The antigonadotropic actions of prostaglandin F2 alpha and phorbol ester are mediated by separate processes in rat luteal cells.

abstract：:The effects of electrical stimulation of the brain on the ovarian venous plasma concentrations of estradiol (E2) and progesterone (P) were investigated in female rats hypophysectomized and adrenalectomized at 1000 h on the day of proestrus. Stimulation was applied during the proestrous critical period under pentobarbi...

journal_title：Endocrinology

authors： Kawakami M,Kubo K,Uemura T,Nagase M,Hayashi R

更新日期：1981-07-01 00:00:00

abstract：:Alpha-calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. Despite well-documented pharmacological effects, its primary physiological role has thus far remained obscure. Increased lipid content, particularly in skeletal muscle and liver, is ...

journal_title：Endocrinology

authors： Danaher RN,Loomes KM,Leonard BL,Whiting L,Hay DL,Xu LY,Kraegen EW,Phillips AR,Cooper GJ

更新日期：2008-01-01 00:00:00

abstract：:The Djungarian hamster displays photoperiodic variations in gonadal size synchronized to the seasons by the nightly secretion of the pineal hormone melatonin. In short photoperiod (SP), the gonads regress in size, and circulating sex steroids levels decline. Thus, the brain is subject to seasonal variations of both me...

journal_title：Endocrinology

authors： Bolborea M,Laran-Chich MP,Rasri K,Hildebrandt H,Govitrapong P,Simonneaux V,Pévet P,Steinlechner S,Klosen P

更新日期：2011-10-01 00:00:00

abstract：:Reproductive fitness in females is susceptible to obesogenic diets. Energy balance and reproduction are tightly regulated, in part, by hypothalamic neurons in the arcuate nucleus (ARC), and high-fat diet (HFD) can steadily increase estradiol levels in rodents. Estradiol regulates the reproductive axis via negative fee...

journal_title：Endocrinology

authors： Negrón AL,Radovick S

更新日期：2020-10-01 00:00:00

abstract：:Hypothyroidism is the most frequent and earliest endocrine complication in cystinosis, a multisystemic lysosomal storage disease caused by defective transmembrane cystine transporter, cystinosin (CTNS gene). We recently demonstrated in Ctns(-/-) mice that altered thyroglobulin biosynthesis associated with endoplasmic ...

journal_title：Endocrinology

authors： Gaide Chevronnay HP,Janssens V,Van Der Smissen P,Rocca CJ,Liao XH,Refetoff S,Pierreux CE,Cherqui S,Courtoy PJ

更新日期：2016-04-01 00:00:00

abstract：:We have measured the concentrations of vasopressin in sequential samples of cerebrospinal fluid (CSF) obtained from fetal lambs between 108 and 130 days gestation. There was a clear and significant (F = 4.46; P less than 0.005) rhythm in vasopressin concentrations in the CSF of nine fetuses, characterized by a mean tr...

journal_title：Endocrinology

authors： Stark RI,Daniel SS

更新日期：1989-06-01 00:00:00

abstract：:Thyromimetics represent a class of experimental drugs that can stimulate tissue-selective thyroid hormone action. As such, thyromimetics should have effects on the hypothalamic-pituitary-thyroid (HPT) axis, but details of this action and the subsequent effects on systemic thyroid hormone levels have not been reported ...

journal_title：Endocrinology

authors： Ferrara SJ,Bourdette D,Scanlan TS

更新日期：2018-07-01 00:00:00

abstract：:GH secretion is markedly blunted in obesity; however, the mechanism(s) mediating this response remains to be elucidated. In the present study we examined the involvement of the two hypothalamic GH-regulatory hormones, GH-releasing factor (GRF) and somatostatin (SRIF), using the genetically obese male Zucker rat. Spont...

journal_title：Endocrinology

authors： Tannenbaum GS,Lapointe M,Gurd W,Finkelstein JA

更新日期：1990-12-01 00:00:00

abstract：:We have previously established the value of 2-dimensional electrophoretic mRNA activity profiles for investigating the hepatic genomic response to several metabolic perturbations, such as thyroid hormone or GH treatment, diabetes, high carbohydrate diet, starvation, and uremia. We now report the effects of adrenalecto...

journal_title：Endocrinology

authors： Beyer HS,Carr FE,Mariash CN,Oppenheimer JH

更新日期：1985-06-01 00:00:00

abstract：:Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...

journal_title：Endocrinology

authors： Shibata M,Banno R,Sugiyama M,Tominaga T,Onoue T,Tsunekawa T,Azuma Y,Hagiwara D,Lu W,Ito Y,Goto M,Suga H,Sugimura Y,Oiso Y,Arima H

更新日期：2016-04-01 00:00:00

abstract：:We studied the role of aldosterone (aldo) in myocardial injury in a model of angiotensin (Ang) II-hypertension. Wistar rats were given 1% NaCl (salt) to drink and randomized into one of the following groups (n = 10; treatment, 21 d): 1) vehicle control (VEH); 2) Ang II infusion (25 ng/min, sc); 3) Ang II infusion plus...

journal_title：Endocrinology

authors： Rocha R,Martin-Berger CL,Yang P,Scherrer R,Delyani J,McMahon E

更新日期：2002-12-01 00:00:00

abstract：:For insight into transcriptional mechanisms mediating physiological responses to GH, data mining was performed on a profile of GH-regulated genes induced or inhibited at different times in highly responsive 3T3-F442A adipocytes. Gene set enrichment analysis indicated that GH-regulated genes are enriched in pathways in...

journal_title：Endocrinology

authors： Chen Y,Lin G,Huo JS,Barney D,Wang Z,Livshiz T,States DJ,Qin ZS,Schwartz J

更新日期：2009-08-01 00:00:00

abstract：:GH controls its own secretion through a mechanism involving short-loop feedback regulation of the synthesis and release of GH-releasing hormone (GHRH). GHRH neurons coexpress the peptide galanin, but the functional significance of this coexpression is unknown. In this study, we tested the hypotheses that 1) galanin ge...

journal_title：Endocrinology

authors： Chan YY,Grafstein-Dunn E,Delemarre-van de Waal HA,Burton KA,Clifton DK,Steiner RA

更新日期：1996-12-01 00:00:00

abstract：:In this study, the potential interactions between dihydrotestosterone (DHT), a survival factor, and transforming growth factor-beta (TGF-beta), an apoptotic inducer, were examined in a derivative of the hormone-sensitive prostate cancer cell line LNCAP: The LNCaP TGF-beta receptor II cells, engineered to express TGF-b...

journal_title：Endocrinology

authors： Bruckheimer EM,Kyprianou N

更新日期：2001-06-01 00:00:00

abstract：:Studies were carried out to determine whether the actions of prolactin on the metabolism of the mammary gland may involve polyamines. In mouse mammary gland explants that were preincubated for 2 days with insulin plus hydrocortisone, the rate of [3H]leucine incorporation into casein was enhanced in a prolactin-like ma...

journal_title：Endocrinology

authors： Rillema JA,Linebaugh BE,Mulder JA

更新日期：1977-02-01 00:00:00

abstract：:To ascertain if reductions in fetal plasma cortisol cause increases in fetal plasma ACTH, we treated pregnant ewes or their fetuses with aminoglutethimide (10 mg/kg BW) and metyrapone (20 mg/kg BW) and measured the hormonal responses with RIAs. When given to fetuses (n = 9) at 0.90 +/- 0.01 gestation (term-145 days), ...

journal_title：Endocrinology

authors： Rose JC,Turner CS,Ray D,Rawashdeh N

更新日期：1988-09-01 00:00:00

abstract：:The mechanism by which aluminum chloride stimulates de novo bone formation is unknown. To evaluate the role of bone remodeling and mature osteoblastic function in aluminum-induced neoosteogenesis, we compared the osteogenic effects of aluminum in normal beagles to those in animals with low turnover osteomalacia induce...

journal_title：Endocrinology

authors： Quarles LD,Drezner MK

更新日期：1992-07-01 00:00:00

abstract：:Groups of female ferrets born in the laboratory received sc Silastic capsules containing testosterone (T), 5 alpha-dihydrotestosterone (DHT), 17 beta-estradiol (E), or no steroid for 15 days beginning on the day of birth; an additional group of male ferrets received empty sc capsules neonatally. All ferrets were gonad...

journal_title：Endocrinology

authors： Baum MJ,Gallagher CA,Martin JT,Damassa DA

更新日期：1982-09-01 00:00:00

abstract：:Nucleic acid-based therapies offer great potential for treatment of a variety of diseases including cancer by modulating protein expression with DNA or small interfering RNA. However, realization of their full therapeutic potential is currently limited due to an inability to reach the target site in an active form. Id...

journal_title：Endocrinology

authors： Christie RJ,Nishiyama N,Kataoka K

更新日期：2010-02-01 00:00:00

abstract：:Induction of cyclin proteins is required for progression of cells through the G(1)-S and G(2)-M cell cycle checkpoints and is a primary mechanism by which mitogens regulate cell cycle progression. IGF-I and the epidermal growth factor (EGF)-related ligands are mitogens for mammary epithelial cells in vitro and are ess...

journal_title：Endocrinology

authors： Stull MA,Richert MM,Loladze AV,Wood TL

更新日期：2002-05-01 00:00:00

abstract：:The effects of rat CRF, arginine vasopressin (VP), oxytocin (OXY), and isoproterenol (ISO) on the biosynthesis and release of pro-ACTH/endorphin-derived peptides by monolayer cultures of rat anterior pituitary cells in complete serum-free medium (CSFM) were studied. When cells were exposed to hormone for 3 h, CRF, VP,...

journal_title：Endocrinology

authors： Wand GS,Eipper BA

更新日期：1987-03-01 00:00:00

abstract：:We investigated the effect of TSH on calcium transport in mouse thyroid, as well as the influence of iodide thereupon. Thyroid lobes were incubated in Krebs-Ringer bicarbonate buffer containing [45Ca2+] and the time-dependent uptake of [45Ca2+] by the lobes was observed. In the presence of 0.5 mU/ml TSH, the uptake of...

journal_title：Endocrinology

authors： Hashizume K,Ichikawa K,Komiya I,Onaya T

更新日期：1984-05-01 00:00:00

abstract：:The present studies were conducted to further evaluate inositol phosphate formation and metabolism in prostaglandin F2 alpha (PGF2 alpha)-stimulated bovine luteal cells. Corpora lutea were dispersed with collagenase, and luteal cells were prelabeled for 3 h with [3H]inositol. Inositol phosphates produced in response t...

journal_title：Endocrinology

authors： Duncan RA,Davis JS

更新日期：1991-03-01 00:00:00

abstract：:The extensive colocalization of insulin receptor (IR) and insulin-like growth factor-I receptor (IGFR) messenger RNAs during central nervous system development, together with the effects of insulin and IGF-I in neurogenesis, raises the question of how stage- and factor-specific signaling occurs. Thus, it is necessary ...

journal_title：Endocrinology

authors： García-de Lacoba M,Alarcón C,de la Rosa EJ,de Pablo F

更新日期：1999-01-01 00:00:00

abstract：:The mammalian suprachiasmatic nucleus is the site of the circadian rhythm generator. The degrees of expression there of several neuropeptides, including vasopressin and vasoactive intestinal polypeptide, follow a diurnal rhythm. The vasopressin V1a receptor, whose activation results in phosphoinositol hydrolysis and m...

journal_title：Endocrinology

authors： Young WS 3rd,Kovács K,Lolait SJ

更新日期：1993-08-01 00:00:00

abstract：:We evaluated the capacity of estradiol (E(2)) to regulate PTHrP production, cell growth, tumor growth, and metastasis to the skeleton in breast cancer. In estrogen receptor (ER)-negative human breast cancer cells, MDA-MB-231, and cells transfected with full-length cDNA encoding ER (S-30), E(2) caused a marked decrease...

journal_title：Endocrinology

authors： Rabbani SA,Khalili P,Arakelian A,Pizzi H,Chen G,Goltzman D

更新日期：2005-07-01 00:00:00

abstract：:Native PRL and des-amido forms 1, 2, and 3 were tested for their individual immunochemical and receptor-binding abilities. The results show that deamidation of either secreted mouse PRL or stored ovine PRL alters their binding in a radioreceptor assay. For each accumulated deamidation there was a statistically signifi...

journal_title：Endocrinology

authors： Haro LS,Talamantes FJ

更新日期：1985-01-01 00:00:00

abstract：:Glucocorticoid hormones are involved in functional differentiation of GH-producing somatotrophs. Glucocorticoid treatment prematurely induces GH expression in mammals and birds in a process requiring protein synthesis and Rat sarcoma (Ras) signaling. The objective of this study was to investigate mechanisms through wh...

journal_title：Endocrinology

authors： Ellestad LE,Puckett SA,Porter TE

更新日期：2015-03-01 00:00:00

abstract：:Using a Leydig tumor cell line (MA-10) transiently transfected with the human lutropin receptor (hLHR) and mutants thereof, we examined the identity of the G proteins activated by the agonist-engaged hLHR-wild type (wt) and by three of its naturally occurring constitutively active mutants. Two of the mutants examined,...

journal_title：Endocrinology

authors： Hirakawa T,Ascoli M

更新日期：2003-09-01 00:00:00

abstract：:Heart failure is a leading cause of death, especially in the elderly or obese and diabetic populations. Various remodeling events have been characterized, which collectively contribute to the progression of heart failure. Of particular interest, autophagy has recently emerged as an important determinant of cardiac rem...

journal_title：Endocrinology

authors： Jahng JW,Turdi S,Kovacevic V,Dadson K,Li RK,Sweeney G

更新日期：2015-07-01 00:00:00