Germ cell stimulation of Sertoli cell protein phosphorylation.

abstract：:The secretory pattern of GH secretion is markedly sexually dimorphic in the adult rat. The patterning of GH secretion is determined by the coordinated activity of somatostatin (SS)- and GH-releasing hormone (GHRH)-containing neurosecretory cells located in the hypothalamus. In this study we examined whether there is s...

journal_title：Endocrinology

authors： Argente J,Chowen JA,Zeitler P,Clifton DK,Steiner RA

更新日期：1991-05-01 00:00:00

abstract：:Morphological plasticity in response to estradiol is a hallmark of astrocytes in the arcuate nucleus. The functional consequences of these morphological changes have remained relatively unexplored. Here we report that in the arcuate nucleus estradiol significantly increased the protein levels of the two enzymes in the...

journal_title：Endocrinology

authors： Blutstein T,Baab PJ,Zielke HR,Mong JA

更新日期：2009-07-01 00:00:00

abstract：:The fate of cell-bound [125I]iodo-human GH ([125I]iodo-hGH) was studied in monolayer cultures of hepatocytes from pregnant and nonpregnant rats. Both the binding of [125I]iodo-hGH and its degradation were significantly higher in cells from pregnant than from nonpregnant rats. The positive correlation between the numbe...

journal_title：Endocrinology

authors： Wakai K,Tsushima T,Isozaki O,Sato Y,Sato K,Shizume K

更新日期：1984-05-01 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by myocyte loss and myocardial fibrosis, leading to decreased elasticity and impaired contractile function. The study examines the downstream signaling whereby oxidative stress, induced by hyperglycemia, leads to myocardial fibrosis and impaired contractile function in the left...

journal_title：Endocrinology

authors： Aragno M,Mastrocola R,Alloatti G,Vercellinatto I,Bardini P,Geuna S,Catalano MG,Danni O,Boccuzzi G

更新日期：2008-01-01 00:00:00

abstract：:We have developed a highly sensitive and specific RIA for propylthiouracil (PTU) which uses 125I-labeled PTU as the radioactive ligand. At a final antibody dilution of 1:10,000, the detection limit for PTU was 100 pg; cross-reactivity with circulating, urinary, and intrathyroid PTU metabolites was negligible. Using th...

journal_title：Endocrinology

authors： Halpern R,Cooper DS,Kieffer JD,Saxe V,Mover H,Maloof F,Ridgway EC

更新日期：1983-09-01 00:00:00

abstract：:The atrophy and hypofunction of the adrenal cortex following long-term pharmacologic glucocorticoid therapy is a major health problem necessitating chronic glucocorticoid replacement that often prolongs the ultimate return of endogenous adrenocortical function. Underlying this functional recovery is anatomic regenerat...

journal_title：Endocrinology

authors： Finco I,Lerario AM,Hammer GD

更新日期：2018-02-01 00:00:00

abstract：:Normal fetal preoptic area (POA), a site of GnRH production, was implanted into the third ventricle of adult female hypogonadal (hpg) mice. When the grafts were successful, the mice (genetically deficient in hypothalamic GnRH) responded with vaginal opening, cornified vaginal cells, ovarian and uterine development, an...

journal_title：Endocrinology

authors： Gibson MJ,Charlton HM,Perlow MJ,Zimmerman EA,Davies TF,Krieger DT

更新日期：1984-05-01 00:00:00

abstract：:Hepcidin plays an essential role in maintaining normal iron homeostasis outside the brain. This recently discovered iron regulation hormone is predominantly expressed in the liver, and regulated by iron and hypoxia. As an antimicrobial peptide, this hormone is also elevated during infections and inflammation. In this ...

journal_title：Endocrinology

authors： Wang Q,Du F,Qian ZM,Ge XH,Zhu L,Yung WH,Yang L,Ke Y

更新日期：2008-08-01 00:00:00

abstract：:Thyroid dysfunction during human pregnancy is closely related to serious pregnancy outcome. However, the regulation and function of thyroid hormones during early pregnancy are largely unknown. We found that type II deiodinase, an enzyme converting T4 to activated T3, is highly expressed in the mouse uterus on days 3 a...

journal_title：Endocrinology

authors： Deng WB,Liang XH,Liu JL,Yang ZM

更新日期：2014-07-01 00:00:00

abstract：:The effects of insulin and glucose, alone and combined, on diacylglycerol (DAG), protein kinase-C (PKC), and glucose transport were compared in rat adipocytes and solei incubated in medium containing 0-20 mM glucose. In both tissues insulin rapidly stimulated [3H]DAG production from [3H]glycerol; extracellular glucose...

journal_title：Endocrinology

authors： Hoffman JM,Ishizuka T,Farese RV

更新日期：1991-06-01 00:00:00

abstract：:Starvation depresses thyroid gland function. In addition, the peripheral turnover of thyroxine (T4) is reduced, in part due to decreased fecal elimination of T4. The present studies were performed to determine if starvation also affects the deiodinative pathway for T4 degradation. Rats were isotopically equilibrated w...

journal_title：Endocrinology

authors： Ingbar DH,Galton VA

更新日期：1975-06-01 00:00:00

abstract：:TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 overexpression and enhanced production of prostaglandin (PG)E2 have been implicated in cancer progression; however, there are no studies ind...

journal_title：Endocrinology

authors： Vo BT,Morton D Jr,Komaragiri S,Millena AC,Leath C,Khan SA

更新日期：2013-05-01 00:00:00

abstract：:Extracts of rat pancreas contain significant amounts of an [3H]estradiol-binding protein. The amount of steroid-binding activity that could be measured varied considerably depending on the tonicity of the homogenizing medium. High speed supernatants of homogenates initially prepared in isotonic buffer contained about ...

journal_title：Endocrinology

authors： Grossman A,Richardson SB,Altszuler N,Lane B

更新日期：1985-06-01 00:00:00

abstract：:Central administration of melanocortin 3 and 4 receptor (MC3/4-R) agonists increases energy expenditure, with the hypothalamus commonly held as the primary site of action. It is also clear, however, that MC4-R are expressed in caudal brainstem structures of relevance to the control of energy expenditure. Three experim...

journal_title：Endocrinology

authors： Williams DL,Bowers RR,Bartness TJ,Kaplan JM,Grill HJ

更新日期：2003-11-01 00:00:00

abstract：:Insulin resistance and smoking are significant risk factors for cardiac and cerebral vascular diseases. Because vascular smooth muscle cells play a key role in the development and progression of atherosclerosis, we investigated the effect of nicotine on insulin-induced mitogenic signaling in aortic vascular smooth mus...

journal_title：Endocrinology

authors： Wada T,Naito M,Kenmochi H,Tsuneki H,Sasaoka T

更新日期：2007-02-01 00:00:00

abstract：:Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...

journal_title：Endocrinology

authors： Chin YP,Keni J,Wan J,Mehta H,Anene F,Jia Y,Lue YH,Swerdloff R,Cobb LJ,Wang C,Cohen P

更新日期：2013-10-01 00:00:00

abstract：:The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T4. We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre recombinase. Pituitary D2 activity was reduced 90% in the Cga-cre D2 knockout (KO) mice compared with control Dio2(fl/fl) mice. There wa...

journal_title：Endocrinology

authors： Luongo C,Martin C,Vella K,Marsili A,Ambrosio R,Dentice M,Harney JW,Salvatore D,Zavacki AM,Larsen PR

更新日期：2015-02-01 00:00:00

abstract：:Arginine-vasopressin (AVP) is known to be involved in maintaining glucose homeostasis, and AVP-resistance is observed in poorly controlled non-insulin-dependent diabetes mellitus subjects, resulting in a lowered plasma volume. Recently we reported that V1a vasopressin receptor-deficient (V1aR(-/-)) mice exhibited a de...

journal_title：Endocrinology

authors： Aoyagi T,Birumachi J,Hiroyama M,Fujiwara Y,Sanbe A,Yamauchi J,Tanoue A

更新日期：2007-05-01 00:00:00

abstract：:To investigate the respective role in PRL secretion of gamma-aminobutyric acid (GABA), either derived from the central nervous system or circulating in plasma, experiments were performed using ethanolamine-O-sulfate (EOS), a specific inhibitor of GABA catabolism. Intracerebroventricular injection of EOS (2 mg/kg) indu...

journal_title：Endocrinology

authors： Apud JA,Racagni G,Iuliano E,Cocchi D,Casanueva F,Müller EE

更新日期：1981-04-01 00:00:00

abstract：:We have investigated the effect of GH on microtubular physiology in Chinese hamster ovary (CHO) cells stably transfected with the complementary DNA for the rat GH receptor (CHO-GHR(1-638)). We show here that after 30 min of human GH (hGH) treatment of CHO-GHR(1-638) cells, there was a significant increase in the level...

journal_title：Endocrinology

authors： Goh EL,Pircher TJ,Lobie PE

更新日期：1998-10-01 00:00:00

abstract：:This report describes properties of highly purified cathepsin-B and an additional cysteine proteinase, designated cysteine proteinase I, obtained from human thyroids. Both enzymes are localized to lysosomes. The activity profile of cysteine proteinase I combined with its sensitivity to the active site inhibitor Z-Phe-...

journal_title：Endocrinology

authors： Dunn AD,Dunn JT

更新日期：1988-08-01 00:00:00

abstract：:An estrogen-binding protein (EBP) has been identified and characterized in the cytosol of the pathogenic yeast Candida albicans. Binding of [3H]estradiol was found to be optimal at pH 7.4 in the presence of 0.3 M KCl and was linearly related to protein concentration. Binding was very rapid, reaching maximal levels in ...

journal_title：Endocrinology

authors： Skowronski R,Feldman D

更新日期：1989-04-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is produced in multiple tissues and is believed to exert its action in a paracrine or autocrine fashion. We have investigated the GH dependency of tissue IGF-I gene expression in rats harboring implanted somatomammotropic tumors. Circulating GH and radioimmunoassayable IGF-I levels...

journal_title：Endocrinology

authors： Fagin JA,Brown A,Melmed S

更新日期：1988-05-01 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta HSD-2) enzyme is thought to confer aldosterone specificity upon mineralocorticoid target tissues by protecting the mineralocorticoid receptor from binding by the more abundant glucocorticoids, corticosterone and cortisol. We have developed a Chinese hamster ovar...

journal_title：Endocrinology

authors： Morita H,Zhou M,Foecking MF,Gomez-Sanchez EP,Cozza EN,Gomez-Sanchez CE

更新日期：1996-06-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been shown to induce insulin resistance in cultured cells as well as in animal models. The aim of this study was to map the in vivo mechanism whereby TNF-alpha contributes to the pathogenesis of impaired insulin signaling, using obese and lean Zucker rats in which TNF-alpha ...

journal_title：Endocrinology

authors： Cheung AT,Ree D,Kolls JK,Fuselier J,Coy DH,Bryer-Ash M

更新日期：1998-12-01 00:00:00

abstract：:Studies were carried out to determine the regional central nervous system and species specificity of the previously observed [125I]iodoavian pancreatic polypeptide ( [125I]iodo-APP) specific binding to chick brain membranes. The avian species examined were chicken, pigeon, duck, quail, chukar, and pheasant. In all spe...

journal_title：Endocrinology

authors： Adamo ML,Hazelwood RL

更新日期：1984-03-01 00:00:00

abstract：:On the basis of our previous observations indicating that a principle [possibly transforming growth factor-beta1 (TGFbeta1)] secreted by type 1 astrocytes may increase the release of LHRH in the GT1 cell line, it was deemed of interest to analyze whether TGFbeta1 might influence LHRH gene expression in addition to LHR...

journal_title：Endocrinology

authors： Galbiati M,Zanisi M,Messi E,Cavarretta I,Martini L,Melcangi RC

更新日期：1996-12-01 00:00:00

abstract：:Traditionally, it has been thought that the bioavailable fraction of circulating serum hormones, i.e. that which is available for cellular uptake and is physiologically active, is limited to the free (nonprotein bound) hormone. However, recent evidence, based on acute organ uptake of labeled hormone, suggests that the...

journal_title：Endocrinology

authors： Glass AR,Vigersky RA,Rajatanavin R,Pardridge W,Smallridge RC,Wartofsky L,Burman KD

更新日期：1984-05-01 00:00:00

abstract：:Although LHRH can stimulate the release of both LH and FSH from the pituitary, there are a number of instances in which the secretion of LH and FSH are divergent. Previous studies from our laboratory have indicated that pulsatile LH and FSH secretion are independently regulated by gonadal factors. We have, therefore, ...

journal_title：Endocrinology

authors： Culler MD,Negro-Vilar A

更新日期：1986-02-01 00:00:00

abstract：:The effect of progesterone on the secretion of LH was studied in intact and castrated immature female sheep between 12 and 42 weeks of age. (First spontaneous ovulation occurs between 30 and 50 weeks of age.) Progesterone was administered by means of Silastic capsules inserted SC to achieve circulating progesterone co...

journal_title：Endocrinology

authors： Foster DL,Karsch FJ

更新日期：1976-07-01 00:00:00