Preoptic area brain grafts in hypogonadal (hpg) female mice abolish effects of congenital hypothalamic gonadotropin-releasing hormone (GnRH) deficiency.

abstract：:We describe an in vitro system for evaluating the direct effects of catecholamines on the activity of the type II iodothyronine 5'-deiodinase in dispersed rat brown adipocytes. Incubation with norepinephrine or phenylephrine for 3-4 h causes up to a 5-fold increase in deiodinase activity in these cells. As found in vi...

journal_title：Endocrinology

authors： Obregon MJ,Mills I,Silva JE,Larsen PR

更新日期：1987-03-01 00:00:00

abstract：:Hypoglycemia associated with diabetes management is a potential risk for cardiovascular diseases. However, the effect of hypoglycemic episodes including a surge of sympathetic activity on the progression of neointima formation after vascular injury remains largely unknown. In this study, insulin was injected intraperi...

journal_title：Endocrinology

authors： Yasunari E,Mita T,Osonoi Y,Azuma K,Goto H,Ohmura C,Kanazawa A,Kawamori R,Fujitani Y,Watada H

更新日期：2014-06-01 00:00:00

abstract：:Monoclonal antibodies that bind to the TSH receptor were obtained by an autoantiidiotypic approach in which immunization of BALB/c mice was performed with mixtures of bovine (b) and human (h) TSH. Two of 28 positive wells were selected for cloning and characterization: D2 and 4G11. Their antiidiotypic character was ev...

journal_title：Endocrinology

authors： Hill BL,Erlanger BF

更新日期：1988-06-01 00:00:00

abstract：:Alterations in the maternal endocrine, nutritional, and metabolic environment disrupt the developmental trajectory of the fetus, leading to adult diseases. Female offspring of rats, subhuman primates, and sheep treated prenatally with testosterone (T) develop reproductive/metabolic defects during adult life similar to...

journal_title：Endocrinology

authors： Manikkam M,Crespi EJ,Doop DD,Herkimer C,Lee JS,Yu S,Brown MB,Foster DL,Padmanabhan V

更新日期：2004-02-01 00:00:00

abstract：:The nuclear receptor steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP) is an essential regulator of endocrine development and function, and the expression of the corresponding gene (sf-1/ad4bp) is precisely regulated in a time- and tissue-dependent manner. We previously demonstrated that the basal promoter...

journal_title：Endocrinology

authors： Hoivik EA,Bjanesoy TE,Mai O,Okamoto S,Minokoshi Y,Shima Y,Morohashi K,Boehm U,Bakke M

更新日期：2011-05-01 00:00:00

abstract：:The primary culture of rat luteal cells and their long-term maintenance have been difficult. Low cellular yields have limited the possibility for the study of gene regulation in luteal cells. The goal of this study was to develop a cell line to serve as a model by which to study the expression and regulation of variou...

journal_title：Endocrinology

authors： Sugino N,Zilberstein M,Srivastava RK,Telleria CM,Nelson SE,Risk M,Chou JY,Gibori G

更新日期：1998-04-01 00:00:00

abstract：:Induction of cyclin proteins is required for progression of cells through the G(1)-S and G(2)-M cell cycle checkpoints and is a primary mechanism by which mitogens regulate cell cycle progression. IGF-I and the epidermal growth factor (EGF)-related ligands are mitogens for mammary epithelial cells in vitro and are ess...

journal_title：Endocrinology

authors： Stull MA,Richert MM,Loladze AV,Wood TL

更新日期：2002-05-01 00:00:00

abstract：:Peptide-YY (PYY) is a novel enteric peptide that is structurally related to pancreatic polypeptide and neuropeptide-Y. The objectives of the present experiments were to characterize the following aspects of PYY metabolism: the distribution of PYY in the canine gastrointestinal tract, the release of PYY in response to ...

journal_title：Endocrinology

authors： Greeley GH Jr,Jeng YJ,Gomez G,Hashimoto T,Hill FL,Kern K,Kurosky T,Chuo HF,Thompson JC

更新日期：1989-03-01 00:00:00

abstract：:The basal concentration and metabolic clearance of radiolabeled and endogenous thyroglobulin (Tg) were measured in normal male rats. Serum Tg concentrations (by RIA) in Sprague-Dawley adult males ranged from 70-680 ng/ml (mean +/- SD, 218 +/- 177). In male Fisher rats, basal serum Tg concentrations were 32-263 ng/ml. ...

journal_title：Endocrinology

authors： Izumi M,Larsen PR

更新日期：1978-07-01 00:00:00

abstract：:The nuclear translocation of PRL is demonstrated at the immunofluorescence and electron microscopic (EM) levels in interleukin-2 (IL2)-stimulated cloned T-cells and concanavalin A-stimulated splenocytes. This translocation occurs 2-10 h after IL2 stimulation, and is reversed by the addition of anti-PRL antiserum into ...

journal_title：Endocrinology

authors： Clevenger CV,Sillman AL,Prystowsky MB

更新日期：1990-12-01 00:00:00

abstract：:Current drug therapies for obesity are ineffective, and existing treatments for lipid disorders can be further improved. Thyroid hormones affect both conditions, although currently available nonselective thyromimetics are not clinically useful for such treatment due to cardiac side effects. Recent studies suggest that...

journal_title：Endocrinology

authors： Grover GJ,Egan DM,Sleph PG,Beehler BC,Chiellini G,Nguyen NH,Baxter JD,Scanlan TS

更新日期：2004-04-01 00:00:00

abstract：:We previously identified a highly conserved specificity protein 1 (Sp1) DNA element in mammalian PTH promoters that acted as an enhancer of gene transcription and bound Sp1 and Sp3 proteins present in parathyroid gland nuclear extracts. More recently, a nuclear factor (NF)-Y element (NF-Y(prox)) was also described by ...

journal_title：Endocrinology

authors： Alimov AP,Park-Sarge OK,Sarge KD,Malluche HH,Koszewski NJ

更新日期：2005-08-01 00:00:00

abstract：:We sequenced the complementary DNA (cDNA) encoding guinea pig LHRH from an expression library derived from the preoptic area-anterior hypothalamus. Data from in situ hybridization and RNase protection assays verified that the cloned cDNA was complementary to guinea pig LHRH messenger RNA. The architecture of the deduc...

journal_title：Endocrinology

authors： Jimenez-Liñan M,Rubin BS,King JC

更新日期：1997-10-01 00:00:00

abstract：:The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself. In this study, we have cloned and characterized the mouse promoter of PTG. We identified multiple FoxA2...

journal_title：Endocrinology

authors： Cheng A,Zhang M,Crosson SM,Bao ZQ,Saltiel AR

更新日期：2006-07-01 00:00:00

abstract：:While uterine stromal cells (USC) appear to modify the function of uterine epithelial cells (UEC) under certain conditions in vivo, relatively little is known about the effect of epithelial cells on stromal cell differentiation and function. To determine if UEC modulate USC function in vitro, highly enriched (> 95%) c...

journal_title：Endocrinology

authors： Wegner CC,Carson DD

更新日期：1992-12-01 00:00:00

abstract：:We have previously documented that raloxifene enhances the mechanical properties of dog vertebrae independent of changes in bone mass, suggesting a positive effect of raloxifene on material-level mechanical properties. The goal of this study was to determine the separate effects of raloxifene on the material-level mec...

journal_title：Endocrinology

authors： Allen MR,Hogan HA,Hobbs WA,Koivuniemi AS,Koivuniemi MC,Burr DB

更新日期：2007-08-01 00:00:00

abstract：:The administration of testosterone via Silastic capsules has been shown previously to maintain advanced spermatid number quantitatively in intact rats in which LH but not FSH was suppressed, but not in hypophysectomized rats, indicating that pituitary factors in addition to LH are required for the quantitative mainten...

journal_title：Endocrinology

authors： Awoniyi CA,Zirkin BR,Chandrashekar V,Schlaff WD

更新日期：1992-06-01 00:00:00

abstract：:Transcriptional regulation of metabolic genes in the liver is the key to maintaining systemic energy homeostasis during starvation. The membrane-bound transcription factor cAMP-responsive element-binding protein 3-like 3 (CREB3L3) has been reported to be activated during fasting and to regulate triglyceride metabolism...

journal_title：Endocrinology

authors： Nakagawa Y,Satoh A,Yabe S,Furusawa M,Tokushige N,Tezuka H,Mikami M,Iwata W,Shingyouchi A,Matsuzaka T,Kiwata S,Fujimoto Y,Shimizu H,Danno H,Yamamoto T,Ishii K,Karasawa T,Takeuchi Y,Iwasaki H,Shimada M,Kawakami Y,

更新日期：2014-12-01 00:00:00

abstract：:TSH receptor (TSHR) DNA vaccination induces high TSHR antibody levels in BALB/c mice housed in a conventional facility. However, under pathogen-free conditions, we observed a Th1 cellular response to TSHR antigen characterized by interferon-gamma (IFN gamma) production. In the present study we investigated the effect ...

journal_title：Endocrinology

authors： Pichurin P,Pichurina O,Chazenbalk GD,Paras C,Chen CR,Rapoport B,McLachlan SM

更新日期：2002-04-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) plays an important role in development of the central nervous system and is neurotropic for a variety of neurons. In this study, we investigated whether bFGF is neurotropic for GT1 GnRH neuronal cell lines and if these cells express functional FGF receptors (FGFRs). The GT1 cell l...

journal_title：Endocrinology

authors： Tsai PS,Werner S,Weiner RI

更新日期：1995-09-01 00:00:00

abstract：:The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We used a Pax6-deficient model in rat primary enriched-α cells with specifi...

journal_title：Endocrinology

authors： Gosmain Y,Cheyssac C,Masson MH,Guérardel A,Poisson C,Philippe J

更新日期：2012-09-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is more severe in male than female mice eating a soy-based diet. We sought to determine whether the detrimental effects are mediated by the phytoestrogens present in soy, the mechanism by which phytoestrogens act, and to test whether estrogen modulates the sexually dimorphic phenotype...

journal_title：Endocrinology

authors： Haines CD,Harvey PA,Luczak ED,Barthel KK,Konhilas JP,Watson PA,Stauffer BL,Leinwand LA

更新日期：2012-09-01 00:00:00

abstract：:Using immunocytochemistry and electron microscopy, we demonstrate that oxytocin (OT) exerts a trophic effect on its target myoepithelial cells in the mammary gland. In vitro, in organotypic cultures of mouse mammary gland, we examined proliferation and differentiation of the different cell types induced by OT added to...

journal_title：Endocrinology

authors： Sapino A,Macrì L,Tonda L,Bussolati G

更新日期：1993-08-01 00:00:00

abstract：:Regulation of galanin gene expression in the anterior pituitary (AP) is positively influenced by estrogen in rodents and undetermined in humans. The objective of this study was to investigate the mechanism behind estrogen induction of galanin by identifying any putative estrogen receptor (ER) binding sequences within ...

journal_title：Endocrinology

authors： Howard G,Peng L,Hyde JF

更新日期：1997-11-01 00:00:00

abstract：:Leucine-rich repeat-containing G protein-coupled receptor (LGR)-5 is a recently identified marker of stem cells in adult intestinal epithelium and hair follicles. Because of this characteristic, we studied the status of Lgr5 expression in the mouse uterus under various conditions. Lgr5 is highly expressed in the uteri...

journal_title：Endocrinology

authors： Sun X,Jackson L,Dey SK,Daikoku T

更新日期：2009-11-01 00:00:00

abstract：:Steroids mediate the gonadotropic stimulus of oocyte maturation in fish and amphibians. Such a role of steroids in mammals has not been confirmed until recently. A series of studies presented data suggesting that steroids might be involved in meiosis of mouse oocytes. Here we examined this suggestion using in vitro cu...

journal_title：Endocrinology

authors： Motola S,Popliker M,Tsafriri A

更新日期：2007-09-01 00:00:00

abstract：:As4.1 cells are derived from a renin-expressing kidney tumor induced by tissue-specific oncogene-mediated tumorigenesis in transgenic mice. These cells express high levels of renin messenger RNA (mRNA) and synthesize prorenin and renin; they were therefore used as a model to further investigate the molecular biology o...

journal_title：Endocrinology

authors： Thompson HA,Burson JM,Lang JA,Gross KW,Sigmund CD

更新日期：1995-07-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the United States and is strongly associated with hepatic insulin resistance. We examined whether the thyroid hormone receptor-α (Thra) would be a potential therapeutic target to prevent diet-induced NAFLD and insulin resistance. Fo...

journal_title：Endocrinology

authors： Jornayvaz FR,Lee HY,Jurczak MJ,Alves TC,Guebre-Egziabher F,Guigni BA,Zhang D,Samuel VT,Silva JE,Shulman GI

更新日期：2012-02-01 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1), the primary substrate for the insulin receptor tyrosine kinase in most cells and tissues, is a key component of the insulin signaling network. Numerous studies have documented the trafficking of IRS-1 from the cell membrane to intracellular, extranuclear compartments. During the c...

journal_title：Endocrinology

authors： Boylan JM,Gruppuso PA

更新日期：2002-11-01 00:00:00

abstract：:Isolated renal cortical slices were used to study the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-dihydroxyvitamin D3 [24,25](OH2)D3] by the rat kidney. Production of 1,25-(OH)2D3 and 24,25-(OH)2D3 was linear with time (30-90 min) and tissue weight (40-250 mg). Production of...

journal_title：Endocrinology

authors： Armbrecht HJ,Zenser TV,Davis BB

更新日期：1981-07-01 00:00:00