically stable GnRH agonist), t...

journal_title：Endocrinology

authors： Stanislaus D,Arora V,Awara WM,Conn PM

更新日期：1996-03-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms whereby ovarian hormones, and particularly estrogens, modulate fat cell metabolism, we investigated the effects of estradiol administration on c-fos and c-jun expressions in fat cells from ovariectomized (OVX) rats. Estradiol treatment resulted in a rapid increase in c-fo...

journal_title：Endocrinology

authors： Garcia E,Lacasa D,Giudicelli Y

更新日期：2000-08-01 00:00:00